Motif ID: Pknox2_Pknox1

Z-value: 0.901

Transcription factors associated with Pknox2_Pknox1:

Gene SymbolEntrez IDGene Name
Pknox1 ENSMUSG00000006705.6 Pknox1
Pknox2 ENSMUSG00000035934.9 Pknox2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Pknox1mm10_v2_chr17_+_31564749_315648540.635.1e-04Click!
Pknox2mm10_v2_chr9_-_37147257_37147323-0.271.8e-01Click!


Activity profile for motif Pknox2_Pknox1.

activity profile for motif Pknox2_Pknox1


Sorted Z-values histogram for motif Pknox2_Pknox1

Sorted Z-values for motif Pknox2_Pknox1



Network of associatons between targets according to the STRING database.



First level regulatory network of Pknox2_Pknox1

PNG image of the network

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Top targets:


Showing 1 to 20 of 136 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_+_78324200 2.891 ENSMUST00000102478.3
 Aldoc
aldolase C, fructose-bisphosphate
chr9_+_44134562 2.452 ENSMUST00000034650.8
ENSMUST00000098852.2
 Mcam

melanoma cell adhesion molecule

chr17_-_70851189 2.303 ENSMUST00000059775.8
 Tgif1
TGFB-induced factor homeobox 1
chr7_-_48881032 1.873 ENSMUST00000058745.8
 E2f8
E2F transcription factor 8
chr1_+_194619815 1.808 ENSMUST00000027952.5
 Plxna2
plexin A2
chr11_+_23256001 1.699 ENSMUST00000020538.6
ENSMUST00000109551.1
ENSMUST00000102870.1
ENSMUST00000102869.1
 Xpo1



exportin 1, CRM1 homolog (yeast)



chr2_+_105682463 1.623 ENSMUST00000140173.1
ENSMUST00000135412.1
ENSMUST00000138365.1
ENSMUST00000145744.1
 Pax6



paired box gene 6



chr10_+_41810528 1.568 ENSMUST00000099931.3
 Sesn1
sestrin 1
chr10_-_123196916 1.530 ENSMUST00000020334.7
 Usp15
ubiquitin specific peptidase 15
chr18_+_49832622 1.528 ENSMUST00000180611.1
 Dmxl1
Dmx-like 1
chr7_-_131410495 1.496 ENSMUST00000121033.1
ENSMUST00000046306.8
 Ikzf5

IKAROS family zinc finger 5

chr7_-_131410325 1.338 ENSMUST00000154602.1
 Ikzf5
IKAROS family zinc finger 5
chr5_+_150673739 1.321 ENSMUST00000016569.4
ENSMUST00000038900.8
 Pds5b

PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)

chr2_-_34913976 1.308 ENSMUST00000028232.3
 Phf19
PHD finger protein 19
chr19_-_9899450 1.251 ENSMUST00000025562.7
 Incenp
inner centromere protein
chr5_-_138619653 1.223 ENSMUST00000129832.1
 Zfp68
zinc finger protein 68
chr5_-_138619751 1.187 ENSMUST00000085852.4
ENSMUST00000110905.2
 Zfp68

zinc finger protein 68

chr3_-_51560816 1.154 ENSMUST00000037141.7
 Setd7
SET domain containing (lysine methyltransferase) 7
chr5_-_138619702 1.148 ENSMUST00000063262.4
 Zfp68
zinc finger protein 68
chr9_+_113930934 1.108 ENSMUST00000084885.5
ENSMUST00000009885.7
 Ubp1

upstream binding protein 1


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 54 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 3.4 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.3 2.9 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.9 2.7 GO:0032877 positive regulation of DNA endoreduplication(GO:0032877)
0.1 2.5 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.2 1.8 GO:0021785 branchiomotor neuron axon guidance(GO:0021785)
0.3 1.7 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
0.3 1.6 GO:0021905 pancreatic A cell development(GO:0003322) forebrain-midbrain boundary formation(GO:0021905) somatic motor neuron fate commitment(GO:0021917) regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitment(GO:0021918)
0.1 1.6 GO:1904262 negative regulation of TORC1 signaling(GO:1904262)
0.4 1.5 GO:0035616 histone H2B conserved C-terminal lysine deubiquitination(GO:0035616)
0.1 1.4 GO:0007064 mitotic sister chromatid cohesion(GO:0007064)
0.2 1.3 GO:0061087 positive regulation of histone H3-K27 methylation(GO:0061087)
0.2 1.2 GO:0030643 cellular phosphate ion homeostasis(GO:0030643) cellular trivalent inorganic anion homeostasis(GO:0072502)
0.1 1.2 GO:0018026 peptidyl-lysine monomethylation(GO:0018026)
0.0 1.1 GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger(GO:0007187)
0.1 1.0 GO:0060736 prostate gland growth(GO:0060736)
0.0 1.0 GO:0008542 visual learning(GO:0008542)
0.1 0.9 GO:0071803 positive regulation of podosome assembly(GO:0071803)
0.0 0.8 GO:0006749 glutathione metabolic process(GO:0006749)
0.1 0.7 GO:2000124 regulation of endocannabinoid signaling pathway(GO:2000124)
0.1 0.7 GO:0006307 DNA dealkylation involved in DNA repair(GO:0006307)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 21 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 1.8 GO:0002116 semaphorin receptor complex(GO:0002116)
0.2 1.7 GO:0005642 annulate lamellae(GO:0005642)
0.1 1.4 GO:0061700 GATOR2 complex(GO:0061700)
0.4 1.3 GO:0000801 central element(GO:0000801)
0.1 1.3 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 1.1 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.3 0.9 GO:0071953 elastic fiber(GO:0071953)
0.0 0.9 GO:0002102 podosome(GO:0002102)
0.0 0.8 GO:0005905 clathrin-coated pit(GO:0005905)
0.0 0.7 GO:0043196 varicosity(GO:0043196)
0.0 0.7 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.1 0.6 GO:0031415 NatA complex(GO:0031415)
0.0 0.6 GO:0044666 MLL3/4 complex(GO:0044666)
0.1 0.5 GO:0035749 myelin sheath adaxonal region(GO:0035749)
0.0 0.5 GO:0031464 Cul4A-RING E3 ubiquitin ligase complex(GO:0031464)
0.1 0.4 GO:0098536 deuterosome(GO:0098536)
0.0 0.4 GO:0030014 CCR4-NOT complex(GO:0030014)
0.0 0.3 GO:0071598 neuronal ribonucleoprotein granule(GO:0071598)
0.0 0.2 GO:0044352 pinosome(GO:0044352) macropinosome(GO:0044354)
0.0 0.1 GO:0036195 muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 36 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 6.5 GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977)
0.2 5.0 GO:0070410 co-SMAD binding(GO:0070410)
0.0 3.8 GO:0001047 core promoter binding(GO:0001047)
0.5 2.9 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.1 1.8 GO:0017154 semaphorin receptor activity(GO:0017154)
0.0 1.8 GO:0018024 histone-lysine N-methyltransferase activity(GO:0018024)
0.1 1.7 GO:0005487 nucleocytoplasmic transporter activity(GO:0005487)
0.3 1.6 GO:0070728 leucine binding(GO:0070728)
0.0 1.5 GO:0005160 transforming growth factor beta receptor binding(GO:0005160)
0.0 1.3 GO:0020037 heme binding(GO:0020037)
0.0 1.3 GO:0035064 methylated histone binding(GO:0035064)
0.3 1.2 GO:0047389 glycerophosphocholine phosphodiesterase activity(GO:0047389)
0.0 0.9 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 0.8 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.1 0.7 GO:0043140 ATP-dependent 3'-5' DNA helicase activity(GO:0043140)
0.1 0.7 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.0 0.7 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.2 0.6 GO:0008142 oxysterol binding(GO:0008142)
0.1 0.6 GO:0061665 SUMO ligase activity(GO:0061665)
0.1 0.6 GO:0043184 vascular endothelial growth factor receptor 2 binding(GO:0043184)