Motif ID: Smad2

Z-value: 0.402


Transcription factors associated with Smad2:

Gene SymbolEntrez IDGene Name
Smad2 ENSMUSG00000024563.9 Smad2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Smad2mm10_v2_chr18_+_76241580_76241741-0.242.4e-01Click!


Activity profile for motif Smad2.

activity profile for motif Smad2


Sorted Z-values histogram for motif Smad2

Sorted Z-values for motif Smad2



Network of associatons between targets according to the STRING database.



First level regulatory network of Smad2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr14_-_12345847 1.898 ENSMUST00000022262.4
 Fezf2
Fez family zinc finger 2
chr17_+_3397189 0.995 ENSMUST00000072156.6
 Tiam2
T cell lymphoma invasion and metastasis 2
chr9_-_119578981 0.751 ENSMUST00000117911.1
ENSMUST00000120420.1
 Scn5a

sodium channel, voltage-gated, type V, alpha

chr3_+_127633134 0.701 ENSMUST00000029587.7
 Neurog2
neurogenin 2
chr11_-_116654245 0.603 ENSMUST00000021166.5
 Cygb
cytoglobin
chr14_+_21500879 0.509 ENSMUST00000182964.1
 Kat6b
K(lysine) acetyltransferase 6B
chr3_-_116968969 0.483 ENSMUST00000143611.1
ENSMUST00000040097.7
 Palmd

palmdelphin

chr10_-_42583628 0.467 ENSMUST00000019938.4
 Nr2e1
nuclear receptor subfamily 2, group E, member 1
chr19_+_59458372 0.453 ENSMUST00000062216.3
 Emx2
empty spiracles homeobox 2
chr3_-_116968827 0.403 ENSMUST00000119557.1
 Palmd
palmdelphin
chr16_+_64851991 0.382 ENSMUST00000067744.7
 Cggbp1
CGG triplet repeat binding protein 1
chr7_-_116237767 0.365 ENSMUST00000182834.1
 Plekha7
pleckstrin homology domain containing, family A member 7
chr1_-_172297989 0.352 ENSMUST00000085913.4
ENSMUST00000097464.2
ENSMUST00000137679.1
 Atp1a2


ATPase, Na+/K+ transporting, alpha 2 polypeptide


chr4_-_155010984 0.314 ENSMUST00000105631.2
ENSMUST00000139976.2
ENSMUST00000145662.2
 Plch2


phospholipase C, eta 2


chr13_+_23752267 0.303 ENSMUST00000091703.2
 Hist1h3b
histone cluster 1, H3b
chr9_+_53771499 0.273 ENSMUST00000048670.8
 Slc35f2
solute carrier family 35, member F2
chr4_+_117849193 0.241 ENSMUST00000132043.2
ENSMUST00000169990.1
 Slc6a9

solute carrier family 6 (neurotransmitter transporter, glycine), member 9

chr8_-_87959560 0.239 ENSMUST00000109655.2
 Zfp423
zinc finger protein 423
chr6_-_55175019 0.234 ENSMUST00000003569.5
 Inmt
indolethylamine N-methyltransferase
chr10_-_118868903 0.233 ENSMUST00000004281.8
 Dyrk2
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
chr10_+_80150448 0.210 ENSMUST00000153477.1
 Midn
midnolin
chr4_+_117849361 0.210 ENSMUST00000163288.1
 Slc6a9
solute carrier family 6 (neurotransmitter transporter, glycine), member 9
chr7_+_82867327 0.191 ENSMUST00000082237.5
 Mex3b
mex3 homolog B (C. elegans)
chr2_-_91950386 0.186 ENSMUST00000111303.1
 Dgkz
diacylglycerol kinase zeta
chr15_-_103251465 0.183 ENSMUST00000133600.1
ENSMUST00000134554.1
ENSMUST00000156927.1
ENSMUST00000149111.1
ENSMUST00000132836.1
 Nfe2




nuclear factor, erythroid derived 2




chr17_-_25861456 0.182 ENSMUST00000079461.8
ENSMUST00000176923.1
 Wdr90

WD repeat domain 90

chr12_+_33147754 0.179 ENSMUST00000146040.1
ENSMUST00000125192.1
 Atxn7l1

ataxin 7-like 1

chr17_-_34615965 0.172 ENSMUST00000097345.3
ENSMUST00000015611.7
 Egfl8

EGF-like domain 8

chr15_+_57694651 0.171 ENSMUST00000096430.4
 Zhx2
zinc fingers and homeoboxes 2
chr7_-_34654342 0.162 ENSMUST00000108069.1
 Kctd15
potassium channel tetramerisation domain containing 15
chr2_+_156863110 0.162 ENSMUST00000029165.3
 1110008F13Rik
RIKEN cDNA 1110008F13 gene
chrX_-_94123359 0.148 ENSMUST00000137853.1
ENSMUST00000088102.5
ENSMUST00000113927.1
 Zfx


zinc finger protein X-linked


chr11_-_33147400 0.146 ENSMUST00000020507.7
 Fgf18
fibroblast growth factor 18
chr8_-_69184177 0.145 ENSMUST00000185176.1
 Lzts1
leucine zipper, putative tumor suppressor 1
chr14_-_20496780 0.134 ENSMUST00000022353.3
 Mss51
MSS51 mitochondrial translational activator
chr10_-_49788743 0.129 ENSMUST00000105483.1
ENSMUST00000105487.1
 Grik2

glutamate receptor, ionotropic, kainate 2 (beta 2)

chr2_+_177768044 0.109 ENSMUST00000108942.3
 Gm14322
predicted gene 14322
chr4_+_11191726 0.108 ENSMUST00000029866.9
ENSMUST00000108324.3
 Ccne2

cyclin E2

chr7_+_101321703 0.105 ENSMUST00000174291.1
ENSMUST00000167888.2
ENSMUST00000172662.1
ENSMUST00000173270.1
ENSMUST00000174083.1
 Stard10




START domain containing 10




chr15_+_102102926 0.104 ENSMUST00000169627.1
ENSMUST00000046144.9
 Tenc1

tensin like C1 domain-containing phosphatase

chr10_-_37138863 0.104 ENSMUST00000092584.5
 Marcks
myristoylated alanine rich protein kinase C substrate
chrX_+_99821021 0.090 ENSMUST00000096363.2
 Tmem28
transmembrane protein 28
chr6_-_142702259 0.085 ENSMUST00000073173.5
ENSMUST00000111771.1
ENSMUST00000087527.4
ENSMUST00000100827.2
 Abcc9



ATP-binding cassette, sub-family C (CFTR/MRP), member 9



chr8_-_90908415 0.084 ENSMUST00000098517.1
 Gm6658
predicted gene 6658
chr11_-_75190458 0.083 ENSMUST00000044949.4
 Dph1
DPH1 homolog (S. cerevisiae)
chr17_+_7925990 0.082 ENSMUST00000036370.7
 Tagap
T cell activation Rho GTPase activating protein
chr17_-_46032366 0.082 ENSMUST00000071648.5
ENSMUST00000142351.2
ENSMUST00000167860.1
 Vegfa


vascular endothelial growth factor A


chr11_+_4135233 0.080 ENSMUST00000124670.1
 Rnf215
ring finger protein 215
chr4_-_129261394 0.077 ENSMUST00000145261.1
 C77080
expressed sequence C77080
chr3_+_89136133 0.076 ENSMUST00000047111.6
 Pklr
pyruvate kinase liver and red blood cell
chr10_+_80151154 0.064 ENSMUST00000146516.1
ENSMUST00000144526.1
 Midn

midnolin

chr3_+_135438722 0.061 ENSMUST00000166033.1
 Ube2d3
ubiquitin-conjugating enzyme E2D 3
chr13_-_100104064 0.056 ENSMUST00000038104.5
 Bdp1
B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB
chr4_+_148591482 0.048 ENSMUST00000006611.8
 Srm
spermidine synthase
chr8_+_109705549 0.048 ENSMUST00000034163.8
 Zfp821
zinc finger protein 821
chr7_-_45052865 0.044 ENSMUST00000057293.6
 Prr12
proline rich 12
chr11_+_101119938 0.041 ENSMUST00000043680.8
 Tubg1
tubulin, gamma 1
chr7_-_29180454 0.033 ENSMUST00000182328.1
 Psmd8
proteasome (prosome, macropain) 26S subunit, non-ATPase, 8
chr13_-_104816908 0.025 ENSMUST00000022228.6
 Cwc27
CWC27 spliceosome-associated protein homolog (S. cerevisiae)
chr3_+_135438280 0.023 ENSMUST00000106291.3
 Ube2d3
ubiquitin-conjugating enzyme E2D 3
chr7_-_29180699 0.020 ENSMUST00000059642.10
 Psmd8
proteasome (prosome, macropain) 26S subunit, non-ATPase, 8
chr14_-_18331855 0.017 ENSMUST00000022296.6
 Ube2e1
ubiquitin-conjugating enzyme E2E 1
chrX_-_94123087 0.016 ENSMUST00000113925.1
 Zfx
zinc finger protein X-linked
chr6_+_125009665 0.016 ENSMUST00000046064.10
ENSMUST00000152752.1
ENSMUST00000088308.3
ENSMUST00000112425.1
ENSMUST00000084275.5
 Zfp384




zinc finger protein 384




chr18_-_31609893 0.015 ENSMUST00000060396.6
 Slc25a46
solute carrier family 25, member 46
chrX_-_20931520 0.014 ENSMUST00000001156.7
 Cfp
complement factor properdin
chr13_+_104817171 0.012 ENSMUST00000022230.8
 Srek1ip1
splicing regulatory glutamine/lysine-rich protein 1interacting protein 1
chr9_+_44107286 0.012 ENSMUST00000152956.1
ENSMUST00000114815.1
 C1qtnf5

C1q and tumor necrosis factor related protein 5

chr8_-_105637350 0.011 ENSMUST00000182863.1
 Gm5914
predicted gene 5914
chr17_-_35700520 0.010 ENSMUST00000119825.1
 Ddr1
discoidin domain receptor family, member 1
chr17_-_35980197 0.009 ENSMUST00000055454.7
 Prr3
proline-rich polypeptide 3

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.9 GO:1904936 forebrain anterior/posterior pattern specification(GO:0021797) cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
0.3 0.8 GO:0086017 response to inactivity(GO:0014854) response to muscle inactivity(GO:0014870) response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894) Purkinje myocyte action potential(GO:0086017) membrane depolarization during SA node cell action potential(GO:0086046)
0.2 0.5 GO:0061537 glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537)
0.1 0.6 GO:0015671 oxygen transport(GO:0015671)
0.1 0.4 GO:1903279 regulation of calcium:sodium antiporter activity(GO:1903279)
0.1 0.5 GO:0021764 amygdala development(GO:0021764)
0.1 0.4 GO:0045218 zonula adherens maintenance(GO:0045218)
0.0 0.2 GO:0072697 protein localization to cell cortex(GO:0072697)
0.0 0.3 GO:1903300 negative regulation of glucokinase activity(GO:0033132) negative regulation of hexokinase activity(GO:1903300)
0.0 0.1 GO:2000546 positive regulation of cell chemotaxis to fibroblast growth factor(GO:1904849) positive regulation of endothelial cell chemotaxis to fibroblast growth factor(GO:2000546)
0.0 0.2 GO:0051534 negative regulation of NFAT protein import into nucleus(GO:0051534)
0.0 0.1 GO:1902336 neuropilin signaling pathway(GO:0038189) VEGF-activated neuropilin signaling pathway(GO:0038190) positive regulation of retinal ganglion cell axon guidance(GO:1902336)
0.0 0.4 GO:0021796 cerebral cortex regionalization(GO:0021796)
0.0 0.1 GO:0017183 peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.0 0.2 GO:0034242 negative regulation of syncytium formation by plasma membrane fusion(GO:0034242)
0.0 0.1 GO:0032782 bile acid secretion(GO:0032782) positive regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035360)
0.0 0.1 GO:0051967 negative regulation of synaptic transmission, glutamatergic(GO:0051967)
0.0 0.1 GO:0042866 pyruvate biosynthetic process(GO:0042866)
0.0 0.0 GO:0008295 spermidine biosynthetic process(GO:0008295)
0.0 0.2 GO:0060746 parental behavior(GO:0060746)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.0 0.8 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.0 0.1 GO:0042585 germinal vesicle(GO:0042585)
0.0 0.4 GO:0005915 zonula adherens(GO:0005915)
0.0 0.1 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)
0.0 0.1 GO:0032983 kainate selective glutamate receptor complex(GO:0032983)
0.0 0.1 GO:0046581 intercellular canaliculus(GO:0046581)
0.0 0.8 GO:0000786 nucleosome(GO:0000786)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0004096 catalase activity(GO:0004096)
0.1 0.8 GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
0.1 0.5 GO:0015375 glycine:sodium symporter activity(GO:0015375)
0.0 0.1 GO:0005105 type 1 fibroblast growth factor receptor binding(GO:0005105)
0.0 0.4 GO:0103116 alpha-D-galactofuranose transporter activity(GO:0103116) steroid hormone binding(GO:1990239)
0.0 0.4 GO:0070097 delta-catenin binding(GO:0070097)
0.0 0.1 GO:0043183 vascular endothelial growth factor receptor 1 binding(GO:0043183)
0.0 0.1 GO:0004743 pyruvate kinase activity(GO:0004743)
0.0 0.1 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.0 0.2 GO:0001727 lipid kinase activity(GO:0001727)
0.0 0.3 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.0 0.7 GO:0070888 E-box binding(GO:0070888)
0.0 2.7 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)