Motif ID: Rora
Z-value: 0.824
Transcription factors associated with Rora:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| Rora | ENSMUSG00000032238.11 | Rora |
Activity-expression correlation:
| Gene Symbol | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Rora | mm10_v2_chr9_+_68653761_68653786 | -0.41 | 3.9e-02 | Click! |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 3.7 | GO:1900365 | positive regulation of mRNA polyadenylation(GO:1900365) |
| 1.0 | 3.1 | GO:0048686 | regulation of sprouting of injured axon(GO:0048686) regulation of axon extension involved in regeneration(GO:0048690) |
| 1.0 | 3.0 | GO:0021933 | radial glia guided migration of cerebellar granule cell(GO:0021933) |
| 0.7 | 2.1 | GO:0086017 | Purkinje myocyte action potential(GO:0086017) |
| 0.7 | 2.0 | GO:0071929 | alpha-tubulin acetylation(GO:0071929) |
| 0.6 | 1.7 | GO:0017055 | negative regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0017055) |
| 0.4 | 1.8 | GO:0033540 | fatty acid beta-oxidation using acyl-CoA oxidase(GO:0033540) |
| 0.4 | 1.2 | GO:0002447 | eosinophil activation involved in immune response(GO:0002278) eosinophil mediated immunity(GO:0002447) eosinophil degranulation(GO:0043308) |
| 0.4 | 2.0 | GO:0015803 | branched-chain amino acid transport(GO:0015803) leucine transport(GO:0015820) |
| 0.4 | 2.2 | GO:0000160 | phosphorelay signal transduction system(GO:0000160) |
| 0.4 | 1.1 | GO:1990034 | calcium ion export from cell(GO:1990034) |
| 0.3 | 1.4 | GO:1903288 | regulation of potassium ion import(GO:1903286) positive regulation of potassium ion import(GO:1903288) |
| 0.3 | 2.0 | GO:1901524 | regulation of autophagosome maturation(GO:1901096) regulation of macromitophagy(GO:1901524) negative regulation of macromitophagy(GO:1901525) |
| 0.3 | 2.1 | GO:0006685 | sphingomyelin catabolic process(GO:0006685) |
| 0.3 | 1.2 | GO:0034975 | protein folding in endoplasmic reticulum(GO:0034975) |
| 0.3 | 1.5 | GO:2000507 | positive regulation of energy homeostasis(GO:2000507) |
| 0.3 | 2.1 | GO:0060267 | positive regulation of respiratory burst(GO:0060267) |
| 0.3 | 0.9 | GO:0048239 | negative regulation of DNA recombination at telomere(GO:0048239) regulation of DNA recombination at telomere(GO:0072695) |
| 0.3 | 2.9 | GO:0051386 | regulation of neurotrophin TRK receptor signaling pathway(GO:0051386) |
| 0.3 | 0.8 | GO:1901731 | calcium-mediated signaling using extracellular calcium source(GO:0035585) positive regulation of platelet aggregation(GO:1901731) |
| 0.2 | 1.2 | GO:0006659 | phosphatidylserine biosynthetic process(GO:0006659) negative regulation of phospholipid biosynthetic process(GO:0071072) |
| 0.2 | 1.0 | GO:0051562 | negative regulation of mitochondrial calcium ion concentration(GO:0051562) |
| 0.2 | 0.9 | GO:0006642 | triglyceride mobilization(GO:0006642) |
| 0.2 | 0.7 | GO:1904457 | positive regulation of neuronal action potential(GO:1904457) |
| 0.2 | 1.3 | GO:0051694 | pointed-end actin filament capping(GO:0051694) |
| 0.2 | 1.7 | GO:0030432 | peristalsis(GO:0030432) |
| 0.2 | 0.9 | GO:0021856 | cerebral cortex tangential migration using cell-axon interactions(GO:0021824) gonadotrophin-releasing hormone neuronal migration to the hypothalamus(GO:0021828) hypothalamic tangential migration using cell-axon interactions(GO:0021856) facioacoustic ganglion development(GO:1903375) |
| 0.2 | 1.4 | GO:0036376 | sodium ion export from cell(GO:0036376) |
| 0.2 | 1.2 | GO:0048069 | eye pigmentation(GO:0048069) |
| 0.2 | 1.5 | GO:0071420 | cellular response to histamine(GO:0071420) |
| 0.2 | 1.2 | GO:2000809 | neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118) positive regulation of synaptic vesicle clustering(GO:2000809) |
| 0.2 | 1.1 | GO:0046103 | inosine biosynthetic process(GO:0046103) |
| 0.1 | 1.1 | GO:0033601 | positive regulation of mammary gland epithelial cell proliferation(GO:0033601) |
| 0.1 | 0.7 | GO:1902031 | regulation of NADP metabolic process(GO:1902031) |
| 0.1 | 0.5 | GO:0010756 | positive regulation of plasminogen activation(GO:0010756) |
| 0.1 | 0.3 | GO:0060785 | regulation of apoptosis involved in tissue homeostasis(GO:0060785) |
| 0.1 | 0.3 | GO:2000642 | negative regulation of early endosome to late endosome transport(GO:2000642) |
| 0.1 | 0.7 | GO:0032811 | negative regulation of gamma-aminobutyric acid secretion(GO:0014053) negative regulation of epinephrine secretion(GO:0032811) |
| 0.1 | 0.7 | GO:0035902 | response to immobilization stress(GO:0035902) |
| 0.1 | 2.4 | GO:0032011 | ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012) |
| 0.1 | 0.9 | GO:0030322 | stabilization of membrane potential(GO:0030322) |
| 0.1 | 0.5 | GO:1903961 | positive regulation of plasma membrane long-chain fatty acid transport(GO:0010747) positive regulation of anion transmembrane transport(GO:1903961) |
| 0.1 | 1.0 | GO:2000821 | regulation of grooming behavior(GO:2000821) |
| 0.1 | 0.2 | GO:0071374 | cellular response to parathyroid hormone stimulus(GO:0071374) |
| 0.1 | 0.3 | GO:0036151 | phosphatidylcholine acyl-chain remodeling(GO:0036151) |
| 0.1 | 1.2 | GO:0048172 | regulation of short-term neuronal synaptic plasticity(GO:0048172) |
| 0.1 | 0.4 | GO:0006102 | isocitrate metabolic process(GO:0006102) |
| 0.1 | 0.2 | GO:0097212 | lysosomal membrane organization(GO:0097212) |
| 0.1 | 1.3 | GO:0007340 | acrosome reaction(GO:0007340) |
| 0.1 | 2.4 | GO:0071277 | cellular response to calcium ion(GO:0071277) |
| 0.1 | 0.4 | GO:1900194 | negative regulation of oocyte maturation(GO:1900194) |
| 0.0 | 0.5 | GO:0033572 | transferrin transport(GO:0033572) |
| 0.0 | 0.4 | GO:0090074 | negative regulation of protein homodimerization activity(GO:0090074) |
| 0.0 | 4.3 | GO:0007601 | visual perception(GO:0007601) |
| 0.0 | 1.5 | GO:0051693 | actin filament capping(GO:0051693) |
| 0.0 | 1.4 | GO:0090162 | establishment of epithelial cell polarity(GO:0090162) |
| 0.0 | 1.3 | GO:0031103 | axon regeneration(GO:0031103) |
| 0.0 | 1.1 | GO:0061098 | positive regulation of protein tyrosine kinase activity(GO:0061098) |
| 0.0 | 0.1 | GO:0018214 | peptidyl-glutamic acid carboxylation(GO:0017187) protein carboxylation(GO:0018214) |
| 0.0 | 0.3 | GO:0051683 | establishment of Golgi localization(GO:0051683) |
| 0.0 | 0.5 | GO:0003417 | growth plate cartilage development(GO:0003417) |
| 0.0 | 0.5 | GO:1901897 | regulation of relaxation of cardiac muscle(GO:1901897) |
| 0.0 | 2.8 | GO:0030010 | establishment of cell polarity(GO:0030010) |
| 0.0 | 0.2 | GO:0032959 | inositol trisphosphate biosynthetic process(GO:0032959) |
| 0.0 | 0.2 | GO:0006122 | mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122) |
| 0.0 | 0.1 | GO:0002036 | regulation of L-glutamate transport(GO:0002036) endoplasmic reticulum tubular network assembly(GO:0071787) |
| 0.0 | 0.5 | GO:0045724 | positive regulation of cilium assembly(GO:0045724) |
| 0.0 | 0.7 | GO:0051647 | nucleus localization(GO:0051647) |
| 0.0 | 0.1 | GO:0045041 | protein import into mitochondrial intermembrane space(GO:0045041) |
| 0.0 | 0.1 | GO:0043313 | regulation of neutrophil degranulation(GO:0043313) |
| 0.0 | 0.3 | GO:0001539 | cilium or flagellum-dependent cell motility(GO:0001539) cilium-dependent cell motility(GO:0060285) |
| 0.0 | 1.1 | GO:0030032 | lamellipodium assembly(GO:0030032) |
| 0.0 | 0.2 | GO:0015813 | L-glutamate transport(GO:0015813) |
| 0.0 | 0.9 | GO:0006821 | chloride transport(GO:0006821) |
| 0.0 | 0.6 | GO:0045670 | regulation of osteoclast differentiation(GO:0045670) |
| 0.0 | 1.6 | GO:0007088 | regulation of mitotic nuclear division(GO:0007088) |
| 0.0 | 3.4 | GO:0050890 | cognition(GO:0050890) |
| 0.0 | 0.1 | GO:0030718 | germ-line stem cell population maintenance(GO:0030718) |
| 0.0 | 0.2 | GO:0007183 | SMAD protein complex assembly(GO:0007183) |
| 0.0 | 0.1 | GO:0006228 | UTP biosynthetic process(GO:0006228) |
| 0.0 | 0.2 | GO:0008340 | determination of adult lifespan(GO:0008340) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 3.1 | GO:0072534 | perineuronal net(GO:0072534) |
| 0.5 | 1.5 | GO:0032437 | cuticular plate(GO:0032437) |
| 0.4 | 2.8 | GO:0005890 | sodium:potassium-exchanging ATPase complex(GO:0005890) |
| 0.3 | 2.0 | GO:0097427 | microtubule bundle(GO:0097427) |
| 0.3 | 1.2 | GO:0070032 | synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032) synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex(GO:0070033) |
| 0.2 | 1.2 | GO:0036056 | filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057) |
| 0.2 | 0.8 | GO:0031095 | platelet dense tubular network membrane(GO:0031095) |
| 0.2 | 3.4 | GO:1990124 | messenger ribonucleoprotein complex(GO:1990124) |
| 0.2 | 0.6 | GO:1990879 | CST complex(GO:1990879) |
| 0.1 | 0.7 | GO:0038039 | G-protein coupled receptor heterodimeric complex(GO:0038039) |
| 0.1 | 0.9 | GO:0030870 | Mre11 complex(GO:0030870) |
| 0.1 | 1.3 | GO:0033180 | proton-transporting V-type ATPase, V1 domain(GO:0033180) |
| 0.1 | 1.1 | GO:0001520 | outer dense fiber(GO:0001520) |
| 0.1 | 2.1 | GO:0034706 | voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706) |
| 0.1 | 0.7 | GO:0044316 | cone cell pedicle(GO:0044316) |
| 0.1 | 0.5 | GO:0005594 | collagen type IX trimer(GO:0005594) |
| 0.1 | 1.2 | GO:0072546 | ER membrane protein complex(GO:0072546) |
| 0.1 | 1.2 | GO:0044292 | dendrite terminus(GO:0044292) |
| 0.1 | 0.5 | GO:0001652 | granular component(GO:0001652) |
| 0.1 | 1.5 | GO:1902710 | GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711) |
| 0.1 | 0.5 | GO:0042599 | lamellar body(GO:0042599) |
| 0.1 | 0.7 | GO:0042788 | polysomal ribosome(GO:0042788) |
| 0.0 | 1.0 | GO:0044224 | juxtaparanode region of axon(GO:0044224) |
| 0.0 | 1.3 | GO:0043194 | axon initial segment(GO:0043194) |
| 0.0 | 0.3 | GO:0032009 | early phagosome(GO:0032009) |
| 0.0 | 1.3 | GO:0046658 | anchored component of plasma membrane(GO:0046658) |
| 0.0 | 0.4 | GO:0008074 | guanylate cyclase complex, soluble(GO:0008074) |
| 0.0 | 2.5 | GO:0031594 | neuromuscular junction(GO:0031594) |
| 0.0 | 0.2 | GO:0005750 | mitochondrial respiratory chain complex III(GO:0005750) |
| 0.0 | 4.2 | GO:0008021 | synaptic vesicle(GO:0008021) |
| 0.0 | 1.0 | GO:0032420 | stereocilium(GO:0032420) |
| 0.0 | 1.9 | GO:0005778 | peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903) |
| 0.0 | 0.3 | GO:0030126 | COPI vesicle coat(GO:0030126) |
| 0.0 | 2.0 | GO:0001725 | stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517) |
| 0.0 | 0.1 | GO:0005784 | Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256) |
| 0.0 | 5.2 | GO:0019898 | extrinsic component of membrane(GO:0019898) |
| 0.0 | 0.3 | GO:0044439 | microbody part(GO:0044438) peroxisomal part(GO:0044439) |
| 0.0 | 1.2 | GO:0005901 | caveola(GO:0005901) |
| 0.0 | 11.2 | GO:0005768 | endosome(GO:0005768) |
| 0.0 | 1.0 | GO:0030175 | filopodium(GO:0030175) |
| 0.0 | 3.0 | GO:0031965 | nuclear membrane(GO:0031965) |
| 0.0 | 0.1 | GO:0005745 | m-AAA complex(GO:0005745) |
| 0.0 | 1.4 | GO:0005923 | bicellular tight junction(GO:0005923) |
| 0.0 | 1.1 | GO:0016363 | nuclear matrix(GO:0016363) |
| 0.0 | 2.1 | GO:0031461 | cullin-RING ubiquitin ligase complex(GO:0031461) |
| 0.0 | 1.3 | GO:0030426 | growth cone(GO:0030426) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 4.1 | GO:0019841 | retinol binding(GO:0019841) |
| 0.6 | 1.7 | GO:0004994 | somatostatin receptor activity(GO:0004994) |
| 0.6 | 1.7 | GO:0002153 | steroid receptor RNA activator RNA binding(GO:0002153) |
| 0.4 | 1.5 | GO:0005237 | inhibitory extracellular ligand-gated ion channel activity(GO:0005237) |
| 0.4 | 2.2 | GO:0000155 | phosphorelay sensor kinase activity(GO:0000155) |
| 0.3 | 0.9 | GO:0008195 | phosphatidate phosphatase activity(GO:0008195) |
| 0.3 | 2.1 | GO:0086006 | voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006) |
| 0.3 | 1.8 | GO:0016401 | palmitoyl-CoA oxidase activity(GO:0016401) |
| 0.3 | 3.4 | GO:0035925 | mRNA 3'-UTR AU-rich region binding(GO:0035925) |
| 0.3 | 2.8 | GO:0008556 | sodium:potassium-exchanging ATPase activity(GO:0005391) potassium-transporting ATPase activity(GO:0008556) |
| 0.3 | 2.1 | GO:0004767 | sphingomyelin phosphodiesterase activity(GO:0004767) |
| 0.3 | 1.0 | GO:0016453 | acetyl-CoA C-acetyltransferase activity(GO:0003985) C-acetyltransferase activity(GO:0016453) |
| 0.2 | 1.2 | GO:0047696 | beta-adrenergic receptor kinase activity(GO:0047696) |
| 0.2 | 0.7 | GO:0004471 | malic enzyme activity(GO:0004470) malate dehydrogenase (decarboxylating) (NAD+) activity(GO:0004471) |
| 0.2 | 0.7 | GO:0016493 | C-C chemokine receptor activity(GO:0016493) |
| 0.2 | 3.8 | GO:0008599 | protein phosphatase type 1 regulator activity(GO:0008599) |
| 0.2 | 1.2 | GO:0070699 | type II activin receptor binding(GO:0070699) |
| 0.2 | 3.1 | GO:0046625 | sphingolipid binding(GO:0046625) |
| 0.2 | 3.1 | GO:0050811 | GABA receptor binding(GO:0050811) |
| 0.1 | 0.4 | GO:0004449 | isocitrate dehydrogenase (NAD+) activity(GO:0004449) |
| 0.1 | 1.3 | GO:0005523 | tropomyosin binding(GO:0005523) |
| 0.1 | 0.8 | GO:0003828 | alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828) |
| 0.1 | 1.1 | GO:0005432 | calcium:sodium antiporter activity(GO:0005432) |
| 0.1 | 1.0 | GO:0031811 | G-protein coupled nucleotide receptor binding(GO:0031811) P2Y1 nucleotide receptor binding(GO:0031812) |
| 0.1 | 2.0 | GO:0005328 | neurotransmitter:sodium symporter activity(GO:0005328) |
| 0.1 | 0.7 | GO:0004965 | G-protein coupled GABA receptor activity(GO:0004965) |
| 0.1 | 1.2 | GO:0015245 | fatty acid transporter activity(GO:0015245) |
| 0.1 | 2.3 | GO:0008143 | poly(A) binding(GO:0008143) |
| 0.1 | 0.3 | GO:0072541 | peroxynitrite reductase activity(GO:0072541) |
| 0.1 | 0.5 | GO:0030144 | alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity(GO:0030144) |
| 0.1 | 0.9 | GO:0098505 | G-rich strand telomeric DNA binding(GO:0098505) |
| 0.1 | 1.6 | GO:0004435 | phosphatidylinositol phospholipase C activity(GO:0004435) |
| 0.1 | 0.9 | GO:0005229 | intracellular calcium activated chloride channel activity(GO:0005229) |
| 0.1 | 2.7 | GO:0034930 | N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517) heparan sulfate 2-O-sulfotransferase activity(GO:0004394) HNK-1 sulfotransferase activity(GO:0016232) heparan sulfate 6-O-sulfotransferase activity(GO:0017095) trans-9R,10R-dihydrodiolphenanthrene sulfotransferase activity(GO:0018721) 1-phenanthrol sulfotransferase activity(GO:0018722) 3-phenanthrol sulfotransferase activity(GO:0018723) 4-phenanthrol sulfotransferase activity(GO:0018724) trans-3,4-dihydrodiolphenanthrene sulfotransferase activity(GO:0018725) 9-phenanthrol sulfotransferase activity(GO:0018726) 2-phenanthrol sulfotransferase activity(GO:0018727) phenanthrol sulfotransferase activity(GO:0019111) 1-hydroxypyrene sulfotransferase activity(GO:0034930) proteoglycan sulfotransferase activity(GO:0050698) cholesterol sulfotransferase activity(GO:0051922) hydroxyjasmonate sulfotransferase activity(GO:0080131) |
| 0.1 | 0.9 | GO:0038191 | neuropilin binding(GO:0038191) |
| 0.1 | 0.9 | GO:0022841 | potassium ion leak channel activity(GO:0022841) |
| 0.1 | 0.3 | GO:0030156 | benzodiazepine receptor binding(GO:0030156) |
| 0.1 | 0.4 | GO:0016941 | natriuretic peptide receptor activity(GO:0016941) |
| 0.1 | 2.4 | GO:0005086 | ARF guanyl-nucleotide exchange factor activity(GO:0005086) |
| 0.1 | 1.4 | GO:0004602 | glutathione peroxidase activity(GO:0004602) |
| 0.1 | 1.1 | GO:0004550 | nucleoside diphosphate kinase activity(GO:0004550) |
| 0.1 | 2.6 | GO:0005158 | insulin receptor binding(GO:0005158) |
| 0.1 | 1.2 | GO:0017075 | syntaxin-1 binding(GO:0017075) |
| 0.0 | 1.7 | GO:0004683 | calmodulin-dependent protein kinase activity(GO:0004683) |
| 0.0 | 2.3 | GO:0030507 | spectrin binding(GO:0030507) |
| 0.0 | 0.2 | GO:0004691 | cAMP-dependent protein kinase activity(GO:0004691) |
| 0.0 | 0.2 | GO:0019784 | NEDD8-specific protease activity(GO:0019784) |
| 0.0 | 0.4 | GO:0048273 | mitogen-activated protein kinase p38 binding(GO:0048273) |
| 0.0 | 0.7 | GO:0017091 | AU-rich element binding(GO:0017091) |
| 0.0 | 0.2 | GO:0016004 | phospholipase activator activity(GO:0016004) lipase activator activity(GO:0060229) |
| 0.0 | 0.2 | GO:0008121 | ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681) |
| 0.0 | 0.3 | GO:0010314 | phosphatidylinositol-5-phosphate binding(GO:0010314) |
| 0.0 | 1.3 | GO:0005179 | hormone activity(GO:0005179) |
| 0.0 | 0.5 | GO:0097602 | cullin family protein binding(GO:0097602) |
| 0.0 | 0.7 | GO:0000217 | DNA secondary structure binding(GO:0000217) |
| 0.0 | 0.1 | GO:0008488 | gamma-glutamyl carboxylase activity(GO:0008488) |
| 0.0 | 1.3 | GO:0061733 | peptide-lysine-N-acetyltransferase activity(GO:0061733) |
| 0.0 | 0.7 | GO:0030552 | cAMP binding(GO:0030552) |
| 0.0 | 1.0 | GO:0017137 | Rab GTPase binding(GO:0017137) |
| 0.0 | 1.4 | GO:0030674 | protein binding, bridging(GO:0030674) |
| 0.0 | 1.2 | GO:0016881 | acid-amino acid ligase activity(GO:0016881) |
| 0.0 | 1.3 | GO:0004860 | protein kinase inhibitor activity(GO:0004860) |
| 0.0 | 0.2 | GO:0005313 | L-glutamate transmembrane transporter activity(GO:0005313) |
| 0.0 | 0.2 | GO:0005545 | 1-phosphatidylinositol binding(GO:0005545) |
| 0.0 | 2.1 | GO:0035091 | phosphatidylinositol binding(GO:0035091) |
| 0.0 | 0.9 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
