Motif ID: Spib

Z-value: 1.534


Transcription factors associated with Spib:

Gene SymbolEntrez IDGene Name
Spib ENSMUSG00000008193.7 Spib



Activity profile for motif Spib.

activity profile for motif Spib


Sorted Z-values histogram for motif Spib

Sorted Z-values for motif Spib



Network of associatons between targets according to the STRING database.



First level regulatory network of Spib

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_-_66812593 13.726 ENSMUST00000100572.3
 Sla
src-like adaptor
chr4_-_136886187 8.216 ENSMUST00000046384.8
 C1qb
complement component 1, q subcomponent, beta polypeptide
chr4_-_136898803 8.102 ENSMUST00000046285.5
 C1qa
complement component 1, q subcomponent, alpha polypeptide
chr4_-_136892867 8.065 ENSMUST00000046332.5
 C1qc
complement component 1, q subcomponent, C chain
chr1_-_171059390 6.805 ENSMUST00000164044.1
ENSMUST00000169017.1
 Fcgr3

Fc receptor, IgG, low affinity III

chr3_-_87263518 6.233 ENSMUST00000090986.4
 Fcrls
Fc receptor-like S, scavenger receptor
chr1_-_171234290 5.957 ENSMUST00000079957.6
 Fcer1g
Fc receptor, IgE, high affinity I, gamma polypeptide
chr4_+_130913264 5.746 ENSMUST00000156225.1
ENSMUST00000156742.1
 Laptm5

lysosomal-associated protein transmembrane 5

chr4_+_130913120 5.629 ENSMUST00000151698.1
 Laptm5
lysosomal-associated protein transmembrane 5
chr3_-_87263703 5.176 ENSMUST00000146512.1
 Fcrls
Fc receptor-like S, scavenger receptor
chr2_+_14229390 4.255 ENSMUST00000028045.2
 Mrc1
mannose receptor, C type 1
chr19_-_11336107 4.191 ENSMUST00000056035.2
ENSMUST00000067532.4
 Ms4a7

membrane-spanning 4-domains, subfamily A, member 7

chr6_+_137410721 4.133 ENSMUST00000167002.1
 Ptpro
protein tyrosine phosphatase, receptor type, O
chr15_+_103453782 3.881 ENSMUST00000047405.7
 Nckap1l
NCK associated protein 1 like
chr10_+_81257277 3.624 ENSMUST00000117488.1
ENSMUST00000105328.3
ENSMUST00000121205.1
 Matk


megakaryocyte-associated tyrosine kinase


chr1_-_170976112 3.610 ENSMUST00000027966.7
ENSMUST00000081103.5
ENSMUST00000159688.1
 Fcgr2b


Fc receptor, IgG, low affinity IIb


chr6_-_136941694 3.586 ENSMUST00000032344.5
 Arhgdib
Rho, GDP dissociation inhibitor (GDI) beta
chr2_+_121357714 3.462 ENSMUST00000125812.1
ENSMUST00000078222.2
ENSMUST00000125221.1
ENSMUST00000150271.1
 Ckmt1



creatine kinase, mitochondrial 1, ubiquitous



chr16_+_36934976 3.351 ENSMUST00000023531.8
 Hcls1
hematopoietic cell specific Lyn substrate 1
chr5_+_81021202 3.313 ENSMUST00000117253.1
ENSMUST00000120128.1
 Lphn3

latrophilin 3


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 96 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.3 24.4 GO:0006958 complement activation, classical pathway(GO:0006958)
5.1 15.2 GO:0001803 type III hypersensitivity(GO:0001802) regulation of type III hypersensitivity(GO:0001803) positive regulation of type III hypersensitivity(GO:0001805)
1.6 6.2 GO:1904425 negative regulation of GTP binding(GO:1904425)
1.2 6.2 GO:1901164 negative regulation of trophoblast cell migration(GO:1901164)
0.1 5.7 GO:0032091 negative regulation of protein binding(GO:0032091)
0.1 5.0 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.2 4.3 GO:0071353 cellular response to interleukin-4(GO:0071353)
0.8 4.1 GO:0003105 negative regulation of glomerular filtration(GO:0003105)
0.7 4.0 GO:0032796 uropod organization(GO:0032796)
1.3 3.9 GO:2001187 positive regulation of CD8-positive, alpha-beta T cell activation(GO:2001187)
0.1 3.9 GO:0071277 cellular response to calcium ion(GO:0071277)
3.6 3.6 GO:0016068 regulation of type I hypersensitivity(GO:0001810) type I hypersensitivity(GO:0016068)
0.7 3.6 GO:1902683 regulation of receptor localization to synapse(GO:1902683)
0.5 3.4 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.1 3.4 GO:0072583 clathrin-mediated endocytosis(GO:0072583)
0.2 3.1 GO:0007194 negative regulation of adenylate cyclase activity(GO:0007194)
0.2 3.1 GO:0007035 vacuolar acidification(GO:0007035)
1.0 3.0 GO:0002538 arachidonic acid metabolite production involved in inflammatory response(GO:0002538)
0.6 3.0 GO:0002667 lymphocyte anergy(GO:0002249) regulation of T cell anergy(GO:0002667) T cell anergy(GO:0002870) regulation of lymphocyte anergy(GO:0002911)
0.4 2.8 GO:0071361 cellular response to ethanol(GO:0071361)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 49 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 24.5 GO:0005581 collagen trimer(GO:0005581)
0.1 22.9 GO:0009897 external side of plasma membrane(GO:0009897)
0.1 13.5 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.0 12.9 GO:0005768 endosome(GO:0005768)
0.0 12.8 GO:0030054 cell junction(GO:0030054)
0.0 6.8 GO:0005887 integral component of plasma membrane(GO:0005887)
0.3 6.4 GO:0001891 phagocytic cup(GO:0001891)
0.0 6.4 GO:0043209 myelin sheath(GO:0043209)
0.0 4.5 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.1 4.1 GO:0016328 lateral plasma membrane(GO:0016328)
0.1 4.0 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 3.6 GO:0001726 ruffle(GO:0001726)
0.3 3.4 GO:0071439 clathrin complex(GO:0071439)
0.4 3.1 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.7 2.7 GO:0043020 NADPH oxidase complex(GO:0043020)
0.1 2.7 GO:0071564 npBAF complex(GO:0071564)
0.0 2.7 GO:0055037 recycling endosome(GO:0055037)
0.2 2.6 GO:0042581 specific granule(GO:0042581)
0.2 2.6 GO:0031143 pseudopodium(GO:0031143)
0.1 2.6 GO:0048786 presynaptic active zone(GO:0048786)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 76 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.8 15.2 GO:0019763 immunoglobulin receptor activity(GO:0019763)
0.1 10.3 GO:0017124 SH3 domain binding(GO:0017124)
0.0 8.1 GO:0042803 protein homodimerization activity(GO:0042803)
0.0 6.5 GO:0005096 GTPase activator activity(GO:0005096)
0.9 6.2 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
1.5 6.1 GO:0004111 creatine kinase activity(GO:0004111)
0.1 5.0 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 4.8 GO:0019209 kinase activator activity(GO:0019209)
0.1 4.5 GO:0004714 transmembrane receptor protein tyrosine kinase activity(GO:0004714)
0.0 4.3 GO:0030246 carbohydrate binding(GO:0030246)
0.3 4.1 GO:0005537 mannose binding(GO:0005537)
0.4 4.0 GO:0032036 myosin heavy chain binding(GO:0032036)
0.3 4.0 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
3.6 3.6 GO:0019864 IgG binding(GO:0019864)
0.4 3.4 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.4 3.1 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.5 3.0 GO:0050544 arachidonic acid binding(GO:0050544)
0.0 2.9 GO:0051015 actin filament binding(GO:0051015)
0.7 2.8 GO:0031727 CCR2 chemokine receptor binding(GO:0031727)
0.7 2.7 GO:0016175 superoxide-generating NADPH oxidase activity(GO:0016175)