Motif ID: Smad1

Z-value: 1.699


Transcription factors associated with Smad1:

Gene SymbolEntrez IDGene Name
Smad1 ENSMUSG00000031681.8 Smad1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Smad1mm10_v2_chr8_-_79399513_79399532-0.222.9e-01Click!


Activity profile for motif Smad1.

activity profile for motif Smad1


Sorted Z-values histogram for motif Smad1

Sorted Z-values for motif Smad1



Network of associatons between targets according to the STRING database.



First level regulatory network of Smad1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chrX_+_73483602 8.078 ENSMUST00000033741.8
ENSMUST00000169489.1
 Bgn

biglycan

chr15_-_66812593 4.241 ENSMUST00000100572.3
 Sla
src-like adaptor
chr11_+_32296489 3.702 ENSMUST00000093207.3
 Hba-a2
hemoglobin alpha, adult chain 2
chr1_-_171234290 3.009 ENSMUST00000079957.6
 Fcer1g
Fc receptor, IgE, high affinity I, gamma polypeptide
chr7_-_103813913 2.895 ENSMUST00000098192.3
 Hbb-bt
hemoglobin, beta adult t chain
chr7_-_103827922 2.843 ENSMUST00000023934.6
ENSMUST00000153218.1
 Hbb-bs

hemoglobin, beta adult s chain

chr5_-_139129662 2.501 ENSMUST00000026973.7
 Prkar1b
protein kinase, cAMP dependent regulatory, type I beta
chr4_-_133498538 2.409 ENSMUST00000125541.1
 Trnp1
TMF1-regulated nuclear protein 1
chr18_+_20665250 2.321 ENSMUST00000075312.3
 Ttr
transthyretin
chr10_-_81025406 2.238 ENSMUST00000055125.4
 Diras1
DIRAS family, GTP-binding RAS-like 1
chr6_+_121300227 2.051 ENSMUST00000064580.7
 Slc6a13
solute carrier family 6 (neurotransmitter transporter, GABA), member 13
chr6_+_4504814 2.051 ENSMUST00000141483.1
 Col1a2
collagen, type I, alpha 2
chr2_-_129371131 2.046 ENSMUST00000028881.7
 Il1b
interleukin 1 beta
chr2_-_152951547 1.929 ENSMUST00000037715.6
 Dusp15
dual specificity phosphatase-like 15
chr5_+_137553517 1.907 ENSMUST00000136088.1
ENSMUST00000139395.1
ENSMUST00000136565.1
ENSMUST00000149292.1
ENSMUST00000125489.1
 Actl6b




actin-like 6B




chr18_+_37435602 1.888 ENSMUST00000055495.5
 Pcdhb12
protocadherin beta 12
chr2_-_25470031 1.880 ENSMUST00000114251.1
 Ptgds
prostaglandin D2 synthase (brain)
chr9_-_98032983 1.842 ENSMUST00000162295.1
 Clstn2
calsyntenin 2
chr11_+_49794157 1.820 ENSMUST00000020629.4
 Gfpt2
glutamine fructose-6-phosphate transaminase 2
chr8_+_104101625 1.819 ENSMUST00000034339.8
 Cdh5
cadherin 5

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 659 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 8.1 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.1 6.9 GO:0030032 lamellipodium assembly(GO:0030032)
0.1 5.2 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.2 4.4 GO:0015812 gamma-aminobutyric acid transport(GO:0015812)
1.4 4.3 GO:0001803 type III hypersensitivity(GO:0001802) regulation of type III hypersensitivity(GO:0001803) positive regulation of type III hypersensitivity(GO:0001805)
0.3 4.0 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.2 3.6 GO:0019835 cytolysis(GO:0019835)
0.1 3.4 GO:0015992 proton transport(GO:0015992)
0.1 3.3 GO:2000649 regulation of sodium ion transmembrane transporter activity(GO:2000649)
0.4 3.0 GO:0018149 peptide cross-linking(GO:0018149)
0.1 2.9 GO:0070208 protein heterotrimerization(GO:0070208)
0.9 2.8 GO:0002586 positive regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002582) regulation of antigen processing and presentation of peptide antigen via MHC class II(GO:0002586) positive regulation of antigen processing and presentation of peptide antigen via MHC class II(GO:0002588)
0.7 2.8 GO:2000551 regulation of T-helper 2 cell cytokine production(GO:2000551) positive regulation of T-helper 2 cell cytokine production(GO:2000553)
0.3 2.8 GO:0032482 Rab protein signal transduction(GO:0032482)
0.0 2.8 GO:0036503 ERAD pathway(GO:0036503)
0.4 2.7 GO:1902847 macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518) regulation of neuronal signal transduction(GO:1902847) positive regulation of tau-protein kinase activity(GO:1902949)
0.0 2.6 GO:0071805 potassium ion transmembrane transport(GO:0071805)
0.1 2.5 GO:0048821 erythrocyte development(GO:0048821)
0.1 2.5 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.2 2.4 GO:0050832 defense response to fungus(GO:0050832)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 271 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 11.1 GO:0045211 postsynaptic membrane(GO:0045211)
2.4 9.4 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.1 9.4 GO:0072562 blood microparticle(GO:0072562)
0.1 7.9 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.1 7.3 GO:0042383 sarcolemma(GO:0042383)
0.0 6.2 GO:0005764 lytic vacuole(GO:0000323) lysosome(GO:0005764)
0.0 6.2 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.1 5.4 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.4 4.6 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.2 4.0 GO:0071565 nBAF complex(GO:0071565)
0.1 3.8 GO:0005746 mitochondrial respiratory chain(GO:0005746)
0.0 3.8 GO:0097708 cytoplasmic vesicle(GO:0031410) intracellular vesicle(GO:0097708)
0.0 3.7 GO:0030133 transport vesicle(GO:0030133)
0.0 3.6 GO:0055037 recycling endosome(GO:0055037)
0.1 3.4 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.0 3.4 GO:0031225 anchored component of membrane(GO:0031225)
0.4 3.1 GO:0097433 dense body(GO:0097433)
0.1 3.0 GO:0033268 node of Ranvier(GO:0033268)
0.6 2.9 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237)
0.2 2.9 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 429 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 11.5 GO:0003735 structural constituent of ribosome(GO:0003735)
2.4 9.4 GO:0031720 haptoglobin binding(GO:0031720)
0.1 6.4 GO:0050840 extracellular matrix binding(GO:0050840)
0.0 5.8 GO:0003779 actin binding(GO:0003779)
1.3 5.2 GO:0019763 immunoglobulin receptor activity(GO:0019763)
0.0 5.0 GO:0003924 GTPase activity(GO:0003924)
0.1 4.2 GO:0004364 glutathione transferase activity(GO:0004364)
0.4 3.9 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
0.3 3.3 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.2 3.3 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.2 3.3 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.1 3.2 GO:0045296 cadherin binding(GO:0045296)
0.1 3.2 GO:0051019 mitogen-activated protein kinase binding(GO:0051019)
0.0 3.2 GO:0005516 calmodulin binding(GO:0005516)
0.8 3.0 GO:0070891 lipoteichoic acid binding(GO:0070891)
0.8 3.0 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.1 3.0 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
1.0 2.9 GO:0016167 glial cell-derived neurotrophic factor receptor activity(GO:0016167)
0.1 2.9 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.1 2.7 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)