Motif ID: Six6

Z-value: 0.621


Transcription factors associated with Six6:

Gene SymbolEntrez IDGene Name
Six6 ENSMUSG00000021099.5 Six6

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Six6mm10_v2_chr12_+_72939724_72939758-0.125.6e-01Click!


Activity profile for motif Six6.

activity profile for motif Six6


Sorted Z-values histogram for motif Six6

Sorted Z-values for motif Six6



Network of associatons between targets according to the STRING database.



First level regulatory network of Six6

PNG image of the network

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Top targets:


Showing 1 to 20 of 162 entries
PromoterScoreRefseqGene SymbolGene Name
chr13_-_66852017 1.715 ENSMUST00000059329.6
 Gm17449
predicted gene, 17449
chr6_-_23248264 1.695 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr5_+_21543525 1.669 ENSMUST00000035651.4
 Lrrc17
leucine rich repeat containing 17
chr15_+_98571004 1.560 ENSMUST00000023728.6
 4930415O20Rik
RIKEN cDNA 4930415O20 gene
chr7_+_46847128 1.298 ENSMUST00000005051.4
 Ldha
lactate dehydrogenase A
chr1_+_74713551 1.158 ENSMUST00000027356.5
 Cyp27a1
cytochrome P450, family 27, subfamily a, polypeptide 1
chr11_-_11627824 1.008 ENSMUST00000081896.4
 4930512M02Rik
RIKEN cDNA 4930512M02 gene
chrX_+_169685191 0.985 ENSMUST00000112104.1
ENSMUST00000112107.1
 Mid1

midline 1

chrX_-_142966709 0.976 ENSMUST00000041317.2
 Ammecr1
Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
chr2_-_180824596 0.968 ENSMUST00000148700.1
 Gm14340
predicted gene 14340
chr14_+_67234620 0.922 ENSMUST00000176029.1
 Ebf2
early B cell factor 2
chr11_-_46166397 0.892 ENSMUST00000020679.2
 Nipal4
NIPA-like domain containing 4
chr4_-_97584605 0.816 ENSMUST00000107067.1
 E130114P18Rik
RIKEN cDNA E130114P18 gene
chr9_-_114564315 0.812 ENSMUST00000111816.2
 Trim71
tripartite motif-containing 71
chr10_-_78487842 0.779 ENSMUST00000069431.4
 Gm9978
predicted gene 9978
chr8_+_34115030 0.762 ENSMUST00000095345.3
 Mboat4
membrane bound O-acyltransferase domain containing 4
chr9_+_104002546 0.750 ENSMUST00000035167.8
ENSMUST00000117054.1
 Nphp3

nephronophthisis 3 (adolescent)

chr13_-_66851513 0.731 ENSMUST00000169322.1
 Gm17404
predicted gene, 17404
chr7_+_30231884 0.728 ENSMUST00000019882.9
 Polr2i
polymerase (RNA) II (DNA directed) polypeptide I
chr6_+_128662379 0.694 ENSMUST00000032518.4
 Clec2h
C-type lectin domain family 2, member h

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 54 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 1.7 GO:0048539 bone marrow development(GO:0048539)
0.3 1.7 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.3 1.3 GO:0019659 lactate biosynthetic process from pyruvate(GO:0019244) lactate biosynthetic process(GO:0019249) glucose catabolic process to lactate(GO:0019659) glycolytic fermentation(GO:0019660) glucose catabolic process to lactate via pyruvate(GO:0019661)
0.1 1.1 GO:0006968 cellular defense response(GO:0006968)
0.1 1.0 GO:2000002 negative regulation of DNA damage checkpoint(GO:2000002)
0.0 1.0 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026)
0.1 0.9 GO:0035563 positive regulation of chromatin binding(GO:0035563)
0.1 0.9 GO:0015693 magnesium ion transport(GO:0015693)
0.3 0.8 GO:0048496 maintenance of organ identity(GO:0048496)
0.2 0.8 GO:0072488 ammonium transmembrane transport(GO:0072488)
0.1 0.8 GO:0061158 3'-UTR-mediated mRNA destabilization(GO:0061158)
0.2 0.7 GO:0001193 maintenance of transcriptional fidelity during DNA-templated transcription elongation(GO:0001192) maintenance of transcriptional fidelity during DNA-templated transcription elongation from RNA polymerase II promoter(GO:0001193)
0.1 0.6 GO:0007320 insemination(GO:0007320)
0.0 0.6 GO:0035025 positive regulation of Rho protein signal transduction(GO:0035025)
0.0 0.6 GO:0046685 response to arsenic-containing substance(GO:0046685)
0.0 0.6 GO:0001523 retinoid metabolic process(GO:0001523)
0.2 0.5 GO:0002314 germinal center B cell differentiation(GO:0002314)
0.2 0.5 GO:0044849 estrous cycle(GO:0044849)
0.1 0.5 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.1 0.5 GO:0071474 cellular hyperosmotic response(GO:0071474)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 22 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.3 GO:0035686 sperm fibrous sheath(GO:0035686)
0.1 1.0 GO:0005688 U6 snRNP(GO:0005688)
0.3 0.8 GO:0097543 ciliary inversin compartment(GO:0097543)
0.0 0.8 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 0.7 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.0 0.7 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.0 0.5 GO:0031080 nuclear pore outer ring(GO:0031080)
0.0 0.5 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0 0.5 GO:0043219 lateral loop(GO:0043219)
0.0 0.5 GO:0001772 immunological synapse(GO:0001772)
0.0 0.4 GO:0016514 SWI/SNF complex(GO:0016514)
0.0 0.3 GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)
0.0 0.2 GO:0042555 MCM complex(GO:0042555)
0.0 0.2 GO:0001741 XY body(GO:0001741)
0.0 0.1 GO:0097057 TRAF2-GSTP1 complex(GO:0097057)
0.0 0.1 GO:0030915 Smc5-Smc6 complex(GO:0030915)
0.0 0.1 GO:0019815 B cell receptor complex(GO:0019815)
0.0 0.1 GO:0000815 ESCRT III complex(GO:0000815)
0.0 0.1 GO:0030056 hemidesmosome(GO:0030056)
0.0 0.1 GO:0042405 nuclear inclusion body(GO:0042405)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 39 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 1.3 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)
0.1 1.2 GO:0008395 steroid hydroxylase activity(GO:0008395)
0.2 1.0 GO:0030621 U4 snRNA binding(GO:0030621)
0.0 0.9 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.0 0.8 GO:0008519 ammonium transmembrane transporter activity(GO:0008519)
0.0 0.8 GO:0035198 miRNA binding(GO:0035198)
0.0 0.8 GO:0034945 dihydrolipoamide branched chain acyltransferase activity(GO:0004147) palmitoleoyl [acyl-carrier-protein]-dependent acyltransferase activity(GO:0008951) serine O-acyltransferase activity(GO:0016412) O-succinyltransferase activity(GO:0016750) sinapoyltransferase activity(GO:0016752) O-sinapoyltransferase activity(GO:0016753) peptidyl-lysine N6-myristoyltransferase activity(GO:0018030) peptidyl-lysine N6-palmitoyltransferase activity(GO:0018031) benzoyl acetate-CoA thiolase activity(GO:0018711) 3-hydroxybutyryl-CoA thiolase activity(GO:0018712) 3-ketopimelyl-CoA thiolase activity(GO:0018713) N-palmitoyltransferase activity(GO:0019105) acyl-CoA N-acyltransferase activity(GO:0019186) protein-cysteine S-myristoyltransferase activity(GO:0019705) glucosaminyl-phosphotidylinositol O-acyltransferase activity(GO:0032216) ergosterol O-acyltransferase activity(GO:0034737) lanosterol O-acyltransferase activity(GO:0034738) naphthyl-2-oxomethyl-succinyl-CoA succinyl transferase activity(GO:0034848) 2,4,4-trimethyl-3-oxopentanoyl-CoA 2-C-propanoyl transferase activity(GO:0034851) 2-methylhexanoyl-CoA C-acetyltransferase activity(GO:0034915) butyryl-CoA 2-C-propionyltransferase activity(GO:0034919) 2,6-dimethyl-5-methylene-3-oxo-heptanoyl-CoA C-acetyltransferase activity(GO:0034945) L-2-aminoadipate N-acetyltransferase activity(GO:0043741) keto acid formate lyase activity(GO:0043806) azetidine-2-carboxylic acid acetyltransferase activity(GO:0046941) peptidyl-lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0052858) acetyl-CoA:L-lysine N6-acetyltransferase(GO:0090595)
0.1 0.7 GO:0046703 natural killer cell lectin-like receptor binding(GO:0046703)
0.0 0.7 GO:0003899 DNA-directed RNA polymerase activity(GO:0003899)
0.1 0.6 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.1 0.6 GO:0004745 retinol dehydrogenase activity(GO:0004745)
0.0 0.6 GO:0015106 bicarbonate transmembrane transporter activity(GO:0015106)
0.0 0.6 GO:0005035 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.0 0.6 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.2 0.5 GO:0035673 oligopeptide transmembrane transporter activity(GO:0035673)
0.2 0.5 GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding(GO:0050656)
0.1 0.5 GO:0031727 CCR2 chemokine receptor binding(GO:0031727)
0.1 0.5 GO:0004716 receptor signaling protein tyrosine kinase activity(GO:0004716)
0.0 0.5 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.1 0.4 GO:0022865 transmembrane electron transfer carrier(GO:0022865)