Motif ID: Rest

Z-value: 4.497


Transcription factors associated with Rest:

Gene SymbolEntrez IDGene Name
Rest ENSMUSG00000029249.9 Rest

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Restmm10_v2_chr5_+_77266196_77266232-0.902.8e-10Click!


Activity profile for motif Rest.

activity profile for motif Rest


Sorted Z-values histogram for motif Rest

Sorted Z-values for motif Rest



Network of associatons between targets according to the STRING database.



First level regulatory network of Rest

PNG image of the network

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Top targets:


Showing 1 to 20 of 94 entries
PromoterScoreRefseqGene SymbolGene Name
chr16_-_23890805 45.126 ENSMUST00000004480.3
 Sst
somatostatin
chr19_+_42255704 43.922 ENSMUST00000087123.5
 Golga7b
golgi autoantigen, golgin subfamily a, 7B
chrX_-_73869804 34.741 ENSMUST00000066576.5
ENSMUST00000114430.1
 L1cam

L1 cell adhesion molecule

chr18_-_31447383 32.739 ENSMUST00000025110.3
 Syt4
synaptotagmin IV
chr11_-_35798884 29.963 ENSMUST00000160726.2
 Fbll1
fibrillarin-like 1
chr6_-_121473630 29.812 ENSMUST00000046373.5
 Iqsec3
IQ motif and Sec7 domain 3
chr2_+_153031852 28.138 ENSMUST00000037235.6
 Xkr7
X Kell blood group precursor related family member 7 homolog
chr2_-_25319095 25.384 ENSMUST00000114318.3
ENSMUST00000114310.3
ENSMUST00000114308.3
ENSMUST00000114317.3
ENSMUST00000028335.6
ENSMUST00000114314.3
ENSMUST00000114307.1
 Grin1






glutamate receptor, ionotropic, NMDA1 (zeta 1)






chr15_-_76521902 24.978 ENSMUST00000164703.1
ENSMUST00000096365.3
 Scrt1

scratch homolog 1, zinc finger protein (Drosophila)

chr2_+_155775333 24.296 ENSMUST00000029141.5
 Mmp24
matrix metallopeptidase 24
chr11_+_80477015 24.166 ENSMUST00000053413.10
ENSMUST00000147694.1
 Cdk5r1

cyclin-dependent kinase 5, regulatory subunit 1 (p35)

chr9_+_40269430 24.148 ENSMUST00000171835.2
 Scn3b
sodium channel, voltage-gated, type III, beta
chr1_+_34579693 23.477 ENSMUST00000052670.8
 Amer3
APC membrane recruitment 3
chr12_-_112511136 22.400 ENSMUST00000066791.5
 Tmem179
transmembrane protein 179
chr11_+_74619594 21.918 ENSMUST00000100866.2
 E130309D14Rik
RIKEN cDNA E130309D14 gene
chr9_+_40269202 21.686 ENSMUST00000114956.3
ENSMUST00000049941.5
 Scn3b

sodium channel, voltage-gated, type III, beta

chr9_+_40269273 21.662 ENSMUST00000176185.1
 Scn3b
sodium channel, voltage-gated, type III, beta
chr7_-_81493725 20.995 ENSMUST00000119121.1
 Ap3b2
adaptor-related protein complex 3, beta 2 subunit
chr5_-_121009510 20.863 ENSMUST00000079204.5
 Rph3a
rabphilin 3A
chr11_+_77930800 20.233 ENSMUST00000093995.3
ENSMUST00000000646.7
 Sez6

seizure related gene 6


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 63 entries
Log-likelihood per target Total log-likelihoodTermDescription
7.5 67.5 GO:0060373 regulation of atrial cardiac muscle cell membrane depolarization(GO:0060371) regulation of ventricular cardiac muscle cell membrane depolarization(GO:0060373)
16.1 64.3 GO:0021586 pons maturation(GO:0021586)
5.3 47.5 GO:0031339 negative regulation of vesicle fusion(GO:0031339)
0.1 45.1 GO:0030334 regulation of cell migration(GO:0030334)
2.0 39.5 GO:0099517 anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517)
3.5 34.7 GO:0033631 cell-cell adhesion mediated by integrin(GO:0033631)
1.4 33.3 GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
6.0 30.0 GO:0018364 peptidyl-glutamine methylation(GO:0018364)
1.2 29.8 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.6 25.0 GO:2001222 regulation of neuron migration(GO:2001222)
2.2 24.3 GO:0044331 cell-cell adhesion mediated by cadherin(GO:0044331)
0.1 22.2 GO:0060828 regulation of canonical Wnt signaling pathway(GO:0060828)
0.8 20.9 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
1.0 20.2 GO:0090036 regulation of protein kinase C signaling(GO:0090036)
0.3 20.1 GO:0061077 chaperone-mediated protein folding(GO:0061077)
0.2 18.6 GO:0099643 neurotransmitter secretion(GO:0007269) signal release from synapse(GO:0099643)
6.2 18.5 GO:0030827 negative regulation of cGMP metabolic process(GO:0030824) negative regulation of cGMP biosynthetic process(GO:0030827) negative regulation of guanylate cyclase activity(GO:0031283)
3.1 18.5 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
5.8 17.4 GO:1900736 regulation of phospholipase C-activating G-protein coupled receptor signaling pathway(GO:1900736)
5.8 17.4 GO:0035021 negative regulation of Rac protein signal transduction(GO:0035021)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 39 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 75.2 GO:0005794 Golgi apparatus(GO:0005794)
0.0 68.0 GO:0016021 integral component of membrane(GO:0016021)
4.2 67.5 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.1 65.0 GO:0044297 cell body(GO:0044297)
1.1 52.7 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.8 50.4 GO:0042734 presynaptic membrane(GO:0042734)
10.0 40.1 GO:0044307 dendritic branch(GO:0044307)
3.6 39.5 GO:1904115 axon cytoplasm(GO:1904115)
0.0 39.0 GO:0005886 plasma membrane(GO:0005886)
1.2 38.0 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.9 33.5 GO:0097440 apical dendrite(GO:0097440)
0.8 33.3 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
2.2 32.7 GO:0031045 dense core granule(GO:0031045)
3.7 30.0 GO:0031428 box C/D snoRNP complex(GO:0031428)
1.0 29.8 GO:0060077 inhibitory synapse(GO:0060077)
0.0 28.4 GO:0042995 cell projection(GO:0042995)
8.1 24.2 GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
0.1 20.1 GO:0005789 endoplasmic reticulum membrane(GO:0005789)
3.1 18.5 GO:0008091 spectrin(GO:0008091)
1.8 18.5 GO:0044327 dendritic spine head(GO:0044327)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 48 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 204.7 GO:0003674 molecular_function(GO:0003674)
9.6 67.5 GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
1.1 65.5 GO:0005179 hormone activity(GO:0005179)
3.6 40.1 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
6.9 34.7 GO:0033691 sialic acid binding(GO:0033691)
0.8 33.3 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
1.1 32.0 GO:0001786 phosphatidylserine binding(GO:0001786)
0.3 31.2 GO:0051219 phosphoprotein binding(GO:0051219)
0.5 30.0 GO:0042054 histone methyltransferase activity(GO:0042054)
0.8 29.8 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.5 24.3 GO:0045296 cadherin binding(GO:0045296)
1.1 24.2 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.5 23.5 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
2.1 20.9 GO:0042301 phosphate ion binding(GO:0042301)
0.2 20.4 GO:0000149 SNARE binding(GO:0000149)
0.7 20.1 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.3 18.6 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.4 18.5 GO:0030507 spectrin binding(GO:0030507)
0.0 18.5 GO:0003779 actin binding(GO:0003779)
0.1 17.4 GO:0008022 protein C-terminus binding(GO:0008022)