Motif ID: Sox6_Sox9

Z-value: 0.737

Transcription factors associated with Sox6_Sox9:

Gene SymbolEntrez IDGene Name
Sox6 ENSMUSG00000051910.7 Sox6
Sox9 ENSMUSG00000000567.5 Sox9

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Sox9mm10_v2_chr11_+_112782182_112782248-0.385.7e-02Click!
Sox6mm10_v2_chr7_-_116031047_116031122-0.281.7e-01Click!


Activity profile for motif Sox6_Sox9.

activity profile for motif Sox6_Sox9


Sorted Z-values histogram for motif Sox6_Sox9

Sorted Z-values for motif Sox6_Sox9



Network of associatons between targets according to the STRING database.



First level regulatory network of Sox6_Sox9

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr12_+_29528382 2.914 ENSMUST00000049784.9
 Myt1l
myelin transcription factor 1-like
chr18_+_37484955 2.531 ENSMUST00000053856.4
 Pcdhb17
protocadherin beta 17
chr9_-_29411736 2.308 ENSMUST00000115236.1
 Ntm
neurotrimin
chr5_+_66968416 2.206 ENSMUST00000038188.7
 Limch1
LIM and calponin homology domains 1
chr11_-_98329641 2.134 ENSMUST00000041685.6
 Neurod2
neurogenic differentiation 2
chr5_+_66968559 2.048 ENSMUST00000127184.1
 Limch1
LIM and calponin homology domains 1
chr9_+_27790947 2.044 ENSMUST00000115243.2
 Opcml
opioid binding protein/cell adhesion molecule-like
chr9_-_29412204 1.971 ENSMUST00000115237.1
 Ntm
neurotrimin
chr8_-_84773381 1.954 ENSMUST00000109764.1
 Nfix
nuclear factor I/X
chr2_-_36104060 1.765 ENSMUST00000112961.3
ENSMUST00000112966.3
 Lhx6

LIM homeobox protein 6

chr11_+_67586520 1.664 ENSMUST00000108682.2
 Gas7
growth arrest specific 7
chr10_-_83534130 1.605 ENSMUST00000020497.7
 Aldh1l2
aldehyde dehydrogenase 1 family, member L2
chr17_+_55445550 1.575 ENSMUST00000025000.3
 St6gal2
beta galactoside alpha 2,6 sialyltransferase 2
chr18_-_43059418 1.547 ENSMUST00000025377.7
 Ppp2r2b
protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), beta isoform
chr18_-_23038656 1.453 ENSMUST00000081423.6
 Nol4
nucleolar protein 4
chr2_+_180598219 1.408 ENSMUST00000103059.1
 Col9a3
collagen, type IX, alpha 3
chr1_-_56972437 1.405 ENSMUST00000042857.7
 Satb2
special AT-rich sequence binding protein 2
chr11_+_67586675 1.386 ENSMUST00000108680.1
 Gas7
growth arrest specific 7
chr10_+_29143996 1.371 ENSMUST00000092629.2
 Soga3
SOGA family member 3
chr18_+_37307445 1.342 ENSMUST00000056712.2
 Pcdhb4
protocadherin beta 4

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 128 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 2.7 GO:2000297 negative regulation of synapse maturation(GO:2000297)
0.0 2.7 GO:0010977 negative regulation of neuron projection development(GO:0010977)
0.0 2.4 GO:0030041 actin filament polymerization(GO:0030041)
0.2 2.1 GO:0060665 regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
0.1 2.0 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.1 1.9 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0 1.9 GO:0007019 microtubule depolymerization(GO:0007019)
0.3 1.8 GO:1904936 cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
0.0 1.8 GO:0031032 actomyosin structure organization(GO:0031032)
0.2 1.7 GO:0005513 detection of calcium ion(GO:0005513)
0.1 1.7 GO:0007194 negative regulation of adenylate cyclase activity(GO:0007194)
0.5 1.6 GO:0042560 10-formyltetrahydrofolate catabolic process(GO:0009258) folic acid-containing compound catabolic process(GO:0009397) pteridine-containing compound catabolic process(GO:0042560)
0.1 1.6 GO:0006054 N-acetylneuraminate metabolic process(GO:0006054)
0.2 1.5 GO:0034047 regulation of protein phosphatase type 2A activity(GO:0034047)
0.1 1.5 GO:0046543 development of secondary female sexual characteristics(GO:0046543)
0.0 1.5 GO:0030705 cytoskeleton-dependent intracellular transport(GO:0030705)
0.3 1.4 GO:1900740 regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900739) positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900740)
0.0 1.4 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.1 1.2 GO:1903608 protein localization to cytoplasmic stress granule(GO:1903608)
0.1 1.2 GO:0021819 layer formation in cerebral cortex(GO:0021819)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 54 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.0 GO:0031225 anchored component of membrane(GO:0031225)
0.0 3.4 GO:0001726 ruffle(GO:0001726)
0.0 3.2 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.9 2.7 GO:0005595 collagen type XII trimer(GO:0005595) anchoring collagen complex(GO:0030934)
0.4 1.7 GO:0044307 dendritic branch(GO:0044307)
0.1 1.5 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.4 1.4 GO:0005593 FACIT collagen trimer(GO:0005593)
0.0 1.3 GO:0005871 kinesin complex(GO:0005871)
0.3 1.2 GO:0097165 nuclear stress granule(GO:0097165)
0.0 1.2 GO:0000118 histone deacetylase complex(GO:0000118)
0.1 1.1 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.1 1.1 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.0 1.0 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.0 1.0 GO:0009925 basal plasma membrane(GO:0009925)
0.1 0.9 GO:0000138 Golgi trans cisterna(GO:0000138)
0.0 0.9 GO:0045334 clathrin-coated endocytic vesicle(GO:0045334)
0.0 0.9 GO:0005657 replication fork(GO:0005657)
0.2 0.8 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.2 0.8 GO:0043259 laminin-1 complex(GO:0005606) laminin-10 complex(GO:0043259)
0.1 0.8 GO:0031315 extrinsic component of mitochondrial outer membrane(GO:0031315)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 90 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.0 GO:0005096 GTPase activator activity(GO:0005096)
0.2 2.9 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.0 2.7 GO:0003779 actin binding(GO:0003779)
0.5 2.5 GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835)
0.0 2.3 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.0 2.3 GO:0015631 tubulin binding(GO:0015631)
0.1 1.9 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
0.1 1.9 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 1.9 GO:0051015 actin filament binding(GO:0051015)
0.1 1.7 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.5 1.6 GO:0016155 formyltetrahydrofolate dehydrogenase activity(GO:0016155)
0.1 1.6 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.1 1.5 GO:0008601 protein phosphatase type 2A regulator activity(GO:0008601)
0.0 1.5 GO:0005080 protein kinase C binding(GO:0005080)
0.3 1.4 GO:0005008 hepatocyte growth factor-activated receptor activity(GO:0005008)
0.0 1.4 GO:0017137 Rab GTPase binding(GO:0017137)
0.0 1.4 GO:0051117 ATPase binding(GO:0051117)
0.0 1.3 GO:0017091 AU-rich element binding(GO:0017091)
0.0 1.3 GO:0030332 cyclin binding(GO:0030332)
0.0 1.3 GO:0003777 microtubule motor activity(GO:0003777)