Motif ID: Pbx1_Pbx3

Z-value: 1.554

Transcription factors associated with Pbx1_Pbx3:

Gene SymbolEntrez IDGene Name
Pbx1 ENSMUSG00000052534.9 Pbx1
Pbx3 ENSMUSG00000038718.9 Pbx3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Pbx1mm10_v2_chr1_-_168431502_168431513-0.715.5e-05Click!
Pbx3mm10_v2_chr2_-_34372004_343720440.681.3e-04Click!


Activity profile for motif Pbx1_Pbx3.

activity profile for motif Pbx1_Pbx3


Sorted Z-values histogram for motif Pbx1_Pbx3

Sorted Z-values for motif Pbx1_Pbx3



Network of associatons between targets according to the STRING database.



First level regulatory network of Pbx1_Pbx3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr19_+_55741810 10.665 ENSMUST00000111657.3
ENSMUST00000061496.9
ENSMUST00000041717.7
ENSMUST00000111662.4
 Tcf7l2



transcription factor 7 like 2, T cell specific, HMG box



chr9_-_63711969 9.565 ENSMUST00000154323.1
 Smad3
SMAD family member 3
chr17_+_85620816 8.784 ENSMUST00000175898.2
 Six3
sine oculis-related homeobox 3
chr19_+_55894508 8.678 ENSMUST00000142291.1
 Tcf7l2
transcription factor 7 like 2, T cell specific, HMG box
chr14_-_48667508 8.282 ENSMUST00000144465.1
ENSMUST00000133479.1
ENSMUST00000119070.1
ENSMUST00000152018.1
 Otx2



orthodenticle homolog 2 (Drosophila)



chr4_-_3938354 8.074 ENSMUST00000003369.3
 Plag1
pleiomorphic adenoma gene 1
chr13_+_15463837 7.630 ENSMUST00000110510.3
 Gli3
GLI-Kruppel family member GLI3
chr11_-_19018956 6.719 ENSMUST00000068264.7
ENSMUST00000144988.1
ENSMUST00000185131.1
 Meis1


Meis homeobox 1


chr17_-_70853482 6.618 ENSMUST00000118283.1
 Tgif1
TGFB-induced factor homeobox 1
chrX_+_58030622 6.303 ENSMUST00000088627.4
 Zic3
zinc finger protein of the cerebellum 3
chr11_-_22001605 5.836 ENSMUST00000006071.7
 Otx1
orthodenticle homolog 1 (Drosophila)
chr11_-_19018714 5.801 ENSMUST00000177417.1
 Meis1
Meis homeobox 1
chr17_+_85621017 5.637 ENSMUST00000162695.2
 Six3
sine oculis-related homeobox 3
chr14_-_122465677 5.491 ENSMUST00000039118.6
 Zic5
zinc finger protein of the cerebellum 5
chr4_-_43523388 4.753 ENSMUST00000107913.3
ENSMUST00000030184.5
 Tpm2

tropomyosin 2, beta

chr19_-_9899450 4.687 ENSMUST00000025562.7
 Incenp
inner centromere protein
chr3_+_37639985 4.670 ENSMUST00000108107.1
 Spry1
sprouty homolog 1 (Drosophila)
chr5_+_103425181 4.390 ENSMUST00000048957.9
 Ptpn13
protein tyrosine phosphatase, non-receptor type 13
chr3_+_37639945 4.386 ENSMUST00000108109.1
ENSMUST00000038569.1
 Spry1

sprouty homolog 1 (Drosophila)

chr13_+_44730726 4.328 ENSMUST00000173704.1
ENSMUST00000044608.7
ENSMUST00000173367.1
 Jarid2


jumonji, AT rich interactive domain 2



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 153 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.8 30.5 GO:0048625 myoblast fate commitment(GO:0048625)
4.8 14.4 GO:0097402 neuroblast migration(GO:0097402)
0.5 12.5 GO:0035855 megakaryocyte development(GO:0035855)
3.2 9.6 GO:0044413 evasion or tolerance of host defenses by virus(GO:0019049) positive regulation of transforming growth factor beta3 production(GO:0032916) avoidance of host defenses(GO:0044413) evasion or tolerance of host defenses(GO:0044415) avoidance of defenses of other organism involved in symbiotic interaction(GO:0051832) evasion or tolerance of defenses of other organism involved in symbiotic interaction(GO:0051834)
1.8 9.1 GO:0051387 negative regulation of neurotrophin TRK receptor signaling pathway(GO:0051387)
2.1 8.3 GO:0046552 eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
0.5 8.1 GO:0060736 prostate gland growth(GO:0060736)
2.5 7.6 GO:0060364 frontal suture morphogenesis(GO:0060364)
0.4 6.6 GO:0038092 nodal signaling pathway(GO:0038092)
1.1 6.3 GO:0035469 determination of pancreatic left/right asymmetry(GO:0035469)
0.3 6.1 GO:0036010 protein localization to endosome(GO:0036010)
1.2 5.8 GO:0048852 diencephalon morphogenesis(GO:0048852)
0.1 5.4 GO:0031122 cytoplasmic microtubule organization(GO:0031122)
0.0 4.7 GO:0000910 cytokinesis(GO:0000910)
0.0 4.7 GO:0001843 neural tube closure(GO:0001843)
1.5 4.5 GO:0043456 regulation of pentose-phosphate shunt(GO:0043456)
0.1 4.4 GO:0014066 regulation of phosphatidylinositol 3-kinase signaling(GO:0014066)
0.9 4.3 GO:0003199 endocardial cushion to mesenchymal transition involved in heart valve formation(GO:0003199)
0.4 4.3 GO:0051574 positive regulation of histone H3-K9 methylation(GO:0051574)
0.5 4.2 GO:0050957 equilibrioception(GO:0050957)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 73 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.4 30.5 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.1 22.5 GO:0005667 transcription factor complex(GO:0005667)
1.2 11.0 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
1.9 9.6 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.2 7.6 GO:0016592 mediator complex(GO:0016592)
0.0 6.3 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
1.6 4.7 GO:0000801 central element(GO:0000801)
0.1 4.7 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.2 4.3 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.8 4.2 GO:0008623 CHRAC(GO:0008623)
0.4 3.6 GO:0072687 meiotic spindle(GO:0072687)
0.1 3.5 GO:0032839 dendrite cytoplasm(GO:0032839)
0.0 3.5 GO:0030496 midbody(GO:0030496)
0.1 2.9 GO:0055038 recycling endosome membrane(GO:0055038)
0.5 2.8 GO:0001674 female germ cell nucleus(GO:0001674)
0.4 2.6 GO:0031262 Ndc80 complex(GO:0031262)
0.0 2.6 GO:0005769 early endosome(GO:0005769)
0.2 2.4 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.0 2.4 GO:0000922 spindle pole(GO:0000922)
0.4 2.3 GO:0070937 CRD-mediated mRNA stability complex(GO:0070937)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 116 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 44.2 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
1.3 31.0 GO:0045295 gamma-catenin binding(GO:0045295)
0.2 21.8 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.8 15.6 GO:0001222 transcription corepressor binding(GO:0001222)
0.1 11.5 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.1 9.7 GO:0048306 calcium-dependent protein binding(GO:0048306)
1.9 9.6 GO:0030618 transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618)
0.1 9.0 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.4 6.6 GO:0070410 co-SMAD binding(GO:0070410)
0.5 5.4 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.0 5.3 GO:0005178 integrin binding(GO:0005178)
0.3 4.8 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.1 4.6 GO:0097472 cyclin-dependent protein serine/threonine kinase activity(GO:0004693) cyclin-dependent protein kinase activity(GO:0097472)
1.5 4.5 GO:0046538 bisphosphoglycerate mutase activity(GO:0004082) bisphosphoglycerate 2-phosphatase activity(GO:0004083) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538)
1.4 4.3 GO:0035939 microsatellite binding(GO:0035939)
0.3 4.1 GO:0048018 receptor agonist activity(GO:0048018)
0.1 4.1 GO:0008748 N-ethylmaleimide reductase activity(GO:0008748) reduced coenzyme F420 dehydrogenase activity(GO:0043738) sulfur oxygenase reductase activity(GO:0043826) malolactic enzyme activity(GO:0043883) epoxyqueuosine reductase activity(GO:0052693)
0.3 3.9 GO:0015197 peptide transporter activity(GO:0015197)
0.1 3.6 GO:0035064 methylated histone binding(GO:0035064)
0.2 3.5 GO:0032794 GTPase activating protein binding(GO:0032794)