Motif ID: Rest

Z-value: 4.497


Transcription factors associated with Rest:

Gene SymbolEntrez IDGene Name
Rest ENSMUSG00000029249.9 Rest

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Restmm10_v2_chr5_+_77266196_77266232-0.902.8e-10Click!


Activity profile for motif Rest.

activity profile for motif Rest


Sorted Z-values histogram for motif Rest

Sorted Z-values for motif Rest



Network of associatons between targets according to the STRING database.



First level regulatory network of Rest

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr16_-_23890805 45.126 ENSMUST00000004480.3
Sst
somatostatin
chr19_+_42255704 43.922 ENSMUST00000087123.5
Golga7b
golgi autoantigen, golgin subfamily a, 7B
chrX_-_73869804 34.741 ENSMUST00000066576.5
ENSMUST00000114430.1
L1cam

L1 cell adhesion molecule

chr18_-_31447383 32.739 ENSMUST00000025110.3
Syt4
synaptotagmin IV
chr11_-_35798884 29.963 ENSMUST00000160726.2
Fbll1
fibrillarin-like 1
chr6_-_121473630 29.812 ENSMUST00000046373.5
Iqsec3
IQ motif and Sec7 domain 3
chr2_+_153031852 28.138 ENSMUST00000037235.6
Xkr7
X Kell blood group precursor related family member 7 homolog
chr2_-_25319095 25.384 ENSMUST00000114318.3
ENSMUST00000114310.3
ENSMUST00000114308.3
ENSMUST00000114317.3
ENSMUST00000028335.6
ENSMUST00000114314.3
ENSMUST00000114307.1
Grin1






glutamate receptor, ionotropic, NMDA1 (zeta 1)






chr15_-_76521902 24.978 ENSMUST00000164703.1
ENSMUST00000096365.3
Scrt1

scratch homolog 1, zinc finger protein (Drosophila)

chr2_+_155775333 24.296 ENSMUST00000029141.5
Mmp24
matrix metallopeptidase 24
chr11_+_80477015 24.166 ENSMUST00000053413.10
ENSMUST00000147694.1
Cdk5r1

cyclin-dependent kinase 5, regulatory subunit 1 (p35)

chr9_+_40269430 24.148 ENSMUST00000171835.2
Scn3b
sodium channel, voltage-gated, type III, beta
chr1_+_34579693 23.477 ENSMUST00000052670.8
Amer3
APC membrane recruitment 3
chr12_-_112511136 22.400 ENSMUST00000066791.5
Tmem179
transmembrane protein 179
chr11_+_74619594 21.918 ENSMUST00000100866.2
E130309D14Rik
RIKEN cDNA E130309D14 gene
chr9_+_40269202 21.686 ENSMUST00000114956.3
ENSMUST00000049941.5
Scn3b

sodium channel, voltage-gated, type III, beta

chr9_+_40269273 21.662 ENSMUST00000176185.1
Scn3b
sodium channel, voltage-gated, type III, beta
chr7_-_81493725 20.995 ENSMUST00000119121.1
Ap3b2
adaptor-related protein complex 3, beta 2 subunit
chr5_-_121009510 20.863 ENSMUST00000079204.5
Rph3a
rabphilin 3A
chr11_+_77930800 20.233 ENSMUST00000093995.3
ENSMUST00000000646.7
Sez6

seizure related gene 6

chr7_+_27653906 20.123 ENSMUST00000008088.7
Ttc9b
tetratricopeptide repeat domain 9B
chrX_-_20920911 18.638 ENSMUST00000081893.6
ENSMUST00000115345.1
Syn1

synapsin I

chr7_-_81493883 18.552 ENSMUST00000082090.7
Ap3b2
adaptor-related protein complex 3, beta 2 subunit
chr7_-_27396542 18.488 ENSMUST00000108363.1
Sptbn4
spectrin beta, non-erythrocytic 4
chr4_-_129121234 18.450 ENSMUST00000030572.3
Hpca
hippocalcin
chr12_+_102554966 17.442 ENSMUST00000021610.5
Chga
chromogranin A
chr2_-_181314500 17.390 ENSMUST00000103045.3
Stmn3
stathmin-like 3
chr7_+_122671401 17.284 ENSMUST00000182095.1
Cacng3
calcium channel, voltage-dependent, gamma subunit 3
chr13_-_54749627 16.983 ENSMUST00000099506.1
Gprin1
G protein-regulated inducer of neurite outgrowth 1
chr5_+_137030275 16.669 ENSMUST00000041543.8
Vgf
VGF nerve growth factor inducible
chr2_+_132781278 16.282 ENSMUST00000028826.3
Chgb
chromogranin B
chr7_+_122671378 15.990 ENSMUST00000182563.1
Cacng3
calcium channel, voltage-dependent, gamma subunit 3
chr6_+_117168535 15.688 ENSMUST00000112866.1
ENSMUST00000112871.1
ENSMUST00000073043.4
Cxcl12


chemokine (C-X-C motif) ligand 12


chr17_-_91092715 15.651 ENSMUST00000160800.2
ENSMUST00000159778.1
ENSMUST00000160844.3
Nrxn1


neurexin I


chr2_-_27142429 15.502 ENSMUST00000151224.2
Fam163b
family with sequence similarity 163, member B
chr15_-_76722161 15.497 ENSMUST00000049956.4
Lrrc24
leucine rich repeat containing 24
chr9_+_108826320 15.081 ENSMUST00000024238.5
Celsr3
cadherin, EGF LAG seven-pass G-type receptor 3 (flamingo homolog, Drosophila)
chr9_-_57467985 14.957 ENSMUST00000046587.6
Scamp5
secretory carrier membrane protein 5
chr2_-_25319187 14.746 ENSMUST00000114312.1
Grin1
glutamate receptor, ionotropic, NMDA1 (zeta 1)
chr12_-_70347536 14.740 ENSMUST00000110520.2
ENSMUST00000110522.2
ENSMUST00000167755.1
Trim9


tripartite motif-containing 9


chr4_+_101550411 14.613 ENSMUST00000094953.4
ENSMUST00000106933.1
Dnajc6

DnaJ (Hsp40) homolog, subfamily C, member 6

chr13_-_54749849 13.688 ENSMUST00000135343.1
Gprin1
G protein-regulated inducer of neurite outgrowth 1
chr12_+_102949450 13.458 ENSMUST00000179002.1
Unc79
unc-79 homolog (C. elegans)
chr11_-_3774706 13.269 ENSMUST00000155197.1
Osbp2
oxysterol binding protein 2
chr3_-_80802789 12.931 ENSMUST00000107745.1
ENSMUST00000075316.4
Gria2

glutamate receptor, ionotropic, AMPA2 (alpha 2)

chr3_-_89764581 12.858 ENSMUST00000029562.3
Chrnb2
cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal)
chr12_-_84698769 12.514 ENSMUST00000095550.2
Syndig1l
synapse differentiation inducing 1 like
chr6_+_8948608 12.074 ENSMUST00000160300.1
Nxph1
neurexophilin 1
chr9_+_59578192 12.015 ENSMUST00000118549.1
ENSMUST00000034840.3
Celf6

CUGBP, Elav-like family member 6

chr15_-_11037968 10.970 ENSMUST00000058007.5
Rxfp3
relaxin family peptide receptor 3
chr17_+_28575718 10.419 ENSMUST00000080780.6
Lhfpl5
lipoma HMGIC fusion partner-like 5
chrX_+_7638674 10.264 ENSMUST00000128890.1
Syp
synaptophysin
chr17_-_72603709 9.323 ENSMUST00000086639.4
Alk
anaplastic lymphoma kinase
chr11_+_102393403 8.955 ENSMUST00000107105.2
ENSMUST00000107102.1
ENSMUST00000107103.1
ENSMUST00000006750.7
Rundc3a



RUN domain containing 3A



chr1_-_34579613 8.085 ENSMUST00000062557.3
1700101I19Rik
RIKEN cDNA 1700101I19 gene
chr17_-_83631892 7.503 ENSMUST00000051482.1
Kcng3
potassium voltage-gated channel, subfamily G, member 3
chr1_+_81077274 7.502 ENSMUST00000068275.5
ENSMUST00000113494.2
Nyap2

neuronal tyrosine-phophorylated phosphoinositide 3-kinase adaptor 2

chr1_-_84696182 7.439 ENSMUST00000049126.6
Dner
delta/notch-like EGF-related receptor
chr13_-_56895737 6.874 ENSMUST00000022023.6
ENSMUST00000109871.1
Trpc7

transient receptor potential cation channel, subfamily C, member 7

chr9_+_104569671 6.614 ENSMUST00000057742.8
Cpne4
copine IV
chr13_-_105054895 6.532 ENSMUST00000063551.5
Rgs7bp
regulator of G-protein signalling 7 binding protein
chr9_+_104569754 6.094 ENSMUST00000077190.6
Cpne4
copine IV
chr1_+_81077204 5.856 ENSMUST00000123720.1
Nyap2
neuronal tyrosine-phophorylated phosphoinositide 3-kinase adaptor 2
chr16_-_37384915 5.849 ENSMUST00000114787.1
ENSMUST00000114782.1
ENSMUST00000023526.2
ENSMUST00000114775.1
Stxbp5l



syntaxin binding protein 5-like



chr4_+_129136948 5.789 ENSMUST00000102600.3
Fndc5
fibronectin type III domain containing 5
chr5_-_116591811 5.553 ENSMUST00000076124.5
Srrm4
serine/arginine repetitive matrix 4
chr2_-_28916668 5.497 ENSMUST00000113847.1
Barhl1
BarH-like 1 (Drosophila)
chr12_+_113140198 5.053 ENSMUST00000084882.4
Crip2
cysteine rich protein 2
chr2_-_28916412 4.926 ENSMUST00000050776.2
ENSMUST00000113849.1
Barhl1

BarH-like 1 (Drosophila)

chr9_-_22085391 4.730 ENSMUST00000179422.1
ENSMUST00000098937.3
ENSMUST00000177967.1
ENSMUST00000180180.1
Ecsit



ECSIT homolog (Drosophila)



chr9_+_122117258 4.716 ENSMUST00000146832.1
ENSMUST00000139181.1
Snrk

SNF related kinase

chr17_-_23740301 4.582 ENSMUST00000024702.3
Paqr4
progestin and adipoQ receptor family member IV
chr7_+_63444741 4.540 ENSMUST00000058476.7
Otud7a
OTU domain containing 7A
chr9_+_122117375 4.008 ENSMUST00000118886.1
Snrk
SNF related kinase
chr19_-_45046614 3.425 ENSMUST00000145391.1
Pdzd7
PDZ domain containing 7
chr2_-_180104463 3.222 ENSMUST00000056480.3
Hrh3
histamine receptor H3
chr2_-_92401237 3.126 ENSMUST00000050312.2
Mapk8ip1
mitogen-activated protein kinase 8 interacting protein 1
chr4_+_15881255 3.065 ENSMUST00000029876.1
Calb1
calbindin 1
chr9_+_40873981 3.064 ENSMUST00000067375.3
Bsx
brain specific homeobox
chr13_+_54371340 2.967 ENSMUST00000026985.8
Cplx2
complexin 2
chr11_-_117873433 2.630 ENSMUST00000033230.7
Tha1
threonine aldolase 1
chr8_+_18846251 2.419 ENSMUST00000149565.1
ENSMUST00000033847.4
Agpat5

1-acylglycerol-3-phosphate O-acyltransferase 5 (lysophosphatidic acid acyltransferase, epsilon)

chr2_+_152143552 2.390 ENSMUST00000089112.5
Tcf15
transcription factor 15
chr16_-_37384940 2.198 ENSMUST00000114781.1
ENSMUST00000114780.1
Stxbp5l

syntaxin binding protein 5-like

chr19_+_22139028 2.159 ENSMUST00000099569.2
ENSMUST00000087576.4
ENSMUST00000074770.5
Trpm3


transient receptor potential cation channel, subfamily M, member 3


chr9_+_122117338 1.797 ENSMUST00000120173.1
ENSMUST00000134949.1
ENSMUST00000119215.1
Snrk


SNF related kinase


chr10_+_90829409 1.632 ENSMUST00000182202.1
ENSMUST00000182966.1
Anks1b

ankyrin repeat and sterile alpha motif domain containing 1B

chr17_-_25240112 1.413 ENSMUST00000038973.6
ENSMUST00000115154.4
Gnptg

N-acetylglucosamine-1-phosphotransferase, gamma subunit

chr10_+_90829538 1.397 ENSMUST00000179694.2
Anks1b
ankyrin repeat and sterile alpha motif domain containing 1B
chr19_+_5038826 1.178 ENSMUST00000053705.6
B3gnt1
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1
chr8_+_69088646 1.087 ENSMUST00000006435.7
Atp6v1b2
ATPase, H+ transporting, lysosomal V1 subunit B2
chr2_+_157456917 0.535 ENSMUST00000109529.1
Src
Rous sarcoma oncogene
chr1_-_162548484 0.504 ENSMUST00000028017.9
Mettl13
methyltransferase like 13
chr7_+_19345135 0.441 ENSMUST00000160369.1
Ercc1
excision repair cross-complementing rodent repair deficiency, complementation group 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
16.1 64.3 GO:0021586 pons maturation(GO:0021586)
7.5 67.5 GO:0060373 regulation of atrial cardiac muscle cell membrane depolarization(GO:0060371) regulation of ventricular cardiac muscle cell membrane depolarization(GO:0060373)
6.2 18.5 GO:0030827 negative regulation of cGMP metabolic process(GO:0030824) negative regulation of cGMP biosynthetic process(GO:0030827) negative regulation of guanylate cyclase activity(GO:0031283)
6.0 30.0 GO:0018364 peptidyl-glutamine methylation(GO:0018364)
5.8 17.4 GO:1900736 regulation of phospholipase C-activating G-protein coupled receptor signaling pathway(GO:1900736)
5.8 17.4 GO:0035021 negative regulation of Rac protein signal transduction(GO:0035021)
5.3 47.5 GO:0031339 negative regulation of vesicle fusion(GO:0031339)
4.3 12.9 GO:0001661 conditioned taste aversion(GO:0001661)
3.9 15.7 GO:1903237 negative regulation of leukocyte tethering or rolling(GO:1903237)
3.5 34.7 GO:0033631 cell-cell adhesion mediated by integrin(GO:0033631)
3.4 10.3 GO:0038003 opioid receptor signaling pathway(GO:0038003) regulation of opioid receptor signaling pathway(GO:2000474)
3.1 15.7 GO:0097116 gephyrin clustering involved in postsynaptic density assembly(GO:0097116)
3.1 18.5 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
2.5 15.1 GO:0036515 serotonergic neuron axon guidance(GO:0036515)
2.3 13.9 GO:0072318 clathrin coat disassembly(GO:0072318)
2.2 24.3 GO:0044331 cell-cell adhesion mediated by cadherin(GO:0044331)
2.0 39.5 GO:0099517 anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517)
1.4 16.7 GO:0043084 penile erection(GO:0043084)
1.4 33.3 GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
1.3 13.5 GO:0048149 behavioral response to ethanol(GO:0048149)
1.2 29.8 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
1.1 3.2 GO:0014063 negative regulation of serotonin secretion(GO:0014063)
1.0 20.2 GO:0090036 regulation of protein kinase C signaling(GO:0090036)
0.9 13.8 GO:0050910 detection of mechanical stimulus involved in sensory perception of sound(GO:0050910)
0.9 4.5 GO:0071947 protein deubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0071947)
0.9 2.6 GO:0006566 threonine metabolic process(GO:0006566)
0.8 11.0 GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482)
0.8 5.8 GO:0090336 positive regulation of brown fat cell differentiation(GO:0090336)
0.8 20.9 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.7 15.0 GO:0045956 positive regulation of calcium ion-dependent exocytosis(GO:0045956)
0.7 12.9 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
0.7 7.4 GO:0007220 Notch receptor processing(GO:0007220)
0.6 9.0 GO:0030828 positive regulation of cGMP biosynthetic process(GO:0030828)
0.6 3.0 GO:0031915 positive regulation of synaptic plasticity(GO:0031915)
0.6 12.0 GO:0071625 vocalization behavior(GO:0071625)
0.6 25.0 GO:2001222 regulation of neuron migration(GO:2001222)
0.5 3.1 GO:0007258 JUN phosphorylation(GO:0007258)
0.5 1.4 GO:0016256 N-glycan processing to lysosome(GO:0016256)
0.3 2.4 GO:0045198 establishment of epithelial cell apical/basal polarity(GO:0045198)
0.3 6.9 GO:0006828 manganese ion transport(GO:0006828)
0.3 20.1 GO:0061077 chaperone-mediated protein folding(GO:0061077)
0.3 0.5 GO:0086098 angiotensin-activated signaling pathway involved in heart process(GO:0086098)
0.3 3.1 GO:0060056 mammary gland involution(GO:0060056)
0.3 3.0 GO:1900383 regulation of synaptic plasticity by receptor localization to synapse(GO:1900383)
0.2 3.1 GO:0007614 short-term memory(GO:0007614)
0.2 18.6 GO:0099643 neurotransmitter secretion(GO:0007269) signal release from synapse(GO:0099643)
0.2 15.5 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.2 8.0 GO:0046676 negative regulation of insulin secretion(GO:0046676)
0.1 0.4 GO:0006295 pyrimidine dimer repair by nucleotide-excision repair(GO:0000720) nucleotide-excision repair, DNA incision, 3'-to lesion(GO:0006295) nucleotide-excision repair, DNA incision, 5'-to lesion(GO:0006296) positive regulation of t-circle formation(GO:1904431)
0.1 13.4 GO:0014065 phosphatidylinositol 3-kinase signaling(GO:0014065)
0.1 16.0 GO:0007605 sensory perception of sound(GO:0007605)
0.1 13.3 GO:0007286 spermatid development(GO:0007286)
0.1 22.2 GO:0060828 regulation of canonical Wnt signaling pathway(GO:0060828)
0.1 4.7 GO:0051341 regulation of oxidoreductase activity(GO:0051341)
0.1 9.3 GO:0000187 activation of MAPK activity(GO:0000187)
0.1 45.1 GO:0030334 regulation of cell migration(GO:0030334)
0.1 7.5 GO:0071805 potassium ion transmembrane transport(GO:0071805)
0.0 1.1 GO:0015991 energy coupled proton transmembrane transport, against electrochemical gradient(GO:0015988) ATP hydrolysis coupled proton transport(GO:0015991) ATP hydrolysis coupled transmembrane transport(GO:0090662)
0.0 2.4 GO:0006639 neutral lipid metabolic process(GO:0006638) acylglycerol metabolic process(GO:0006639)
0.0 12.5 GO:0009607 response to biotic stimulus(GO:0009607)
0.0 5.1 GO:0008284 positive regulation of cell proliferation(GO:0008284)
0.0 9.6 GO:0006468 protein phosphorylation(GO:0006468)
0.0 4.1 GO:0007186 G-protein coupled receptor signaling pathway(GO:0007186)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
10.0 40.1 GO:0044307 dendritic branch(GO:0044307)
8.1 24.2 GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
4.2 67.5 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
3.7 30.0 GO:0031428 box C/D snoRNP complex(GO:0031428)
3.6 39.5 GO:1904115 axon cytoplasm(GO:1904115)
3.5 17.4 GO:0042583 chromaffin granule(GO:0042583)
3.1 18.5 GO:0008091 spectrin(GO:0008091)
2.2 32.7 GO:0031045 dense core granule(GO:0031045)
2.1 10.4 GO:0032426 stereocilium tip(GO:0032426)
1.8 18.5 GO:0044327 dendritic spine head(GO:0044327)
1.5 3.0 GO:0070033 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex(GO:0070033)
1.2 38.0 GO:0032588 trans-Golgi network membrane(GO:0032588)
1.2 12.9 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
1.1 3.4 GO:0002141 stereocilia ankle link(GO:0002141)
1.1 52.7 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
1.0 3.1 GO:0044302 dentate gyrus mossy fiber(GO:0044302)
1.0 29.8 GO:0060077 inhibitory synapse(GO:0060077)
0.9 33.5 GO:0097440 apical dendrite(GO:0097440)
0.8 33.3 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.8 50.4 GO:0042734 presynaptic membrane(GO:0042734)
0.4 16.7 GO:0030667 secretory granule membrane(GO:0030667)
0.2 8.0 GO:0031201 SNARE complex(GO:0031201)
0.1 0.4 GO:0000110 nucleotide-excision repair factor 1 complex(GO:0000110) ERCC4-ERCC1 complex(GO:0070522)
0.1 6.9 GO:0005801 cis-Golgi network(GO:0005801)
0.1 14.0 GO:0008021 synaptic vesicle(GO:0008021)
0.1 1.1 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.1 7.5 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.1 14.2 GO:0030141 secretory granule(GO:0030141)
0.1 15.1 GO:0014069 postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
0.1 65.0 GO:0044297 cell body(GO:0044297)
0.1 15.7 GO:0009897 external side of plasma membrane(GO:0009897)
0.1 20.1 GO:0005789 endoplasmic reticulum membrane(GO:0005789)
0.1 75.2 GO:0005794 Golgi apparatus(GO:0005794)
0.0 39.0 GO:0005886 plasma membrane(GO:0005886)
0.0 5.8 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.0 5.1 GO:0005938 cell cortex(GO:0005938)
0.0 3.0 GO:0045211 postsynaptic membrane(GO:0045211)
0.0 68.0 GO:0016021 integral component of membrane(GO:0016021)
0.0 28.4 GO:0042995 cell projection(GO:0042995)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
9.6 67.5 GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
6.9 34.7 GO:0033691 sialic acid binding(GO:0033691)
3.6 40.1 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
3.0 9.0 GO:0030249 guanylate cyclase regulator activity(GO:0030249)
2.2 12.9 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
2.1 20.9 GO:0042301 phosphate ion binding(GO:0042301)
1.4 15.7 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
1.3 15.7 GO:0097109 neuroligin family protein binding(GO:0097109)
1.2 12.9 GO:0004889 acetylcholine-activated cation-selective channel activity(GO:0004889)
1.1 65.5 GO:0005179 hormone activity(GO:0005179)
1.1 32.0 GO:0001786 phosphatidylserine binding(GO:0001786)
1.1 24.2 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.9 2.6 GO:0008732 threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732)
0.8 29.8 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.8 33.3 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.7 20.1 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.6 13.2 GO:0017075 syntaxin-1 binding(GO:0017075)
0.6 6.9 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.5 3.2 GO:0015464 acetylcholine receptor activity(GO:0015464) G-protein coupled acetylcholine receptor activity(GO:0016907)
0.5 24.3 GO:0045296 cadherin binding(GO:0045296)
0.5 30.0 GO:0042054 histone methyltransferase activity(GO:0042054)
0.5 23.5 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.4 18.5 GO:0030507 spectrin binding(GO:0030507)
0.4 1.4 GO:0003976 UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity(GO:0003976)
0.3 13.3 GO:0015485 cholesterol binding(GO:0015485)
0.3 31.2 GO:0051219 phosphoprotein binding(GO:0051219)
0.3 7.5 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.3 18.6 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.2 7.4 GO:0005112 Notch binding(GO:0005112)
0.2 11.0 GO:0008528 G-protein coupled peptide receptor activity(GO:0008528)
0.2 20.4 GO:0000149 SNARE binding(GO:0000149)
0.2 4.5 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.2 3.1 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.1 14.6 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.1 9.3 GO:0004714 transmembrane receptor protein tyrosine kinase activity(GO:0004714)
0.1 2.4 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.1 3.1 GO:0043178 alcohol binding(GO:0043178)
0.1 13.6 GO:0004930 G-protein coupled receptor activity(GO:0004930)
0.1 3.0 GO:0046875 ephrin receptor binding(GO:0046875)
0.1 0.4 GO:0001094 TFIID-class transcription factor binding(GO:0001094)
0.1 4.7 GO:0016651 oxidoreductase activity, acting on NAD(P)H(GO:0016651)
0.1 17.4 GO:0008022 protein C-terminus binding(GO:0008022)
0.0 10.5 GO:0000287 magnesium ion binding(GO:0000287)
0.0 18.5 GO:0003779 actin binding(GO:0003779)
0.0 11.0 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.0 5.6 GO:0003729 mRNA binding(GO:0003729)
0.0 2.2 GO:0005261 cation channel activity(GO:0005261)
0.0 204.7 GO:0003674 molecular_function(GO:0003674)