Motif ID: Sp1

Z-value: 2.030


Transcription factors associated with Sp1:

Gene SymbolEntrez IDGene Name
Sp1 ENSMUSG00000001280.6 Sp1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Sp1mm10_v2_chr15_+_102406143_102406380-0.653.3e-04Click!


Activity profile for motif Sp1.

activity profile for motif Sp1


Sorted Z-values histogram for motif Sp1

Sorted Z-values for motif Sp1



Network of associatons between targets according to the STRING database.



First level regulatory network of Sp1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_56971762 11.091 ENSMUST00000114415.3
 Satb2
special AT-rich sequence binding protein 2
chr15_-_66969616 9.301 ENSMUST00000170903.1
ENSMUST00000166420.1
ENSMUST00000005256.6
ENSMUST00000164070.1
 Ndrg1



N-myc downstream regulated gene 1



chr12_+_12262139 9.244 ENSMUST00000069066.6
ENSMUST00000069005.8
 Fam49a

family with sequence similarity 49, member A

chr2_+_172345565 8.926 ENSMUST00000028995.4
 Fam210b
family with sequence similarity 210, member B
chr5_-_109558957 8.701 ENSMUST00000044579.7
 Crlf2
cytokine receptor-like factor 2
chr8_-_84800024 8.364 ENSMUST00000126806.1
ENSMUST00000076715.6
 Nfix

nuclear factor I/X

chr11_-_102296618 8.328 ENSMUST00000107132.2
ENSMUST00000073234.2
 Atxn7l3

ataxin 7-like 3

chr4_-_133498538 8.228 ENSMUST00000125541.1
 Trnp1
TMF1-regulated nuclear protein 1
chr5_+_134986191 8.170 ENSMUST00000094245.2
 Cldn3
claudin 3
chr1_-_56972437 7.931 ENSMUST00000042857.7
 Satb2
special AT-rich sequence binding protein 2
chr9_+_44043384 7.294 ENSMUST00000114840.1
 Thy1
thymus cell antigen 1, theta
chr12_-_4841583 7.146 ENSMUST00000020964.5
 Fkbp1b
FK506 binding protein 1b
chr15_-_75566811 7.128 ENSMUST00000065417.8
 Ly6h
lymphocyte antigen 6 complex, locus H
chr6_-_85502858 6.808 ENSMUST00000161546.1
ENSMUST00000161078.1
 Fbxo41

F-box protein 41

chr12_-_100725028 6.767 ENSMUST00000043599.6
 Rps6ka5
ribosomal protein S6 kinase, polypeptide 5
chr16_+_93711907 6.714 ENSMUST00000045004.9
 Dopey2
dopey family member 2
chr7_+_44310213 6.581 ENSMUST00000107938.1
 Shank1
SH3/ankyrin domain gene 1
chr7_-_27396542 6.564 ENSMUST00000108363.1
 Sptbn4
spectrin beta, non-erythrocytic 4
chr8_-_29219338 6.434 ENSMUST00000168630.2
 Unc5d
unc-5 homolog D (C. elegans)
chr5_-_139129662 6.421 ENSMUST00000026973.7
 Prkar1b
protein kinase, cAMP dependent regulatory, type I beta

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 958 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 34.7 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
1.7 24.2 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
1.0 23.6 GO:0032011 ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
1.4 22.0 GO:1900454 positive regulation of long term synaptic depression(GO:1900454)
1.4 20.3 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
1.4 18.7 GO:0097688 AMPA glutamate receptor clustering(GO:0097113) glutamate receptor clustering(GO:0097688)
0.9 16.9 GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
0.6 16.2 GO:0060074 synapse maturation(GO:0060074)
0.7 14.7 GO:0050650 chondroitin sulfate proteoglycan biosynthetic process(GO:0050650)
0.3 14.6 GO:1904893 negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
1.3 14.4 GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway(GO:0007191)
0.8 14.4 GO:0032287 peripheral nervous system myelin maintenance(GO:0032287)
0.8 14.4 GO:0071625 vocalization behavior(GO:0071625)
4.3 12.8 GO:0030827 negative regulation of cGMP metabolic process(GO:0030824) negative regulation of cGMP biosynthetic process(GO:0030827) negative regulation of guanylate cyclase activity(GO:0031283)
2.0 12.0 GO:0032229 negative regulation of synaptic transmission, GABAergic(GO:0032229)
1.1 12.0 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.6 11.9 GO:0001574 ganglioside biosynthetic process(GO:0001574)
0.8 11.7 GO:0032793 positive regulation of CREB transcription factor activity(GO:0032793)
1.7 11.6 GO:0032811 negative regulation of epinephrine secretion(GO:0032811)
0.4 11.6 GO:0036465 synaptic vesicle recycling(GO:0036465)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 308 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 135.2 GO:0016021 integral component of membrane(GO:0016021)
0.7 69.5 GO:0043195 terminal bouton(GO:0043195)
0.4 57.2 GO:0070382 exocytic vesicle(GO:0070382)
0.3 54.5 GO:0045211 postsynaptic membrane(GO:0045211)
0.6 48.4 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.1 46.6 GO:0044297 cell body(GO:0044297)
1.1 46.4 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.1 39.6 GO:0005764 lytic vacuole(GO:0000323) lysosome(GO:0005764)
0.3 36.2 GO:0055037 recycling endosome(GO:0055037)
0.4 34.0 GO:0031225 anchored component of membrane(GO:0031225)
0.1 28.2 GO:0005743 mitochondrial inner membrane(GO:0005743)
2.1 21.0 GO:0044327 dendritic spine head(GO:0044327)
0.4 20.6 GO:0005905 clathrin-coated pit(GO:0005905)
0.5 19.6 GO:0031901 early endosome membrane(GO:0031901)
1.1 18.3 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.5 17.7 GO:0097440 apical dendrite(GO:0097440)
0.4 16.7 GO:0031941 filamentous actin(GO:0031941)
0.5 16.2 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.4 15.6 GO:0042734 presynaptic membrane(GO:0042734)
1.5 15.0 GO:0045298 tubulin complex(GO:0045298)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 580 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 26.3 GO:0019210 protein kinase inhibitor activity(GO:0004860) kinase inhibitor activity(GO:0019210)
0.6 26.2 GO:0045296 cadherin binding(GO:0045296)
1.1 24.9 GO:0034185 apolipoprotein binding(GO:0034185)
1.0 23.3 GO:0031489 myosin V binding(GO:0031489)
0.1 22.6 GO:0005096 GTPase activator activity(GO:0005096)
0.8 22.3 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.6 21.9 GO:0030215 semaphorin receptor binding(GO:0030215)
0.5 21.7 GO:0005246 calcium channel regulator activity(GO:0005246)
0.6 20.3 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
2.5 19.8 GO:0030550 acetylcholine receptor inhibitor activity(GO:0030550)
0.8 19.3 GO:0017075 syntaxin-1 binding(GO:0017075)
0.6 15.7 GO:0022824 transmitter-gated ion channel activity(GO:0022824) transmitter-gated channel activity(GO:0022835)
1.1 15.5 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.2 15.5 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.1 15.5 GO:0017124 SH3 domain binding(GO:0017124)
0.1 15.4 GO:0050839 cell adhesion molecule binding(GO:0050839)
0.1 15.1 GO:0051015 actin filament binding(GO:0051015)
0.6 14.8 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.4 14.4 GO:0005484 SNAP receptor activity(GO:0005484)
1.4 14.0 GO:0008140 cAMP response element binding protein binding(GO:0008140)