Motif ID: Pitx1

Z-value: 0.611


Transcription factors associated with Pitx1:

Gene SymbolEntrez IDGene Name
Pitx1 ENSMUSG00000021506.7 Pitx1



Activity profile for motif Pitx1.

activity profile for motif Pitx1


Sorted Z-values histogram for motif Pitx1

Sorted Z-values for motif Pitx1



Network of associatons between targets according to the STRING database.



First level regulatory network of Pitx1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_-_137766474 2.767 ENSMUST00000139951.1
 Alpl
alkaline phosphatase, liver/bone/kidney
chr17_-_58991343 2.093 ENSMUST00000025064.7
 2610034M16Rik
RIKEN cDNA 2610034M16 gene
chr9_-_37433138 1.925 ENSMUST00000115038.1
 Robo3
roundabout homolog 3 (Drosophila)
chr6_-_93913678 1.857 ENSMUST00000093769.5
 Magi1
membrane associated guanylate kinase, WW and PDZ domain containing 1
chr4_-_41697040 1.684 ENSMUST00000102962.3
ENSMUST00000084701.5
 Cntfr

ciliary neurotrophic factor receptor

chr14_+_27039001 1.622 ENSMUST00000035336.3
 Il17rd
interleukin 17 receptor D
chr7_+_16781341 1.558 ENSMUST00000108496.2
 Slc1a5
solute carrier family 1 (neutral amino acid transporter), member 5
chr6_-_124840192 1.475 ENSMUST00000024206.5
 Gnb3
guanine nucleotide binding protein (G protein), beta 3
chr2_-_64097994 1.464 ENSMUST00000131615.2
 Fign
fidgetin
chr13_-_116309639 1.420 ENSMUST00000036060.6
 Isl1
ISL1 transcription factor, LIM/homeodomain
chr18_+_60925612 1.343 ENSMUST00000102888.3
ENSMUST00000025519.4
 Camk2a

calcium/calmodulin-dependent protein kinase II alpha

chr7_-_4752972 1.289 ENSMUST00000183971.1
ENSMUST00000182173.1
ENSMUST00000182738.1
ENSMUST00000184143.1
ENSMUST00000182111.1
ENSMUST00000182048.1
ENSMUST00000063324.7
 Cox6b2






cytochrome c oxidase subunit VIb polypeptide 2






chr14_+_26122609 1.281 ENSMUST00000100810.6
 Duxbl2
doubl homeobox B-like 2
chr15_+_4375462 1.270 ENSMUST00000061925.4
 Plcxd3
phosphatidylinositol-specific phospholipase C, X domain containing 3
chr14_+_67745229 1.261 ENSMUST00000111095.2
 Gnrh1
gonadotropin releasing hormone 1
chr18_+_73863672 1.256 ENSMUST00000134847.1
 Mro
maestro
chr17_+_35861318 1.206 ENSMUST00000074259.8
ENSMUST00000174873.1
 Nrm

nurim (nuclear envelope membrane protein)

chr14_+_25983005 1.096 ENSMUST00000049793.8
 Duxbl1
double homeobox B-like 1
chr2_+_91259822 1.043 ENSMUST00000138470.1
 Pacsin3
protein kinase C and casein kinase substrate in neurons 3
chr7_-_133015248 1.024 ENSMUST00000169570.1
 Ctbp2
C-terminal binding protein 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 81 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.8 GO:0046677 response to antibiotic(GO:0046677)
0.4 1.9 GO:0061642 chemoattraction of axon(GO:0061642)
0.2 1.9 GO:0014816 skeletal muscle satellite cell differentiation(GO:0014816)
0.1 1.9 GO:0038166 angiotensin-activated signaling pathway(GO:0038166)
0.4 1.7 GO:0003360 brainstem development(GO:0003360)
0.1 1.6 GO:0015825 L-serine transport(GO:0015825)
0.3 1.5 GO:0003383 apical constriction(GO:0003383)
0.1 1.5 GO:0010569 regulation of double-strand break repair via homologous recombination(GO:0010569)
0.5 1.4 GO:0032650 regulation of interleukin-1 alpha production(GO:0032650) positive regulation of interleukin-1 alpha production(GO:0032730) cardiac cell fate determination(GO:0060913)
0.3 1.3 GO:0033087 negative regulation of immature T cell proliferation(GO:0033087)
0.1 1.2 GO:0048386 positive regulation of retinoic acid receptor signaling pathway(GO:0048386)
0.0 1.1 GO:0045580 regulation of T cell differentiation(GO:0045580)
0.3 1.0 GO:0060853 arterial endothelial cell fate commitment(GO:0060844) blood vessel endothelial cell fate commitment(GO:0060846) endothelial cell fate specification(GO:0060847) Notch signaling pathway involved in arterial endothelial cell fate commitment(GO:0060853) blood vessel endothelial cell fate specification(GO:0097101)
0.2 1.0 GO:0070120 ciliary neurotrophic factor-mediated signaling pathway(GO:0070120)
0.2 1.0 GO:0089711 L-glutamate transmembrane transport(GO:0089711)
0.1 1.0 GO:0000055 ribosomal large subunit export from nucleus(GO:0000055)
0.1 1.0 GO:0097154 GABAergic neuron differentiation(GO:0097154)
0.0 1.0 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.0 1.0 GO:0009649 entrainment of circadian clock(GO:0009649)
0.3 0.9 GO:0070315 G1 to G0 transition involved in cell differentiation(GO:0070315)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 39 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.3 GO:0005667 transcription factor complex(GO:0005667)
0.2 2.8 GO:0065010 extracellular membrane-bounded organelle(GO:0065010)
0.1 2.1 GO:0005652 nuclear lamina(GO:0005652)
0.6 1.7 GO:0097059 CNTFR-CLCF1 complex(GO:0097059)
0.2 1.5 GO:0033269 internode region of axon(GO:0033269)
0.0 1.5 GO:0016363 nuclear matrix(GO:0016363)
0.2 1.3 GO:0098554 cytoplasmic side of endoplasmic reticulum membrane(GO:0098554)
0.1 1.3 GO:0030061 mitochondrial crista(GO:0030061)
0.1 1.2 GO:0097470 ribbon synapse(GO:0097470)
0.3 1.0 GO:0097058 CRLF-CLCF1 complex(GO:0097058)
0.0 1.0 GO:0030673 axolemma(GO:0030673)
0.2 0.9 GO:0017071 intracellular cyclic nucleotide activated cation channel complex(GO:0017071)
0.1 0.8 GO:0005642 annulate lamellae(GO:0005642)
0.1 0.8 GO:0035253 ciliary rootlet(GO:0035253)
0.0 0.8 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 0.8 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 0.7 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.0 0.7 GO:0005921 gap junction(GO:0005921)
0.1 0.5 GO:0030677 nucleolar ribonuclease P complex(GO:0005655) ribonuclease P complex(GO:0030677) multimeric ribonuclease P complex(GO:0030681)
0.0 0.5 GO:0005689 U12-type spliceosomal complex(GO:0005689)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 55 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 2.8 GO:0004035 alkaline phosphatase activity(GO:0004035)
0.0 2.0 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.1 1.9 GO:0051393 alpha-actinin binding(GO:0051393)
0.1 1.9 GO:0032794 GTPase activating protein binding(GO:0032794)
0.1 1.8 GO:0022889 L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.3 1.7 GO:0004897 ciliary neurotrophic factor receptor activity(GO:0004897)
0.5 1.6 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.1 1.6 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.0 1.6 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.3 1.3 GO:0005127 ciliary neurotrophic factor receptor binding(GO:0005127)
0.0 1.3 GO:0005179 hormone activity(GO:0005179)
0.1 1.2 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 1.1 GO:0042974 retinoic acid receptor binding(GO:0042974)
0.2 1.0 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.1 1.0 GO:0030957 Tat protein binding(GO:0030957)
0.1 1.0 GO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983)
0.0 1.0 GO:0005487 nucleocytoplasmic transporter activity(GO:0005487)
0.2 0.9 GO:0005052 peroxisome matrix targeting signal-1 binding(GO:0005052)
0.1 0.9 GO:0031432 titin binding(GO:0031432)
0.0 0.9 GO:0017160 Ral GTPase binding(GO:0017160)