Motif ID: Sox4

Z-value: 0.275


Transcription factors associated with Sox4:

Gene SymbolEntrez IDGene Name
Sox4 ENSMUSG00000076431.4 Sox4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Sox4mm10_v2_chr13_-_28953690_28953713-0.281.6e-01Click!


Activity profile for motif Sox4.

activity profile for motif Sox4


Sorted Z-values histogram for motif Sox4

Sorted Z-values for motif Sox4



Network of associatons between targets according to the STRING database.



First level regulatory network of Sox4

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr7_-_103853199 1.523 ENSMUST00000033229.3
 Hbb-y
hemoglobin Y, beta-like embryonic chain
chr17_-_70851189 0.537 ENSMUST00000059775.8
 Tgif1
TGFB-induced factor homeobox 1
chr7_+_45216671 0.514 ENSMUST00000134420.1
 Tead2
TEA domain family member 2
chr4_+_115057683 0.443 ENSMUST00000161601.1
 Tal1
T cell acute lymphocytic leukemia 1
chrX_+_73639414 0.403 ENSMUST00000019701.8
 Dusp9
dual specificity phosphatase 9
chr3_+_131110350 0.375 ENSMUST00000066849.6
ENSMUST00000106341.2
ENSMUST00000029611.7
 Lef1


lymphoid enhancer binding factor 1


chr9_-_103480328 0.353 ENSMUST00000124310.2
 Bfsp2
beaded filament structural protein 2, phakinin
chr7_+_100493795 0.349 ENSMUST00000129324.1
 Ucp2
uncoupling protein 2 (mitochondrial, proton carrier)
chr15_+_102296256 0.341 ENSMUST00000064924.4
 Espl1
extra spindle poles-like 1 (S. cerevisiae)
chr1_+_135729147 0.333 ENSMUST00000027677.7
 Csrp1
cysteine and glycine-rich protein 1
chr12_+_24708984 0.333 ENSMUST00000154588.1
 Rrm2
ribonucleotide reductase M2
chr5_+_75075464 0.321 ENSMUST00000160104.1
ENSMUST00000040477.3
 Gsx2

GS homeobox 2

chr17_-_70853482 0.315 ENSMUST00000118283.1
 Tgif1
TGFB-induced factor homeobox 1
chr12_-_54986363 0.314 ENSMUST00000173433.1
ENSMUST00000173803.1
 Baz1a
Gm20403
bromodomain adjacent to zinc finger domain 1A
predicted gene 20403
chr1_+_153665274 0.314 ENSMUST00000152114.1
ENSMUST00000111812.1
 Rgs8

regulator of G-protein signaling 8

chr13_+_117220584 0.305 ENSMUST00000022242.7
 Emb
embigin
chr2_-_180776749 0.297 ENSMUST00000061098.2
 Bhlhe23
basic helix-loop-helix family, member e23
chr2_-_180776900 0.295 ENSMUST00000108878.1
 Bhlhe23
basic helix-loop-helix family, member e23
chr11_-_115813621 0.293 ENSMUST00000041684.4
ENSMUST00000156812.1
 Caskin2

CASK-interacting protein 2

chr5_+_115908644 0.285 ENSMUST00000141101.1
 Cit
citron
chr9_+_85842852 0.283 ENSMUST00000098500.3
 Tpbg
trophoblast glycoprotein
chr14_+_27039001 0.276 ENSMUST00000035336.3
 Il17rd
interleukin 17 receptor D
chr8_+_108714644 0.275 ENSMUST00000043896.8
 Zfhx3
zinc finger homeobox 3
chr18_-_62756275 0.271 ENSMUST00000067450.1
ENSMUST00000048109.5
 2700046A07Rik

RIKEN cDNA 2700046A07 gene

chr7_+_100494044 0.262 ENSMUST00000153287.1
 Ucp2
uncoupling protein 2 (mitochondrial, proton carrier)
chr11_-_98625661 0.260 ENSMUST00000104933.1
 Gm12355
predicted gene 12355
chr11_+_88068242 0.260 ENSMUST00000018521.4
 Vezf1
vascular endothelial zinc finger 1
chr3_+_146500071 0.252 ENSMUST00000119130.1
 Gng5
guanine nucleotide binding protein (G protein), gamma 5
chr12_+_19954505 0.246 ENSMUST00000179133.1
 Gm21863
predicted gene, 21863
chr17_-_35704000 0.237 ENSMUST00000097333.3
ENSMUST00000003628.6
 Ddr1

discoidin domain receptor family, member 1

chr6_-_39557830 0.233 ENSMUST00000036877.3
ENSMUST00000154149.1
 Dennd2a

DENN/MADD domain containing 2A

chr4_+_41762309 0.215 ENSMUST00000108042.2
 Il11ra1
interleukin 11 receptor, alpha chain 1
chr10_+_80150448 0.211 ENSMUST00000153477.1
 Midn
midnolin
chr2_-_101649501 0.210 ENSMUST00000160722.1
ENSMUST00000160037.1
ENSMUST00000078494.5
 B230118H07Rik

Rag1
RIKEN cDNA B230118H07 gene

recombination activating gene 1
chr7_+_127233044 0.206 ENSMUST00000106312.3
 Zfp553
zinc finger protein 553
chr17_-_35704574 0.200 ENSMUST00000117301.1
ENSMUST00000134995.1
 Ddr1

discoidin domain receptor family, member 1

chr9_+_13765970 0.197 ENSMUST00000152532.1
 Mtmr2
myotubularin related protein 2
chr7_+_127233227 0.188 ENSMUST00000056232.6
 Zfp553
zinc finger protein 553
chr11_-_114066174 0.179 ENSMUST00000041627.7
 Sdk2
sidekick homolog 2 (chicken)
chr12_-_98577940 0.178 ENSMUST00000110113.1
 Kcnk10
potassium channel, subfamily K, member 10
chr10_+_80151154 0.177 ENSMUST00000146516.1
ENSMUST00000144526.1
 Midn

midnolin

chr12_-_54986328 0.174 ENSMUST00000038926.6
 Baz1a
bromodomain adjacent to zinc finger domain 1A
chr12_+_19606929 0.168 ENSMUST00000105167.1
 Gm9257
predicted gene 9257
chr19_+_56874249 0.158 ENSMUST00000026068.7
 Vwa2
von Willebrand factor A domain containing 2
chrX_+_71556874 0.158 ENSMUST00000123100.1
 Hmgb3
high mobility group box 3
chr7_-_105752193 0.150 ENSMUST00000033184.4
 Tpp1
tripeptidyl peptidase I
chr9_+_104002546 0.149 ENSMUST00000035167.8
ENSMUST00000117054.1
 Nphp3

nephronophthisis 3 (adolescent)

chr19_+_40831248 0.149 ENSMUST00000025983.6
ENSMUST00000120057.1
 Ccnj

cyclin J

chr18_+_82554463 0.146 ENSMUST00000062446.7
ENSMUST00000102812.4
ENSMUST00000075372.5
ENSMUST00000080658.4
ENSMUST00000152071.1
ENSMUST00000114674.3
ENSMUST00000142850.1
ENSMUST00000133193.1
ENSMUST00000123251.1
ENSMUST00000153478.1
ENSMUST00000132369.1
 Mbp










myelin basic protein










chr17_-_35697971 0.145 ENSMUST00000146472.1
 Ddr1
discoidin domain receptor family, member 1
chr19_+_34922351 0.125 ENSMUST00000087341.5
 Kif20b
kinesin family member 20B
chr3_-_95882031 0.124 ENSMUST00000161994.1
 Gm129
predicted gene 129
chr6_-_38875965 0.116 ENSMUST00000160360.1
 Hipk2
homeodomain interacting protein kinase 2
chr2_+_78869009 0.113 ENSMUST00000028398.7
 Ube2e3
ubiquitin-conjugating enzyme E2E 3
chr11_+_101442440 0.113 ENSMUST00000107249.1
 Rpl27
ribosomal protein L27
chr3_-_50443603 0.112 ENSMUST00000029297.4
 Slc7a11
solute carrier family 7 (cationic amino acid transporter, y+ system), member 11
chr11_+_101442298 0.111 ENSMUST00000077856.6
 Rpl27
ribosomal protein L27
chrX_-_145505175 0.105 ENSMUST00000143610.1
 Amot
angiomotin
chrX_-_145505136 0.100 ENSMUST00000112835.1
 Amot
angiomotin
chr16_-_84835557 0.098 ENSMUST00000138279.1
ENSMUST00000023608.7
 Atp5j

ATP synthase, H+ transporting, mitochondrial F0 complex, subunit F

chr18_-_15063560 0.096 ENSMUST00000168989.1
 Kctd1
potassium channel tetramerisation domain containing 1
chr16_+_20516962 0.090 ENSMUST00000003318.5
 Dvl3
dishevelled 3, dsh homolog (Drosophila)
chr9_-_32541589 0.087 ENSMUST00000016231.7
 Fli1
Friend leukemia integration 1
chr5_-_114380459 0.087 ENSMUST00000001125.5
 Kctd10
potassium channel tetramerisation domain containing 10
chr1_+_165788681 0.083 ENSMUST00000161971.1
ENSMUST00000178336.1
ENSMUST00000005907.5
ENSMUST00000027849.4
 Cd247



CD247 antigen



chr5_-_114380505 0.080 ENSMUST00000102581.4
 Kctd10
potassium channel tetramerisation domain containing 10
chr14_+_54936456 0.080 ENSMUST00000037814.6
 Cmtm5
CKLF-like MARVEL transmembrane domain containing 5
chr3_+_135826075 0.078 ENSMUST00000029810.5
 Slc39a8
solute carrier family 39 (metal ion transporter), member 8
chr11_-_106159902 0.077 ENSMUST00000064545.4
 Limd2
LIM domain containing 2
chr13_-_97747373 0.077 ENSMUST00000123535.1
 5330416C01Rik
RIKEN cDNA 5330416C01 gene
chr14_+_47298260 0.075 ENSMUST00000166743.1
 Mapk1ip1l
mitogen-activated protein kinase 1 interacting protein 1-like
chr11_-_106160101 0.065 ENSMUST00000045923.3
 Limd2
LIM domain containing 2
chr7_-_105787544 0.065 ENSMUST00000078482.5
ENSMUST00000154659.1
 Dchs1

dachsous 1 (Drosophila)

chr3_-_75956888 0.059 ENSMUST00000038563.7
ENSMUST00000167078.1
ENSMUST00000117242.1
 Golim4


golgi integral membrane protein 4


chr1_+_165788746 0.055 ENSMUST00000161559.2
 Cd247
CD247 antigen
chr16_-_84835484 0.055 ENSMUST00000114191.1
 Atp5j
ATP synthase, H+ transporting, mitochondrial F0 complex, subunit F
chr11_+_70432627 0.048 ENSMUST00000084954.6
ENSMUST00000108568.3
ENSMUST00000079056.2
ENSMUST00000102564.4
ENSMUST00000124943.1
ENSMUST00000150076.1
ENSMUST00000102563.1
 Arrb2






arrestin, beta 2






chr7_-_105787567 0.045 ENSMUST00000144189.1
 Dchs1
dachsous 1 (Drosophila)
chr1_+_181150926 0.043 ENSMUST00000134115.1
ENSMUST00000111059.1
 Cnih4

cornichon homolog 4 (Drosophila)

chr11_-_100650693 0.037 ENSMUST00000103119.3
 Zfp385c
zinc finger protein 385C
chr12_-_79296266 0.035 ENSMUST00000021547.6
 Zfyve26
zinc finger, FYVE domain containing 26
chr18_+_56707725 0.034 ENSMUST00000025486.8
 Lmnb1
lamin B1
chr16_-_90284412 0.031 ENSMUST00000039280.7
 Scaf4
SR-related CTD-associated factor 4
chr5_-_134456702 0.030 ENSMUST00000073161.5
ENSMUST00000171794.2
ENSMUST00000111245.2
ENSMUST00000100654.3
ENSMUST00000167084.2
ENSMUST00000100652.3
ENSMUST00000100650.3
ENSMUST00000074114.5
 Gtf2ird1







general transcription factor II I repeat domain-containing 1







chr12_-_112674193 0.030 ENSMUST00000001780.3
 Akt1
thymoma viral proto-oncogene 1
chr11_+_22512088 0.028 ENSMUST00000059319.7
 Tmem17
transmembrane protein 17
chr15_-_76656905 0.028 ENSMUST00000176274.1
 Cyhr1
cysteine and histidine rich 1
chr5_-_31291026 0.026 ENSMUST00000041565.7
 Ift172
intraflagellar transport 172
chr7_-_100514800 0.025 ENSMUST00000054923.7
 Dnajb13
DnaJ (Hsp40) related, subfamily B, member 13
chr2_-_33942111 0.025 ENSMUST00000130988.1
ENSMUST00000127936.1
ENSMUST00000134271.1
 Gm13403


predicted gene 13403


chr17_+_37193889 0.025 ENSMUST00000038844.6
 Ubd
ubiquitin D
chr15_-_44428303 0.023 ENSMUST00000038719.6
 Nudcd1
NudC domain containing 1
chr5_-_24445166 0.020 ENSMUST00000115043.1
ENSMUST00000115041.1
 Fastk

Fas-activated serine/threonine kinase

chr12_-_112673944 0.020 ENSMUST00000130342.1
 Akt1
thymoma viral proto-oncogene 1
chr5_+_44100442 0.015 ENSMUST00000072800.4
 Gm16401
predicted gene 16401
chr2_-_168206875 0.013 ENSMUST00000057793.4
 Adnp
activity-dependent neuroprotective protein
chr11_+_69846610 0.012 ENSMUST00000152566.1
ENSMUST00000108633.2
 Plscr3

phospholipid scramblase 3

chr16_+_20517000 0.012 ENSMUST00000171572.1
 Dvl3
dishevelled 3, dsh homolog (Drosophila)
chr2_+_32570858 0.011 ENSMUST00000140592.1
ENSMUST00000028151.6
 Dpm2

dolichol-phosphate (beta-D) mannosyltransferase 2

chr5_-_24445254 0.010 ENSMUST00000030800.6
 Fastk
Fas-activated serine/threonine kinase
chr12_+_21111778 0.009 ENSMUST00000050990.9
 Asap2
ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
chr17_+_75005523 0.007 ENSMUST00000001927.5
 Ltbp1
latent transforming growth factor beta binding protein 1
chr4_+_129513581 0.006 ENSMUST00000062356.6
 Marcksl1
MARCKS-like 1
chr16_-_90284300 0.005 ENSMUST00000163419.1
 Scaf4
SR-related CTD-associated factor 4
chr15_+_44428073 0.003 ENSMUST00000060652.3
 Eny2
enhancer of yellow 2 homolog (Drosophila)
chr2_-_26910569 0.001 ENSMUST00000015920.5
ENSMUST00000139815.1
ENSMUST00000102899.3
 Med22


mediator complex subunit 22


chr11_+_69846374 0.001 ENSMUST00000108632.1
 Plscr3
phospholipid scramblase 3
chr11_-_86807624 0.000 ENSMUST00000018569.7
 Dhx40
DEAH (Asp-Glu-Ala-His) box polypeptide 40

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.5 GO:0015671 oxygen transport(GO:0015671)
0.2 0.6 GO:0046671 negative regulation of retinal cell programmed cell death(GO:0046671)
0.1 0.4 GO:0060217 hemangioblast cell differentiation(GO:0060217)
0.1 0.4 GO:0032696 negative regulation of interleukin-13 production(GO:0032696) trachea submucosa development(GO:0061152) trachea gland development(GO:0061153) odontoblast differentiation(GO:0071895) regulation of estrogen receptor binding(GO:0071898) negative regulation of estrogen receptor binding(GO:0071899)
0.1 0.3 GO:1904059 regulation of locomotor rhythm(GO:1904059)
0.1 0.2 GO:0002331 pre-B cell allelic exclusion(GO:0002331)
0.1 0.4 GO:1903300 negative regulation of glucokinase activity(GO:0033132) negative regulation of hexokinase activity(GO:1903300)
0.1 0.2 GO:0007161 calcium-independent cell-matrix adhesion(GO:0007161)
0.1 0.6 GO:0061179 negative regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061179)
0.1 0.2 GO:0003365 establishment of cell polarity involved in ameboidal cell migration(GO:0003365)
0.1 0.8 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.0 0.1 GO:0048496 maintenance of organ identity(GO:0048496)
0.0 0.6 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.0 0.3 GO:0072513 positive regulation of secondary heart field cardioblast proliferation(GO:0072513)
0.0 0.3 GO:1901970 positive regulation of mitotic sister chromatid separation(GO:1901970)
0.0 0.3 GO:0009186 deoxyribonucleoside diphosphate metabolic process(GO:0009186)
0.0 0.2 GO:0045578 negative regulation of B cell differentiation(GO:0045578)
0.0 0.1 GO:0072137 condensed mesenchymal cell proliferation(GO:0072137)
0.0 0.2 GO:0031642 negative regulation of myelination(GO:0031642)
0.0 0.5 GO:0030903 notochord development(GO:0030903)
0.0 0.3 GO:0060159 regulation of dopamine receptor signaling pathway(GO:0060159)
0.0 0.4 GO:0070307 lens fiber cell development(GO:0070307)
0.0 0.3 GO:0048853 forebrain morphogenesis(GO:0048853)
0.0 0.4 GO:0000188 inactivation of MAPK activity(GO:0000188)
0.0 0.1 GO:1902410 mitotic cytokinetic process(GO:1902410)
0.0 0.1 GO:0089711 L-glutamate transmembrane transport(GO:0089711)
0.0 0.2 GO:0030322 stabilization of membrane potential(GO:0030322)
0.0 0.3 GO:0050774 negative regulation of dendrite morphogenesis(GO:0050774)
0.0 0.2 GO:0046697 decidualization(GO:0046697)
0.0 0.1 GO:0050882 voluntary musculoskeletal movement(GO:0050882)
0.0 0.0 GO:0060709 glycogen cell differentiation involved in embryonic placenta development(GO:0060709)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.5 GO:0005833 hemoglobin complex(GO:0005833)
0.1 0.4 GO:0033193 Lsd1/2 complex(GO:0033193)
0.1 0.5 GO:0008623 CHRAC(GO:0008623)
0.1 0.3 GO:0031680 G-protein beta/gamma-subunit complex(GO:0031680)
0.1 0.3 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
0.0 0.1 GO:0097543 ciliary inversin compartment(GO:0097543)
0.0 0.1 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.0 0.4 GO:1990907 beta-catenin-TCF complex(GO:1990907)
0.0 0.1 GO:0033269 internode region of axon(GO:0033269)
0.0 0.2 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 0.2 GO:0036038 MKS complex(GO:0036038)
0.0 0.1 GO:1990023 mitotic spindle midzone(GO:1990023)
0.0 0.1 GO:1990909 Wnt signalosome(GO:1990909)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.5 GO:0031721 hemoglobin alpha binding(GO:0031721)
0.1 0.3 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.1 0.2 GO:0043532 angiostatin binding(GO:0043532)
0.1 0.3 GO:0061731 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.1 0.6 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.1 0.4 GO:0030284 estrogen receptor activity(GO:0030284)
0.1 0.2 GO:0004921 interleukin-11 receptor activity(GO:0004921) interleukin-11 binding(GO:0019970)
0.0 0.4 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 0.9 GO:0070410 co-SMAD binding(GO:0070410)
0.0 0.2 GO:0008240 tripeptidyl-peptidase activity(GO:0008240)
0.0 0.1 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.0 0.1 GO:0000099 sulfur amino acid transmembrane transporter activity(GO:0000099)
0.0 0.2 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.0 0.0 GO:0031826 type 2A serotonin receptor binding(GO:0031826)
0.0 0.1 GO:0046790 virion binding(GO:0046790)
0.0 0.2 GO:0004438 phosphatidylinositol-3-phosphatase activity(GO:0004438)
0.0 0.4 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)