Motif ID: Snai1_Zeb1_Snai2

Z-value: 2.544

Transcription factors associated with Snai1_Zeb1_Snai2:

Gene SymbolEntrez IDGene Name
Snai1 ENSMUSG00000042821.7 Snai1
Snai2 ENSMUSG00000022676.6 Snai2
Zeb1 ENSMUSG00000024238.7 Zeb1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Zeb1mm10_v2_chr18_+_5591860_5591902-0.791.5e-06Click!
Snai1mm10_v2_chr2_+_167538192_167538210-0.193.5e-01Click!
Snai2mm10_v2_chr16_+_14705832_14705858-0.183.8e-01Click!


Activity profile for motif Snai1_Zeb1_Snai2.

activity profile for motif Snai1_Zeb1_Snai2


Sorted Z-values histogram for motif Snai1_Zeb1_Snai2

Sorted Z-values for motif Snai1_Zeb1_Snai2



Network of associatons between targets according to the STRING database.



First level regulatory network of Snai1_Zeb1_Snai2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_-_67922136 13.689 ENSMUST00000021288.3
ENSMUST00000108677.1
 Usp43

ubiquitin specific peptidase 43

chr12_+_82616885 13.460 ENSMUST00000161801.1
 Rgs6
regulator of G-protein signaling 6
chr15_-_66831625 11.792 ENSMUST00000164163.1
 Sla
src-like adaptor
chr13_-_57907587 11.512 ENSMUST00000172326.1
 Spock1
sparc/osteonectin, cwcv and kazal-like domains proteoglycan 1
chr4_+_85205417 11.176 ENSMUST00000030212.8
ENSMUST00000107189.1
ENSMUST00000107184.1
 Sh3gl2


SH3-domain GRB2-like 2


chr1_-_134234492 10.887 ENSMUST00000169927.1
 Adora1
adenosine A1 receptor
chr18_-_61911783 9.231 ENSMUST00000049378.8
ENSMUST00000166783.1
 Ablim3

actin binding LIM protein family, member 3

chr19_-_57314896 8.514 ENSMUST00000111524.1
 Ablim1
actin-binding LIM protein 1
chr8_+_70493156 7.931 ENSMUST00000008032.7
 Crlf1
cytokine receptor-like factor 1
chr7_-_27446599 7.926 ENSMUST00000011895.7
 Sptbn4
spectrin beta, non-erythrocytic 4
chr14_+_101729907 7.851 ENSMUST00000100337.3
 Lmo7
LIM domain only 7
chr5_+_37028329 7.788 ENSMUST00000173836.1
 Jakmip1
janus kinase and microtubule interacting protein 1
chr4_+_85205120 7.605 ENSMUST00000107188.3
 Sh3gl2
SH3-domain GRB2-like 2
chr15_+_83791939 7.518 ENSMUST00000172115.1
ENSMUST00000172398.1
 Mpped1

metallophosphoesterase domain containing 1

chr5_-_139130159 7.348 ENSMUST00000129851.1
 Prkar1b
protein kinase, cAMP dependent regulatory, type I beta
chr8_-_70439557 7.279 ENSMUST00000076615.5
 Crtc1
CREB regulated transcription coactivator 1
chr4_-_64046925 7.235 ENSMUST00000107377.3
 Tnc
tenascin C
chr5_-_147076482 7.086 ENSMUST00000016664.7
 Lnx2
ligand of numb-protein X 2
chr8_-_84773381 6.956 ENSMUST00000109764.1
 Nfix
nuclear factor I/X
chr6_+_114131229 6.456 ENSMUST00000032451.7
 Slc6a11
solute carrier family 6 (neurotransmitter transporter, GABA), member 11

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 880 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 29.0 GO:0048488 synaptic vesicle endocytosis(GO:0048488)
0.8 16.1 GO:1903861 regulation of dendrite extension(GO:1903859) positive regulation of dendrite extension(GO:1903861)
5.3 15.8 GO:0032241 positive regulation of nucleobase-containing compound transport(GO:0032241) regulation of nucleoside transport(GO:0032242)
0.5 13.5 GO:0061098 positive regulation of protein tyrosine kinase activity(GO:0061098)
1.9 13.4 GO:0061502 early endosome to recycling endosome transport(GO:0061502)
0.8 12.8 GO:0032793 positive regulation of CREB transcription factor activity(GO:0032793)
2.1 12.5 GO:2000672 negative regulation of motor neuron apoptotic process(GO:2000672)
0.2 12.4 GO:0030032 lamellipodium assembly(GO:0030032)
1.0 12.0 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.7 11.9 GO:1900454 positive regulation of long term synaptic depression(GO:1900454)
0.3 11.5 GO:0032355 response to estradiol(GO:0032355)
1.0 11.3 GO:0032482 Rab protein signal transduction(GO:0032482)
0.3 11.1 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.8 11.0 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.5 10.4 GO:0006958 complement activation, classical pathway(GO:0006958)
0.2 10.3 GO:1901379 regulation of potassium ion transmembrane transport(GO:1901379)
1.1 10.2 GO:0021894 cerebral cortex GABAergic interneuron development(GO:0021894)
0.3 10.2 GO:0003333 amino acid transmembrane transport(GO:0003333)
0.5 10.1 GO:0048268 clathrin coat assembly(GO:0048268)
0.3 8.4 GO:0006198 cAMP catabolic process(GO:0006198)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 309 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 48.8 GO:0045211 postsynaptic membrane(GO:0045211)
0.0 31.3 GO:0016021 integral component of membrane(GO:0016021)
0.1 30.7 GO:0005887 integral component of plasma membrane(GO:0005887)
0.4 22.5 GO:0042734 presynaptic membrane(GO:0042734)
0.7 20.5 GO:0033268 node of Ranvier(GO:0033268)
0.4 20.3 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.2 20.0 GO:0070382 exocytic vesicle(GO:0070382)
0.2 18.8 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.9 17.8 GO:0032279 asymmetric synapse(GO:0032279)
0.3 15.4 GO:0005604 basement membrane(GO:0005604)
0.3 13.8 GO:0098878 ionotropic glutamate receptor complex(GO:0008328) neurotransmitter receptor complex(GO:0098878)
0.3 13.4 GO:0034705 voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)
0.8 13.2 GO:0005614 interstitial matrix(GO:0005614)
2.2 13.1 GO:0008091 spectrin(GO:0008091)
1.0 12.6 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.5 12.4 GO:0001891 phagocytic cup(GO:0001891)
0.1 11.8 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
3.9 11.7 GO:0097058 CRLF-CLCF1 complex(GO:0097058)
0.3 11.3 GO:0032809 neuronal cell body membrane(GO:0032809)
0.2 11.2 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 516 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 22.3 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.4 15.8 GO:0005158 insulin receptor binding(GO:0005158)
0.3 15.8 GO:0045499 chemorepellent activity(GO:0045499)
2.2 15.6 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
2.2 15.2 GO:0032795 heterotrimeric G-protein binding(GO:0032795)
0.6 14.3 GO:0030506 ankyrin binding(GO:0030506)
1.2 13.5 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
0.5 13.1 GO:0004027 alcohol sulfotransferase activity(GO:0004027)
0.2 12.8 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.7 12.1 GO:0050811 GABA receptor binding(GO:0050811)
1.6 11.5 GO:0005127 ciliary neurotrophic factor receptor binding(GO:0005127)
1.1 11.0 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.4 10.9 GO:0030552 cAMP binding(GO:0030552)
0.3 10.5 GO:0046875 ephrin receptor binding(GO:0046875)
0.8 10.3 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
1.0 10.1 GO:0032036 myosin heavy chain binding(GO:0032036)
0.4 10.0 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.5 9.8 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.0 9.7 GO:0005096 GTPase activator activity(GO:0005096)
1.1 9.5 GO:0032050 clathrin heavy chain binding(GO:0032050)