Motif ID: Rara

Z-value: 0.669


Transcription factors associated with Rara:

Gene SymbolEntrez IDGene Name
Rara ENSMUSG00000037992.10 Rara

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Raramm10_v2_chr11_+_98960412_989604850.432.7e-02Click!


Activity profile for motif Rara.

activity profile for motif Rara


Sorted Z-values histogram for motif Rara

Sorted Z-values for motif Rara



Network of associatons between targets according to the STRING database.



First level regulatory network of Rara

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr13_+_94875600 3.987 ENSMUST00000022195.10
 Otp
orthopedia homolog (Drosophila)
chr10_+_4611971 2.498 ENSMUST00000105590.1
ENSMUST00000067086.7
 Esr1

estrogen receptor 1 (alpha)

chr4_-_46991842 1.568 ENSMUST00000107749.2
 Gabbr2
gamma-aminobutyric acid (GABA) B receptor, 2
chr5_-_114273702 1.320 ENSMUST00000144050.1
ENSMUST00000044790.5
 Foxn4

forkhead box N4

chr2_+_169633517 1.277 ENSMUST00000109157.1
 Tshz2
teashirt zinc finger family member 2
chr4_-_141599835 1.254 ENSMUST00000141518.1
ENSMUST00000127455.1
ENSMUST00000105784.1
ENSMUST00000147785.1
 Fblim1



filamin binding LIM protein 1



chr11_+_98960412 1.192 ENSMUST00000107473.2
 Rara
retinoic acid receptor, alpha
chr5_+_135806859 1.147 ENSMUST00000126232.1
 Srrm3
serine/arginine repetitive matrix 3
chr17_-_56133817 1.132 ENSMUST00000167545.1
 Sema6b
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B
chr1_+_134037490 1.035 ENSMUST00000162779.1
 Fmod
fibromodulin
chr10_+_21993890 0.944 ENSMUST00000092673.4
 Sgk1
serum/glucocorticoid regulated kinase 1
chr3_-_36475688 0.813 ENSMUST00000029266.8
 Anxa5
annexin A5
chr14_-_16575456 0.805 ENSMUST00000063750.6
 Rarb
retinoic acid receptor, beta
chr6_+_30723541 0.733 ENSMUST00000115127.1
 Mest
mesoderm specific transcript
chr17_+_34593388 0.646 ENSMUST00000174532.1
 Pbx2
pre B cell leukemia homeobox 2
chr4_-_152318458 0.625 ENSMUST00000170820.1
ENSMUST00000076183.5
 Rnf207

ring finger protein 207

chr7_-_141429351 0.578 ENSMUST00000164387.1
ENSMUST00000137488.1
ENSMUST00000084436.3
 Cend1


cell cycle exit and neuronal differentiation 1


chr7_-_141429433 0.574 ENSMUST00000124444.1
 Cend1
cell cycle exit and neuronal differentiation 1
chr6_+_91157373 0.566 ENSMUST00000155007.1
 Hdac11
histone deacetylase 11
chr10_-_89257790 0.555 ENSMUST00000045601.7
 Ano4
anoctamin 4
chr2_+_26319741 0.480 ENSMUST00000066889.6
 Gpsm1
G-protein signalling modulator 1 (AGS3-like, C. elegans)
chr8_+_106150359 0.434 ENSMUST00000034377.6
 Pla2g15
phospholipase A2, group XV
chr12_+_87026564 0.412 ENSMUST00000110187.1
ENSMUST00000156162.1
 Tmem63c

transmembrane protein 63c

chr15_+_82256023 0.410 ENSMUST00000143238.1
 1500009C09Rik
RIKEN cDNA 1500009C09 gene
chr3_-_54915867 0.383 ENSMUST00000070342.3
 Sertm1
serine rich and transmembrane domain containing 1
chr11_+_4986824 0.379 ENSMUST00000009234.9
ENSMUST00000109897.1
 Ap1b1

adaptor protein complex AP-1, beta 1 subunit

chr14_+_58070547 0.377 ENSMUST00000165526.1
 Fgf9
fibroblast growth factor 9
chr12_-_108893197 0.369 ENSMUST00000161154.1
ENSMUST00000161410.1
 Wars

tryptophanyl-tRNA synthetase

chr14_+_64588112 0.368 ENSMUST00000181808.1
 A930011O12Rik
RIKEN cDNA A930011O12 gene
chr14_+_76488436 0.329 ENSMUST00000101618.2
 Tsc22d1
TSC22 domain family, member 1
chr11_-_5915124 0.311 ENSMUST00000109823.2
ENSMUST00000109822.1
 Gck

glucokinase

chr10_+_79910856 0.299 ENSMUST00000181321.1
 Gm26602
predicted gene, 26602
chr2_+_120977017 0.292 ENSMUST00000067582.7
 Tmem62
transmembrane protein 62
chr7_+_45872772 0.290 ENSMUST00000002855.5
ENSMUST00000107719.1
 Kdelr1

KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1

chr4_+_141444654 0.288 ENSMUST00000006377.6
 Zbtb17
zinc finger and BTB domain containing 17
chr5_+_138255608 0.287 ENSMUST00000062067.6
 Lamtor4
late endosomal/lysosomal adaptor, MAPK and MTOR activator 4
chr1_-_175692624 0.282 ENSMUST00000027809.7
 Opn3
opsin 3
chr7_+_45873127 0.253 ENSMUST00000107718.1
 Kdelr1
KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1
chr11_+_94629741 0.253 ENSMUST00000021239.6
 Lrrc59
leucine rich repeat containing 59
chr3_-_88058446 0.240 ENSMUST00000029708.6
 Apoa1bp
apolipoprotein A-I binding protein
chr2_+_181365384 0.199 ENSMUST00000108807.2
 Zgpat
zinc finger, CCCH-type with G patch domain
chr6_-_54972603 0.178 ENSMUST00000060655.8
 Nod1
nucleotide-binding oligomerization domain containing 1
chr2_-_181365306 0.164 ENSMUST00000108808.1
ENSMUST00000170190.1
ENSMUST00000127988.1
 Arfrp1


ADP-ribosylation factor related protein 1


chr9_-_109074049 0.159 ENSMUST00000161521.1
ENSMUST00000045011.2
 Atrip

ATR interacting protein

chr8_-_94876269 0.150 ENSMUST00000046461.7
 Dok4
docking protein 4
chr6_+_18848571 0.149 ENSMUST00000056398.8
 Naa38
N(alpha)-acetyltransferase 38, NatC auxiliary subunit
chr7_+_120635176 0.140 ENSMUST00000033176.5
 Uqcrc2
ubiquinol cytochrome c reductase core protein 2
chr7_-_44670820 0.138 ENSMUST00000048102.7
 Myh14
myosin, heavy polypeptide 14
chr14_+_20674311 0.129 ENSMUST00000048657.8
 Sec24c
Sec24 related gene family, member C (S. cerevisiae)
chrX_+_74254736 0.126 ENSMUST00000096424.4
 Emd
emerin
chr2_-_91070283 0.121 ENSMUST00000111436.2
ENSMUST00000073575.5
 Slc39a13

solute carrier family 39 (metal ion transporter), member 13

chr3_+_79884576 0.118 ENSMUST00000145992.1
 Fam198b
family with sequence similarity 198, member B
chr4_+_150853919 0.116 ENSMUST00000073600.2
 Errfi1
ERBB receptor feedback inhibitor 1
chr5_-_105239533 0.102 ENSMUST00000065588.6
 Gbp10
guanylate-binding protein 10
chr2_-_91070180 0.087 ENSMUST00000153367.1
ENSMUST00000079976.3
 Slc39a13

solute carrier family 39 (metal ion transporter), member 13

chr11_-_97700327 0.067 ENSMUST00000018681.7
 Pcgf2
polycomb group ring finger 2
chr14_-_74947865 0.057 ENSMUST00000088970.5
 Lrch1
leucine-rich repeats and calponin homology (CH) domain containing 1
chr5_+_53267103 0.055 ENSMUST00000121042.1
 Smim20
small integral membrane protein 20
chr4_-_128609981 0.046 ENSMUST00000141040.1
ENSMUST00000147876.1
ENSMUST00000097877.2
 Zscan20


zinc finger and SCAN domains 20


chr2_-_34754364 0.045 ENSMUST00000142436.1
ENSMUST00000113099.3
ENSMUST00000028224.8
 Gapvd1


GTPase activating protein and VPS9 domains 1


chrX_+_74254782 0.044 ENSMUST00000119197.1
ENSMUST00000088313.4
 Emd

emerin

chr6_-_39810881 0.023 ENSMUST00000114797.1
ENSMUST00000031978.8
 Mrps33

mitochondrial ribosomal protein S33

chr17_-_32388885 0.022 ENSMUST00000087703.5
ENSMUST00000170603.1
 Wiz

widely-interspaced zinc finger motifs

chr4_+_41348996 0.014 ENSMUST00000072866.5
ENSMUST00000108060.3
 Ubap1

ubiquitin-associated protein 1

chr3_+_79884496 0.013 ENSMUST00000118853.1
 Fam198b
family with sequence similarity 198, member B
chr8_-_119778380 0.012 ENSMUST00000049156.5
 Tldc1
TBC/LysM associated domain containing 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 2.5 GO:0060745 mammary gland branching involved in pregnancy(GO:0060745)
0.4 1.2 GO:0060010 Sertoli cell fate commitment(GO:0060010)
0.4 1.2 GO:0021933 radial glia guided migration of cerebellar granule cell(GO:0021933)
0.2 3.3 GO:0021979 hypothalamus cell differentiation(GO:0021979)
0.2 0.8 GO:0097211 response to gonadotropin-releasing hormone(GO:0097210) cellular response to gonadotropin-releasing hormone(GO:0097211)
0.2 0.6 GO:0061588 calcium activated phospholipid scrambling(GO:0061588) calcium activated phosphatidylserine scrambling(GO:0061589) calcium activated phosphatidylcholine scrambling(GO:0061590) calcium activated galactosylceramide scrambling(GO:0061591)
0.2 0.8 GO:0003406 retinal pigment epithelium development(GO:0003406)
0.2 0.6 GO:0098915 membrane repolarization during ventricular cardiac muscle cell action potential(GO:0098915)
0.1 1.3 GO:0035881 amacrine cell differentiation(GO:0035881)
0.1 0.4 GO:0006436 tryptophanyl-tRNA aminoacylation(GO:0006436)
0.1 0.3 GO:0034287 detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) detection of glucose(GO:0051594)
0.1 0.3 GO:0018298 protein-chromophore linkage(GO:0018298)
0.1 1.3 GO:0033623 regulation of integrin activation(GO:0033623)
0.1 0.5 GO:0006621 protein retention in ER lumen(GO:0006621)
0.1 0.9 GO:0043402 glucocorticoid mediated signaling pathway(GO:0043402)
0.1 0.4 GO:0034638 phosphatidylcholine catabolic process(GO:0034638)
0.1 1.6 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.0 0.2 GO:0002606 positive regulation of dendritic cell antigen processing and presentation(GO:0002606)
0.0 0.1 GO:0042536 negative regulation of tumor necrosis factor biosynthetic process(GO:0042536)
0.0 0.7 GO:0010883 regulation of lipid storage(GO:0010883)
0.0 0.4 GO:0060484 male sex determination(GO:0030238) lung-associated mesenchyme development(GO:0060484)
0.0 1.1 GO:0048843 negative regulation of axon extension involved in axon guidance(GO:0048843)
0.0 1.0 GO:0030199 collagen fibril organization(GO:0030199)
0.0 0.6 GO:0009954 proximal/distal pattern formation(GO:0009954)
0.0 0.2 GO:0007175 negative regulation of epidermal growth factor-activated receptor activity(GO:0007175)
0.0 0.3 GO:0007398 ectoderm development(GO:0007398)
0.0 0.4 GO:0048268 clathrin coat assembly(GO:0048268)
0.0 0.3 GO:0061462 protein localization to lysosome(GO:0061462)
0.0 0.1 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
0.0 0.6 GO:0014003 oligodendrocyte development(GO:0014003)
0.0 0.2 GO:0071577 zinc II ion transmembrane transport(GO:0071577)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.6 GO:0038039 G-protein coupled receptor heterodimeric complex(GO:0038039)
0.1 2.5 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.0 0.1 GO:0031417 NatC complex(GO:0031417)
0.0 0.3 GO:0071986 Ragulator complex(GO:0071986)
0.0 0.1 GO:0097513 myosin II filament(GO:0097513)
0.0 0.3 GO:0045180 basal cortex(GO:0045180)
0.0 0.1 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750)
0.0 1.3 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 0.5 GO:0005801 cis-Golgi network(GO:0005801)
0.0 0.2 GO:0005652 nuclear lamina(GO:0005652)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.5 GO:0031798 type 1 metabotropic glutamate receptor binding(GO:0031798) RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052)
0.3 1.6 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.1 0.5 GO:0046923 ER retention sequence binding(GO:0046923)
0.1 1.2 GO:0001972 retinoic acid binding(GO:0001972)
0.1 0.4 GO:0004830 tryptophan-tRNA ligase activity(GO:0004830)
0.1 0.9 GO:0043423 3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.1 0.3 GO:0009881 photoreceptor activity(GO:0009881)
0.1 1.3 GO:0031005 filamin binding(GO:0031005)
0.1 0.8 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.1 0.3 GO:0004340 glucokinase activity(GO:0004340) hexokinase activity(GO:0004396)
0.1 0.6 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.0 0.4 GO:0047499 calcium-independent phospholipase A2 activity(GO:0047499)
0.0 0.8 GO:0003708 retinoic acid receptor activity(GO:0003708)
0.0 0.2 GO:0050700 CARD domain binding(GO:0050700)
0.0 1.1 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 0.6 GO:0031078 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.0 0.5 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.0 0.4 GO:0005227 calcium activated cation channel activity(GO:0005227)
0.0 0.7 GO:0052771 coenzyme F390-A hydrolase activity(GO:0052770) coenzyme F390-G hydrolase activity(GO:0052771)
0.0 0.4 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.0 0.6 GO:0030544 Hsp70 protein binding(GO:0030544)
0.0 0.2 GO:0016854 racemase and epimerase activity(GO:0016854)