Motif ID: Six3_Six1_Six2

Z-value: 0.582

Transcription factors associated with Six3_Six1_Six2:

Gene SymbolEntrez IDGene Name
Six1 ENSMUSG00000051367.8 Six1
Six2 ENSMUSG00000024134.10 Six2
Six3 ENSMUSG00000038805.9 Six3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Six2mm10_v2_chr17_-_85688252_856882750.252.1e-01Click!
Six3mm10_v2_chr17_+_85620816_856208430.203.2e-01Click!
Six1mm10_v2_chr12_-_73047179_730471790.174.0e-01Click!


Activity profile for motif Six3_Six1_Six2.

activity profile for motif Six3_Six1_Six2


Sorted Z-values histogram for motif Six3_Six1_Six2

Sorted Z-values for motif Six3_Six1_Six2



Network of associatons between targets according to the STRING database.



First level regulatory network of Six3_Six1_Six2

PNG image of the network

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Top targets:


Showing 1 to 20 of 70 entries
PromoterScoreRefseqGene SymbolGene Name
chrX_-_142966709 2.500 ENSMUST00000041317.2
 Ammecr1
Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
chr18_+_56432116 2.445 ENSMUST00000070166.5
 Gramd3
GRAM domain containing 3
chr1_+_139454747 2.178 ENSMUST00000053364.8
ENSMUST00000097554.3
 Aspm

asp (abnormal spindle)-like, microcephaly associated (Drosophila)

chr6_-_23248264 1.420 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr9_+_98422961 1.223 ENSMUST00000052068.9
 Rbp1
retinol binding protein 1, cellular
chr13_+_94083490 1.204 ENSMUST00000156071.1
 Lhfpl2
lipoma HMGIC fusion partner-like 2
chr9_+_65141154 1.201 ENSMUST00000034961.4
 Igdcc3
immunoglobulin superfamily, DCC subclass, member 3
chr3_+_146220955 1.039 ENSMUST00000039164.2
 Lpar3
lysophosphatidic acid receptor 3
chr15_-_82244716 0.996 ENSMUST00000089155.4
ENSMUST00000089157.3
 Cenpm

centromere protein M

chr7_-_80115294 0.905 ENSMUST00000107384.3
 Idh2
isocitrate dehydrogenase 2 (NADP+), mitochondrial
chr5_+_140607334 0.903 ENSMUST00000031555.1
 Lfng
LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr15_+_98571004 0.898 ENSMUST00000023728.6
 4930415O20Rik
RIKEN cDNA 4930415O20 gene
chr10_-_128180265 0.803 ENSMUST00000099139.1
 Rbms2
RNA binding motif, single stranded interacting protein 2
chr15_-_75894474 0.708 ENSMUST00000023237.6
 Naprt1
nicotinate phosphoribosyltransferase domain containing 1
chr3_-_37724321 0.662 ENSMUST00000108105.1
ENSMUST00000079755.4
ENSMUST00000099128.1
 Gm5148


predicted gene 5148


chr9_+_104002546 0.639 ENSMUST00000035167.8
ENSMUST00000117054.1
 Nphp3

nephronophthisis 3 (adolescent)

chrX_+_169685191 0.610 ENSMUST00000112104.1
ENSMUST00000112107.1
 Mid1

midline 1

chr1_+_136467958 0.472 ENSMUST00000047817.6
 Kif14
kinesin family member 14
chr8_-_4275886 0.470 ENSMUST00000003029.7
 Timm44
translocase of inner mitochondrial membrane 44
chr3_+_94398517 0.454 ENSMUST00000050975.3
 Lingo4
leucine rich repeat and Ig domain containing 4

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 26 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 2.2 GO:0051661 maintenance of centrosome location(GO:0051661)
0.2 1.4 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.3 1.2 GO:0006776 vitamin A metabolic process(GO:0006776)
0.0 1.1 GO:0050885 neuromuscular process controlling balance(GO:0050885)
0.1 1.0 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.3 0.9 GO:0006097 glyoxylate cycle(GO:0006097)
0.2 0.9 GO:0007386 compartment pattern specification(GO:0007386)
0.1 0.7 GO:2000002 negative regulation of DNA damage checkpoint(GO:2000002)
0.2 0.6 GO:0048496 maintenance of organ identity(GO:0048496)
0.0 0.6 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026)
0.2 0.5 GO:0021698 cerebellar cortex structural organization(GO:0021698)
0.0 0.5 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.1 0.4 GO:0048539 bone marrow development(GO:0048539)
0.1 0.4 GO:0070318 positive regulation of G0 to G1 transition(GO:0070318)
0.0 0.4 GO:0036158 outer dynein arm assembly(GO:0036158)
0.0 0.3 GO:0051923 sulfation(GO:0051923)
0.0 0.3 GO:0050860 negative regulation of T cell receptor signaling pathway(GO:0050860)
0.1 0.2 GO:0002314 germinal center B cell differentiation(GO:0002314)
0.1 0.2 GO:0031581 hemidesmosome assembly(GO:0031581)
0.1 0.2 GO:1990046 positive regulation of mitochondrial DNA replication(GO:0090297) regulation of cardiolipin metabolic process(GO:1900208) positive regulation of cardiolipin metabolic process(GO:1900210) stress-induced mitochondrial fusion(GO:1990046)

Gene overrepresentation in cellular_component category:

Showing 1 to 13 of 13 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.4 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.4 2.2 GO:0036449 microtubule minus-end(GO:0036449)
0.1 0.7 GO:0005688 U6 snRNP(GO:0005688)
0.2 0.6 GO:0097543 ciliary inversin compartment(GO:0097543)
0.0 0.5 GO:0034451 centriolar satellite(GO:0034451)
0.0 0.5 GO:0051233 spindle midzone(GO:0051233)
0.0 0.2 GO:0035068 micro-ribonucleoprotein complex(GO:0035068)
0.0 0.2 GO:0030056 hemidesmosome(GO:0030056)
0.0 0.2 GO:0097542 ciliary tip(GO:0097542)
0.0 0.2 GO:0031209 SCAR complex(GO:0031209)
0.0 0.2 GO:0042101 T cell receptor complex(GO:0042101)
0.0 0.1 GO:0032311 angiogenin-PRI complex(GO:0032311)
0.0 0.1 GO:0061574 ASAP complex(GO:0061574)

Gene overrepresentation in molecular_function category:

Showing 1 to 15 of 15 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 1.2 GO:0019841 retinol binding(GO:0019841)
0.2 1.0 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.3 0.9 GO:0004450 isocitrate dehydrogenase (NADP+) activity(GO:0004450)
0.3 0.9 GO:0033829 O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.2 0.7 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.1 0.7 GO:0030621 U4 snRNA binding(GO:0030621)
0.0 0.5 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.0 0.4 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.1 0.3 GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding(GO:0050656)
0.1 0.2 GO:0016206 catechol O-methyltransferase activity(GO:0016206)
0.1 0.2 GO:0035673 oligopeptide transmembrane transporter activity(GO:0035673)
0.1 0.2 GO:1901611 phosphatidylglycerol binding(GO:1901611) cardiolipin binding(GO:1901612)
0.0 0.2 GO:0008307 structural constituent of muscle(GO:0008307)
0.0 0.1 GO:0008428 ribonuclease inhibitor activity(GO:0008428)
0.0 0.1 GO:0047631 adenosine-diphosphatase activity(GO:0043262) ADP-ribose diphosphatase activity(GO:0047631)