Motif ID: Pitx2_Otx2

Z-value: 1.788

Transcription factors associated with Pitx2_Otx2:

Gene SymbolEntrez IDGene Name
Otx2 ENSMUSG00000021848.9 Otx2
Pitx2 ENSMUSG00000028023.10 Pitx2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Otx2mm10_v2_chr14_-_48662740_486628720.385.5e-02Click!
Pitx2mm10_v2_chr3_+_129199919_129199943-0.019.4e-01Click!


Activity profile for motif Pitx2_Otx2.

activity profile for motif Pitx2_Otx2


Sorted Z-values histogram for motif Pitx2_Otx2

Sorted Z-values for motif Pitx2_Otx2



Network of associatons between targets according to the STRING database.



First level regulatory network of Pitx2_Otx2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_+_34354119 9.103 ENSMUST00000038406.6
 Akr1b8
aldo-keto reductase family 1, member B8
chr2_+_164562579 7.006 ENSMUST00000017867.3
ENSMUST00000109344.2
ENSMUST00000109345.2
 Wfdc2


WAP four-disulfide core domain 2


chr6_-_88898664 5.819 ENSMUST00000058011.6
 Mcm2
minichromosome maintenance deficient 2 mitotin (S. cerevisiae)
chr7_-_75782080 5.733 ENSMUST00000181224.1
 AU020206
expressed sequence AU020206
chr9_+_119357381 5.513 ENSMUST00000039610.8
 Xylb
xylulokinase homolog (H. influenzae)
chr11_-_106998483 5.350 ENSMUST00000124541.1
 Kpna2
karyopherin (importin) alpha 2
chr17_+_35861318 4.546 ENSMUST00000074259.8
ENSMUST00000174873.1
 Nrm

nurim (nuclear envelope membrane protein)

chr11_-_60811228 4.093 ENSMUST00000018744.8
 Shmt1
serine hydroxymethyltransferase 1 (soluble)
chr14_-_20181773 3.762 ENSMUST00000024011.8
 Kcnk5
potassium channel, subfamily K, member 5
chr18_-_60501983 3.647 ENSMUST00000042710.6
 Smim3
small integral membrane protein 3
chr3_-_153912966 3.591 ENSMUST00000089950.4
 Rabggtb
RAB geranylgeranyl transferase, b subunit
chr17_+_35861343 3.561 ENSMUST00000172931.1
 Nrm
nurim (nuclear envelope membrane protein)
chr10_-_77089428 3.560 ENSMUST00000156009.1
 Col18a1
collagen, type XVIII, alpha 1
chr19_-_41896132 3.517 ENSMUST00000038677.3
 Rrp12
ribosomal RNA processing 12 homolog (S. cerevisiae)
chr7_+_16781341 3.494 ENSMUST00000108496.2
 Slc1a5
solute carrier family 1 (neutral amino acid transporter), member 5
chr10_-_128180265 3.372 ENSMUST00000099139.1
 Rbms2
RNA binding motif, single stranded interacting protein 2
chr3_+_116878227 3.356 ENSMUST00000040260.6
 Frrs1
ferric-chelate reductase 1
chr17_+_87635974 3.301 ENSMUST00000053577.8
 Epcam
epithelial cell adhesion molecule
chr11_+_97029925 3.197 ENSMUST00000021249.4
 Scrn2
secernin 2
chr9_-_100486788 3.188 ENSMUST00000098458.3
 Il20rb
interleukin 20 receptor beta

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 389 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.0 9.1 GO:0016095 polyprenol catabolic process(GO:0016095) terpenoid catabolic process(GO:0016115) primary alcohol catabolic process(GO:0034310)
0.4 8.9 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.1 7.2 GO:0010466 negative regulation of peptidase activity(GO:0010466)
2.0 6.0 GO:0042732 D-xylose metabolic process(GO:0042732)
0.4 5.8 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
1.7 5.2 GO:0015938 coenzyme A catabolic process(GO:0015938) nucleoside bisphosphate catabolic process(GO:0033869) ribonucleoside bisphosphate catabolic process(GO:0034031) purine nucleoside bisphosphate catabolic process(GO:0034034)
0.1 4.3 GO:0045454 cell redox homeostasis(GO:0045454)
1.4 4.1 GO:0009177 deoxyribonucleoside monophosphate biosynthetic process(GO:0009157) pyrimidine deoxyribonucleoside monophosphate biosynthetic process(GO:0009177)
0.1 3.9 GO:0042274 ribosomal small subunit biogenesis(GO:0042274)
0.4 3.8 GO:0030322 stabilization of membrane potential(GO:0030322)
0.2 3.6 GO:2000353 positive regulation of endothelial cell apoptotic process(GO:2000353)
0.1 3.6 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.3 3.4 GO:0015825 L-serine transport(GO:0015825)
0.1 3.4 GO:0000387 spliceosomal snRNP assembly(GO:0000387)
0.8 3.3 GO:2000048 negative regulation of cell-cell adhesion mediated by cadherin(GO:2000048)
0.7 3.3 GO:0015705 iodide transport(GO:0015705)
0.4 3.3 GO:1900262 regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264)
1.1 3.2 GO:0002765 immune response-inhibiting signal transduction(GO:0002765)
0.4 3.2 GO:0018344 protein geranylgeranylation(GO:0018344)
1.0 3.1 GO:0046166 glyceraldehyde-3-phosphate biosynthetic process(GO:0046166)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 202 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 14.8 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.3 12.8 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.1 10.6 GO:0005643 nuclear pore(GO:0005643)
0.5 8.4 GO:0005652 nuclear lamina(GO:0005652)
0.0 8.1 GO:0005667 transcription factor complex(GO:0005667)
0.9 7.3 GO:0005664 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.0 4.7 GO:0000790 nuclear chromatin(GO:0000790)
0.1 4.6 GO:0030964 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.3 4.5 GO:0031616 spindle pole centrosome(GO:0031616)
0.2 4.1 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.0 4.1 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.0 4.0 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.1 3.9 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.4 3.8 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.0 3.7 GO:0032587 ruffle membrane(GO:0032587)
0.7 3.6 GO:0005968 Rab-protein geranylgeranyltransferase complex(GO:0005968)
0.5 3.4 GO:0001940 male pronucleus(GO:0001940)
0.4 3.3 GO:0031390 Ctf18 RFC-like complex(GO:0031390)
0.3 3.3 GO:0031597 cytosolic proteasome complex(GO:0031597)
0.1 3.3 GO:0034707 chloride channel complex(GO:0034707)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 281 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 24.0 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 17.4 GO:0044822 poly(A) RNA binding(GO:0044822)
0.2 9.9 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
1.5 9.1 GO:0001758 retinal dehydrogenase activity(GO:0001758)
0.3 8.6 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.7 5.8 GO:0003688 DNA replication origin binding(GO:0003688)
1.7 5.2 GO:0003986 acetyl-CoA hydrolase activity(GO:0003986)
1.6 4.8 GO:0008732 threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732)
0.4 4.6 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.3 4.1 GO:0070180 large ribosomal subunit rRNA binding(GO:0070180)
0.1 4.0 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.3 3.8 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.2 3.8 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.9 3.6 GO:0004663 Rab geranylgeranyltransferase activity(GO:0004663)
0.1 3.5 GO:0050694 galactose 3-O-sulfotransferase activity(GO:0050694)
0.0 3.5 GO:0005198 structural molecule activity(GO:0005198)
0.0 3.5 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.7 3.4 GO:0000293 ferric-chelate reductase activity(GO:0000293)
0.2 3.4 GO:0022889 L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.8 3.3 GO:0015111 iodide transmembrane transporter activity(GO:0015111)