Motif ID: Sox3_Sox10

Z-value: 1.899

Transcription factors associated with Sox3_Sox10:

Gene SymbolEntrez IDGene Name
Sox10 ENSMUSG00000033006.9 Sox10
Sox3 ENSMUSG00000045179.8 Sox3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Sox3mm10_v2_chrX_-_60893430_60893440-0.491.2e-02Click!
Sox10mm10_v2_chr15_-_79164477_79164496-0.087.0e-01Click!


Activity profile for motif Sox3_Sox10.

activity profile for motif Sox3_Sox10


Sorted Z-values histogram for motif Sox3_Sox10

Sorted Z-values for motif Sox3_Sox10



Network of associatons between targets according to the STRING database.



First level regulatory network of Sox3_Sox10

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_+_67586520 13.837 ENSMUST00000108682.2
 Gas7
growth arrest specific 7
chr11_+_67586675 12.074 ENSMUST00000108680.1
 Gas7
growth arrest specific 7
chr18_+_37484955 11.105 ENSMUST00000053856.4
 Pcdhb17
protocadherin beta 17
chr2_-_156312470 10.385 ENSMUST00000079125.6
 Scand1
SCAN domain-containing 1
chr8_-_84773381 10.221 ENSMUST00000109764.1
 Nfix
nuclear factor I/X
chr2_+_158666690 9.206 ENSMUST00000103116.3
 Ppp1r16b
protein phosphatase 1, regulatory (inhibitor) subunit 16B
chr5_-_34187670 8.479 ENSMUST00000042701.6
ENSMUST00000119171.1
 Mxd4

Max dimerization protein 4

chr6_-_13839916 8.440 ENSMUST00000060442.7
 Gpr85
G protein-coupled receptor 85
chr1_+_34579693 8.233 ENSMUST00000052670.8
 Amer3
APC membrane recruitment 3
chr4_-_148130678 7.896 ENSMUST00000030862.4
 Draxin
dorsal inhibitory axon guidance protein
chr18_-_43059418 7.641 ENSMUST00000025377.7
 Ppp2r2b
protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), beta isoform
chr5_+_66968416 7.623 ENSMUST00000038188.7
 Limch1
LIM and calponin homology domains 1
chr6_-_136171722 7.534 ENSMUST00000053880.6
 Grin2b
glutamate receptor, ionotropic, NMDA2B (epsilon 2)
chr11_-_98329641 7.396 ENSMUST00000041685.6
 Neurod2
neurogenic differentiation 2
chr7_+_24507099 7.394 ENSMUST00000177228.1
 Zfp428
zinc finger protein 428
chr9_+_112234257 7.304 ENSMUST00000149308.3
ENSMUST00000144424.2
ENSMUST00000139552.2
 2900079G21Rik


RIKEN cDNA 2900079G21 gene


chr6_+_51432663 7.200 ENSMUST00000005103.5
 Nfe2l3
nuclear factor, erythroid derived 2, like 3
chr2_-_119271202 6.969 ENSMUST00000037360.7
 Rhov
ras homolog gene family, member V
chrX_-_143933089 6.844 ENSMUST00000087313.3
 Dcx
doublecortin
chr17_-_79355082 6.594 ENSMUST00000068958.7
 Cdc42ep3
CDC42 effector protein (Rho GTPase binding) 3

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 324 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 23.4 GO:0030041 actin filament polymerization(GO:0030041)
1.4 22.8 GO:1900454 positive regulation of long term synaptic depression(GO:1900454)
1.0 21.9 GO:0021819 layer formation in cerebral cortex(GO:0021819)
0.6 10.6 GO:0014049 positive regulation of glutamate secretion(GO:0014049)
0.7 9.9 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.1 9.8 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.7 9.7 GO:1901898 negative regulation of relaxation of muscle(GO:1901078) negative regulation of relaxation of cardiac muscle(GO:1901898)
3.2 9.5 GO:2000297 negative regulation of synapse maturation(GO:2000297)
2.3 9.2 GO:1903587 regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903587)
0.8 9.1 GO:0046543 development of secondary female sexual characteristics(GO:0046543)
1.1 8.9 GO:0005513 detection of calcium ion(GO:0005513)
0.3 8.4 GO:1901385 regulation of voltage-gated calcium channel activity(GO:1901385)
2.7 8.0 GO:0042560 10-formyltetrahydrofolate catabolic process(GO:0009258) folic acid-containing compound catabolic process(GO:0009397) pteridine-containing compound catabolic process(GO:0042560)
0.1 7.8 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
1.1 7.6 GO:0034047 regulation of protein phosphatase type 2A activity(GO:0034047)
0.1 7.6 GO:0000045 autophagosome assembly(GO:0000045)
1.5 7.3 GO:2001025 positive regulation of response to drug(GO:2001025)
0.5 7.3 GO:1901629 regulation of presynaptic membrane organization(GO:1901629)
0.6 7.0 GO:0031274 positive regulation of pseudopodium assembly(GO:0031274)
0.1 6.9 GO:0021954 central nervous system neuron development(GO:0021954)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 144 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.7 27.2 GO:0045298 tubulin complex(GO:0045298)
0.1 23.5 GO:0005874 microtubule(GO:0005874)
0.2 23.4 GO:0005884 actin filament(GO:0005884)
0.5 21.8 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.8 20.5 GO:0071565 nBAF complex(GO:0071565)
0.1 19.4 GO:0045211 postsynaptic membrane(GO:0045211)
0.3 13.7 GO:0031941 filamentous actin(GO:0031941)
0.1 11.7 GO:0043204 perikaryon(GO:0043204)
1.5 8.8 GO:1990635 proximal dendrite(GO:1990635)
0.5 8.6 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.1 8.2 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.9 8.1 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.4 8.0 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.2 7.6 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.7 7.5 GO:0043083 synaptic cleft(GO:0043083)
0.1 7.2 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.9 6.9 GO:0001520 outer dense fiber(GO:0001520)
0.1 6.8 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.4 6.7 GO:0032279 asymmetric synapse(GO:0032279)
0.2 6.6 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 225 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 27.5 GO:0008017 microtubule binding(GO:0008017)
0.1 23.6 GO:0003779 actin binding(GO:0003779)
1.0 23.0 GO:0034185 apolipoprotein binding(GO:0034185)
0.1 15.2 GO:0043774 UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity(GO:0008766) ribosomal S6-glutamic acid ligase activity(GO:0018169) coenzyme F420-0 gamma-glutamyl ligase activity(GO:0043773) coenzyme F420-2 alpha-glutamyl ligase activity(GO:0043774) protein-glycine ligase activity(GO:0070735) protein-glycine ligase activity, initiating(GO:0070736) protein-glycine ligase activity, elongating(GO:0070737) tubulin-glycine ligase activity(GO:0070738)
0.5 12.9 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.7 12.7 GO:0008599 protein phosphatase type 1 regulator activity(GO:0008599)
0.3 11.8 GO:0030552 cAMP binding(GO:0030552)
0.1 10.5 GO:0008201 heparin binding(GO:0008201)
1.3 10.2 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.3 9.2 GO:0003785 actin monomer binding(GO:0003785)
0.4 8.7 GO:0001784 phosphotyrosine binding(GO:0001784)
0.0 8.4 GO:0005096 GTPase activator activity(GO:0005096)
0.1 8.1 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
2.7 8.0 GO:0016155 formyltetrahydrofolate dehydrogenase activity(GO:0016155)
0.8 7.9 GO:0031749 D2 dopamine receptor binding(GO:0031749)
0.5 7.6 GO:0008601 protein phosphatase type 2A regulator activity(GO:0008601)
0.0 7.4 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.6 7.3 GO:0031005 filamin binding(GO:0031005)
0.5 7.0 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.5 7.0 GO:0015269 calcium-activated potassium channel activity(GO:0015269)