Motif ID: Spdef

Z-value: 0.501


Transcription factors associated with Spdef:

Gene SymbolEntrez IDGene Name
Spdef ENSMUSG00000024215.7 Spdef

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Spdefmm10_v2_chr17_-_27728889_27728956-0.183.9e-01Click!


Activity profile for motif Spdef.

activity profile for motif Spdef


Sorted Z-values histogram for motif Spdef

Sorted Z-values for motif Spdef



Network of associatons between targets according to the STRING database.



First level regulatory network of Spdef

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr18_+_34861200 1.156 ENSMUST00000165033.1
 Egr1
early growth response 1
chr10_-_58675631 1.104 ENSMUST00000003312.4
 Edar
ectodysplasin-A receptor
chr2_+_35132194 1.010 ENSMUST00000113034.1
ENSMUST00000113037.3
ENSMUST00000113033.2
 Cep110


centrosomal protein 110


chr6_+_4755327 0.931 ENSMUST00000176551.1
 Peg10
paternally expressed 10
chr19_+_23687385 0.903 ENSMUST00000099560.3
 Ptar1
protein prenyltransferase alpha subunit repeat containing 1
chr14_-_70207637 0.900 ENSMUST00000022682.5
 Sorbs3
sorbin and SH3 domain containing 3
chr9_-_65908676 0.845 ENSMUST00000119245.1
ENSMUST00000134338.1
ENSMUST00000179395.1
 Trip4


thyroid hormone receptor interactor 4


chrX_+_100625737 0.828 ENSMUST00000048962.3
 Kif4
kinesin family member 4
chr14_-_52197216 0.812 ENSMUST00000046709.7
 Supt16
suppressor of Ty 16
chr13_+_12395362 0.807 ENSMUST00000059270.8
 Heatr1
HEAT repeat containing 1
chr3_+_27938638 0.782 ENSMUST00000120834.1
 Pld1
phospholipase D1
chr4_-_116627921 0.774 ENSMUST00000030456.7
 Nasp
nuclear autoantigenic sperm protein (histone-binding)
chr3_-_122984404 0.718 ENSMUST00000090379.2
 Usp53
ubiquitin specific peptidase 53
chr1_+_51987139 0.670 ENSMUST00000168302.1
 Stat4
signal transducer and activator of transcription 4
chr14_+_54254124 0.662 ENSMUST00000180359.1
 Abhd4
abhydrolase domain containing 4
chr6_-_72390659 0.658 ENSMUST00000059983.9
 Vamp8
vesicle-associated membrane protein 8
chr14_-_98169542 0.648 ENSMUST00000069334.7
ENSMUST00000071533.6
 Dach1

dachshund 1 (Drosophila)

chr2_-_18392736 0.643 ENSMUST00000091418.5
ENSMUST00000166495.1
 Dnajc1

DnaJ (Hsp40) homolog, subfamily C, member 1

chr17_+_34589799 0.622 ENSMUST00000038244.8
 Gpsm3
G-protein signalling modulator 3 (AGS3-like, C. elegans)
chr4_-_116627478 0.609 ENSMUST00000081182.4
ENSMUST00000030457.5
 Nasp

nuclear autoantigenic sperm protein (histone-binding)


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 114 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.4 GO:0043486 histone exchange(GO:0043486)
0.4 1.2 GO:0072223 metanephric glomerular mesangium development(GO:0072223) metanephric glomerular mesangial cell proliferation involved in metanephros development(GO:0072262)
0.2 1.1 GO:0044314 protein K27-linked ubiquitination(GO:0044314)
0.1 1.1 GO:0060662 tube lumen cavitation(GO:0060605) salivary gland cavitation(GO:0060662)
0.3 1.0 GO:0002447 eosinophil activation involved in immune response(GO:0002278) eosinophil mediated immunity(GO:0002447) eosinophil degranulation(GO:0043308) regulation of eosinophil activation(GO:1902566)
0.2 1.0 GO:0034421 post-translational protein acetylation(GO:0034421)
0.2 0.9 GO:0051387 negative regulation of neurotrophin TRK receptor signaling pathway(GO:0051387)
0.2 0.9 GO:0046864 retinol transport(GO:0034633) isoprenoid transport(GO:0046864) terpenoid transport(GO:0046865) alveolar primary septum development(GO:0061143)
0.1 0.9 GO:0018342 protein prenylation(GO:0018342) prenylation(GO:0097354)
0.0 0.9 GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512) negative regulation of cellular response to transforming growth factor beta stimulus(GO:1903845)
0.2 0.8 GO:0044565 dendritic cell proliferation(GO:0044565)
0.1 0.8 GO:0000022 mitotic spindle elongation(GO:0000022) mitotic spindle midzone assembly(GO:0051256)
0.1 0.8 GO:0032534 regulation of microvillus assembly(GO:0032534)
0.0 0.8 GO:0034315 regulation of Arp2/3 complex-mediated actin nucleation(GO:0034315)
0.0 0.8 GO:0045943 positive regulation of transcription from RNA polymerase I promoter(GO:0045943)
0.0 0.8 GO:0030520 intracellular estrogen receptor signaling pathway(GO:0030520)
0.0 0.8 GO:0051496 positive regulation of stress fiber assembly(GO:0051496)
0.2 0.7 GO:0090187 zymogen granule exocytosis(GO:0070625) positive regulation of pancreatic juice secretion(GO:0090187)
0.1 0.7 GO:0035330 regulation of hippo signaling(GO:0035330)
0.1 0.7 GO:0071257 cellular response to electrical stimulus(GO:0071257)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 47 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.3 GO:0016605 PML body(GO:0016605)
0.0 1.1 GO:0005871 kinesin complex(GO:0005871)
0.1 1.0 GO:0000322 storage vacuole(GO:0000322)
0.0 1.0 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 0.9 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.3 0.8 GO:0034455 t-UTP complex(GO:0034455)
0.0 0.8 GO:0031985 Golgi cisterna(GO:0031985)
0.1 0.6 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.1 0.6 GO:0030062 mitochondrial tricarboxylic acid cycle enzyme complex(GO:0030062)
0.1 0.6 GO:0031080 nuclear pore outer ring(GO:0031080)
0.0 0.6 GO:0000788 nuclear nucleosome(GO:0000788)
0.0 0.6 GO:0032420 stereocilium(GO:0032420)
0.0 0.6 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.2 0.5 GO:0097543 ciliary inversin compartment(GO:0097543)
0.2 0.5 GO:0071001 U4/U6 snRNP(GO:0071001)
0.2 0.5 GO:0000801 central element(GO:0000801)
0.0 0.5 GO:0042582 primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.0 0.5 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.0 0.5 GO:0071004 U2-type prespliceosome(GO:0071004)
0.0 0.5 GO:0045334 clathrin-coated endocytic vesicle(GO:0045334)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 85 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 1.5 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 1.3 GO:0051879 Hsp90 protein binding(GO:0051879)
0.1 1.2 GO:0017166 vinculin binding(GO:0017166)
0.0 1.1 GO:0016300 tRNA (uracil) methyltransferase activity(GO:0016300)
0.2 1.0 GO:0016230 sphingomyelin phosphodiesterase activator activity(GO:0016230)
0.0 1.0 GO:0070273 phosphatidylinositol-4-phosphate binding(GO:0070273)
0.0 1.0 GO:0050681 androgen receptor binding(GO:0050681)
0.0 1.0 GO:0043022 ribosome binding(GO:0043022)
0.1 0.9 GO:0008318 protein prenyltransferase activity(GO:0008318)
0.0 0.9 GO:0051183 vitamin transporter activity(GO:0051183)
0.0 0.9 GO:0045309 protein phosphorylated amino acid binding(GO:0045309)
0.3 0.8 GO:0047256 beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity(GO:0008457) lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity(GO:0047256)
0.1 0.8 GO:0070290 N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.1 0.8 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.0 0.8 GO:0030515 snoRNA binding(GO:0030515)
0.0 0.8 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.0 0.8 GO:0016416 O-palmitoyltransferase activity(GO:0016416)
0.0 0.7 GO:0052771 coenzyme F390-A hydrolase activity(GO:0052770) coenzyme F390-G hydrolase activity(GO:0052771)
0.0 0.7 GO:0050840 extracellular matrix binding(GO:0050840)
0.2 0.6 GO:0001075 transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075)