Motif ID: Pitx3

Z-value: 0.656


Transcription factors associated with Pitx3:

Gene SymbolEntrez IDGene Name
Pitx3 ENSMUSG00000025229.9 Pitx3



Activity profile for motif Pitx3.

activity profile for motif Pitx3


Sorted Z-values histogram for motif Pitx3

Sorted Z-values for motif Pitx3



Network of associatons between targets according to the STRING database.



First level regulatory network of Pitx3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_-_75782080 3.242 ENSMUST00000181224.1
 AU020206
expressed sequence AU020206
chr9_+_119357381 1.975 ENSMUST00000039610.8
 Xylb
xylulokinase homolog (H. influenzae)
chrX_+_7909542 1.875 ENSMUST00000086274.2
 Gm10490
predicted gene 10490
chr10_+_62947011 1.735 ENSMUST00000131422.1
 Dna2
DNA replication helicase 2 homolog (yeast)
chr10_-_62899118 1.713 ENSMUST00000174189.1
 Tet1
tet methylcytosine dioxygenase 1
chr14_+_27039001 1.705 ENSMUST00000035336.3
 Il17rd
interleukin 17 receptor D
chr10_-_12861735 1.574 ENSMUST00000076817.4
 Utrn
utrophin
chr11_-_106998483 1.572 ENSMUST00000124541.1
 Kpna2
karyopherin (importin) alpha 2
chr4_-_116627921 1.535 ENSMUST00000030456.7
 Nasp
nuclear autoantigenic sperm protein (histone-binding)
chr7_-_144738520 1.521 ENSMUST00000118556.2
ENSMUST00000033393.8
 Ano1

anoctamin 1, calcium activated chloride channel

chr1_-_153408429 1.506 ENSMUST00000097535.4
 E330020D12Rik
Riken cDNA E330020D12 gene
chr9_-_100486788 1.473 ENSMUST00000098458.3
 Il20rb
interleukin 20 receptor beta
chr4_-_86612009 1.407 ENSMUST00000125481.1
ENSMUST00000070607.7
 Haus6

HAUS augmin-like complex, subunit 6

chr9_+_103305156 1.351 ENSMUST00000035164.3
 Topbp1
topoisomerase (DNA) II binding protein 1
chr3_+_116878227 1.312 ENSMUST00000040260.6
 Frrs1
ferric-chelate reductase 1
chr1_+_135232045 1.285 ENSMUST00000110798.3
 Gm4204
predicted gene 4204
chr18_-_74207771 1.284 ENSMUST00000040188.8
ENSMUST00000177604.1
 Ska1

spindle and kinetochore associated complex subunit 1

chr11_+_105146893 1.244 ENSMUST00000100338.1
 Gm10842
predicted gene 10842
chr10_-_92722356 1.229 ENSMUST00000020163.6
 Nedd1
neural precursor cell expressed, developmentally down-regulated gene 1
chr5_+_90759299 1.217 ENSMUST00000031318.4
 Cxcl5
chemokine (C-X-C motif) ligand 5

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 160 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 2.7 GO:0015705 iodide transport(GO:0015705)
0.0 2.3 GO:0001824 blastocyst development(GO:0001824)
0.1 2.0 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.0 1.9 GO:0051225 spindle assembly(GO:0051225)
0.6 1.7 GO:0042732 D-xylose metabolic process(GO:0042732)
0.4 1.7 GO:1902990 mitotic telomere maintenance via semi-conservative replication(GO:1902990)
0.4 1.7 GO:2000346 negative regulation of hepatocyte proliferation(GO:2000346)
0.3 1.7 GO:0090310 negative regulation of methylation-dependent chromatin silencing(GO:0090310)
0.5 1.6 GO:0007525 somatic muscle development(GO:0007525)
0.3 1.6 GO:1900095 regulation of dosage compensation by inactivation of X chromosome(GO:1900095)
0.2 1.6 GO:0018344 protein geranylgeranylation(GO:0018344)
0.5 1.5 GO:0002765 immune response-inhibiting signal transduction(GO:0002765)
0.1 1.5 GO:0034724 DNA replication-independent nucleosome assembly(GO:0006336) DNA replication-independent nucleosome organization(GO:0034724)
0.5 1.4 GO:0015938 coenzyme A catabolic process(GO:0015938) nucleoside bisphosphate catabolic process(GO:0033869) ribonucleoside bisphosphate catabolic process(GO:0034031) purine nucleoside bisphosphate catabolic process(GO:0034034)
0.1 1.4 GO:0007131 reciprocal meiotic recombination(GO:0007131) reciprocal DNA recombination(GO:0035825)
0.0 1.4 GO:0042462 eye photoreceptor cell development(GO:0042462)
0.0 1.4 GO:0000725 double-strand break repair via homologous recombination(GO:0000724) recombinational repair(GO:0000725)
0.1 1.3 GO:0036297 interstrand cross-link repair(GO:0036297)
0.0 1.3 GO:0031110 regulation of microtubule polymerization or depolymerization(GO:0031110)
0.4 1.2 GO:0070944 neutrophil mediated killing of bacterium(GO:0070944)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 74 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.7 GO:0034707 chloride channel complex(GO:0034707)
0.0 2.5 GO:0005643 nuclear pore(GO:0005643)
0.1 2.2 GO:0042555 MCM complex(GO:0042555)
0.1 2.0 GO:0031616 spindle pole centrosome(GO:0031616)
0.0 1.7 GO:0005925 focal adhesion(GO:0005925)
0.1 1.6 GO:0070938 contractile ring(GO:0070938)
0.0 1.6 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.1 1.5 GO:0001673 male germ cell nucleus(GO:0001673)
0.2 1.4 GO:0070652 HAUS complex(GO:0070652)
0.1 1.4 GO:0042575 DNA polymerase complex(GO:0042575)
0.3 1.3 GO:0000120 RNA polymerase I transcription factor complex(GO:0000120)
0.1 1.3 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.0 1.3 GO:0016605 PML body(GO:0016605)
0.3 1.2 GO:0000931 gamma-tubulin large complex(GO:0000931) gamma-tubulin ring complex(GO:0008274)
0.0 1.2 GO:0043596 nuclear replication fork(GO:0043596)
0.2 1.1 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.2 1.1 GO:0005968 Rab-protein geranylgeranyltransferase complex(GO:0005968)
0.1 1.1 GO:0031597 cytosolic proteasome complex(GO:0031597)
0.0 1.1 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.3 1.0 GO:1990393 3M complex(GO:1990393)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 104 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 3.1 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.7 2.7 GO:0015111 iodide transmembrane transporter activity(GO:0015111)
0.4 2.2 GO:0017108 5'-flap endonuclease activity(GO:0017108)
0.6 1.7 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.3 1.7 GO:0070579 methylcytosine dioxygenase activity(GO:0070579)
0.1 1.6 GO:0017166 vinculin binding(GO:0017166)
0.4 1.5 GO:0042015 interleukin-20 binding(GO:0042015)
0.0 1.5 GO:0002039 p53 binding(GO:0002039)
0.5 1.4 GO:0003986 acetyl-CoA hydrolase activity(GO:0003986)
0.3 1.4 GO:0004839 ubiquitin activating enzyme activity(GO:0004839)
0.1 1.4 GO:0008301 DNA binding, bending(GO:0008301)
0.0 1.4 GO:0051879 Hsp90 protein binding(GO:0051879)
0.3 1.3 GO:0000293 ferric-chelate reductase activity(GO:0000293)
0.1 1.2 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.0 1.2 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.4 1.1 GO:0008732 threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732)
0.3 1.1 GO:0004663 Rab geranylgeranyltransferase activity(GO:0004663)
0.1 1.1 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.1 1.1 GO:0036310 annealing helicase activity(GO:0036310)
0.0 1.1 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)