Motif ID: Six3_Six1_Six2

Z-value: 0.582

Transcription factors associated with Six3_Six1_Six2:

Gene SymbolEntrez IDGene Name
Six1 ENSMUSG00000051367.8 Six1
Six2 ENSMUSG00000024134.10 Six2
Six3 ENSMUSG00000038805.9 Six3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Six2mm10_v2_chr17_-_85688252_856882750.252.1e-01Click!
Six3mm10_v2_chr17_+_85620816_856208430.203.2e-01Click!
Six1mm10_v2_chr12_-_73047179_730471790.174.0e-01Click!


Activity profile for motif Six3_Six1_Six2.

activity profile for motif Six3_Six1_Six2


Sorted Z-values histogram for motif Six3_Six1_Six2

Sorted Z-values for motif Six3_Six1_Six2



Network of associatons between targets according to the STRING database.



First level regulatory network of Six3_Six1_Six2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chrX_-_142966709 2.500 ENSMUST00000041317.2
 Ammecr1
Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
chr18_+_56432116 2.445 ENSMUST00000070166.5
 Gramd3
GRAM domain containing 3
chr1_+_139454747 2.178 ENSMUST00000053364.8
ENSMUST00000097554.3
 Aspm

asp (abnormal spindle)-like, microcephaly associated (Drosophila)

chr6_-_23248264 1.420 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr9_+_98422961 1.223 ENSMUST00000052068.9
 Rbp1
retinol binding protein 1, cellular
chr13_+_94083490 1.204 ENSMUST00000156071.1
 Lhfpl2
lipoma HMGIC fusion partner-like 2
chr9_+_65141154 1.201 ENSMUST00000034961.4
 Igdcc3
immunoglobulin superfamily, DCC subclass, member 3
chr3_+_146220955 1.039 ENSMUST00000039164.2
 Lpar3
lysophosphatidic acid receptor 3
chr15_-_82244716 0.996 ENSMUST00000089155.4
ENSMUST00000089157.3
 Cenpm

centromere protein M

chr7_-_80115294 0.905 ENSMUST00000107384.3
 Idh2
isocitrate dehydrogenase 2 (NADP+), mitochondrial
chr5_+_140607334 0.903 ENSMUST00000031555.1
 Lfng
LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr15_+_98571004 0.898 ENSMUST00000023728.6
 4930415O20Rik
RIKEN cDNA 4930415O20 gene
chr10_-_128180265 0.803 ENSMUST00000099139.1
 Rbms2
RNA binding motif, single stranded interacting protein 2
chr15_-_75894474 0.708 ENSMUST00000023237.6
 Naprt1
nicotinate phosphoribosyltransferase domain containing 1
chr3_-_37724321 0.662 ENSMUST00000108105.1
ENSMUST00000079755.4
ENSMUST00000099128.1
 Gm5148


predicted gene 5148


chr9_+_104002546 0.639 ENSMUST00000035167.8
ENSMUST00000117054.1
 Nphp3

nephronophthisis 3 (adolescent)

chrX_+_169685191 0.610 ENSMUST00000112104.1
ENSMUST00000112107.1
 Mid1

midline 1

chr1_+_136467958 0.472 ENSMUST00000047817.6
 Kif14
kinesin family member 14
chr8_-_4275886 0.470 ENSMUST00000003029.7
 Timm44
translocase of inner mitochondrial membrane 44
chr3_+_94398517 0.454 ENSMUST00000050975.3
 Lingo4
leucine rich repeat and Ig domain containing 4
chr5_+_21543525 0.431 ENSMUST00000035651.4
 Lrrc17
leucine rich repeat containing 17
chr13_+_104229366 0.430 ENSMUST00000022227.6
 Cenpk
centromere protein K
chr10_+_24595623 0.392 ENSMUST00000176228.1
ENSMUST00000129142.1
 Ctgf

connective tissue growth factor

chr17_+_35241838 0.382 ENSMUST00000173731.1
 Ddx39b
DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B
chr9_-_121839460 0.375 ENSMUST00000135986.2
 Ccdc13
coiled-coil domain containing 13
chrX_-_74373260 0.369 ENSMUST00000073067.4
ENSMUST00000037967.5
 Slc10a3

solute carrier family 10 (sodium/bile acid cotransporter family), member 3

chr9_+_72958785 0.359 ENSMUST00000098567.2
ENSMUST00000034734.8
 Dyx1c1

dyslexia susceptibility 1 candidate 1 homolog (human)

chr7_-_126676357 0.346 ENSMUST00000106371.1
ENSMUST00000106372.3
ENSMUST00000155419.1
 Sult1a1


sulfotransferase family 1A, phenol-preferring, member 1


chr17_+_35241746 0.343 ENSMUST00000068056.5
ENSMUST00000174757.1
 Ddx39b

DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B

chrX_-_74373218 0.307 ENSMUST00000178691.1
ENSMUST00000114146.1
 Ubl4
Slc10a3
ubiquitin-like 4
solute carrier family 10 (sodium/bile acid cotransporter family), member 3
chr11_-_101987004 0.289 ENSMUST00000107173.2
ENSMUST00000107172.1
 Dusp3

dual specificity phosphatase 3 (vaccinia virus phosphatase VH1-related)

chr7_+_30231884 0.287 ENSMUST00000019882.9
 Polr2i
polymerase (RNA) II (DNA directed) polypeptide I
chr10_+_100488289 0.278 ENSMUST00000164751.1
 Cep290
centrosomal protein 290
chr19_-_55315980 0.253 ENSMUST00000076891.5
 Zdhhc6
zinc finger, DHHC domain containing 6
chr15_-_76206309 0.239 ENSMUST00000073418.6
ENSMUST00000171634.1
ENSMUST00000076442.5
 Plec


plectin


chr1_-_118982551 0.228 ENSMUST00000159678.1
 Gli2
GLI-Kruppel family member GLI2
chr4_+_133176336 0.221 ENSMUST00000105912.1
 Wasf2
WAS protein family, member 2
chr11_-_69695521 0.215 ENSMUST00000181261.1
 Tnfsf12
tumor necrosis factor (ligand) superfamily, member 12
chr7_-_101903783 0.213 ENSMUST00000106969.1
 Tomt
transmembrane O-methyltransferase
chr4_+_11758147 0.208 ENSMUST00000029871.5
ENSMUST00000108303.1
 Cdh17

cadherin 17

chr2_-_13271268 0.200 ENSMUST00000137670.1
ENSMUST00000114791.2
 Rsu1

Ras suppressor protein 1

chr12_+_30584429 0.182 ENSMUST00000057151.8
 Tmem18
transmembrane protein 18
chr5_-_62765618 0.181 ENSMUST00000159470.1
 Arap2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr2_-_13271419 0.180 ENSMUST00000028059.2
 Rsu1
Ras suppressor protein 1
chr7_+_123123870 0.175 ENSMUST00000094053.5
 Tnrc6a
trinucleotide repeat containing 6a
chr4_-_43030440 0.173 ENSMUST00000135660.1
 Stoml2
stomatin (Epb7.2)-like 2
chr8_+_69832633 0.151 ENSMUST00000131637.2
ENSMUST00000081503.6
 Pbx4

pre B cell leukemia homeobox 4

chr12_+_84773262 0.146 ENSMUST00000021667.5
 Isca2
iron-sulfur cluster assembly 2 homolog (S. cerevisiae)
chr3_+_88207308 0.141 ENSMUST00000180582.1
 Gm3764
predicted gene 3764
chr10_-_78487842 0.120 ENSMUST00000069431.4
 Gm9978
predicted gene 9978
chr13_-_74292297 0.107 ENSMUST00000109640.1
ENSMUST00000022059.7
 Ahrr

aryl-hydrocarbon receptor repressor

chr8_-_86885222 0.104 ENSMUST00000034074.7
 N4bp1
NEDD4 binding protein 1
chr8_+_71951038 0.102 ENSMUST00000131237.1
ENSMUST00000136516.1
ENSMUST00000109997.2
ENSMUST00000132848.1
 Zfp961



zinc finger protein 961



chr5_+_104046869 0.100 ENSMUST00000031250.7
 Nudt9
nudix (nucleoside diphosphate linked moiety X)-type motif 9
chrX_-_111536325 0.097 ENSMUST00000156639.1
 Rps6ka6
ribosomal protein S6 kinase polypeptide 6
chr14_+_57798156 0.095 ENSMUST00000128764.1
 Sap18
Sin3-associated polypeptide 18
chr17_-_53539411 0.092 ENSMUST00000056198.3
 Pp2d1
protein phosphatase 2C-like domain containing 1
chr7_-_141168671 0.089 ENSMUST00000106033.3
 Rnh1
ribonuclease/angiogenin inhibitor 1
chr6_+_38534823 0.082 ENSMUST00000019833.4
 1110001J03Rik
RIKEN cDNA 1110001J03 gene
chr2_+_158028481 0.081 ENSMUST00000103123.3
 Rprd1b
regulation of nuclear pre-mRNA domain containing 1B
chr2_+_117249725 0.071 ENSMUST00000028825.4
 Fam98b
family with sequence similarity 98, member B
chr16_-_11203259 0.068 ENSMUST00000119953.1
 Rsl1d1
ribosomal L1 domain containing 1
chr19_+_8764934 0.056 ENSMUST00000184663.1
 Nxf1
nuclear RNA export factor 1
chr14_+_57798182 0.047 ENSMUST00000111269.1
 Sap18
Sin3-associated polypeptide 18
chr11_-_99230998 0.044 ENSMUST00000103133.3
 Smarce1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1
chrY_-_6237995 0.020 ENSMUST00000177612.1
 Gm21746
predicted gene, 21746
chr6_-_115675871 0.020 ENSMUST00000112949.1
 Raf1
v-raf-leukemia viral oncogene 1
chr17_+_40811089 0.013 ENSMUST00000024721.7
 Rhag
Rhesus blood group-associated A glycoprotein
chr8_+_57455898 0.004 ENSMUST00000034023.3
 Scrg1
scrapie responsive gene 1
chr7_-_126676428 0.003 ENSMUST00000106373.1
 Sult1a1
sulfotransferase family 1A, phenol-preferring, member 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.2 GO:0051661 maintenance of centrosome location(GO:0051661)
0.3 1.2 GO:0006776 vitamin A metabolic process(GO:0006776)
0.3 0.9 GO:0006097 glyoxylate cycle(GO:0006097)
0.2 1.4 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.2 0.6 GO:0048496 maintenance of organ identity(GO:0048496)
0.2 0.9 GO:0007386 compartment pattern specification(GO:0007386)
0.2 0.5 GO:0021698 cerebellar cortex structural organization(GO:0021698)
0.1 0.4 GO:0048539 bone marrow development(GO:0048539)
0.1 0.7 GO:2000002 negative regulation of DNA damage checkpoint(GO:2000002)
0.1 0.4 GO:0070318 positive regulation of G0 to G1 transition(GO:0070318)
0.1 1.0 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.1 0.2 GO:0002314 germinal center B cell differentiation(GO:0002314)
0.1 0.2 GO:0031581 hemidesmosome assembly(GO:0031581)
0.1 0.2 GO:1990046 positive regulation of mitochondrial DNA replication(GO:0090297) regulation of cardiolipin metabolic process(GO:1900208) positive regulation of cardiolipin metabolic process(GO:1900210) stress-induced mitochondrial fusion(GO:1990046)
0.1 0.2 GO:0060032 notochord regression(GO:0060032)
0.1 0.2 GO:0019614 catechol-containing compound catabolic process(GO:0019614) catecholamine catabolic process(GO:0042424)
0.0 0.4 GO:0036158 outer dynein arm assembly(GO:0036158)
0.0 0.1 GO:0097428 protein maturation by iron-sulfur cluster transfer(GO:0097428)
0.0 0.5 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.0 0.1 GO:0046032 ADP catabolic process(GO:0046032)
0.0 0.3 GO:0051923 sulfation(GO:0051923)
0.0 0.3 GO:0050860 negative regulation of T cell receptor signaling pathway(GO:0050860)
0.0 0.2 GO:0045974 miRNA mediated inhibition of translation(GO:0035278) negative regulation of translation, ncRNA-mediated(GO:0040033) regulation of translation, ncRNA-mediated(GO:0045974)
0.0 0.6 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026)
0.0 0.2 GO:0010592 positive regulation of lamellipodium assembly(GO:0010592)
0.0 1.1 GO:0050885 neuromuscular process controlling balance(GO:0050885)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.2 GO:0036449 microtubule minus-end(GO:0036449)
0.2 0.6 GO:0097543 ciliary inversin compartment(GO:0097543)
0.1 0.7 GO:0005688 U6 snRNP(GO:0005688)
0.0 2.4 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 0.1 GO:0032311 angiogenin-PRI complex(GO:0032311)
0.0 0.2 GO:0035068 micro-ribonucleoprotein complex(GO:0035068)
0.0 0.5 GO:0034451 centriolar satellite(GO:0034451)
0.0 0.2 GO:0030056 hemidesmosome(GO:0030056)
0.0 0.2 GO:0097542 ciliary tip(GO:0097542)
0.0 0.2 GO:0031209 SCAR complex(GO:0031209)
0.0 0.1 GO:0061574 ASAP complex(GO:0061574)
0.0 0.5 GO:0051233 spindle midzone(GO:0051233)
0.0 0.2 GO:0042101 T cell receptor complex(GO:0042101)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.9 GO:0004450 isocitrate dehydrogenase (NADP+) activity(GO:0004450)
0.3 0.9 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.2 1.2 GO:0019841 retinol binding(GO:0019841)
0.2 1.0 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.2 0.7 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.1 0.7 GO:0030621 U4 snRNA binding(GO:0030621)
0.1 0.3 GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding(GO:0050656)
0.1 0.2 GO:0016206 catechol O-methyltransferase activity(GO:0016206)
0.1 0.2 GO:0035673 oligopeptide transmembrane transporter activity(GO:0035673)
0.1 0.2 GO:1901611 phosphatidylglycerol binding(GO:1901611) cardiolipin binding(GO:1901612)
0.0 0.5 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.0 0.4 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.0 0.2 GO:0008307 structural constituent of muscle(GO:0008307)
0.0 0.1 GO:0008428 ribonuclease inhibitor activity(GO:0008428)
0.0 0.1 GO:0047631 adenosine-diphosphatase activity(GO:0043262) ADP-ribose diphosphatase activity(GO:0047631)