Motif ID: Rreb1

Z-value: 0.968


Transcription factors associated with Rreb1:

Gene SymbolEntrez IDGene Name
Rreb1 ENSMUSG00000039087.10 Rreb1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Rreb1mm10_v2_chr13_+_37826225_37826315-0.715.2e-05Click!


Activity profile for motif Rreb1.

activity profile for motif Rreb1


Sorted Z-values histogram for motif Rreb1

Sorted Z-values for motif Rreb1



Network of associatons between targets according to the STRING database.



First level regulatory network of Rreb1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chrX_+_7919816 6.812 ENSMUST00000041096.3
 Pcsk1n
proprotein convertase subtilisin/kexin type 1 inhibitor
chr17_+_35076902 4.363 ENSMUST00000172494.1
ENSMUST00000172678.1
ENSMUST00000013910.4
 Ly6g6e


lymphocyte antigen 6 complex, locus G6E


chr3_+_96181151 3.960 ENSMUST00000035371.8
 Sv2a
synaptic vesicle glycoprotein 2 a
chr13_+_43615710 3.835 ENSMUST00000059986.2
 Rnf182
ring finger protein 182
chr8_+_57455898 3.797 ENSMUST00000034023.3
 Scrg1
scrapie responsive gene 1
chr11_+_67586520 3.510 ENSMUST00000108682.2
 Gas7
growth arrest specific 7
chr3_+_55461758 3.278 ENSMUST00000070418.4
 Dclk1
doublecortin-like kinase 1
chr5_+_37047464 3.258 ENSMUST00000137019.1
 Jakmip1
janus kinase and microtubule interacting protein 1
chr15_+_83791939 3.120 ENSMUST00000172115.1
ENSMUST00000172398.1
 Mpped1

metallophosphoesterase domain containing 1

chr11_+_67586675 2.981 ENSMUST00000108680.1
 Gas7
growth arrest specific 7
chr3_-_89245159 2.894 ENSMUST00000090924.6
 Trim46
tripartite motif-containing 46
chr2_-_33371486 2.854 ENSMUST00000113165.1
 Ralgps1
Ral GEF with PH domain and SH3 binding motif 1
chr3_-_73056943 2.820 ENSMUST00000059407.7
 Slitrk3
SLIT and NTRK-like family, member 3
chr3_-_89245005 2.799 ENSMUST00000107464.1
 Trim46
tripartite motif-containing 46
chr11_-_69369377 2.673 ENSMUST00000092971.6
ENSMUST00000108661.1
 Chd3

chromodomain helicase DNA binding protein 3

chr17_+_35077080 2.566 ENSMUST00000172959.1
 Ly6g6e
lymphocyte antigen 6 complex, locus G6E
chr12_+_12262139 2.441 ENSMUST00000069066.6
ENSMUST00000069005.8
 Fam49a

family with sequence similarity 49, member A

chr12_+_29528382 2.410 ENSMUST00000049784.9
 Myt1l
myelin transcription factor 1-like
chr16_-_67620880 2.378 ENSMUST00000114292.1
ENSMUST00000120898.1
 Cadm2

cell adhesion molecule 2

chr4_+_152338619 2.352 ENSMUST00000030775.5
ENSMUST00000164662.1
 Chd5

chromodomain helicase DNA binding protein 5


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 153 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 8.2 GO:0051017 actin filament bundle assembly(GO:0051017)
0.4 7.2 GO:0002021 response to dietary excess(GO:0002021)
0.2 6.9 GO:0022401 desensitization of G-protein coupled receptor protein signaling pathway(GO:0002029) negative adaptation of signaling pathway(GO:0022401)
1.0 5.1 GO:0032485 regulation of Ral protein signal transduction(GO:0032485)
0.9 4.7 GO:0035093 spermatogenesis, exchange of chromosomal proteins(GO:0035093)
0.0 4.7 GO:0051297 centrosome organization(GO:0051297)
0.0 4.5 GO:0006836 neurotransmitter transport(GO:0006836)
0.2 3.6 GO:0043045 DNA methylation involved in embryo development(GO:0043045) changes to DNA methylation involved in embryo development(GO:1901538)
0.1 3.6 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.0 3.6 GO:0006814 sodium ion transport(GO:0006814)
1.1 3.3 GO:0030827 negative regulation of cGMP metabolic process(GO:0030824) negative regulation of cGMP biosynthetic process(GO:0030827) negative regulation of guanylate cyclase activity(GO:0031283)
0.1 3.3 GO:0021952 central nervous system projection neuron axonogenesis(GO:0021952)
0.5 3.1 GO:1903056 regulation of lens fiber cell differentiation(GO:1902746) positive regulation of lens fiber cell differentiation(GO:1902748) regulation of melanosome organization(GO:1903056)
0.1 3.1 GO:0090004 positive regulation of establishment of protein localization to plasma membrane(GO:0090004)
0.1 2.5 GO:1904030 negative regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045736) negative regulation of cyclin-dependent protein kinase activity(GO:1904030)
0.0 2.5 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.3 2.4 GO:0060665 regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
0.4 2.2 GO:0046684 response to pyrethroid(GO:0046684)
0.7 2.1 GO:0045110 intermediate filament bundle assembly(GO:0045110)
0.3 2.0 GO:2000049 positive regulation of cell-cell adhesion mediated by cadherin(GO:2000049)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 68 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 7.4 GO:0014069 postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
0.3 7.3 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 6.1 GO:0005802 trans-Golgi network(GO:0005802)
0.1 5.7 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.0 5.7 GO:0005884 actin filament(GO:0005884)
0.0 4.4 GO:0019898 extrinsic component of membrane(GO:0019898)
0.1 3.8 GO:0048786 presynaptic active zone(GO:0048786)
0.1 3.8 GO:0032809 neuronal cell body membrane(GO:0032809)
0.0 3.8 GO:0044306 neuron projection terminus(GO:0044306)
1.2 3.7 GO:0005595 collagen type XII trimer(GO:0005595) anchoring collagen complex(GO:0030934)
0.3 3.3 GO:0044327 dendritic spine head(GO:0044327)
0.0 3.1 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.1 2.2 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.0 2.2 GO:0008021 synaptic vesicle(GO:0008021)
0.7 2.1 GO:0033596 TSC1-TSC2 complex(GO:0033596)
0.0 2.1 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.2 2.0 GO:0031254 uropod(GO:0001931) cell trailing edge(GO:0031254)
0.1 1.9 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.1 1.4 GO:0032433 filopodium tip(GO:0032433)
0.0 1.4 GO:0032391 photoreceptor connecting cilium(GO:0032391)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 109 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.3 6.9 GO:0030549 acetylcholine receptor activator activity(GO:0030549)
0.0 6.7 GO:0051015 actin filament binding(GO:0051015)
0.1 6.2 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.8 5.1 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.0 4.7 GO:0008026 ATP-dependent helicase activity(GO:0008026) purine NTP-dependent helicase activity(GO:0070035)
0.1 3.9 GO:0070412 R-SMAD binding(GO:0070412)
0.2 3.3 GO:0050811 GABA receptor binding(GO:0050811)
0.4 3.1 GO:0097322 7SK snRNA binding(GO:0097322)
0.1 3.1 GO:0044824 integrase activity(GO:0008907) T/G mismatch-specific endonuclease activity(GO:0043765) retroviral integrase activity(GO:0044823) retroviral 3' processing activity(GO:0044824)
0.2 2.7 GO:0008599 protein phosphatase type 1 regulator activity(GO:0008599)
0.0 2.7 GO:0008565 protein transporter activity(GO:0008565)
0.1 2.6 GO:0004120 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118) cGMP-inhibited cyclic-nucleotide phosphodiesterase activity(GO:0004119) photoreceptor cyclic-nucleotide phosphodiesterase activity(GO:0004120) 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate phosphodiesterase activity(GO:0044688) inositol phosphosphingolipid phospholipase activity(GO:0052712) inositol phosphorylceramide phospholipase activity(GO:0052713) mannosyl-inositol phosphorylceramide phospholipase activity(GO:0052714) mannosyl-diinositol phosphorylceramide phospholipase activity(GO:0052715)
0.4 2.5 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.1 2.5 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.6 2.4 GO:0005008 hepatocyte growth factor-activated receptor activity(GO:0005008)
0.0 2.3 GO:0004930 G-protein coupled receptor activity(GO:0004930)
0.1 2.2 GO:0031402 sodium ion binding(GO:0031402)
0.1 2.1 GO:0043274 phospholipase binding(GO:0043274)
0.1 2.1 GO:0035255 ionotropic glutamate receptor binding(GO:0035255)
0.1 2.0 GO:0050321 tau-protein kinase activity(GO:0050321)