Motif ID: Smad3

Z-value: 1.393


Transcription factors associated with Smad3:

Gene SymbolEntrez IDGene Name
Smad3 ENSMUSG00000032402.6 Smad3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Smad3mm10_v2_chr9_-_63711969_63711994-0.601.1e-03Click!


Activity profile for motif Smad3.

activity profile for motif Smad3


Sorted Z-values histogram for motif Smad3

Sorted Z-values for motif Smad3



Network of associatons between targets according to the STRING database.



First level regulatory network of Smad3

PNG image of the network

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Top targets:


Showing 1 to 20 of 88 entries
PromoterScoreRefseqGene SymbolGene Name
chr13_+_23533869 8.984 ENSMUST00000073261.2
Hist1h2af
histone cluster 1, H2af
chr13_-_22042949 8.549 ENSMUST00000091741.4
Hist1h2ag
histone cluster 1, H2ag
chr13_-_21833575 7.431 ENSMUST00000081342.5
Hist1h2ap
histone cluster 1, H2ap
chr13_-_22035589 7.084 ENSMUST00000091742.4
Hist1h2ah
histone cluster 1, H2ah
chr13_-_21787218 6.216 ENSMUST00000091751.2
Hist1h2an
histone cluster 1, H2an
chr12_+_12911986 5.991 ENSMUST00000085720.1
Rpl36-ps3
ribosomal protein L36, pseudogene 3
chr13_-_23571151 5.243 ENSMUST00000102969.3
Hist1h2ae
histone cluster 1, H2ae
chr13_+_21810428 5.240 ENSMUST00000091745.5
Hist1h2ao
histone cluster 1, H2ao
chr15_+_81936911 4.662 ENSMUST00000135663.1
Csdc2
cold shock domain containing C2, RNA binding
chr13_+_23531044 4.527 ENSMUST00000102972.3
Hist1h4h
histone cluster 1, H4h
chr13_-_21832194 4.439 ENSMUST00000102979.1
Hist1h4n
histone cluster 1, H4n
chr13_-_21750505 4.216 ENSMUST00000102983.1
Hist1h4k
histone cluster 1, H4k
chr15_+_81936753 3.845 ENSMUST00000038757.7
Csdc2
cold shock domain containing C2, RNA binding
chr19_+_5740885 3.759 ENSMUST00000081496.5
Ltbp3
latent transforming growth factor beta binding protein 3
chr1_-_134235420 3.718 ENSMUST00000038191.6
ENSMUST00000086465.4
Adora1

adenosine A1 receptor

chr13_-_23551648 3.446 ENSMUST00000102971.1
Hist1h4f
histone cluster 1, H4f
chr2_-_173276144 3.421 ENSMUST00000139306.1
Pmepa1
prostate transmembrane protein, androgen induced 1
chr13_+_23581563 3.392 ENSMUST00000102968.1
Hist1h4d
histone cluster 1, H4d
chr9_-_106656081 3.315 ENSMUST00000023959.7
Grm2
glutamate receptor, metabotropic 2
chr6_-_36811361 2.907 ENSMUST00000101534.1
Ptn
pleiotrophin

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 35 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 47.7 GO:0006342 chromatin silencing(GO:0006342)
1.2 22.7 GO:0045653 negative regulation of megakaryocyte differentiation(GO:0045653)
0.0 5.7 GO:0006397 mRNA processing(GO:0006397)
0.4 5.0 GO:0002227 innate immune response in mucosa(GO:0002227)
0.0 3.9 GO:0006334 nucleosome assembly(GO:0006334)
1.3 3.8 GO:1902460 regulation of mesenchymal stem cell proliferation(GO:1902460) positive regulation of mesenchymal stem cell proliferation(GO:1902462)
1.2 3.7 GO:0032241 positive regulation of nucleobase-containing compound transport(GO:0032241) regulation of nucleoside transport(GO:0032242)
0.7 3.4 GO:0010991 negative regulation of SMAD protein complex assembly(GO:0010991)
0.1 3.3 GO:0014047 glutamate secretion(GO:0014047)
1.0 2.9 GO:1904395 regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904393) positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395)
0.1 2.9 GO:0006182 cGMP biosynthetic process(GO:0006182)
0.9 2.7 GO:0071544 diphosphoinositol polyphosphate metabolic process(GO:0071543) diphosphoinositol polyphosphate catabolic process(GO:0071544)
0.0 2.6 GO:0098792 xenophagy(GO:0098792)
0.2 2.4 GO:0031340 positive regulation of vesicle fusion(GO:0031340)
0.6 2.3 GO:0007039 protein catabolic process in the vacuole(GO:0007039) peptidyl-aspartic acid modification(GO:0018197)
0.7 2.2 GO:1905065 hematopoietic stem cell migration(GO:0035701) positive regulation of vascular smooth muscle cell differentiation(GO:1905065)
0.7 2.1 GO:1903054 negative regulation of extracellular matrix organization(GO:1903054)
0.3 1.7 GO:0032804 negative regulation of low-density lipoprotein particle receptor catabolic process(GO:0032804)
0.1 1.4 GO:0006995 cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562)
0.1 1.4 GO:1901898 negative regulation of relaxation of muscle(GO:1901078) negative regulation of relaxation of cardiac muscle(GO:1901898)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 22 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 52.2 GO:0000786 nucleosome(GO:0000786)
0.1 24.4 GO:0000790 nuclear chromatin(GO:0000790)
0.0 6.9 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 3.9 GO:0030133 transport vesicle(GO:0030133)
0.2 3.7 GO:0032279 asymmetric synapse(GO:0032279)
0.1 3.4 GO:0031901 early endosome membrane(GO:0031901)
0.0 3.3 GO:0042734 presynaptic membrane(GO:0042734)
0.3 2.9 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 2.9 GO:0031594 neuromuscular junction(GO:0031594)
0.1 2.3 GO:0005771 multivesicular body(GO:0005771)
0.0 2.2 GO:0009898 cytoplasmic side of plasma membrane(GO:0009898)
0.6 1.7 GO:1990667 PCSK9-AnxA2 complex(GO:1990667)
0.1 1.4 GO:0000421 autophagosome membrane(GO:0000421)
0.1 1.4 GO:0000930 gamma-tubulin complex(GO:0000930)
0.1 1.1 GO:0097449 astrocyte projection(GO:0097449)
0.0 0.8 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.2 0.7 GO:1990682 CSF1-CSF1R complex(GO:1990682)
0.0 0.7 GO:0005798 Golgi-associated vesicle(GO:0005798)
0.0 0.5 GO:0034704 calcium channel complex(GO:0034704)
0.1 0.4 GO:0033503 HULC complex(GO:0033503)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 27 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 33.2 GO:0003677 DNA binding(GO:0003677)
0.0 25.5 GO:0046982 protein heterodimerization activity(GO:0046982)
0.1 23.8 GO:0042393 histone binding(GO:0042393)
0.2 3.8 GO:0050431 transforming growth factor beta binding(GO:0050431)
0.5 3.7 GO:0032795 G-protein coupled adenosine receptor activity(GO:0001609) heterotrimeric G-protein binding(GO:0032795)
0.1 3.7 GO:0050699 WW domain binding(GO:0050699)
0.7 3.3 GO:0001640 adenylate cyclase inhibiting G-protein coupled glutamate receptor activity(GO:0001640)
1.0 2.9 GO:0035373 chondroitin sulfate proteoglycan binding(GO:0035373)
0.3 2.9 GO:0004383 guanylate cyclase activity(GO:0004383)
0.5 2.7 GO:0008486 diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486)
0.1 2.6 GO:0030552 cAMP binding(GO:0030552)
0.1 2.4 GO:0001786 phosphatidylserine binding(GO:0001786)
0.3 2.3 GO:0103116 alpha-D-galactofuranose transporter activity(GO:0103116)
0.3 2.2 GO:0004716 receptor signaling protein tyrosine kinase activity(GO:0004716)
0.1 2.2 GO:0008599 protein phosphatase type 1 regulator activity(GO:0008599)
0.0 2.1 GO:0005518 collagen binding(GO:0005518)
0.4 1.7 GO:0004859 phospholipase inhibitor activity(GO:0004859) phospholipase A2 inhibitor activity(GO:0019834)
0.1 1.5 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.1 1.4 GO:0030957 Tat protein binding(GO:0030957)
0.1 1.4 GO:0005351 sugar:proton symporter activity(GO:0005351)