Motif ID: Spic

Z-value: 1.422


Transcription factors associated with Spic:

Gene SymbolEntrez IDGene Name
Spic ENSMUSG00000004359.10 Spic

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Spicmm10_v2_chr10_-_88683021_886830250.203.2e-01Click!


Activity profile for motif Spic.

activity profile for motif Spic


Sorted Z-values histogram for motif Spic

Sorted Z-values for motif Spic



Network of associatons between targets according to the STRING database.



First level regulatory network of Spic

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_-_136892867 9.129 ENSMUST00000046332.5
 C1qc
complement component 1, q subcomponent, C chain
chr4_-_136886187 7.422 ENSMUST00000046384.8
 C1qb
complement component 1, q subcomponent, beta polypeptide
chr1_-_171234290 6.965 ENSMUST00000079957.6
 Fcer1g
Fc receptor, IgE, high affinity I, gamma polypeptide
chr6_+_5725639 5.850 ENSMUST00000115556.1
ENSMUST00000115555.1
ENSMUST00000115559.3
 Dync1i1


dynein cytoplasmic 1 intermediate chain 1


chr3_+_95526777 5.582 ENSMUST00000015667.2
ENSMUST00000116304.2
 Ctss

cathepsin S

chr1_-_56978534 5.425 ENSMUST00000177282.1
 Satb2
special AT-rich sequence binding protein 2
chr4_+_130913120 5.306 ENSMUST00000151698.1
 Laptm5
lysosomal-associated protein transmembrane 5
chr4_+_130913264 5.235 ENSMUST00000156225.1
ENSMUST00000156742.1
 Laptm5

lysosomal-associated protein transmembrane 5

chr6_+_137410721 4.297 ENSMUST00000167002.1
 Ptpro
protein tyrosine phosphatase, receptor type, O
chr10_-_117282262 4.011 ENSMUST00000092163.7
 Lyz2
lysozyme 2
chr15_-_66812593 3.875 ENSMUST00000100572.3
 Sla
src-like adaptor
chr19_-_11604828 3.234 ENSMUST00000025582.4
 Ms4a6d
membrane-spanning 4-domains, subfamily A, member 6D
chr1_-_170976112 3.109 ENSMUST00000027966.7
ENSMUST00000081103.5
ENSMUST00000159688.1
 Fcgr2b


Fc receptor, IgG, low affinity IIb


chr1_-_171059390 2.952 ENSMUST00000164044.1
ENSMUST00000169017.1
 Fcgr3

Fc receptor, IgG, low affinity III

chr12_+_112760652 2.778 ENSMUST00000063888.3
 Pld4
phospholipase D family, member 4
chr6_-_136941694 2.661 ENSMUST00000032344.5
 Arhgdib
Rho, GDP dissociation inhibitor (GDI) beta
chr15_+_103453782 2.597 ENSMUST00000047405.7
 Nckap1l
NCK associated protein 1 like
chr14_+_57524734 2.570 ENSMUST00000089494.4
 Il17d
interleukin 17D
chr7_-_100964371 2.499 ENSMUST00000060174.4
 P2ry6
pyrimidinergic receptor P2Y, G-protein coupled, 6
chr19_+_12460749 2.471 ENSMUST00000081035.7
 Mpeg1
macrophage expressed gene 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 144 entries
Log-likelihood per target Total log-likelihoodTermDescription
4.0 11.9 GO:0001803 type III hypersensitivity(GO:0001802) regulation of type III hypersensitivity(GO:0001803) positive regulation of type III hypersensitivity(GO:0001805)
1.2 8.5 GO:0045650 negative regulation of macrophage differentiation(GO:0045650)
0.4 7.5 GO:0030574 collagen catabolic process(GO:0030574)
0.5 7.4 GO:0006958 complement activation, classical pathway(GO:0006958)
1.3 6.3 GO:1901164 negative regulation of trophoblast cell migration(GO:1901164)
0.4 5.4 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.1 5.2 GO:0047496 vesicle transport along microtubule(GO:0047496)
0.9 4.4 GO:0003105 negative regulation of glomerular filtration(GO:0003105)
0.7 4.1 GO:0032796 uropod organization(GO:0032796)
0.3 4.0 GO:0019835 cytolysis(GO:0019835)
0.5 3.6 GO:0036506 maintenance of unfolded protein(GO:0036506) protein insertion into ER membrane(GO:0045048) tail-anchored membrane protein insertion into ER membrane(GO:0071816) maintenance of unfolded protein involved in ERAD pathway(GO:1904378)
0.9 3.5 GO:0006742 NADP catabolic process(GO:0006742) pyridine nucleotide catabolic process(GO:0019364)
1.1 3.4 GO:0048611 ectodermal digestive tract development(GO:0007439) embryonic ectodermal digestive tract development(GO:0048611)
0.4 3.2 GO:0071569 protein ufmylation(GO:0071569)
1.0 3.1 GO:0016068 regulation of type I hypersensitivity(GO:0001810) type I hypersensitivity(GO:0016068)
0.7 2.7 GO:0010700 negative regulation of norepinephrine secretion(GO:0010700)
0.9 2.6 GO:2001187 positive regulation of CD8-positive, alpha-beta T cell activation(GO:2001187)
0.9 2.6 GO:0060785 regulation of apoptosis involved in tissue homeostasis(GO:0060785)
0.1 2.6 GO:0007035 vacuolar acidification(GO:0007035)
0.8 2.5 GO:0030321 transepithelial chloride transport(GO:0030321)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 76 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 16.8 GO:0009897 external side of plasma membrane(GO:0009897)
0.2 16.5 GO:0005581 collagen trimer(GO:0005581)
0.1 11.3 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.0 9.2 GO:0005764 lytic vacuole(GO:0000323) lysosome(GO:0005764)
0.2 5.3 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.1 4.3 GO:0016328 lateral plasma membrane(GO:0016328)
0.1 4.2 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.2 4.1 GO:0001891 phagocytic cup(GO:0001891)
0.0 4.1 GO:0000118 histone deacetylase complex(GO:0000118)
0.8 4.0 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237)
0.5 3.6 GO:0071818 BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379)
0.7 3.4 GO:1990745 EARP complex(GO:1990745)
0.1 3.1 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0 3.1 GO:0005768 endosome(GO:0005768)
0.0 2.7 GO:0016324 apical plasma membrane(GO:0016324)
0.4 2.6 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.2 2.3 GO:0031209 SCAR complex(GO:0031209)
0.1 2.3 GO:0001772 immunological synapse(GO:0001772)
0.7 2.2 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.5 2.1 GO:0044307 dendritic branch(GO:0044307)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 107 entries
Log-likelihood per target Total log-likelihoodTermDescription
3.0 15.0 GO:0019864 IgG binding(GO:0019864)
0.9 6.3 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
1.2 5.8 GO:0045503 dynein light chain binding(GO:0045503)
0.1 5.4 GO:0019905 syntaxin binding(GO:0019905)
0.2 4.8 GO:0001968 fibronectin binding(GO:0001968)
0.0 4.8 GO:0017124 SH3 domain binding(GO:0017124)
0.6 4.6 GO:0070290 N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.2 4.5 GO:0070628 proteasome binding(GO:0070628)
0.1 4.3 GO:0017147 Wnt-protein binding(GO:0017147)
0.4 4.1 GO:0032036 myosin heavy chain binding(GO:0032036)
0.6 3.9 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.3 3.8 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
0.9 3.5 GO:0016175 superoxide-generating NADPH oxidase activity(GO:0016175)
0.9 2.6 GO:0072541 peroxynitrite reductase activity(GO:0072541)
0.2 2.6 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.6 2.5 GO:0005459 UDP-galactose transmembrane transporter activity(GO:0005459)
0.1 2.4 GO:0097371 MDM2/MDM4 family protein binding(GO:0097371)
0.0 2.4 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.5 2.3 GO:0051425 PTB domain binding(GO:0051425)
0.4 2.2 GO:0050544 arachidonic acid binding(GO:0050544)