Motif ID: Smad2

Z-value: 0.402


Transcription factors associated with Smad2:

Gene SymbolEntrez IDGene Name
Smad2 ENSMUSG00000024563.9 Smad2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Smad2mm10_v2_chr18_+_76241580_76241741-0.242.4e-01Click!


Activity profile for motif Smad2.

activity profile for motif Smad2


Sorted Z-values histogram for motif Smad2

Sorted Z-values for motif Smad2



Network of associatons between targets according to the STRING database.



First level regulatory network of Smad2

PNG image of the network

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Top targets:


Showing 1 to 20 of 71 entries
PromoterScoreRefseqGene SymbolGene Name
chr14_-_12345847 1.898 ENSMUST00000022262.4
 Fezf2
Fez family zinc finger 2
chr17_+_3397189 0.995 ENSMUST00000072156.6
 Tiam2
T cell lymphoma invasion and metastasis 2
chr9_-_119578981 0.751 ENSMUST00000117911.1
ENSMUST00000120420.1
 Scn5a

sodium channel, voltage-gated, type V, alpha

chr3_+_127633134 0.701 ENSMUST00000029587.7
 Neurog2
neurogenin 2
chr11_-_116654245 0.603 ENSMUST00000021166.5
 Cygb
cytoglobin
chr14_+_21500879 0.509 ENSMUST00000182964.1
 Kat6b
K(lysine) acetyltransferase 6B
chr3_-_116968969 0.483 ENSMUST00000143611.1
ENSMUST00000040097.7
 Palmd

palmdelphin

chr10_-_42583628 0.467 ENSMUST00000019938.4
 Nr2e1
nuclear receptor subfamily 2, group E, member 1
chr19_+_59458372 0.453 ENSMUST00000062216.3
 Emx2
empty spiracles homeobox 2
chr3_-_116968827 0.403 ENSMUST00000119557.1
 Palmd
palmdelphin
chr16_+_64851991 0.382 ENSMUST00000067744.7
 Cggbp1
CGG triplet repeat binding protein 1
chr7_-_116237767 0.365 ENSMUST00000182834.1
 Plekha7
pleckstrin homology domain containing, family A member 7
chr1_-_172297989 0.352 ENSMUST00000085913.4
ENSMUST00000097464.2
ENSMUST00000137679.1
 Atp1a2


ATPase, Na+/K+ transporting, alpha 2 polypeptide


chr4_-_155010984 0.314 ENSMUST00000105631.2
ENSMUST00000139976.2
ENSMUST00000145662.2
 Plch2


phospholipase C, eta 2


chr13_+_23752267 0.303 ENSMUST00000091703.2
 Hist1h3b
histone cluster 1, H3b
chr9_+_53771499 0.273 ENSMUST00000048670.8
 Slc35f2
solute carrier family 35, member F2
chr4_+_117849193 0.241 ENSMUST00000132043.2
ENSMUST00000169990.1
 Slc6a9

solute carrier family 6 (neurotransmitter transporter, glycine), member 9

chr8_-_87959560 0.239 ENSMUST00000109655.2
 Zfp423
zinc finger protein 423
chr6_-_55175019 0.234 ENSMUST00000003569.5
 Inmt
indolethylamine N-methyltransferase
chr10_-_118868903 0.233 ENSMUST00000004281.8
 Dyrk2
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 20 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 1.9 GO:1904936 forebrain anterior/posterior pattern specification(GO:0021797) cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
0.3 0.8 GO:0086017 response to inactivity(GO:0014854) response to muscle inactivity(GO:0014870) response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894) Purkinje myocyte action potential(GO:0086017) membrane depolarization during SA node cell action potential(GO:0086046)
0.1 0.6 GO:0015671 oxygen transport(GO:0015671)
0.2 0.5 GO:0061537 glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537)
0.1 0.5 GO:0021764 amygdala development(GO:0021764)
0.1 0.4 GO:1903279 regulation of calcium:sodium antiporter activity(GO:1903279)
0.1 0.4 GO:0045218 zonula adherens maintenance(GO:0045218)
0.0 0.4 GO:0021796 cerebral cortex regionalization(GO:0021796)
0.0 0.3 GO:1903300 negative regulation of glucokinase activity(GO:0033132) negative regulation of hexokinase activity(GO:1903300)
0.0 0.2 GO:0072697 protein localization to cell cortex(GO:0072697)
0.0 0.2 GO:0051534 negative regulation of NFAT protein import into nucleus(GO:0051534)
0.0 0.2 GO:0034242 negative regulation of syncytium formation by plasma membrane fusion(GO:0034242)
0.0 0.2 GO:0060746 parental behavior(GO:0060746)
0.0 0.1 GO:2000546 positive regulation of cell chemotaxis to fibroblast growth factor(GO:1904849) positive regulation of endothelial cell chemotaxis to fibroblast growth factor(GO:2000546)
0.0 0.1 GO:1902336 neuropilin signaling pathway(GO:0038189) VEGF-activated neuropilin signaling pathway(GO:0038190) positive regulation of retinal ganglion cell axon guidance(GO:1902336)
0.0 0.1 GO:0017183 peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.0 0.1 GO:0032782 bile acid secretion(GO:0032782) positive regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035360)
0.0 0.1 GO:0051967 negative regulation of synaptic transmission, glutamatergic(GO:0051967)
0.0 0.1 GO:0042866 pyruvate biosynthetic process(GO:0042866)
0.0 0.0 GO:0008295 spermidine biosynthetic process(GO:0008295)

Gene overrepresentation in cellular_component category:

Showing 1 to 8 of 8 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 0.8 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.0 0.8 GO:0000786 nucleosome(GO:0000786)
0.1 0.4 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.0 0.4 GO:0005915 zonula adherens(GO:0005915)
0.0 0.1 GO:0042585 germinal vesicle(GO:0042585)
0.0 0.1 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)
0.0 0.1 GO:0032983 kainate selective glutamate receptor complex(GO:0032983)
0.0 0.1 GO:0046581 intercellular canaliculus(GO:0046581)

Gene overrepresentation in molecular_function category:

Showing 1 to 13 of 13 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.7 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.1 0.8 GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
0.0 0.7 GO:0070888 E-box binding(GO:0070888)
0.2 0.6 GO:0004096 catalase activity(GO:0004096)
0.1 0.5 GO:0015375 glycine:sodium symporter activity(GO:0015375)
0.0 0.4 GO:0103116 alpha-D-galactofuranose transporter activity(GO:0103116) steroid hormone binding(GO:1990239)
0.0 0.4 GO:0070097 delta-catenin binding(GO:0070097)
0.0 0.3 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.0 0.2 GO:0001727 lipid kinase activity(GO:0001727)
0.0 0.1 GO:0005105 type 1 fibroblast growth factor receptor binding(GO:0005105)
0.0 0.1 GO:0043183 vascular endothelial growth factor receptor 1 binding(GO:0043183)
0.0 0.1 GO:0004743 pyruvate kinase activity(GO:0004743)
0.0 0.1 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)