Motif ID: Smad4

Z-value: 0.835


Transcription factors associated with Smad4:

Gene SymbolEntrez IDGene Name
Smad4 ENSMUSG00000024515.7 Smad4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Smad4mm10_v2_chr18_-_73703739_737038060.019.5e-01Click!


Activity profile for motif Smad4.

activity profile for motif Smad4


Sorted Z-values histogram for motif Smad4

Sorted Z-values for motif Smad4



Network of associatons between targets according to the STRING database.



First level regulatory network of Smad4

PNG image of the network

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Top targets:


Showing 1 to 20 of 191 entries
PromoterScoreRefseqGene SymbolGene Name
chr13_-_22042949 2.768 ENSMUST00000091741.4
 Hist1h2ag
histone cluster 1, H2ag
chr7_+_24862193 2.444 ENSMUST00000052897.4
ENSMUST00000170837.2
 Gm9844
Gm9844
predicted pseudogene 9844
predicted pseudogene 9844
chr10_-_127534540 2.360 ENSMUST00000095266.2
 Nxph4
neurexophilin 4
chr13_-_21832194 2.244 ENSMUST00000102979.1
 Hist1h4n
histone cluster 1, H4n
chr1_-_16770138 2.159 ENSMUST00000071842.8
 Gm5828
predicted gene 5828
chr11_-_95514570 1.953 ENSMUST00000058866.7
 Nxph3
neurexophilin 3
chr13_+_23581563 1.674 ENSMUST00000102968.1
 Hist1h4d
histone cluster 1, H4d
chr14_-_104467984 1.657 ENSMUST00000053016.8
 Pou4f1
POU domain, class 4, transcription factor 1
chr13_-_23551648 1.519 ENSMUST00000102971.1
 Hist1h4f
histone cluster 1, H4f
chr13_+_23531044 1.499 ENSMUST00000102972.3
 Hist1h4h
histone cluster 1, H4h
chr19_+_5740885 1.249 ENSMUST00000081496.5
 Ltbp3
latent transforming growth factor beta binding protein 3
chr13_+_21735055 1.239 ENSMUST00000087714.4
 Hist1h4j
histone cluster 1, H4j
chr3_-_96220880 1.157 ENSMUST00000090782.3
 Hist2h2ac
histone cluster 2, H2ac
chr10_+_80150448 1.150 ENSMUST00000153477.1
 Midn
midnolin
chr8_+_54954728 1.109 ENSMUST00000033915.7
 Gpm6a
glycoprotein m6a
chr4_-_148130678 1.065 ENSMUST00000030862.4
 Draxin
dorsal inhibitory axon guidance protein
chr8_-_109251698 1.051 ENSMUST00000079189.3
 4922502B01Rik
RIKEN cDNA 4922502B01 gene
chr8_-_92356103 0.942 ENSMUST00000034183.3
 4933436C20Rik
RIKEN cDNA 4933436C20 gene
chr19_+_46328179 0.862 ENSMUST00000026256.2
ENSMUST00000177667.1
 Fbxl15

F-box and leucine-rich repeat protein 15

chr6_-_72958097 0.828 ENSMUST00000114049.1
 Tmsb10
thymosin, beta 10

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 66 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.4 8.2 GO:0045653 negative regulation of megakaryocyte differentiation(GO:0045653)
0.0 4.1 GO:0006342 chromatin silencing(GO:0006342)
0.3 1.7 GO:0003223 ventricular compact myocardium morphogenesis(GO:0003223) proprioception(GO:0019230)
0.4 1.2 GO:1902460 regulation of mesenchymal stem cell proliferation(GO:1902460) positive regulation of mesenchymal stem cell proliferation(GO:1902462)
0.2 1.2 GO:1903300 negative regulation of glucokinase activity(GO:0033132) negative regulation of hexokinase activity(GO:1903300)
0.1 1.1 GO:0021516 dorsal spinal cord development(GO:0021516)
0.0 1.1 GO:0003407 neural retina development(GO:0003407)
0.2 0.9 GO:1901204 regulation of adrenergic receptor signaling pathway involved in heart process(GO:1901204)
0.0 0.9 GO:0032967 positive regulation of collagen biosynthetic process(GO:0032967)
0.0 0.9 GO:0030513 positive regulation of BMP signaling pathway(GO:0030513)
0.0 0.9 GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors(GO:0008625)
0.2 0.8 GO:0035093 spermatogenesis, exchange of chromosomal proteins(GO:0035093)
0.1 0.8 GO:0006172 ADP biosynthetic process(GO:0006172)
0.0 0.8 GO:0048368 lateral mesoderm development(GO:0048368)
0.0 0.8 GO:0010972 negative regulation of G2/M transition of mitotic cell cycle(GO:0010972)
0.0 0.8 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.2 0.7 GO:1905065 hematopoietic stem cell migration(GO:0035701) positive regulation of vascular smooth muscle cell differentiation(GO:1905065)
0.2 0.7 GO:2000546 positive regulation of cell chemotaxis to fibroblast growth factor(GO:1904849) positive regulation of endothelial cell chemotaxis to fibroblast growth factor(GO:2000546)
0.1 0.7 GO:0045657 positive regulation of monocyte differentiation(GO:0045657) cellular response to potassium ion starvation(GO:0051365)
0.1 0.7 GO:0010991 negative regulation of SMAD protein complex assembly(GO:0010991)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 32 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 11.1 GO:0000786 nucleosome(GO:0000786)
0.0 4.2 GO:0000790 nuclear chromatin(GO:0000790)
0.0 1.1 GO:0044295 axonal growth cone(GO:0044295)
0.0 1.1 GO:0005581 collagen trimer(GO:0005581)
0.3 0.9 GO:0038045 large latent transforming growth factor-beta complex(GO:0038045)
0.0 0.9 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.1 0.8 GO:0001520 outer dense fiber(GO:0001520)
0.1 0.7 GO:0000137 Golgi cis cisterna(GO:0000137)
0.0 0.7 GO:0005719 nuclear euchromatin(GO:0005719)
0.0 0.7 GO:0031901 early endosome membrane(GO:0031901)
0.0 0.6 GO:0071564 npBAF complex(GO:0071564)
0.0 0.6 GO:0045171 intercellular bridge(GO:0045171)
0.2 0.5 GO:0044302 dentate gyrus mossy fiber(GO:0044302)
0.0 0.5 GO:0042582 primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.0 0.5 GO:0071598 neuronal ribonucleoprotein granule(GO:0071598)
0.0 0.5 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 0.5 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 0.4 GO:0031258 lamellipodium membrane(GO:0031258)
0.0 0.4 GO:0097228 sperm principal piece(GO:0097228)
0.0 0.4 GO:0035102 PRC1 complex(GO:0035102)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 36 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 8.2 GO:0042393 histone binding(GO:0042393)
0.0 1.7 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.0 1.3 GO:0070412 R-SMAD binding(GO:0070412)
0.3 1.2 GO:0050436 microfibril binding(GO:0050436)
0.1 1.2 GO:0050431 transforming growth factor beta binding(GO:0050431)
0.0 1.1 GO:0005262 calcium channel activity(GO:0005262)
0.0 0.9 GO:0050321 tau-protein kinase activity(GO:0050321)
0.0 0.9 GO:0005123 death receptor binding(GO:0005123)
0.0 0.9 GO:0003785 actin monomer binding(GO:0003785)
0.1 0.8 GO:0004017 adenylate kinase activity(GO:0004017)
0.0 0.8 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.2 0.7 GO:0005105 type 1 fibroblast growth factor receptor binding(GO:0005105)
0.1 0.7 GO:0004716 receptor signaling protein tyrosine kinase activity(GO:0004716)
0.0 0.6 GO:0045294 alpha-catenin binding(GO:0045294)
0.0 0.6 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.2 0.5 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.2 0.5 GO:0004517 nitric-oxide synthase activity(GO:0004517)
0.2 0.5 GO:0036004 GAF domain binding(GO:0036004)
0.1 0.5 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0 0.5 GO:0017128 phospholipid scramblase activity(GO:0017128)