Motif ID: Stat2

Z-value: 1.783


Transcription factors associated with Stat2:

Gene SymbolEntrez IDGene Name
Stat2 ENSMUSG00000040033.9 Stat2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Stat2mm10_v2_chr10_+_128270546_1282705770.461.8e-02Click!


Activity profile for motif Stat2.

activity profile for motif Stat2


Sorted Z-values histogram for motif Stat2

Sorted Z-values for motif Stat2



Network of associatons between targets according to the STRING database.



First level regulatory network of Stat2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr6_+_90550789 7.628 ENSMUST00000130418.1
ENSMUST00000032175.8
 Aldh1l1

aldehyde dehydrogenase 1 family, member L1

chr12_+_103434211 7.335 ENSMUST00000079294.5
ENSMUST00000076788.5
ENSMUST00000076702.5
ENSMUST00000066701.6
ENSMUST00000085065.5
ENSMUST00000140838.1
 Ifi27





interferon, alpha-inducible protein 27





chr15_-_66812593 6.860 ENSMUST00000100572.3
 Sla
src-like adaptor
chr7_-_141010759 5.501 ENSMUST00000026565.6
 Ifitm3
interferon induced transmembrane protein 3
chr1_-_173942445 5.036 ENSMUST00000042228.8
ENSMUST00000081216.5
ENSMUST00000129829.1
ENSMUST00000123708.1
ENSMUST00000111210.2
 Ifi203



Mndal
interferon activated gene 203



myeloid nuclear differentiation antigen like
chr8_-_84773381 4.907 ENSMUST00000109764.1
 Nfix
nuclear factor I/X
chr1_-_170110491 4.794 ENSMUST00000027985.2
 Ddr2
discoidin domain receptor family, member 2
chr16_+_23609895 4.752 ENSMUST00000038423.5
 Rtp4
receptor transporter protein 4
chr16_+_43363855 4.611 ENSMUST00000156367.1
 Zbtb20
zinc finger and BTB domain containing 20
chr16_+_26581704 4.310 ENSMUST00000096129.2
ENSMUST00000166294.2
ENSMUST00000174202.1
ENSMUST00000023156.6
 Il1rap



interleukin 1 receptor accessory protein



chr2_-_51972990 4.018 ENSMUST00000145481.1
ENSMUST00000112705.2
 Nmi

N-myc (and STAT) interactor

chr16_-_22439719 4.012 ENSMUST00000079601.6
 Etv5
ets variant gene 5
chr12_-_78980758 3.892 ENSMUST00000174072.1
 Tmem229b
transmembrane protein 229B
chr18_+_61045139 3.863 ENSMUST00000025522.4
ENSMUST00000115274.1
 Pdgfrb

platelet derived growth factor receptor, beta polypeptide

chr16_+_43235856 3.832 ENSMUST00000146708.1
 Zbtb20
zinc finger and BTB domain containing 20
chr3_-_137981523 3.819 ENSMUST00000136613.1
ENSMUST00000029806.6
 Dapp1

dual adaptor for phosphotyrosine and 3-phosphoinositides 1

chr11_+_119393060 3.704 ENSMUST00000131035.2
ENSMUST00000093902.5
 Rnf213

ring finger protein 213

chr3_-_107760221 3.651 ENSMUST00000153114.1
ENSMUST00000118593.1
ENSMUST00000120243.1
 Csf1


colony stimulating factor 1 (macrophage)


chr18_-_78142119 3.516 ENSMUST00000160639.1
 Slc14a1
solute carrier family 14 (urea transporter), member 1
chr16_+_42907563 3.505 ENSMUST00000151244.1
ENSMUST00000114694.2
 Zbtb20

zinc finger and BTB domain containing 20


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 88 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 15.6 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.4 9.6 GO:0034340 response to type I interferon(GO:0034340)
2.5 7.6 GO:0042560 10-formyltetrahydrofolate catabolic process(GO:0009258) folic acid-containing compound catabolic process(GO:0009397) pteridine-containing compound catabolic process(GO:0042560)
0.3 7.6 GO:0035458 cellular response to interferon-beta(GO:0035458)
0.5 7.5 GO:2001275 positive regulation of glucose import in response to insulin stimulus(GO:2001275)
1.3 6.7 GO:1900170 negative regulation of glucocorticoid mediated signaling pathway(GO:1900170)
2.0 6.1 GO:0002302 CD8-positive, alpha-beta T cell differentiation involved in immune response(GO:0002302)
0.1 5.8 GO:0001919 regulation of receptor recycling(GO:0001919)
0.9 5.5 GO:0010528 regulation of transposition(GO:0010528) negative regulation of transposition(GO:0010529)
0.7 5.1 GO:0060762 regulation of branching involved in mammary gland duct morphogenesis(GO:0060762)
1.7 5.0 GO:1904139 microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139)
0.4 4.9 GO:0021684 cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
1.6 4.8 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.7 4.8 GO:0090091 positive regulation of extracellular matrix disassembly(GO:0090091)
0.5 4.3 GO:0072602 interleukin-4 secretion(GO:0072602)
1.3 4.0 GO:1902524 negative regulation of interferon-alpha production(GO:0032687) interferon-alpha biosynthetic process(GO:0045349) regulation of interferon-alpha biosynthetic process(GO:0045354) negative regulation of interferon-beta biosynthetic process(GO:0045358) positive regulation of protein K48-linked ubiquitination(GO:1902524)
1.3 3.9 GO:0035441 cell migration involved in vasculogenesis(GO:0035441) metanephric glomerular mesangium development(GO:0072223) metanephric glomerular mesangial cell proliferation involved in metanephros development(GO:0072262)
0.4 3.7 GO:2000051 negative regulation of non-canonical Wnt signaling pathway(GO:2000051)
0.5 3.5 GO:0015840 urea transport(GO:0015840) urea transmembrane transport(GO:0071918)
0.8 3.2 GO:0044565 dendritic cell proliferation(GO:0044565)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 42 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 19.8 GO:0005764 lytic vacuole(GO:0000323) lysosome(GO:0005764)
0.1 7.5 GO:0016363 nuclear matrix(GO:0016363)
0.2 7.3 GO:0005637 nuclear inner membrane(GO:0005637)
0.5 5.8 GO:0043083 synaptic cleft(GO:0043083)
0.0 4.1 GO:0043197 dendritic spine(GO:0043197)
1.2 3.7 GO:1990682 CSF1-CSF1R complex(GO:1990682)
0.0 3.5 GO:0016324 apical plasma membrane(GO:0016324)
0.1 3.4 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.2 2.7 GO:0020005 symbiont-containing vacuole membrane(GO:0020005)
0.0 2.6 GO:0032587 ruffle membrane(GO:0032587)
0.2 2.5 GO:0002116 semaphorin receptor complex(GO:0002116)
0.0 2.4 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.3 1.9 GO:0060293 P granule(GO:0043186) pole plasm(GO:0045495) germ plasm(GO:0060293)
0.2 1.8 GO:0044352 pinosome(GO:0044352) macropinosome(GO:0044354)
0.0 1.7 GO:0031901 early endosome membrane(GO:0031901)
0.1 1.6 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.2 1.5 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.4 1.4 GO:0031084 BLOC-2 complex(GO:0031084)
0.1 1.3 GO:0009925 basal plasma membrane(GO:0009925)
0.2 1.1 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 75 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 17.4 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
2.5 7.6 GO:0016155 formyltetrahydrofolate dehydrogenase activity(GO:0016155)
0.6 7.5 GO:0016443 bidentate ribonuclease III activity(GO:0016443)
0.0 7.5 GO:0005525 GTP binding(GO:0005525)
0.3 7.3 GO:0005521 lamin binding(GO:0005521)
1.7 6.7 GO:0038049 glucocorticoid receptor activity(GO:0004883) transcription factor activity, ligand-activated RNA polymerase II transcription factor binding(GO:0038049) glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity(GO:0038051)
0.1 6.1 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.8 5.8 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
1.4 5.5 GO:0047844 deoxycytidine deaminase activity(GO:0047844)
0.5 4.8 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.2 4.8 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.3 4.3 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.2 4.0 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.8 3.9 GO:0038085 vascular endothelial growth factor binding(GO:0038085)
0.0 3.7 GO:0008083 growth factor activity(GO:0008083)
0.1 3.6 GO:0070412 R-SMAD binding(GO:0070412)
0.6 3.5 GO:0015265 urea channel activity(GO:0015265)
0.0 2.9 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.7 2.7 GO:0004699 calcium-independent protein kinase C activity(GO:0004699)
0.7 2.7 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)