Motif ID: Runx2_Bcl11a

Z-value: 1.522

Transcription factors associated with Runx2_Bcl11a:

Gene SymbolEntrez IDGene Name
Bcl11a ENSMUSG00000000861.9 Bcl11a
Runx2 ENSMUSG00000039153.10 Runx2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Bcl11amm10_v2_chr11_+_24080664_240807060.553.6e-03Click!


Activity profile for motif Runx2_Bcl11a.

activity profile for motif Runx2_Bcl11a


Sorted Z-values histogram for motif Runx2_Bcl11a

Sorted Z-values for motif Runx2_Bcl11a



Network of associatons between targets according to the STRING database.



First level regulatory network of Runx2_Bcl11a

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_-_103827922 17.910 ENSMUST00000023934.6
ENSMUST00000153218.1
 Hbb-bs

hemoglobin, beta adult s chain

chr11_-_83649349 8.695 ENSMUST00000001008.5
 Ccl3
chemokine (C-C motif) ligand 3
chr15_-_66801577 7.633 ENSMUST00000168589.1
 Sla
src-like adaptor
chr4_+_144892813 6.070 ENSMUST00000105744.1
ENSMUST00000171001.1
 Dhrs3

dehydrogenase/reductase (SDR family) member 3

chr1_+_58210397 5.619 ENSMUST00000040442.5
 Aox4
aldehyde oxidase 4
chr11_-_98329641 5.612 ENSMUST00000041685.6
 Neurod2
neurogenic differentiation 2
chr19_+_3935186 5.277 ENSMUST00000162708.1
ENSMUST00000165711.1
 Unc93b1

unc-93 homolog B1 (C. elegans)

chr3_-_87263518 5.175 ENSMUST00000090986.4
 Fcrls
Fc receptor-like S, scavenger receptor
chr4_-_136892867 5.090 ENSMUST00000046332.5
 C1qc
complement component 1, q subcomponent, C chain
chr5_+_37047464 4.920 ENSMUST00000137019.1
 Jakmip1
janus kinase and microtubule interacting protein 1
chr1_-_140183404 4.695 ENSMUST00000066859.6
ENSMUST00000111976.2
 Cfh

complement component factor h

chrX_+_159697308 4.454 ENSMUST00000123433.1
 Sh3kbp1
SH3-domain kinase binding protein 1
chr15_-_75567176 4.211 ENSMUST00000156032.1
ENSMUST00000127095.1
 Ly6h

lymphocyte antigen 6 complex, locus H

chr11_-_116654245 4.078 ENSMUST00000021166.5
 Cygb
cytoglobin
chr10_+_61171954 4.061 ENSMUST00000122261.1
ENSMUST00000121297.1
ENSMUST00000035894.5
 Tbata


thymus, brain and testes associated


chr4_+_144893127 4.057 ENSMUST00000142808.1
 Dhrs3
dehydrogenase/reductase (SDR family) member 3
chr3_-_87263703 3.996 ENSMUST00000146512.1
 Fcrls
Fc receptor-like S, scavenger receptor
chr13_-_37050237 3.950 ENSMUST00000164727.1
 F13a1
coagulation factor XIII, A1 subunit
chr5_+_37050854 3.839 ENSMUST00000043794.4
 Jakmip1
janus kinase and microtubule interacting protein 1
chr9_-_103219823 3.833 ENSMUST00000168142.1
 Trf
transferrin

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 268 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.2 13.2 GO:0042572 retinol metabolic process(GO:0042572)
1.1 9.5 GO:0043615 astrocyte cell migration(GO:0043615)
1.2 7.3 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.8 5.9 GO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)
1.9 5.6 GO:0046110 xanthine metabolic process(GO:0046110)
1.9 5.6 GO:2000297 negative regulation of synapse maturation(GO:2000297)
0.8 5.5 GO:0043553 negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
1.8 5.3 GO:0034162 toll-like receptor 9 signaling pathway(GO:0034162)
0.7 5.1 GO:0045650 negative regulation of macrophage differentiation(GO:0045650)
0.1 5.1 GO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway(GO:0045744)
0.0 4.3 GO:0050890 cognition(GO:0050890)
0.8 4.1 GO:0015671 oxygen transport(GO:0015671)
0.1 4.0 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
1.3 3.9 GO:0050975 sensory perception of touch(GO:0050975)
0.3 3.9 GO:0018149 peptide cross-linking(GO:0018149)
0.5 3.8 GO:0097460 positive regulation of oligodendrocyte progenitor proliferation(GO:0070447) ferrous iron import into cell(GO:0097460)
1.2 3.7 GO:0038095 positive regulation of mast cell cytokine production(GO:0032765) Fc-epsilon receptor signaling pathway(GO:0038095)
0.2 3.7 GO:0046069 cGMP catabolic process(GO:0046069)
0.1 3.5 GO:0015807 L-amino acid transport(GO:0015807)
0.3 3.3 GO:0036376 sodium ion export from cell(GO:0036376)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 133 entries
Log-likelihood per target Total log-likelihoodTermDescription
4.5 17.9 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.2 16.0 GO:0072562 blood microparticle(GO:0072562)
0.0 14.3 GO:0005615 extracellular space(GO:0005615)
0.0 7.2 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.8 6.6 GO:0032009 early phagosome(GO:0032009)
0.0 6.4 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 5.9 GO:0019898 extrinsic component of membrane(GO:0019898)
0.5 5.8 GO:0031232 extrinsic component of external side of plasma membrane(GO:0031232)
0.1 5.6 GO:0031225 anchored component of membrane(GO:0031225)
0.8 5.5 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.3 4.4 GO:0016471 vacuolar proton-transporting V-type ATPase complex(GO:0016471)
0.4 4.3 GO:0031091 platelet alpha granule(GO:0031091)
0.1 4.2 GO:0048786 presynaptic active zone(GO:0048786)
0.0 4.2 GO:0030139 endocytic vesicle(GO:0030139)
0.1 3.8 GO:0033270 paranode region of axon(GO:0033270)
0.7 3.4 GO:0038039 G-protein coupled receptor heterodimeric complex(GO:0038039)
0.0 3.4 GO:0055037 recycling endosome(GO:0055037)
0.0 3.0 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.2 2.9 GO:0097228 sperm principal piece(GO:0097228)
0.2 2.6 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 206 entries
Log-likelihood per target Total log-likelihoodTermDescription
4.5 17.9 GO:0031721 haptoglobin binding(GO:0031720) hemoglobin alpha binding(GO:0031721)
1.8 12.7 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.4 9.9 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.5 9.6 GO:0050811 GABA receptor binding(GO:0050811)
0.1 9.2 GO:0017124 SH3 domain binding(GO:0017124)
2.4 7.3 GO:0001851 complement component C3b binding(GO:0001851)
0.3 5.9 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
1.4 5.6 GO:0030151 molybdenum ion binding(GO:0030151)
1.8 5.5 GO:0036313 phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313)
0.7 5.5 GO:0103116 alpha-D-galactofuranose transporter activity(GO:0103116)
0.5 5.3 GO:0035325 Toll-like receptor binding(GO:0035325)
0.1 5.1 GO:0030552 cAMP binding(GO:0030552)
1.1 4.4 GO:0031727 CCR2 chemokine receptor binding(GO:0031727)
0.1 4.4 GO:0015175 neutral amino acid transmembrane transporter activity(GO:0015175)
0.0 4.3 GO:0015631 tubulin binding(GO:0015631)
0.5 4.2 GO:0030550 acetylcholine receptor inhibitor activity(GO:0030550)
1.4 4.1 GO:0005344 oxygen transporter activity(GO:0005344)
1.0 3.9 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.5 3.8 GO:0015091 ferric iron transmembrane transporter activity(GO:0015091) trivalent inorganic cation transmembrane transporter activity(GO:0072510)
0.1 3.7 GO:0035259 glucocorticoid receptor binding(GO:0035259)