Motif ID: Spi1

Z-value: 1.270


Transcription factors associated with Spi1:

Gene SymbolEntrez IDGene Name
Spi1 ENSMUSG00000002111.8 Spi1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Spi1mm10_v2_chr2_+_91082362_91082390-0.252.2e-01Click!


Activity profile for motif Spi1.

activity profile for motif Spi1


Sorted Z-values histogram for motif Spi1

Sorted Z-values for motif Spi1



Network of associatons between targets according to the STRING database.



First level regulatory network of Spi1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_23248264 12.300 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr3_-_95904683 4.396 ENSMUST00000147962.1
ENSMUST00000036181.8
 Car14

carbonic anhydrase 14

chr16_+_32608973 3.781 ENSMUST00000120680.1
 Tfrc
transferrin receptor
chr16_+_32608920 3.777 ENSMUST00000023486.8
 Tfrc
transferrin receptor
chr2_+_105675478 3.482 ENSMUST00000167211.2
ENSMUST00000111083.3
 Pax6

paired box gene 6

chr7_-_127218303 3.292 ENSMUST00000106313.1
 Sept1
septin 1
chr2_+_84840612 3.254 ENSMUST00000111625.1
 Slc43a1
solute carrier family 43, member 1
chr7_-_127218390 3.142 ENSMUST00000142356.1
ENSMUST00000106314.1
 Sept1

septin 1

chr2_+_167777467 3.119 ENSMUST00000139927.1
ENSMUST00000127441.1
 Gm14321

predicted gene 14321

chr4_+_126556935 3.049 ENSMUST00000048391.8
 Clspn
claspin
chr4_+_126556994 2.880 ENSMUST00000147675.1
 Clspn
claspin
chr14_+_115042752 2.877 ENSMUST00000134140.2
 Mir17hg
Mir17 host gene 1 (non-protein coding)
chr2_+_35132194 2.837 ENSMUST00000113034.1
ENSMUST00000113037.3
ENSMUST00000113033.2
 Cep110


centrosomal protein 110


chr2_+_105682463 2.685 ENSMUST00000140173.1
ENSMUST00000135412.1
ENSMUST00000138365.1
ENSMUST00000145744.1
 Pax6



paired box gene 6



chr2_+_105675429 2.672 ENSMUST00000111085.1
 Pax6
paired box gene 6
chr17_+_34589799 2.584 ENSMUST00000038244.8
 Gpsm3
G-protein signalling modulator 3 (AGS3-like, C. elegans)
chr2_-_73485733 2.568 ENSMUST00000102680.1
 Wipf1
WAS/WASL interacting protein family, member 1
chr12_+_118846329 2.553 ENSMUST00000063918.2
 Sp8
trans-acting transcription factor 8
chr9_+_66126611 2.508 ENSMUST00000034945.5
 Fam96a
family with sequence similarity 96, member A
chr8_+_95633500 2.465 ENSMUST00000034094.9
 Gins3
GINS complex subunit 3 (Psf3 homolog)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 718 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.6 15.8 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
0.6 9.6 GO:0030213 hyaluronan biosynthetic process(GO:0030213)
1.8 8.8 GO:0021905 pancreatic A cell development(GO:0003322) forebrain-midbrain boundary formation(GO:0021905) somatic motor neuron fate commitment(GO:0021917) regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitment(GO:0021918)
0.3 8.4 GO:0008608 attachment of spindle microtubules to kinetochore(GO:0008608)
1.0 7.6 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)
0.6 7.5 GO:0033572 transferrin transport(GO:0033572)
0.0 7.2 GO:0000375 RNA splicing, via transesterification reactions(GO:0000375)
1.6 6.4 GO:0051311 spindle assembly involved in female meiosis(GO:0007056) meiotic metaphase plate congression(GO:0051311)
0.3 5.5 GO:0051127 positive regulation of actin nucleation(GO:0051127)
0.9 5.3 GO:0002553 histamine production involved in inflammatory response(GO:0002349) histamine secretion involved in inflammatory response(GO:0002441) histamine secretion by mast cell(GO:0002553)
0.6 4.5 GO:0015670 carbon dioxide transport(GO:0015670)
0.7 4.3 GO:0071883 activation of MAPK activity by adrenergic receptor signaling pathway(GO:0071883)
1.1 4.2 GO:0045608 inhibition of neuroepithelial cell differentiation(GO:0002085) negative regulation of auditory receptor cell differentiation(GO:0045608)
1.0 4.1 GO:0010957 negative regulation of vitamin D biosynthetic process(GO:0010957) negative regulation of vitamin metabolic process(GO:0046137)
0.4 4.1 GO:0045647 negative regulation of erythrocyte differentiation(GO:0045647)
0.3 4.1 GO:1900027 regulation of ruffle assembly(GO:1900027)
0.2 4.1 GO:0006270 DNA replication initiation(GO:0006270)
1.2 3.7 GO:0046022 regulation of transcription from RNA polymerase II promoter, mitotic(GO:0046021) positive regulation of transcription from RNA polymerase II promoter during mitosis(GO:0046022) axial mesoderm morphogenesis(GO:0048319)
0.4 3.7 GO:0051639 actin filament network formation(GO:0051639)
0.4 3.7 GO:0033631 cell-cell adhesion mediated by integrin(GO:0033631)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 283 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 31.3 GO:0005667 transcription factor complex(GO:0005667)
0.0 28.7 GO:0005654 nucleoplasm(GO:0005654)
0.0 21.5 GO:0005730 nucleolus(GO:0005730)
0.2 8.9 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.1 7.4 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.7 6.9 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.3 6.7 GO:0000242 pericentriolar material(GO:0000242)
0.7 6.6 GO:0072687 meiotic spindle(GO:0072687)
0.0 6.6 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.3 6.2 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.2 5.6 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.5 5.4 GO:0042582 primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.9 4.7 GO:0097149 centralspindlin complex(GO:0097149)
0.9 4.6 GO:0008623 CHRAC(GO:0008623)
0.8 4.6 GO:0031262 Ndc80 complex(GO:0031262)
0.2 4.6 GO:0005721 pericentric heterochromatin(GO:0005721)
0.4 4.4 GO:1990907 beta-catenin-TCF complex(GO:1990907)
0.1 3.9 GO:0017053 transcriptional repressor complex(GO:0017053)
0.1 3.8 GO:0015030 Cajal body(GO:0015030)
0.9 3.7 GO:0032127 dense core granule membrane(GO:0032127)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 416 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 25.8 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.0 16.5 GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977)
0.6 13.2 GO:0070410 co-SMAD binding(GO:0070410)
0.3 11.6 GO:0097472 cyclin-dependent protein serine/threonine kinase activity(GO:0004693) cyclin-dependent protein kinase activity(GO:0097472)
0.0 9.0 GO:0005525 GTP binding(GO:0005525)
0.5 7.9 GO:0017166 vinculin binding(GO:0017166)
0.1 7.9 GO:0035064 methylated histone binding(GO:0035064)
2.5 7.6 GO:0004998 transferrin receptor activity(GO:0004998)
0.2 7.2 GO:0070888 E-box binding(GO:0070888)
0.1 6.5 GO:0000049 tRNA binding(GO:0000049)
1.0 5.9 GO:0010997 anaphase-promoting complex binding(GO:0010997)
0.0 5.5 GO:0003713 transcription coactivator activity(GO:0003713)
0.3 5.4 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 5.4 GO:0004386 helicase activity(GO:0004386)
0.2 5.3 GO:0042169 SH2 domain binding(GO:0042169)
0.2 5.1 GO:0017091 AU-rich element binding(GO:0017091)
0.1 5.0 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.1 5.0 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.2 4.8 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.4 4.4 GO:0004089 carbonate dehydratase activity(GO:0004089)