Motif ID: Prrx1_Isx_Prrxl1

Z-value: 0.693

Transcription factors associated with Prrx1_Isx_Prrxl1:

Gene SymbolEntrez IDGene Name
Isx ENSMUSG00000031621.3 Isx
Prrx1 ENSMUSG00000026586.10 Prrx1
Prrxl1 ENSMUSG00000041730.7 Prrxl1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Prrxl1mm10_v2_chr14_+_32599922_32599932-0.767.0e-06Click!
Prrx1mm10_v2_chr1_-_163289214_1632892350.144.8e-01Click!


Activity profile for motif Prrx1_Isx_Prrxl1.

activity profile for motif Prrx1_Isx_Prrxl1


Sorted Z-values histogram for motif Prrx1_Isx_Prrxl1

Sorted Z-values for motif Prrx1_Isx_Prrxl1



Network of associatons between targets according to the STRING database.



First level regulatory network of Prrx1_Isx_Prrxl1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_+_118478344 2.977 ENSMUST00000035020.8
 Eomes
eomesodermin homolog (Xenopus laevis)
chr9_+_118478182 2.833 ENSMUST00000111763.1
 Eomes
eomesodermin homolog (Xenopus laevis)
chr7_-_79386943 2.731 ENSMUST00000053718.8
ENSMUST00000179243.1
 Rlbp1

retinaldehyde binding protein 1

chr18_-_66860458 2.104 ENSMUST00000057942.2
 Mc4r
melanocortin 4 receptor
chr2_+_61804453 1.829 ENSMUST00000048934.8
 Tbr1
T-box brain gene 1
chr9_+_35423582 1.739 ENSMUST00000154652.1
 Cdon
cell adhesion molecule-related/down-regulated by oncogenes
chr4_+_5724304 1.345 ENSMUST00000108380.1
 Fam110b
family with sequence similarity 110, member B
chr2_-_67194695 1.277 ENSMUST00000147939.1
 Gm13598
predicted gene 13598
chr17_+_3397189 1.271 ENSMUST00000072156.6
 Tiam2
T cell lymphoma invasion and metastasis 2
chr14_+_80000292 1.228 ENSMUST00000088735.3
 Olfm4
olfactomedin 4
chr18_+_69593361 1.223 ENSMUST00000114978.2
ENSMUST00000114977.1
 Tcf4

transcription factor 4

chr4_-_87806296 1.133 ENSMUST00000126353.1
ENSMUST00000149357.1
 Mllt3

myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3

chr18_-_78206408 1.128 ENSMUST00000163367.1
 Slc14a2
solute carrier family 14 (urea transporter), member 2
chr14_-_101609033 1.074 ENSMUST00000161991.1
ENSMUST00000100340.3
 Tbc1d4

TBC1 domain family, member 4

chr11_+_94936224 0.974 ENSMUST00000001547.7
 Col1a1
collagen, type I, alpha 1
chr2_+_158666690 0.974 ENSMUST00000103116.3
 Ppp1r16b
protein phosphatase 1, regulatory (inhibitor) subunit 16B
chr1_-_158356258 0.936 ENSMUST00000004133.8
 Brinp2
bone morphogenic protein/retinoic acid inducible neural-specific 2
chr5_-_124095749 0.913 ENSMUST00000031354.4
 Abcb9
ATP-binding cassette, sub-family B (MDR/TAP), member 9
chr1_-_56969864 0.906 ENSMUST00000177424.1
 Satb2
special AT-rich sequence binding protein 2
chr14_-_118052235 0.891 ENSMUST00000022725.2
 Dct
dopachrome tautomerase

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 103 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.9 5.8 GO:0002302 CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302)
0.0 2.5 GO:0007601 visual perception(GO:0007601)
0.6 2.3 GO:2000795 negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
0.4 2.1 GO:0002024 diet induced thermogenesis(GO:0002024) adaptive thermogenesis(GO:1990845)
0.4 2.0 GO:0021764 amygdala development(GO:0021764)
0.2 1.9 GO:0007379 segment specification(GO:0007379)
0.2 1.7 GO:0014816 skeletal muscle satellite cell differentiation(GO:0014816)
0.1 1.7 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.4 1.5 GO:0043490 malate-aspartate shuttle(GO:0043490)
0.0 1.5 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.2 1.4 GO:0015840 urea transport(GO:0015840) urea transmembrane transport(GO:0071918)
0.1 1.1 GO:0031339 negative regulation of vesicle fusion(GO:0031339)
0.1 1.1 GO:0042118 endothelial cell activation(GO:0042118)
0.2 1.0 GO:1903587 regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903587)
0.1 1.0 GO:0019532 oxalate transport(GO:0019532)
0.1 1.0 GO:0036072 intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
0.0 1.0 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.1 0.9 GO:0006570 tyrosine metabolic process(GO:0006570)
0.1 0.9 GO:0002591 positive regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002591)
0.0 0.9 GO:0071300 cellular response to retinoic acid(GO:0071300)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 29 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.3 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.0 1.9 GO:0008023 transcription elongation factor complex(GO:0008023)
0.0 1.7 GO:0097458 neuron part(GO:0097458)
0.0 1.7 GO:0000118 histone deacetylase complex(GO:0000118)
0.1 1.5 GO:0043205 fibril(GO:0043205)
0.0 1.4 GO:0031227 intrinsic component of endoplasmic reticulum membrane(GO:0031227)
0.1 1.2 GO:0042581 specific granule(GO:0042581)
0.3 1.0 GO:0005584 collagen type I trimer(GO:0005584)
0.0 1.0 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 0.9 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.0 0.7 GO:0000930 gamma-tubulin complex(GO:0000930)
0.1 0.3 GO:0044530 supraspliceosomal complex(GO:0044530)
0.0 0.3 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.1 0.2 GO:0031983 vesicle lumen(GO:0031983)
0.0 0.2 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237)
0.0 0.2 GO:1990604 IRE1-TRAF2-ASK1 complex(GO:1990604)
0.0 0.2 GO:0005955 calcineurin complex(GO:0005955)
0.0 0.2 GO:0043083 synaptic cleft(GO:0043083)
0.0 0.2 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.0 0.2 GO:0005675 holo TFIIH complex(GO:0005675)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 68 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.9 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.5 2.7 GO:0019841 retinol binding(GO:0019841)
0.1 2.3 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.7 2.1 GO:0004980 melanocortin receptor activity(GO:0004977) melanocyte-stimulating hormone receptor activity(GO:0004980)
0.0 1.8 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.3 1.5 GO:0005314 high-affinity glutamate transmembrane transporter activity(GO:0005314)
0.2 1.4 GO:0015265 urea channel activity(GO:0015265)
0.3 1.2 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.1 1.2 GO:0008599 protein phosphatase type 1 regulator activity(GO:0008599)
0.0 1.2 GO:0045296 cadherin binding(GO:0045296)
0.0 1.2 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.1 1.0 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.1 1.0 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.2 0.9 GO:0015440 peptide-transporting ATPase activity(GO:0015440)
0.1 0.9 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.1 0.8 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.0 0.8 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.2 0.7 GO:0030151 molybdenum ion binding(GO:0030151)
0.0 0.7 GO:0019855 calcium channel inhibitor activity(GO:0019855)
0.0 0.7 GO:0005201 extracellular matrix structural constituent(GO:0005201)