Motif ID: Rfx3_Rfx1_Rfx4

Z-value: 2.887

Transcription factors associated with Rfx3_Rfx1_Rfx4:

Gene SymbolEntrez IDGene Name
Rfx1 ENSMUSG00000031706.6 Rfx1
Rfx3 ENSMUSG00000040929.10 Rfx3
Rfx4 ENSMUSG00000020037.9 Rfx4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Rfx3mm10_v2_chr19_-_28010995_28011054-0.461.9e-02Click!
Rfx4mm10_v2_chr10_+_84838143_84838153-0.376.0e-02Click!
Rfx1mm10_v2_chr8_+_84066824_840668820.367.0e-02Click!


Activity profile for motif Rfx3_Rfx1_Rfx4.

activity profile for motif Rfx3_Rfx1_Rfx4


Sorted Z-values histogram for motif Rfx3_Rfx1_Rfx4

Sorted Z-values for motif Rfx3_Rfx1_Rfx4



Network of associatons between targets according to the STRING database.



First level regulatory network of Rfx3_Rfx1_Rfx4

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chrX_+_7919816 19.954 ENSMUST00000041096.3
 Pcsk1n
proprotein convertase subtilisin/kexin type 1 inhibitor
chr15_+_98167806 9.678 ENSMUST00000031914.4
 AI836003
expressed sequence AI836003
chr7_+_99268338 8.360 ENSMUST00000107100.2
 Map6
microtubule-associated protein 6
chr11_-_6606053 7.384 ENSMUST00000045713.3
 Nacad
NAC alpha domain containing
chr7_-_140082246 7.357 ENSMUST00000166758.2
 Caly
calcyon neuron-specific vesicular protein
chr9_+_59589288 6.706 ENSMUST00000121266.1
ENSMUST00000118164.1
 Celf6

CUGBP, Elav-like family member 6

chr7_-_140082489 6.618 ENSMUST00000026541.7
 Caly
calcyon neuron-specific vesicular protein
chr7_-_4546567 6.213 ENSMUST00000065957.5
 Syt5
synaptotagmin V
chr19_-_46327121 5.910 ENSMUST00000041391.4
ENSMUST00000096029.5
 Psd

pleckstrin and Sec7 domain containing

chr10_-_81472859 5.765 ENSMUST00000147524.1
ENSMUST00000119060.1
 Celf5

CUGBP, Elav-like family member 5

chr10_+_80295930 5.745 ENSMUST00000105359.1
 Apc2
adenomatosis polyposis coli 2
chr5_+_30814571 5.431 ENSMUST00000031058.8
 Mapre3
microtubule-associated protein, RP/EB family, member 3
chr17_+_34629533 5.377 ENSMUST00000015620.6
 Prrt1
proline-rich transmembrane protein 1
chr17_+_46254017 5.355 ENSMUST00000095262.4
 Lrrc73
leucine rich repeat containing 73
chr7_+_45785331 5.183 ENSMUST00000120005.1
ENSMUST00000123585.1
 Lmtk3

lemur tyrosine kinase 3

chr5_+_30814722 5.045 ENSMUST00000114724.1
 Mapre3
microtubule-associated protein, RP/EB family, member 3
chr12_-_84148449 4.809 ENSMUST00000061425.2
 Pnma1
paraneoplastic antigen MA1
chr5_+_24985840 4.635 ENSMUST00000075081.6
 1500035N22Rik
RIKEN cDNA 1500035N22 gene
chr3_+_13946368 4.609 ENSMUST00000171075.1
ENSMUST00000108372.2
 Ralyl

RALY RNA binding protein-like

chr4_-_119415494 4.585 ENSMUST00000063642.2
 Ccdc30
coiled-coil domain containing 30

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 229 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 20.0 GO:0016486 response to dietary excess(GO:0002021) peptide hormone processing(GO:0016486)
0.6 13.6 GO:0048268 clathrin coat assembly(GO:0048268)
0.2 12.8 GO:0030032 lamellipodium assembly(GO:0030032)
2.6 10.5 GO:1903031 regulation of microtubule plus-end binding(GO:1903031) positive regulation of microtubule plus-end binding(GO:1903033)
0.6 9.4 GO:0035414 negative regulation of catenin import into nucleus(GO:0035414)
0.3 9.4 GO:0060074 synapse maturation(GO:0060074)
1.9 9.3 GO:2000325 regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000325) positive regulation of ligand-dependent nuclear receptor transcription coactivator activity(GO:2000327)
1.8 9.1 GO:0035093 spermatogenesis, exchange of chromosomal proteins(GO:0035093)
0.4 8.9 GO:0071625 vocalization behavior(GO:0071625)
0.3 8.7 GO:0048488 synaptic vesicle endocytosis(GO:0048488)
0.2 8.6 GO:0032418 lysosome localization(GO:0032418)
0.6 7.3 GO:0097688 AMPA glutamate receptor clustering(GO:0097113) glutamate receptor clustering(GO:0097688)
0.3 6.5 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.3 5.7 GO:0045063 T-helper 1 cell differentiation(GO:0045063)
0.2 4.8 GO:0002437 inflammatory response to antigenic stimulus(GO:0002437)
1.5 4.6 GO:0010751 regulation of arginine metabolic process(GO:0000821) negative regulation of nitric oxide mediated signal transduction(GO:0010751) negative regulation of cellular amino acid metabolic process(GO:0045763)
0.1 4.2 GO:0045687 positive regulation of glial cell differentiation(GO:0045687)
1.0 4.1 GO:1904425 negative regulation of GTP binding(GO:1904425)
0.3 4.1 GO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic(GO:0090503)
0.8 4.0 GO:0032423 regulation of mismatch repair(GO:0032423)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 119 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 68.6 GO:0016021 integral component of membrane(GO:0016021)
0.1 27.3 GO:0005802 trans-Golgi network(GO:0005802)
0.1 14.2 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.4 13.5 GO:0035371 microtubule plus-end(GO:0035371)
0.1 10.6 GO:0016607 nuclear speck(GO:0016607)
0.8 8.9 GO:0031258 lamellipodium membrane(GO:0031258)
0.4 8.0 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.3 7.5 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.2 7.2 GO:0030131 clathrin adaptor complex(GO:0030131)
0.4 6.2 GO:0031045 dense core granule(GO:0031045)
0.1 5.7 GO:0016234 inclusion body(GO:0016234)
0.0 5.7 GO:0005769 early endosome(GO:0005769)
0.0 5.1 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.3 4.1 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.3 3.7 GO:0005915 zonula adherens(GO:0005915)
0.2 3.7 GO:0097228 sperm principal piece(GO:0097228)
0.1 3.7 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.1 3.6 GO:0071565 nBAF complex(GO:0071565)
0.1 3.6 GO:0060170 ciliary membrane(GO:0060170)
0.1 3.4 GO:0005881 cytoplasmic microtubule(GO:0005881)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 167 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 20.5 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.1 17.2 GO:0008017 microtubule binding(GO:0008017)
2.3 14.0 GO:0032051 clathrin light chain binding(GO:0032051)
0.2 10.7 GO:0030276 clathrin binding(GO:0030276)
0.0 10.6 GO:0003779 actin binding(GO:0003779)
0.4 9.3 GO:0032183 SUMO binding(GO:0032183)
0.4 8.9 GO:0045295 gamma-catenin binding(GO:0045295)
0.1 7.7 GO:0008026 ATP-dependent helicase activity(GO:0008026) purine NTP-dependent helicase activity(GO:0070035)
0.2 6.5 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.4 6.0 GO:0030346 protein phosphatase 2B binding(GO:0030346)
0.6 5.0 GO:0031811 G-protein coupled nucleotide receptor binding(GO:0031811) P2Y1 nucleotide receptor binding(GO:0031812)
0.1 4.9 GO:0005246 calcium channel regulator activity(GO:0005246)
0.1 4.6 GO:0030215 semaphorin receptor binding(GO:0030215)
0.5 4.4 GO:0055131 C3HC4-type RING finger domain binding(GO:0055131)
0.3 4.1 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.1 4.1 GO:0008748 N-ethylmaleimide reductase activity(GO:0008748) reduced coenzyme F420 dehydrogenase activity(GO:0043738) sulfur oxygenase reductase activity(GO:0043826) malolactic enzyme activity(GO:0043883) epoxyqueuosine reductase activity(GO:0052693)
0.3 4.0 GO:0004698 calcium-dependent protein kinase C activity(GO:0004698)
0.5 3.8 GO:0034452 dynactin binding(GO:0034452)
0.9 3.7 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.2 3.7 GO:0004181 metallocarboxypeptidase activity(GO:0004181)