Motif ID: Sox18_Sox12

Z-value: 0.748

Transcription factors associated with Sox18_Sox12:

Gene SymbolEntrez IDGene Name
Sox12 ENSMUSG00000051817.8 Sox12
Sox18 ENSMUSG00000046470.5 Sox18

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Sox12mm10_v2_chr2_-_152398046_152398076-0.563.2e-03Click!
Sox18mm10_v2_chr2_-_181671622_181671645-0.367.0e-02Click!


Activity profile for motif Sox18_Sox12.

activity profile for motif Sox18_Sox12


Sorted Z-values histogram for motif Sox18_Sox12

Sorted Z-values for motif Sox18_Sox12



Network of associatons between targets according to the STRING database.



First level regulatory network of Sox18_Sox12

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr18_-_74961252 1.891 ENSMUST00000066532.4
 Lipg
lipase, endothelial
chr10_-_53647080 1.693 ENSMUST00000169866.1
 Fam184a
family with sequence similarity 184, member A
chr4_-_58499398 1.518 ENSMUST00000107570.1
 Lpar1
lysophosphatidic acid receptor 1
chr18_+_11633276 1.517 ENSMUST00000115861.2
 Rbbp8
retinoblastoma binding protein 8
chr11_-_11970540 1.451 ENSMUST00000109653.1
 Grb10
growth factor receptor bound protein 10
chr7_+_127800604 1.400 ENSMUST00000046863.5
ENSMUST00000106272.1
ENSMUST00000139068.1
 Hsd3b7


hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7


chr10_-_62792243 1.396 ENSMUST00000020268.5
 Ccar1
cell division cycle and apoptosis regulator 1
chr18_-_88927447 1.369 ENSMUST00000147313.1
 Socs6
suppressor of cytokine signaling 6
chr11_-_90687572 1.358 ENSMUST00000107869.2
ENSMUST00000154599.1
ENSMUST00000107868.1
ENSMUST00000020849.2
 Tom1l1



target of myb1-like 1 (chicken)



chrX_+_106920618 1.355 ENSMUST00000060576.7
 Lpar4
lysophosphatidic acid receptor 4
chr10_+_88091070 1.333 ENSMUST00000048621.7
 Pmch
pro-melanin-concentrating hormone
chr6_-_23248264 1.313 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr12_-_10900296 1.304 ENSMUST00000085735.2
 Pgk1-rs7
phosphoglycerate kinase-1, related sequence-7
chr13_+_14063776 1.246 ENSMUST00000129488.1
ENSMUST00000110536.1
ENSMUST00000110534.1
ENSMUST00000039538.8
ENSMUST00000110533.1
 Arid4b




AT rich interactive domain 4B (RBP1-like)




chr14_+_116925379 1.239 ENSMUST00000088483.3
 Gpc6
glypican 6
chr11_-_109472611 1.215 ENSMUST00000168740.1
 Slc16a6
solute carrier family 16 (monocarboxylic acid transporters), member 6
chr2_+_25180737 1.200 ENSMUST00000104999.2
 Nrarp
Notch-regulated ankyrin repeat protein
chr3_+_67374116 1.094 ENSMUST00000061322.8
 Mlf1
myeloid leukemia factor 1
chr17_-_59013264 1.091 ENSMUST00000174122.1
ENSMUST00000025065.5
 Nudt12

nudix (nucleoside diphosphate linked moiety X)-type motif 12

chr5_+_92809372 1.080 ENSMUST00000113054.2
 Shroom3
shroom family member 3

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 101 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.7 GO:0051028 mRNA transport(GO:0051028)
0.2 2.1 GO:1900169 regulation of glucocorticoid mediated signaling pathway(GO:1900169)
0.6 1.9 GO:0010986 positive regulation of lipoprotein particle clearance(GO:0010986)
0.2 1.7 GO:0002318 myeloid progenitor cell differentiation(GO:0002318)
0.0 1.7 GO:0051489 regulation of filopodium assembly(GO:0051489)
0.4 1.5 GO:1904565 response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904565) cellular response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904566)
0.3 1.5 GO:0010792 DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792)
0.2 1.5 GO:0045719 negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874)
0.0 1.5 GO:0006378 mRNA polyadenylation(GO:0006378)
0.1 1.4 GO:0016127 cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127)
0.1 1.4 GO:0031954 positive regulation of protein autophosphorylation(GO:0031954)
0.4 1.3 GO:0042320 regulation of circadian sleep/wake cycle, REM sleep(GO:0042320) circadian sleep/wake cycle, REM sleep(GO:0042747) positive regulation of circadian sleep/wake cycle, sleep(GO:0045938)
0.2 1.3 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.2 1.2 GO:0097368 establishment of Sertoli cell barrier(GO:0097368)
0.1 1.2 GO:0050957 equilibrioception(GO:0050957)
0.1 1.2 GO:0014807 regulation of somitogenesis(GO:0014807)
0.1 1.2 GO:0035873 lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873) plasma membrane lactate transport(GO:0035879)
0.0 1.2 GO:0050868 negative regulation of T cell activation(GO:0050868)
0.3 1.1 GO:0006742 NADP catabolic process(GO:0006742) pyridine nucleotide catabolic process(GO:0019364)
0.3 0.9 GO:0046381 CMP-N-acetylneuraminate metabolic process(GO:0046381)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 33 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.6 GO:0005769 early endosome(GO:0005769)
0.0 2.3 GO:0031514 motile cilium(GO:0031514)
0.7 2.0 GO:0005595 collagen type XII trimer(GO:0005595) anchoring collagen complex(GO:0030934)
0.0 1.8 GO:0005884 actin filament(GO:0005884)
0.1 1.5 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.0 1.4 GO:0001772 immunological synapse(GO:0001772)
0.3 1.3 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.0 1.3 GO:0016459 myosin complex(GO:0016459)
0.0 1.2 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.0 1.1 GO:0005643 nuclear pore(GO:0005643)
0.1 1.0 GO:0031616 spindle pole centrosome(GO:0031616)
0.0 1.0 GO:0030139 endocytic vesicle(GO:0030139)
0.1 0.9 GO:0051286 cell tip(GO:0051286)
0.1 0.9 GO:0005641 nuclear envelope lumen(GO:0005641)
0.1 0.9 GO:0001527 microfibril(GO:0001527)
0.0 0.9 GO:0051233 spindle midzone(GO:0051233)
0.0 0.6 GO:0035631 CD40 receptor complex(GO:0035631)
0.0 0.6 GO:0016580 Sin3 complex(GO:0016580)
0.0 0.6 GO:0030673 axolemma(GO:0030673)
0.1 0.5 GO:0072487 MSL complex(GO:0072487)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 76 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 2.9 GO:0035727 lysophosphatidic acid binding(GO:0035727) lysophosphatidic acid receptor activity(GO:0070915)
0.0 2.0 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.5 1.9 GO:0008970 phosphatidylcholine 1-acylhydrolase activity(GO:0008970)
0.2 1.5 GO:0000014 single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.1 1.5 GO:0001784 phosphotyrosine binding(GO:0001784)
0.2 1.4 GO:0003854 3-beta-hydroxy-delta5-steroid dehydrogenase activity(GO:0003854)
0.1 1.4 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.1 1.3 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.0 1.3 GO:0030507 spectrin binding(GO:0030507)
0.1 1.2 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.2 1.1 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.3 0.9 GO:0016716 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen(GO:0016716)
0.2 0.9 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.1 0.9 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.1 0.9 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.0 0.9 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.0 0.9 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 0.8 GO:0008186 ATP-dependent RNA helicase activity(GO:0004004) RNA-dependent ATPase activity(GO:0008186)
0.2 0.7 GO:0038049 glucocorticoid receptor activity(GO:0004883) transcription factor activity, ligand-activated RNA polymerase II transcription factor binding(GO:0038049) glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity(GO:0038051)
0.0 0.7 GO:0048027 mRNA 5'-UTR binding(GO:0048027)