Motif ID: Rad21_Smc3

Z-value: 0.842

Transcription factors associated with Rad21_Smc3:

Gene SymbolEntrez IDGene Name
Rad21 ENSMUSG00000022314.9 Rad21
Smc3 ENSMUSG00000024974.10 Smc3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Smc3mm10_v2_chr19_+_53600377_53600435-0.271.7e-01Click!
Rad21mm10_v2_chr15_-_51991679_51991760-0.252.1e-01Click!


Activity profile for motif Rad21_Smc3.

activity profile for motif Rad21_Smc3


Sorted Z-values histogram for motif Rad21_Smc3

Sorted Z-values for motif Rad21_Smc3



Network of associatons between targets according to the STRING database.



First level regulatory network of Rad21_Smc3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_+_147957310 2.009 ENSMUST00000085558.4
ENSMUST00000129092.1
 Mtus2

microtubule associated tumor suppressor candidate 2

chr7_+_16891755 1.861 ENSMUST00000078182.4
 Gng8
guanine nucleotide binding protein (G protein), gamma 8
chr2_+_157914618 1.860 ENSMUST00000109523.1
 Vstm2l
V-set and transmembrane domain containing 2-like
chr9_+_71215779 1.796 ENSMUST00000034723.5
 Aldh1a2
aldehyde dehydrogenase family 1, subfamily A2
chr2_-_158146385 1.731 ENSMUST00000103122.3
 Tgm2
transglutaminase 2, C polypeptide
chr2_-_117342709 1.657 ENSMUST00000173541.1
ENSMUST00000172901.1
ENSMUST00000173252.1
 Rasgrp1


RAS guanyl releasing protein 1


chr18_-_34007206 1.594 ENSMUST00000025234.5
 Epb4.1l4a
erythrocyte protein band 4.1-like 4a
chr8_-_110168204 1.588 ENSMUST00000003754.6
 Calb2
calbindin 2
chr2_+_167538192 1.547 ENSMUST00000052631.7
 Snai1
snail homolog 1 (Drosophila)
chr11_+_32286946 1.538 ENSMUST00000101387.3
 Hbq1b
hemoglobin, theta 1B
chr13_+_98354234 1.537 ENSMUST00000105098.3
 Foxd1
forkhead box D1
chr2_-_166155272 1.455 ENSMUST00000088086.3
 Sulf2
sulfatase 2
chr9_-_108452377 1.428 ENSMUST00000035232.7
 Klhdc8b
kelch domain containing 8B
chr8_+_119446719 1.407 ENSMUST00000098363.3
 Necab2
N-terminal EF-hand calcium binding protein 2
chr18_+_74442551 1.339 ENSMUST00000121875.1
 Myo5b
myosin VB
chr18_+_74442500 1.335 ENSMUST00000074157.6
 Myo5b
myosin VB
chr5_-_36398090 1.319 ENSMUST00000037370.7
ENSMUST00000070720.6
 Sorcs2

sortilin-related VPS10 domain containing receptor 2

chr2_+_31887262 1.295 ENSMUST00000138325.1
ENSMUST00000028187.6
 Lamc3

laminin gamma 3

chr7_+_25686994 1.222 ENSMUST00000002678.9
 Tgfb1
transforming growth factor, beta 1
chr4_+_41755210 1.211 ENSMUST00000108038.1
ENSMUST00000084695.4
 Galt

galactose-1-phosphate uridyl transferase


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 169 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 2.7 GO:0032439 endosome localization(GO:0032439)
0.8 2.4 GO:0006001 fructose catabolic process(GO:0006001) fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate(GO:0061624) glycolytic process through fructose-1-phosphate(GO:0061625)
0.0 2.3 GO:0002181 cytoplasmic translation(GO:0002181)
0.5 2.0 GO:0014846 esophagus smooth muscle contraction(GO:0014846) glial cell-derived neurotrophic factor receptor signaling pathway(GO:0035860)
0.4 1.9 GO:0019236 response to pheromone(GO:0019236)
0.6 1.8 GO:0035799 ureter maturation(GO:0035799)
0.6 1.7 GO:0018199 peptidyl-glutamine modification(GO:0018199)
0.2 1.7 GO:0000050 urea cycle(GO:0000050) urea metabolic process(GO:0019627)
0.2 1.7 GO:1903423 positive regulation of synaptic vesicle recycling(GO:1903423)
0.2 1.7 GO:0033089 positive regulation of T cell differentiation in thymus(GO:0033089) positive regulation of thymocyte aggregation(GO:2000400)
0.5 1.5 GO:0072076 nephrogenic mesenchyme development(GO:0072076)
0.1 1.5 GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic(GO:0090502)
0.1 1.5 GO:0014002 astrocyte development(GO:0014002)
0.5 1.4 GO:0060800 regulation of cell differentiation involved in embryonic placenta development(GO:0060800)
0.4 1.2 GO:2001139 negative regulation of postsynaptic membrane organization(GO:1901627) negative regulation of dendritic spine maintenance(GO:1902951) negative regulation of phospholipid efflux(GO:1902999) regulation of lipid transport across blood brain barrier(GO:1903000) negative regulation of lipid transport across blood brain barrier(GO:1903001) positive regulation of lipid transport across blood brain barrier(GO:1903002) negative regulation of phospholipid transport(GO:2001139)
0.4 1.2 GO:0002295 T-helper cell lineage commitment(GO:0002295) evasion or tolerance of host defenses by virus(GO:0019049) regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0032829) avoidance of host defenses(GO:0044413) evasion or tolerance of host defenses(GO:0044415) isotype switching to IgA isotypes(GO:0048290) regulation of isotype switching to IgA isotypes(GO:0048296) avoidance of defenses of other organism involved in symbiotic interaction(GO:0051832) evasion or tolerance of defenses of other organism involved in symbiotic interaction(GO:0051834) positive regulation of mononuclear cell migration(GO:0071677) negative regulation of hyaluronan biosynthetic process(GO:1900126) regulation of epithelial to mesenchymal transition involved in endocardial cushion formation(GO:1905005)
0.4 1.2 GO:0006011 UDP-glucose metabolic process(GO:0006011)
0.1 1.2 GO:0021785 branchiomotor neuron axon guidance(GO:0021785)
0.4 1.1 GO:0002636 positive regulation of germinal center formation(GO:0002636)
0.2 1.1 GO:0043654 recognition of apoptotic cell(GO:0043654)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 91 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.5 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.5 2.8 GO:0045179 apical cortex(GO:0045179)
0.0 2.0 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.1 1.6 GO:0005921 gap junction(GO:0005921)
0.0 1.6 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 1.4 GO:0005902 microvillus(GO:0005902)
0.0 1.4 GO:0005604 basement membrane(GO:0005604)
0.1 1.3 GO:0043196 varicosity(GO:0043196)
0.0 1.3 GO:0016529 sarcoplasmic reticulum(GO:0016529)
0.4 1.2 GO:0034363 intermediate-density lipoprotein particle(GO:0034363)
0.4 1.2 GO:0036488 CHOP-C/EBP complex(GO:0036488)
0.2 1.2 GO:0032983 kainate selective glutamate receptor complex(GO:0032983)
0.0 1.2 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.2 1.1 GO:0042613 MHC class II protein complex(GO:0042613)
0.0 1.1 GO:0001891 phagocytic cup(GO:0001891)
0.0 1.0 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 0.9 GO:0005581 collagen trimer(GO:0005581)
0.1 0.8 GO:0002116 semaphorin receptor complex(GO:0002116)
0.1 0.8 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0 0.8 GO:0031512 motile primary cilium(GO:0031512)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 115 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.9 GO:0003735 structural constituent of ribosome(GO:0003735)
0.1 2.7 GO:0035255 ionotropic glutamate receptor binding(GO:0035255)
0.8 2.4 GO:0004454 ketohexokinase activity(GO:0004454)
0.1 2.1 GO:0017147 Wnt-protein binding(GO:0017147)
0.4 2.0 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.2 1.9 GO:0019992 diacylglycerol binding(GO:0019992)
0.3 1.8 GO:0001758 retinal dehydrogenase activity(GO:0001758) 3-chloroallyl aldehyde dehydrogenase activity(GO:0004028)
0.4 1.7 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.1 1.5 GO:0008301 DNA binding, bending(GO:0008301)
0.1 1.5 GO:0047429 nucleoside-triphosphate diphosphatase activity(GO:0047429)
0.4 1.2 GO:0046911 hydroxyapatite binding(GO:0046848) metal chelating activity(GO:0046911) phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228)
0.3 1.2 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.1 1.2 GO:0005234 extracellular-glutamate-gated ion channel activity(GO:0005234)
0.1 1.1 GO:0001013 RNA polymerase I regulatory region DNA binding(GO:0001013)
0.1 1.1 GO:0023026 MHC protein complex binding(GO:0023023) MHC class II protein complex binding(GO:0023026)
0.1 1.0 GO:0005087 Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.1 1.0 GO:0070569 uridylyltransferase activity(GO:0070569)
0.1 0.9 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.1 0.9 GO:0031749 D2 dopamine receptor binding(GO:0031749)
0.1 0.9 GO:0004526 ribonuclease P activity(GO:0004526)