Motif ID: Runx1

Z-value: 1.082


Transcription factors associated with Runx1:

Gene SymbolEntrez IDGene Name
Runx1 ENSMUSG00000022952.10 Runx1



Activity profile for motif Runx1.

activity profile for motif Runx1


Sorted Z-values histogram for motif Runx1

Sorted Z-values for motif Runx1



Network of associatons between targets according to the STRING database.



First level regulatory network of Runx1

PNG image of the network

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Top targets:


Showing 1 to 20 of 115 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_-_66801577 12.424 ENSMUST00000168589.1
 Sla
src-like adaptor
chr17_+_3397189 8.225 ENSMUST00000072156.6
 Tiam2
T cell lymphoma invasion and metastasis 2
chr2_+_37516618 5.044 ENSMUST00000065441.6
 Gpr21
G protein-coupled receptor 21
chr11_-_83649349 3.867 ENSMUST00000001008.5
 Ccl3
chemokine (C-C motif) ligand 3
chr1_-_169747634 3.644 ENSMUST00000027991.5
ENSMUST00000111357.1
 Rgs4

regulator of G-protein signaling 4

chr13_+_76579670 3.378 ENSMUST00000126960.1
ENSMUST00000109583.2
 Mctp1

multiple C2 domains, transmembrane 1

chr13_+_49608030 3.232 ENSMUST00000021822.5
 Ogn
osteoglycin
chr5_+_104435112 3.075 ENSMUST00000031243.8
ENSMUST00000086833.6
ENSMUST00000112748.1
ENSMUST00000112746.1
ENSMUST00000145084.1
ENSMUST00000132457.1
 Spp1





secreted phosphoprotein 1





chr16_+_42907563 3.031 ENSMUST00000151244.1
ENSMUST00000114694.2
 Zbtb20

zinc finger and BTB domain containing 20

chr12_-_25096080 2.995 ENSMUST00000020974.6
 Id2
inhibitor of DNA binding 2
chr4_-_14621805 2.915 ENSMUST00000042221.7
 Slc26a7
solute carrier family 26, member 7
chr3_+_96181151 2.887 ENSMUST00000035371.8
 Sv2a
synaptic vesicle glycoprotein 2 a
chrX_+_159697308 2.686 ENSMUST00000123433.1
 Sh3kbp1
SH3-domain kinase binding protein 1
chr14_-_124677089 2.584 ENSMUST00000095529.3
 Fgf14
fibroblast growth factor 14
chr2_+_32629467 2.505 ENSMUST00000068271.4
 Ak1
adenylate kinase 1
chr18_+_37411674 2.403 ENSMUST00000051126.2
 Pcdhb10
protocadherin beta 10
chr11_+_75531690 2.362 ENSMUST00000149727.1
ENSMUST00000042561.7
ENSMUST00000108433.1
ENSMUST00000143035.1
 Slc43a2



solute carrier family 43, member 2



chr15_-_102722150 2.339 ENSMUST00000023818.3
 Calcoco1
calcium binding and coiled coil domain 1
chr17_+_35236556 2.273 ENSMUST00000068261.8
 Atp6v1g2
ATPase, H+ transporting, lysosomal V1 subunit G2
chr15_-_102722120 2.191 ENSMUST00000171838.1
 Calcoco1
calcium binding and coiled coil domain 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 61 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 7.2 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.8 5.7 GO:0019532 oxalate transport(GO:0019532)
0.1 5.2 GO:0015807 L-amino acid transport(GO:0015807)
0.8 5.0 GO:0060158 phospholipase C-activating dopamine receptor signaling pathway(GO:0060158)
0.1 4.6 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.0 4.5 GO:0030518 intracellular steroid hormone receptor signaling pathway(GO:0030518)
0.6 3.9 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.4 3.9 GO:0043615 astrocyte cell migration(GO:0043615)
0.1 3.6 GO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway(GO:0045744)
0.3 3.1 GO:0033280 response to vitamin D(GO:0033280)
0.6 3.0 GO:0045578 negative regulation of B cell differentiation(GO:0045578) epithelial cell differentiation involved in mammary gland alveolus development(GO:0061030)
0.0 2.9 GO:0006836 neurotransmitter transport(GO:0006836)
0.7 2.7 GO:0006780 uroporphyrinogen III biosynthetic process(GO:0006780)
0.5 2.6 GO:1901843 positive regulation of high voltage-gated calcium channel activity(GO:1901843)
0.4 2.5 GO:0006172 ADP biosynthetic process(GO:0006172)
0.2 2.4 GO:0048742 regulation of skeletal muscle fiber development(GO:0048742)
0.4 2.2 GO:1901164 negative regulation of trophoblast cell migration(GO:1901164)
0.2 2.2 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.1 2.2 GO:0097320 membrane tubulation(GO:0097320)
0.4 2.1 GO:0090091 positive regulation of extracellular matrix disassembly(GO:0090091) negative regulation of wound healing, spreading of epidermal cells(GO:1903690)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 30 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.4 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 3.8 GO:0072562 blood microparticle(GO:0072562)
0.1 2.9 GO:0048786 presynaptic active zone(GO:0048786)
0.3 2.5 GO:0001520 outer dense fiber(GO:0001520)
0.0 2.4 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.2 2.3 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.0 2.3 GO:0045211 postsynaptic membrane(GO:0045211)
0.2 2.2 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.1 2.2 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.7 2.1 GO:0030981 cortical microtubule cytoskeleton(GO:0030981)
0.3 2.1 GO:0090571 RNA polymerase II transcription repressor complex(GO:0090571)
0.0 2.1 GO:0043235 receptor complex(GO:0043235)
0.0 2.0 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.2 1.9 GO:0044352 pinosome(GO:0044352) macropinosome(GO:0044354)
0.1 1.9 GO:0005865 striated muscle thin filament(GO:0005865)
0.0 1.8 GO:0042734 presynaptic membrane(GO:0042734)
0.0 1.5 GO:0009925 basal plasma membrane(GO:0009925)
0.1 1.4 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.4 1.1 GO:0038045 large latent transforming growth factor-beta complex(GO:0038045)
0.0 1.1 GO:0030119 AP-type membrane coat adaptor complex(GO:0030119)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 46 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 7.2 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.5 5.7 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.1 5.6 GO:0015175 neutral amino acid transmembrane transporter activity(GO:0015175)
1.7 5.0 GO:0001588 dopamine neurotransmitter receptor activity, coupled via Gs(GO:0001588)
0.0 5.0 GO:0017124 SH3 domain binding(GO:0017124)
0.0 4.6 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.2 4.5 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.1 4.3 GO:0005125 cytokine activity(GO:0005125)
1.3 3.9 GO:0001851 complement component C3b binding(GO:0001851)
0.1 3.9 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.1 3.6 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.2 3.4 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.1 3.2 GO:0008083 growth factor activity(GO:0008083)
0.4 2.7 GO:0004852 uroporphyrinogen-III synthase activity(GO:0004852)
0.2 2.5 GO:0004017 adenylate kinase activity(GO:0004017)
0.2 2.3 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.3 2.2 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.1 2.2 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.3 2.1 GO:0001226 RNA polymerase II transcription corepressor binding(GO:0001226)
0.1 2.1 GO:0051010 microtubule plus-end binding(GO:0051010)