Motif ID: Srf

Z-value: 1.066


Transcription factors associated with Srf:

Gene SymbolEntrez IDGene Name
Srf ENSMUSG00000015605.5 Srf

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Srfmm10_v2_chr17_-_46556158_465561880.281.7e-01Click!


Activity profile for motif Srf.

activity profile for motif Srf


Sorted Z-values histogram for motif Srf

Sorted Z-values for motif Srf



Network of associatons between targets according to the STRING database.



First level regulatory network of Srf

PNG image of the network

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Top targets:


Showing 1 to 20 of 118 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_-_23248264 7.432 ENSMUST00000031709.5
 Fezf1
Fez family zinc finger 1
chr10_-_120899067 6.849 ENSMUST00000092143.5
 Msrb3
methionine sulfoxide reductase B3
chr19_+_53529100 3.735 ENSMUST00000038287.6
 Dusp5
dual specificity phosphatase 5
chr7_-_137314394 3.132 ENSMUST00000168203.1
ENSMUST00000106118.2
ENSMUST00000169486.2
ENSMUST00000033378.5
 Ebf3



early B cell factor 3



chr7_-_44997221 2.064 ENSMUST00000152341.1
 Bcl2l12
BCL2-like 12 (proline rich)
chr18_+_34861200 2.042 ENSMUST00000165033.1
 Egr1
early growth response 1
chr7_-_44997535 1.951 ENSMUST00000124232.1
ENSMUST00000003290.4
 Bcl2l12

BCL2-like 12 (proline rich)

chr19_+_25406661 1.808 ENSMUST00000146647.1
 Kank1
KN motif and ankyrin repeat domains 1
chrX_+_101449078 1.789 ENSMUST00000033674.5
 Itgb1bp2
integrin beta 1 binding protein 2
chr3_+_131112785 1.755 ENSMUST00000098611.3
 Lef1
lymphoid enhancer binding factor 1
chr4_+_101986626 1.746 ENSMUST00000106914.1
 Gm12789
predicted gene 12789
chr4_+_43957678 1.724 ENSMUST00000107855.1
 Glipr2
GLI pathogenesis-related 2
chr4_+_132351768 1.637 ENSMUST00000172202.1
 Gm17300
predicted gene, 17300
chr4_+_137862237 1.547 ENSMUST00000102518.3
 Ece1
endothelin converting enzyme 1
chr7_-_19310035 1.528 ENSMUST00000003640.2
 Fosb
FBJ osteosarcoma oncogene B
chr4_+_43957401 1.504 ENSMUST00000030202.7
 Glipr2
GLI pathogenesis-related 2
chr14_-_7174533 1.436 ENSMUST00000172431.1
 Gm3512
predicted gene 3512
chr14_+_3049285 1.418 ENSMUST00000166494.1
 Gm2897
predicted gene 2897
chr2_-_152415044 1.381 ENSMUST00000099207.3
 Zcchc3
zinc finger, CCHC domain containing 3
chr19_-_4928241 1.369 ENSMUST00000025851.3
 Dpp3
dipeptidylpeptidase 3

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 41 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.2 7.4 GO:0021797 forebrain anterior/posterior pattern specification(GO:0021797)
1.4 6.8 GO:0030091 protein repair(GO:0030091)
0.4 4.0 GO:1902166 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:1902166)
0.1 3.8 GO:0001706 endoderm formation(GO:0001706)
0.1 2.3 GO:0010718 positive regulation of epithelial to mesenchymal transition(GO:0010718)
0.4 2.2 GO:0048133 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
0.7 2.0 GO:0072223 metanephric glomerular mesangium development(GO:0072223) metanephric glomerular mesangial cell proliferation involved in metanephros development(GO:0072262)
0.1 1.9 GO:1903504 regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) regulation of mitotic spindle checkpoint(GO:1903504)
0.0 1.9 GO:0071277 cellular response to calcium ion(GO:0071277)
0.6 1.8 GO:0048352 neural plate mediolateral regionalization(GO:0021998) mesoderm structural organization(GO:0048338) paraxial mesoderm structural organization(GO:0048352)
0.6 1.8 GO:2000393 negative regulation of lamellipodium morphogenesis(GO:2000393)
0.6 1.8 GO:0032696 negative regulation of interleukin-13 production(GO:0032696) trachea submucosa development(GO:0061152) trachea gland development(GO:0061153) odontoblast differentiation(GO:0071895) regulation of estrogen receptor binding(GO:0071898) negative regulation of estrogen receptor binding(GO:0071899)
0.3 1.7 GO:0045583 regulation of cytotoxic T cell differentiation(GO:0045583) positive regulation of cytotoxic T cell differentiation(GO:0045585)
0.5 1.5 GO:0010814 substance P catabolic process(GO:0010814) calcitonin catabolic process(GO:0010816) endothelin maturation(GO:0034959)
0.5 1.5 GO:1900275 negative regulation of phospholipase C activity(GO:1900275)
0.2 1.5 GO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)
0.0 1.4 GO:0007052 mitotic spindle organization(GO:0007052)
0.4 1.3 GO:0097623 potassium ion export across plasma membrane(GO:0097623)
0.4 1.3 GO:0007525 somatic muscle development(GO:0007525)
0.1 1.3 GO:0050765 negative regulation of phagocytosis(GO:0050765)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 20 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.2 GO:0000139 Golgi membrane(GO:0000139)
0.0 2.8 GO:0005901 caveola(GO:0005901)
0.4 2.2 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.1 2.0 GO:0090544 BAF-type complex(GO:0090544)
0.1 1.9 GO:0005680 anaphase-promoting complex(GO:0005680)
0.2 1.8 GO:1990907 beta-catenin-TCF complex(GO:1990907)
0.0 1.8 GO:0032587 ruffle membrane(GO:0032587)
0.3 1.7 GO:0097226 sperm mitochondrial sheath(GO:0097226)
0.3 1.5 GO:0033093 Weibel-Palade body(GO:0033093)
0.0 1.5 GO:0001726 ruffle(GO:0001726)
0.0 1.4 GO:0000794 condensed nuclear chromosome(GO:0000794)
0.2 1.3 GO:0070938 contractile ring(GO:0070938)
0.2 1.2 GO:0005826 actomyosin contractile ring(GO:0005826)
0.1 1.0 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.0 0.7 GO:0002102 podosome(GO:0002102)
0.0 0.6 GO:0016459 myosin complex(GO:0016459)
0.0 0.5 GO:0005682 U5 snRNP(GO:0005682)
0.1 0.4 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.0 0.4 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.1 0.3 GO:0044614 nuclear pore cytoplasmic filaments(GO:0044614)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 40 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 12.9 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
1.0 6.8 GO:0070191 methionine-R-sulfoxide reductase activity(GO:0070191)
0.0 4.0 GO:0002039 p53 binding(GO:0002039)
0.1 3.8 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 2.2 GO:0035064 methylated histone binding(GO:0035064)
0.1 2.0 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.3 1.8 GO:0098821 BMP receptor activity(GO:0098821)
0.3 1.8 GO:0030284 estrogen receptor activity(GO:0030284)
0.0 1.8 GO:0008013 beta-catenin binding(GO:0008013)
0.0 1.8 GO:0005178 integrin binding(GO:0005178)
0.3 1.7 GO:0002135 CTP binding(GO:0002135)
0.1 1.5 GO:0070097 delta-catenin binding(GO:0070097)
0.1 1.5 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.0 1.5 GO:0015459 potassium channel regulator activity(GO:0015459)
0.0 1.5 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.2 1.4 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.2 1.4 GO:0005087 Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.4 1.3 GO:1902282 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization(GO:1902282)
0.1 1.3 GO:0017166 vinculin binding(GO:0017166)
0.1 1.2 GO:0043495 protein anchor(GO:0043495)