Motif ID: Smad3

Z-value: 1.393


Transcription factors associated with Smad3:

Gene SymbolEntrez IDGene Name
Smad3 ENSMUSG00000032402.6 Smad3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Smad3mm10_v2_chr9_-_63711969_63711994-0.601.1e-03Click!


Activity profile for motif Smad3.

activity profile for motif Smad3


Sorted Z-values histogram for motif Smad3

Sorted Z-values for motif Smad3



Network of associatons between targets according to the STRING database.



First level regulatory network of Smad3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr13_+_23533869 8.984 ENSMUST00000073261.2
 Hist1h2af
histone cluster 1, H2af
chr13_-_22042949 8.549 ENSMUST00000091741.4
 Hist1h2ag
histone cluster 1, H2ag
chr13_-_21833575 7.431 ENSMUST00000081342.5
 Hist1h2ap
histone cluster 1, H2ap
chr13_-_22035589 7.084 ENSMUST00000091742.4
 Hist1h2ah
histone cluster 1, H2ah
chr13_-_21787218 6.216 ENSMUST00000091751.2
 Hist1h2an
histone cluster 1, H2an
chr12_+_12911986 5.991 ENSMUST00000085720.1
 Rpl36-ps3
ribosomal protein L36, pseudogene 3
chr13_-_23571151 5.243 ENSMUST00000102969.3
 Hist1h2ae
histone cluster 1, H2ae
chr13_+_21810428 5.240 ENSMUST00000091745.5
 Hist1h2ao
histone cluster 1, H2ao
chr15_+_81936911 4.662 ENSMUST00000135663.1
 Csdc2
cold shock domain containing C2, RNA binding
chr13_+_23531044 4.527 ENSMUST00000102972.3
 Hist1h4h
histone cluster 1, H4h
chr13_-_21832194 4.439 ENSMUST00000102979.1
 Hist1h4n
histone cluster 1, H4n
chr13_-_21750505 4.216 ENSMUST00000102983.1
 Hist1h4k
histone cluster 1, H4k
chr15_+_81936753 3.845 ENSMUST00000038757.7
 Csdc2
cold shock domain containing C2, RNA binding
chr19_+_5740885 3.759 ENSMUST00000081496.5
 Ltbp3
latent transforming growth factor beta binding protein 3
chr1_-_134235420 3.718 ENSMUST00000038191.6
ENSMUST00000086465.4
 Adora1

adenosine A1 receptor

chr13_-_23551648 3.446 ENSMUST00000102971.1
 Hist1h4f
histone cluster 1, H4f
chr2_-_173276144 3.421 ENSMUST00000139306.1
 Pmepa1
prostate transmembrane protein, androgen induced 1
chr13_+_23581563 3.392 ENSMUST00000102968.1
 Hist1h4d
histone cluster 1, H4d
chr9_-_106656081 3.315 ENSMUST00000023959.7
 Grm2
glutamate receptor, metabotropic 2
chr6_-_36811361 2.907 ENSMUST00000101534.1
 Ptn
pleiotrophin
chr14_-_62456286 2.868 ENSMUST00000165651.1
ENSMUST00000022501.3
 Gucy1b2

guanylate cyclase 1, soluble, beta 2

chr11_+_58954675 2.740 ENSMUST00000047697.5
ENSMUST00000108817.3
 Trim17
Hist3h2a
tripartite motif-containing 17
histone cluster 3, H2a
chr13_+_21735055 2.707 ENSMUST00000087714.4
 Hist1h4j
histone cluster 1, H4j
chr2_-_104257400 2.613 ENSMUST00000141159.1
 D430041D05Rik
RIKEN cDNA D430041D05 gene
chr7_+_44384803 2.413 ENSMUST00000120262.1
 Syt3
synaptotagmin III
chr4_+_140986873 2.325 ENSMUST00000168047.1
ENSMUST00000037055.7
ENSMUST00000127833.2
 Atp13a2


ATPase type 13A2


chr13_+_23571382 2.235 ENSMUST00000079251.5
 Hist1h2bg
histone cluster 1, H2bg
chr5_+_75574916 2.200 ENSMUST00000144270.1
ENSMUST00000005815.6
 Kit

kit oncogene

chr2_+_178193075 2.188 ENSMUST00000103065.1
 Phactr3
phosphatase and actin regulator 3
chr15_-_81697256 2.121 ENSMUST00000072910.5
 Chadl
chondroadherin-like
chr13_+_21787461 2.035 ENSMUST00000110473.2
ENSMUST00000102982.1
 Hist1h2bp

histone cluster 1, H2bp

chr1_-_126492683 1.992 ENSMUST00000162877.1
 Nckap5
NCK-associated protein 5
chr17_-_27623263 1.957 ENSMUST00000062397.6
ENSMUST00000176876.1
 Nudt3

nudix (nucleotide diphosphate linked moiety X)-type motif 3

chr13_-_23683941 1.880 ENSMUST00000171127.1
 Hist1h2ac
histone cluster 1, H2ac
chr11_-_102447647 1.838 ENSMUST00000049057.4
 Fam171a2
family with sequence similarity 171, member A2
chr11_-_116110211 1.830 ENSMUST00000106441.1
ENSMUST00000021120.5
 Trim47

tripartite motif-containing 47

chr1_-_126492900 1.739 ENSMUST00000161954.1
 Nckap5
NCK-associated protein 5
chr6_+_136808248 1.728 ENSMUST00000074556.4
 H2afj
H2A histone family, member J
chr9_+_69454066 1.668 ENSMUST00000134907.1
 Anxa2
annexin A2
chr13_+_22035821 1.572 ENSMUST00000110455.2
 Hist1h2bk
histone cluster 1, H2bk
chr12_+_100779074 1.502 ENSMUST00000110073.1
ENSMUST00000110070.1
 9030617O03Rik

RIKEN cDNA 9030617O03 gene

chr14_+_32028989 1.455 ENSMUST00000022460.4
 Galnt15
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 15
chr16_-_45158183 1.434 ENSMUST00000114600.1
 Slc35a5
solute carrier family 35, member A5
chr4_+_102570065 1.409 ENSMUST00000097950.2
 Pde4b
phosphodiesterase 4B, cAMP specific
chr6_+_129533183 1.364 ENSMUST00000032264.6
 Gabarapl1
gamma-aminobutyric acid (GABA) A receptor-associated protein-like 1
chr14_+_119138415 1.317 ENSMUST00000065904.3
 Hs6st3
heparan sulfate 6-O-sulfotransferase 3
chr12_-_12941827 1.280 ENSMUST00000043396.7
 Mycn
v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)
chr9_+_21196705 1.215 ENSMUST00000003395.9
 Pde4a
phosphodiesterase 4A, cAMP specific
chr13_+_23684192 1.202 ENSMUST00000018246.4
 Hist1h2bc
histone cluster 1, H2bc
chr13_+_21833736 1.116 ENSMUST00000180288.1
ENSMUST00000110467.1
 Hist1h2br

histone cluster 1 H2br

chr13_+_23746734 1.104 ENSMUST00000099703.2
 Hist1h2bb
histone cluster 1, H2bb
chr1_+_172341197 1.055 ENSMUST00000056136.3
 Kcnj10
potassium inwardly-rectifying channel, subfamily J, member 10
chr9_-_20879718 0.982 ENSMUST00000043726.6
 Angptl6
angiopoietin-like 6
chr5_+_34543365 0.974 ENSMUST00000101316.3
 Sh3bp2
SH3-domain binding protein 2
chr2_+_129065934 0.851 ENSMUST00000035812.7
 Ttl
tubulin tyrosine ligase
chr2_-_148408146 0.839 ENSMUST00000099270.3
 Thbd
thrombomodulin
chr2_-_30194112 0.791 ENSMUST00000113659.1
ENSMUST00000113660.1
 Ccbl1

cysteine conjugate-beta lyase 1

chr13_+_22043189 0.776 ENSMUST00000110452.1
 Hist1h2bj
histone cluster 1, H2bj
chr17_-_27623441 0.759 ENSMUST00000025050.5
 Nudt3
nudix (nucleotide diphosphate linked moiety X)-type motif 3
chr1_+_75210832 0.738 ENSMUST00000027401.4
ENSMUST00000144355.1
ENSMUST00000123825.1
 Stk16


serine/threonine kinase 16


chrX_-_150814265 0.714 ENSMUST00000026302.6
ENSMUST00000129768.1
ENSMUST00000112699.2
 Maged2


melanoma antigen, family D, 2


chr7_-_100964371 0.696 ENSMUST00000060174.4
 P2ry6
pyrimidinergic receptor P2Y, G-protein coupled, 6
chr1_+_171250416 0.672 ENSMUST00000111315.1
ENSMUST00000006570.5
 Adamts4

a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 4

chr3_-_107760221 0.659 ENSMUST00000153114.1
ENSMUST00000118593.1
ENSMUST00000120243.1
 Csf1


colony stimulating factor 1 (macrophage)


chr7_-_24316590 0.646 ENSMUST00000108436.1
ENSMUST00000032673.8
 Zfp94

zinc finger protein 94

chr13_-_21810190 0.619 ENSMUST00000110469.1
ENSMUST00000091749.2
 Hist1h2bq

histone cluster 1, H2bq

chrX_+_10485121 0.578 ENSMUST00000076354.6
ENSMUST00000115526.1
 Tspan7

tetraspanin 7

chr9_-_66592993 0.555 ENSMUST00000174387.1
 Usp3
ubiquitin specific peptidase 3
chr9_-_66593029 0.520 ENSMUST00000098613.2
 Usp3
ubiquitin specific peptidase 3
chrX_-_144688180 0.505 ENSMUST00000040184.3
 Trpc5
transient receptor potential cation channel, subfamily C, member 5
chr17_-_6827990 0.472 ENSMUST00000181895.1
 Gm2885
predicted gene 2885
chr7_+_127588698 0.393 ENSMUST00000033088.6
 Rnf40
ring finger protein 40
chr6_-_129533267 0.316 ENSMUST00000181594.1
 1700101I11Rik
RIKEN cDNA 1700101I11 gene
chr19_-_23448322 0.275 ENSMUST00000036069.6
 Mamdc2
MAM domain containing 2
chr2_-_152831665 0.270 ENSMUST00000156688.1
ENSMUST00000007803.5
 Bcl2l1

BCL2-like 1

chr1_-_23909687 0.269 ENSMUST00000129254.1
 Smap1
small ArfGAP 1
chr9_+_109038565 0.248 ENSMUST00000112059.3
ENSMUST00000026737.5
 Shisa5

shisa homolog 5 (Xenopus laevis)

chr10_+_79854658 0.239 ENSMUST00000171599.1
ENSMUST00000095457.4
 Ptbp1

polypyrimidine tract binding protein 1

chr10_-_118868903 0.234 ENSMUST00000004281.8
 Dyrk2
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
chr15_-_58823530 0.160 ENSMUST00000072113.5
 Tmem65
transmembrane protein 65
chrX_+_153832225 0.155 ENSMUST00000148708.1
ENSMUST00000123264.1
ENSMUST00000049999.8
 Spin2c


spindlin family, member 2C


chr9_+_53771499 0.151 ENSMUST00000048670.8
 Slc35f2
solute carrier family 35, member F2
chr18_+_60526194 0.117 ENSMUST00000025505.5
 Dctn4
dynactin 4
chr13_-_92354943 0.088 ENSMUST00000022220.6
 Msh3
mutS homolog 3 (E. coli)
chr5_+_105700758 0.068 ENSMUST00000120847.1
 Lrrc8d
leucine rich repeat containing 8D
chr4_+_130055010 0.061 ENSMUST00000123617.1
 Col16a1
collagen, type XVI, alpha 1
chr9_-_66593106 0.038 ENSMUST00000127569.1
 Usp3
ubiquitin specific peptidase 3
chr2_-_152831112 0.014 ENSMUST00000128172.1
 Bcl2l1
BCL2-like 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 3.8 GO:1902460 regulation of mesenchymal stem cell proliferation(GO:1902460) positive regulation of mesenchymal stem cell proliferation(GO:1902462)
1.2 3.7 GO:0032241 positive regulation of nucleobase-containing compound transport(GO:0032241) regulation of nucleoside transport(GO:0032242)
1.2 22.7 GO:0045653 negative regulation of megakaryocyte differentiation(GO:0045653)
1.0 2.9 GO:1904395 regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904393) positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395)
0.9 2.7 GO:0071544 diphosphoinositol polyphosphate metabolic process(GO:0071543) diphosphoinositol polyphosphate catabolic process(GO:0071544)
0.7 2.2 GO:1905065 hematopoietic stem cell migration(GO:0035701) positive regulation of vascular smooth muscle cell differentiation(GO:1905065)
0.7 2.1 GO:1903054 negative regulation of extracellular matrix organization(GO:1903054)
0.7 3.4 GO:0010991 negative regulation of SMAD protein complex assembly(GO:0010991)
0.6 2.3 GO:0007039 protein catabolic process in the vacuole(GO:0007039) peptidyl-aspartic acid modification(GO:0018197)
0.4 47.7 GO:0006342 chromatin silencing(GO:0006342)
0.4 5.0 GO:0002227 innate immune response in mucosa(GO:0002227)
0.4 1.1 GO:0051933 amino acid neurotransmitter reuptake(GO:0051933) glutamate reuptake(GO:0051935)
0.3 1.7 GO:0032804 negative regulation of low-density lipoprotein particle receptor catabolic process(GO:0032804)
0.2 0.7 GO:0030321 transepithelial chloride transport(GO:0030321)
0.2 0.7 GO:1904139 microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139)
0.2 1.3 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.2 0.5 GO:1902630 regulation of membrane hyperpolarization(GO:1902630)
0.2 2.4 GO:0031340 positive regulation of vesicle fusion(GO:0031340)
0.1 1.4 GO:0006995 cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562)
0.1 1.3 GO:0045607 regulation of auditory receptor cell differentiation(GO:0045607) regulation of mechanoreceptor differentiation(GO:0045631) regulation of inner ear receptor cell differentiation(GO:2000980)
0.1 1.4 GO:1901898 negative regulation of relaxation of muscle(GO:1901078) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.1 2.9 GO:0006182 cGMP biosynthetic process(GO:0006182)
0.1 3.3 GO:0014047 glutamate secretion(GO:0014047)
0.1 0.4 GO:2001168 regulation of histone H2B ubiquitination(GO:2001166) positive regulation of histone H2B ubiquitination(GO:2001168)
0.1 0.3 GO:0046898 response to cycloheximide(GO:0046898)
0.1 1.2 GO:0006198 cAMP catabolic process(GO:0006198)
0.0 3.9 GO:0006334 nucleosome assembly(GO:0006334)
0.0 1.1 GO:0016578 histone deubiquitination(GO:0016578)
0.0 0.8 GO:1900047 negative regulation of blood coagulation(GO:0030195) negative regulation of hemostasis(GO:1900047)
0.0 0.3 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.0 0.1 GO:0000710 meiotic mismatch repair(GO:0000710)
0.0 0.2 GO:0051534 negative regulation of NFAT protein import into nucleus(GO:0051534)
0.0 2.6 GO:0098792 xenophagy(GO:0098792)
0.0 0.3 GO:2000369 regulation of clathrin-mediated endocytosis(GO:2000369)
0.0 5.7 GO:0006397 mRNA processing(GO:0006397)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 52.2 GO:0000786 nucleosome(GO:0000786)
0.6 1.7 GO:1990667 PCSK9-AnxA2 complex(GO:1990667)
0.3 2.9 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.2 0.7 GO:1990682 CSF1-CSF1R complex(GO:1990682)
0.2 3.7 GO:0032279 asymmetric synapse(GO:0032279)
0.1 0.4 GO:0033503 HULC complex(GO:0033503)
0.1 2.3 GO:0005771 multivesicular body(GO:0005771)
0.1 1.1 GO:0097449 astrocyte projection(GO:0097449)
0.1 1.4 GO:0000421 autophagosome membrane(GO:0000421)
0.1 3.4 GO:0031901 early endosome membrane(GO:0031901)
0.1 1.4 GO:0000930 gamma-tubulin complex(GO:0000930)
0.1 24.4 GO:0000790 nuclear chromatin(GO:0000790)
0.0 3.3 GO:0042734 presynaptic membrane(GO:0042734)
0.0 0.8 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 2.9 GO:0031594 neuromuscular junction(GO:0031594)
0.0 0.3 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.0 6.9 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 0.7 GO:0005798 Golgi-associated vesicle(GO:0005798)
0.0 3.9 GO:0030133 transport vesicle(GO:0030133)
0.0 2.2 GO:0009898 cytoplasmic side of plasma membrane(GO:0009898)
0.0 0.1 GO:0032300 mismatch repair complex(GO:0032300)
0.0 0.5 GO:0034704 calcium channel complex(GO:0034704)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 2.9 GO:0035373 chondroitin sulfate proteoglycan binding(GO:0035373)
0.7 3.3 GO:0001640 adenylate cyclase inhibiting G-protein coupled glutamate receptor activity(GO:0001640)
0.5 3.7 GO:0032795 G-protein coupled adenosine receptor activity(GO:0001609) heterotrimeric G-protein binding(GO:0032795)
0.5 2.7 GO:0008486 diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486)
0.4 1.7 GO:0004859 phospholipase inhibitor activity(GO:0004859) phospholipase A2 inhibitor activity(GO:0019834)
0.4 1.1 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.3 2.9 GO:0004383 guanylate cyclase activity(GO:0004383)
0.3 2.3 GO:0103116 alpha-D-galactofuranose transporter activity(GO:0103116)
0.3 2.2 GO:0004716 receptor signaling protein tyrosine kinase activity(GO:0004716)
0.2 0.7 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.2 3.8 GO:0050431 transforming growth factor beta binding(GO:0050431)
0.1 2.2 GO:0008599 protein phosphatase type 1 regulator activity(GO:0008599)
0.1 1.4 GO:0030957 Tat protein binding(GO:0030957)
0.1 23.8 GO:0042393 histone binding(GO:0042393)
0.1 3.7 GO:0050699 WW domain binding(GO:0050699)
0.1 2.4 GO:0001786 phosphatidylserine binding(GO:0001786)
0.1 1.5 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.1 2.6 GO:0030552 cAMP binding(GO:0030552)
0.1 1.4 GO:0005351 sugar:proton symporter activity(GO:0005351)
0.0 0.1 GO:0032142 single guanine insertion binding(GO:0032142)
0.0 0.5 GO:0015279 store-operated calcium channel activity(GO:0015279) inositol 1,4,5 trisphosphate binding(GO:0070679)
0.0 25.5 GO:0046982 protein heterodimerization activity(GO:0046982)
0.0 1.3 GO:0034930 N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517) heparan sulfate 2-O-sulfotransferase activity(GO:0004394) HNK-1 sulfotransferase activity(GO:0016232) heparan sulfate 6-O-sulfotransferase activity(GO:0017095) trans-9R,10R-dihydrodiolphenanthrene sulfotransferase activity(GO:0018721) 1-phenanthrol sulfotransferase activity(GO:0018722) 3-phenanthrol sulfotransferase activity(GO:0018723) 4-phenanthrol sulfotransferase activity(GO:0018724) trans-3,4-dihydrodiolphenanthrene sulfotransferase activity(GO:0018725) 9-phenanthrol sulfotransferase activity(GO:0018726) 2-phenanthrol sulfotransferase activity(GO:0018727) phenanthrol sulfotransferase activity(GO:0019111) 1-hydroxypyrene sulfotransferase activity(GO:0034930) proteoglycan sulfotransferase activity(GO:0050698) cholesterol sulfotransferase activity(GO:0051922) hydroxyjasmonate sulfotransferase activity(GO:0080131)
0.0 2.1 GO:0005518 collagen binding(GO:0005518)
0.0 0.4 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 0.7 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 33.2 GO:0003677 DNA binding(GO:0003677)