Motif ID: Prox1

Z-value: 0.556


Transcription factors associated with Prox1:

Gene SymbolEntrez IDGene Name
Prox1 ENSMUSG00000010175.7 Prox1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Prox1mm10_v2_chr1_-_190169399_190169526-0.452.1e-02Click!


Activity profile for motif Prox1.

activity profile for motif Prox1


Sorted Z-values histogram for motif Prox1

Sorted Z-values for motif Prox1



Network of associatons between targets according to the STRING database.



First level regulatory network of Prox1

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr17_-_70924958 2.287 ENSMUST00000180468.1
Gm26510
predicted gene, 26510
chr1_-_169747634 1.887 ENSMUST00000027991.5
ENSMUST00000111357.1
Rgs4

regulator of G-protein signaling 4

chr10_-_81025521 1.411 ENSMUST00000144640.1
Diras1
DIRAS family, GTP-binding RAS-like 1
chr17_-_34959232 1.272 ENSMUST00000165202.1
ENSMUST00000172753.1
Hspa1b

heat shock protein 1B

chr17_-_34972124 1.209 ENSMUST00000087328.2
ENSMUST00000179128.1
Hspa1a

heat shock protein 1A

chr10_-_81025406 1.175 ENSMUST00000055125.4
Diras1
DIRAS family, GTP-binding RAS-like 1
chr2_-_168734236 1.071 ENSMUST00000109175.2
Atp9a
ATPase, class II, type 9A
chr15_-_80014808 1.036 ENSMUST00000000500.6
Pdgfb
platelet derived growth factor, B polypeptide
chr12_-_83487708 0.990 ENSMUST00000177959.1
ENSMUST00000178756.1
Dpf3

D4, zinc and double PHD fingers, family 3

chr17_+_37045963 0.990 ENSMUST00000025338.9
Gabbr1
gamma-aminobutyric acid (GABA) B receptor, 1
chr8_-_99416397 0.971 ENSMUST00000155527.1
ENSMUST00000142129.1
ENSMUST00000093249.4
ENSMUST00000142475.2
ENSMUST00000128860.1
Cdh8




cadherin 8




chr18_-_20682963 0.913 ENSMUST00000165229.2
Gm10269
predicted gene 10269
chr7_-_19458494 0.864 ENSMUST00000085715.5
Mark4
MAP/microtubule affinity-regulating kinase 4
chr4_+_130913264 0.689 ENSMUST00000156225.1
ENSMUST00000156742.1
Laptm5

lysosomal-associated protein transmembrane 5

chr7_-_127448993 0.676 ENSMUST00000106299.1
Zfp689
zinc finger protein 689
chr4_-_68954351 0.673 ENSMUST00000030036.5
Brinp1
bone morphogenic protein/retinoic acid inducible neural specific 1
chr17_+_37045980 0.663 ENSMUST00000174456.1
Gabbr1
gamma-aminobutyric acid (GABA) B receptor, 1
chr4_+_130913120 0.645 ENSMUST00000151698.1
Laptm5
lysosomal-associated protein transmembrane 5
chr4_+_59003121 0.626 ENSMUST00000095070.3
ENSMUST00000174664.1
Dnajc25
Gm20503
DnaJ (Hsp40) homolog, subfamily C, member 25
predicted gene 20503
chr4_+_42950369 0.548 ENSMUST00000084662.5
Dnajb5
DnaJ (Hsp40) homolog, subfamily B, member 5
chr7_-_127449109 0.509 ENSMUST00000053392.4
Zfp689
zinc finger protein 689
chr11_-_120784183 0.497 ENSMUST00000026156.7
Rfng
RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chrX_-_43274786 0.495 ENSMUST00000016294.7
Tenm1
teneurin transmembrane protein 1
chr8_+_99416585 0.473 ENSMUST00000064349.5
A330008L17Rik
RIKEN cDNA A330008L17 gene
chr11_+_4986824 0.424 ENSMUST00000009234.9
ENSMUST00000109897.1
Ap1b1

adaptor protein complex AP-1, beta 1 subunit

chr5_+_124112297 0.421 ENSMUST00000024470.6
ENSMUST00000119269.1
Ogfod2

2-oxoglutarate and iron-dependent oxygenase domain containing 2

chr9_+_118478182 0.355 ENSMUST00000111763.1
Eomes
eomesodermin homolog (Xenopus laevis)
chr2_+_36230426 0.353 ENSMUST00000062069.5
Ptgs1
prostaglandin-endoperoxide synthase 1
chr10_-_81496313 0.350 ENSMUST00000118498.1
Ncln
nicalin homolog (zebrafish)
chr17_+_27839974 0.343 ENSMUST00000071006.7
Snrpc
U1 small nuclear ribonucleoprotein C
chr2_-_26910569 0.340 ENSMUST00000015920.5
ENSMUST00000139815.1
ENSMUST00000102899.3
Med22


mediator complex subunit 22


chr10_-_81496329 0.331 ENSMUST00000020463.7
Ncln
nicalin homolog (zebrafish)
chr17_-_83514311 0.315 ENSMUST00000167741.1
ENSMUST00000025095.7
Cox7a2l

cytochrome c oxidase subunit VIIa polypeptide 2-like

chr4_-_36951223 0.311 ENSMUST00000108122.1
Lingo2
leucine rich repeat and Ig domain containing 2
chr2_+_128967383 0.294 ENSMUST00000110320.2
ENSMUST00000110319.2
Zc3h6

zinc finger CCCH type containing 6

chr12_+_40222758 0.284 ENSMUST00000038121.4
Gm7008
predicted gene 7008
chr9_-_64726583 0.269 ENSMUST00000168366.1
Rab11a
RAB11a, member RAS oncogene family
chr8_-_70476911 0.245 ENSMUST00000066597.5
ENSMUST00000166976.1
Klhl26

kelch-like 26

chr2_-_92459709 0.238 ENSMUST00000136718.1
ENSMUST00000067631.6
Slc35c1

solute carrier family 35, member C1

chr1_-_160792908 0.237 ENSMUST00000028049.7
Rabgap1l
RAB GTPase activating protein 1-like
chr2_+_136891501 0.236 ENSMUST00000141463.1
Slx4ip
SLX4 interacting protein
chr5_-_37824580 0.233 ENSMUST00000063116.9
Msx1
msh homeobox 1
chr9_-_106247730 0.214 ENSMUST00000112524.2
ENSMUST00000074082.6
Alas1

aminolevulinic acid synthase 1

chr11_-_115933464 0.209 ENSMUST00000021097.3
Recql5
RecQ protein-like 5
chr19_+_46152505 0.206 ENSMUST00000026254.7
Gbf1
golgi-specific brefeldin A-resistance factor 1
chr2_-_136891131 0.205 ENSMUST00000144275.1
Mkks
McKusick-Kaufman syndrome
chr8_-_85080652 0.168 ENSMUST00000152785.1
Wdr83
WD repeat domain containing 83
chr9_+_104569671 0.165 ENSMUST00000057742.8
Cpne4
copine IV
chr2_-_167062981 0.160 ENSMUST00000048988.7
Znfx1
zinc finger, NFX1-type containing 1
chr15_-_89149557 0.149 ENSMUST00000088823.3
Mapk11
mitogen-activated protein kinase 11
chr11_+_120784257 0.145 ENSMUST00000100134.3
Gps1
G protein pathway suppressor 1
chr8_-_85080679 0.132 ENSMUST00000093357.5
Wdr83
WD repeat domain containing 83
chr7_-_126861648 0.124 ENSMUST00000129812.1
ENSMUST00000106342.1
Ino80e

INO80 complex subunit E

chr2_+_34406949 0.116 ENSMUST00000040459.4
Mapkap1
mitogen-activated protein kinase associated protein 1
chr2_+_34406845 0.096 ENSMUST00000124443.1
ENSMUST00000113124.1
Mapkap1

mitogen-activated protein kinase associated protein 1

chr5_+_139252343 0.091 ENSMUST00000130326.1
Get4
golgi to ER traffic protein 4 homolog (S. cerevisiae)
chr12_-_36042476 0.090 ENSMUST00000020896.8
Tspan13
tetraspanin 13
chr2_+_34406882 0.081 ENSMUST00000113123.1
Mapkap1
mitogen-activated protein kinase associated protein 1
chr11_+_19924403 0.077 ENSMUST00000093298.5
Spred2
sprouty-related, EVH1 domain containing 2
chr7_-_80947499 0.056 ENSMUST00000120285.1
Sec11a
SEC11 homolog A (S. cerevisiae)
chr5_-_138187177 0.041 ENSMUST00000110937.1
ENSMUST00000139276.1
ENSMUST00000048698.7
ENSMUST00000123415.1
Taf6



TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor



chr5_+_139211934 0.037 ENSMUST00000148772.1
ENSMUST00000110882.1
Sun1

Sad1 and UNC84 domain containing 1

chr5_+_139252314 0.028 ENSMUST00000026976.5
Get4
golgi to ER traffic protein 4 homolog (S. cerevisiae)
chr11_+_19924354 0.028 ENSMUST00000093299.6
Spred2
sprouty-related, EVH1 domain containing 2
chrX_-_73966329 0.027 ENSMUST00000114372.2
ENSMUST00000033761.6
Hcfc1

host cell factor C1

chr6_-_131388417 0.013 ENSMUST00000032309.6
ENSMUST00000087865.2
Ybx3

Y box protein 3

chr8_+_85080939 0.012 ENSMUST00000140621.1
BC056474
cDNA sequence BC056474
chr9_-_110117303 0.008 ENSMUST00000136969.1
Dhx30
DEAH (Asp-Glu-Ala-His) box polypeptide 30

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 GO:0003104 positive regulation of glomerular filtration(GO:0003104) negative regulation of phosphatidylinositol biosynthetic process(GO:0010512) phenotypic switching(GO:0036166) dedifferentiation(GO:0043696) cell dedifferentiation(GO:0043697) glomerular mesangial cell differentiation(GO:0072008) glomerular mesangial cell development(GO:0072144) metanephric glomerular mesangium development(GO:0072223) metanephric glomerular mesangial cell proliferation involved in metanephros development(GO:0072262)
0.3 2.0 GO:0032811 negative regulation of epinephrine secretion(GO:0032811)
0.1 0.4 GO:0002302 CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302)
0.1 0.2 GO:0035880 embryonic nail plate morphogenesis(GO:0035880)
0.1 0.2 GO:0070973 COPI-coated vesicle budding(GO:0035964) protein localization to endoplasmic reticulum exit site(GO:0070973)
0.1 0.3 GO:0010796 regulation of multivesicular body size(GO:0010796)
0.1 1.3 GO:0035036 binding of sperm to zona pellucida(GO:0007339) sperm-egg recognition(GO:0035036)
0.1 0.2 GO:1990414 replication-born double-strand break repair via sister chromatid exchange(GO:1990414)
0.1 0.7 GO:0042711 maternal behavior(GO:0042711)
0.0 0.2 GO:0030259 lipid glycosylation(GO:0030259)
0.0 0.3 GO:0000395 mRNA 5'-splice site recognition(GO:0000395)
0.0 0.2 GO:0038108 negative regulation of appetite by leptin-mediated signaling pathway(GO:0038108)
0.0 1.9 GO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway(GO:0045744)
0.0 1.0 GO:0009409 response to cold(GO:0009409)
0.0 0.1 GO:0010387 COP9 signalosome assembly(GO:0010387)
0.0 1.1 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.0 0.1 GO:0072610 interleukin-12 secretion(GO:0072610) regulation of interleukin-12 secretion(GO:2001182) positive regulation of interleukin-12 secretion(GO:2001184)
0.0 0.3 GO:0002082 regulation of oxidative phosphorylation(GO:0002082)
0.0 0.5 GO:0006359 regulation of transcription from RNA polymerase III promoter(GO:0006359)
0.0 0.4 GO:0048268 clathrin coat assembly(GO:0048268)
0.0 0.7 GO:0031648 protein destabilization(GO:0031648)
0.0 1.2 GO:0035914 skeletal muscle cell differentiation(GO:0035914)
0.0 0.1 GO:0036506 maintenance of unfolded protein(GO:0036506) protein insertion into ER membrane(GO:0045048) tail-anchored membrane protein insertion into ER membrane(GO:0071816) maintenance of unfolded protein involved in ERAD pathway(GO:1904378)
0.0 1.2 GO:0009408 response to heat(GO:0009408)
0.0 0.5 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
0.0 0.1 GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.7 GO:0038039 G-protein coupled receptor heterodimeric complex(GO:0038039)
0.1 1.3 GO:0002199 zona pellucida receptor complex(GO:0002199)
0.1 1.0 GO:0043083 synaptic cleft(GO:0043083)
0.0 1.0 GO:0071565 nBAF complex(GO:0071565)
0.0 0.2 GO:1902636 kinociliary basal body(GO:1902636)
0.0 0.3 GO:0005828 kinetochore microtubule(GO:0005828)
0.0 0.3 GO:0000243 commitment complex(GO:0000243)
0.0 0.3 GO:0031932 TORC2 complex(GO:0031932)
0.0 0.1 GO:0071818 BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379)
0.0 1.2 GO:0016234 inclusion body(GO:0016234)
0.0 0.4 GO:0030131 clathrin adaptor complex(GO:0030131)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.7 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.2 1.0 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.2 0.5 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.2 1.2 GO:0055131 C3HC4-type RING finger domain binding(GO:0055131)
0.1 1.1 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.0 0.9 GO:0050321 tau-protein kinase activity(GO:0050321)
0.0 1.9 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.0 0.3 GO:1990446 U1 snRNP binding(GO:1990446)
0.0 0.2 GO:0009378 four-way junction helicase activity(GO:0009378)
0.0 0.4 GO:0031418 L-ascorbic acid binding(GO:0031418)
0.0 0.5 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.0 0.1 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.0 0.3 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 0.3 GO:0031489 myosin V binding(GO:0031489)