Motif ID: Rhox4e_Rhox6_Vax2

Z-value: 0.937

Transcription factors associated with Rhox4e_Rhox6_Vax2:

Gene SymbolEntrez IDGene Name
Rhox4e ENSMUSG00000071770.4 Rhox4e
Rhox6 ENSMUSG00000006200.3 Rhox6
Vax2 ENSMUSG00000034777.1 Vax2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Vax2mm10_v2_chr6_+_83711232_837112880.262.1e-01Click!


Activity profile for motif Rhox4e_Rhox6_Vax2.

activity profile for motif Rhox4e_Rhox6_Vax2


Sorted Z-values histogram for motif Rhox4e_Rhox6_Vax2

Sorted Z-values for motif Rhox4e_Rhox6_Vax2



Network of associatons between targets according to the STRING database.



First level regulatory network of Rhox4e_Rhox6_Vax2

PNG image of the network

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Top targets:


Showing 1 to 20 of 189 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_23248264 7.488 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr1_-_89933290 3.537 ENSMUST00000036954.7
 Gbx2
gastrulation brain homeobox 2
chr4_+_15881255 3.079 ENSMUST00000029876.1
 Calb1
calbindin 1
chr13_-_102905740 2.611 ENSMUST00000167462.1
 Mast4
microtubule associated serine/threonine kinase family member 4
chr13_-_102906046 2.593 ENSMUST00000171791.1
 Mast4
microtubule associated serine/threonine kinase family member 4
chr13_-_53473074 2.241 ENSMUST00000021922.8
 Msx2
msh homeobox 2
chr19_+_55895508 2.091 ENSMUST00000111646.1
 Tcf7l2
transcription factor 7 like 2, T cell specific, HMG box
chr4_-_129227883 1.704 ENSMUST00000106051.1
 C77080
expressed sequence C77080
chr2_-_168767136 1.636 ENSMUST00000029061.5
ENSMUST00000103074.1
 Sall4

sal-like 4 (Drosophila)

chr9_+_72806874 1.620 ENSMUST00000055535.8
 Prtg
protogenin homolog (Gallus gallus)
chr3_+_55782500 1.555 ENSMUST00000075422.4
 Mab21l1
mab-21-like 1 (C. elegans)
chr6_+_37870786 1.440 ENSMUST00000120428.1
ENSMUST00000031859.7
 Trim24

tripartite motif-containing 24

chr7_+_130774069 1.335 ENSMUST00000048453.5
 Btbd16
BTB (POZ) domain containing 16
chr2_-_168767029 1.321 ENSMUST00000075044.3
 Sall4
sal-like 4 (Drosophila)
chr1_-_144177259 1.227 ENSMUST00000111941.1
ENSMUST00000052375.1
 Rgs13

regulator of G-protein signaling 13

chr2_+_109917639 1.193 ENSMUST00000046548.7
ENSMUST00000111037.2
 Lgr4

leucine-rich repeat-containing G protein-coupled receptor 4

chr4_-_132075250 1.174 ENSMUST00000105970.1
ENSMUST00000105975.1
 Epb4.1

erythrocyte protein band 4.1

chr14_-_6741430 1.161 ENSMUST00000100904.4
 Gm3636
predicted gene 3636
chr12_+_109545390 1.074 ENSMUST00000146701.1
 Meg3
maternally expressed 3
chr9_+_102720287 1.044 ENSMUST00000130602.1
 Amotl2
angiomotin-like 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 68 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.2 7.5 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.0 4.5 GO:0018105 peptidyl-serine phosphorylation(GO:0018105)
0.5 3.5 GO:0021555 midbrain-hindbrain boundary morphogenesis(GO:0021555)
0.1 3.1 GO:0007614 short-term memory(GO:0007614)
0.2 3.0 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.7 2.2 GO:0048818 embryonic nail plate morphogenesis(GO:0035880) positive regulation of hair follicle maturation(GO:0048818) positive regulation of catagen(GO:0051795) frontal suture morphogenesis(GO:0060364)
0.1 2.2 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.3 2.1 GO:0048625 myoblast fate commitment(GO:0048625)
0.2 1.4 GO:0070562 regulation of vitamin D receptor signaling pathway(GO:0070562)
0.1 1.3 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.4 1.2 GO:0072204 cell-cell signaling involved in kidney development(GO:0060995) Wnt signaling pathway involved in kidney development(GO:0061289) canonical Wnt signaling pathway involved in metanephric kidney development(GO:0061290) cell-cell signaling involved in metanephros development(GO:0072204)
0.0 1.2 GO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway(GO:0045744)
0.0 1.1 GO:0008340 determination of adult lifespan(GO:0008340)
0.2 1.0 GO:0006384 transcription initiation from RNA polymerase III promoter(GO:0006384)
0.0 1.0 GO:0035329 hippo signaling(GO:0035329)
0.0 0.9 GO:0010172 embryonic body morphogenesis(GO:0010172)
0.1 0.8 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.0 0.8 GO:2000353 positive regulation of endothelial cell apoptotic process(GO:2000353)
0.0 0.8 GO:0006418 tRNA aminoacylation for protein translation(GO:0006418)
0.0 0.8 GO:0010923 negative regulation of phosphatase activity(GO:0010923)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 36 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.1 GO:0043195 terminal bouton(GO:0043195)
0.0 3.0 GO:0000792 heterochromatin(GO:0000792)
0.2 2.1 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.2 1.4 GO:0005726 perichromatin fibrils(GO:0005726)
0.1 1.3 GO:0042555 MCM complex(GO:0042555)
0.0 1.0 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.3 0.8 GO:0043540 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex(GO:0043540)
0.0 0.8 GO:0005581 collagen trimer(GO:0005581)
0.1 0.7 GO:0033503 HULC complex(GO:0033503)
0.1 0.7 GO:0098536 deuterosome(GO:0098536)
0.0 0.7 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.1 0.6 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890) dendritic spine neck(GO:0044326)
0.0 0.6 GO:0002102 podosome(GO:0002102)
0.1 0.5 GO:0060187 cell pole(GO:0060187)
0.0 0.5 GO:1990391 DNA repair complex(GO:1990391)
0.0 0.4 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.0 0.4 GO:0031527 filopodium membrane(GO:0031527)
0.1 0.3 GO:0097413 Lewy body(GO:0097413)
0.1 0.3 GO:0031313 extrinsic component of endosome membrane(GO:0031313)
0.0 0.3 GO:0001740 Barr body(GO:0001740)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 48 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 9.8 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.0 5.2 GO:0000287 magnesium ion binding(GO:0000287)
0.0 3.5 GO:0098811 transcriptional activator activity, RNA polymerase II transcription factor binding(GO:0001190) transcriptional repressor activity, RNA polymerase II activating transcription factor binding(GO:0098811)
0.0 3.0 GO:0019842 vitamin binding(GO:0019842)
0.1 2.1 GO:0045295 gamma-catenin binding(GO:0045295)
0.2 1.4 GO:0034056 estrogen response element binding(GO:0034056)
0.0 1.3 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.1 1.2 GO:0016500 protein-hormone receptor activity(GO:0016500)
0.0 1.0 GO:0001056 RNA polymerase III activity(GO:0001056)
0.0 1.0 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.1 0.8 GO:0070095 fructose-6-phosphate binding(GO:0070095)
0.0 0.8 GO:0002161 aminoacyl-tRNA editing activity(GO:0002161)
0.0 0.8 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 0.7 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.1 0.6 GO:0103116 alpha-D-galactofuranose transporter activity(GO:0103116)
0.0 0.6 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.2 0.5 GO:0008311 double-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008311)
0.0 0.5 GO:0042162 telomeric DNA binding(GO:0042162)
0.1 0.4 GO:0035727 lysophosphatidic acid binding(GO:0035727)
0.0 0.4 GO:0034951 pivalyl-CoA mutase activity(GO:0034784) o-hydroxylaminobenzoate mutase activity(GO:0034951) lupeol synthase activity(GO:0042299) beta-amyrin synthase activity(GO:0042300) baruol synthase activity(GO:0080011)