Motif ID: Stat4_Stat3_Stat5b

Z-value: 0.917

Transcription factors associated with Stat4_Stat3_Stat5b:

Gene SymbolEntrez IDGene Name
Stat3 ENSMUSG00000004040.10 Stat3
Stat4 ENSMUSG00000062939.5 Stat4
Stat5b ENSMUSG00000020919.5 Stat5b

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Stat4mm10_v2_chr1_+_51987139_51987151-0.491.1e-02Click!
Stat5bmm10_v2_chr11_-_100822525_100822576-0.385.8e-02Click!
Stat3mm10_v2_chr11_-_100939357_1009394560.311.2e-01Click!


Activity profile for motif Stat4_Stat3_Stat5b.

activity profile for motif Stat4_Stat3_Stat5b


Sorted Z-values histogram for motif Stat4_Stat3_Stat5b

Sorted Z-values for motif Stat4_Stat3_Stat5b



Network of associatons between targets according to the STRING database.



First level regulatory network of Stat4_Stat3_Stat5b

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_-_64046925 7.886 ENSMUST00000107377.3
 Tnc
tenascin C
chrX_-_61185558 6.063 ENSMUST00000166381.1
 Cdr1
cerebellar degeneration related antigen 1
chr3_-_80802789 5.682 ENSMUST00000107745.1
ENSMUST00000075316.4
 Gria2

glutamate receptor, ionotropic, AMPA2 (alpha 2)

chr9_+_107296843 4.520 ENSMUST00000167072.1
 Cish
cytokine inducible SH2-containing protein
chr16_-_23988852 3.402 ENSMUST00000023151.5
 Bcl6
B cell leukemia/lymphoma 6
chr16_-_74411292 2.536 ENSMUST00000117200.1
 Robo2
roundabout homolog 2 (Drosophila)
chr16_-_74411776 2.535 ENSMUST00000116586.2
 Robo2
roundabout homolog 2 (Drosophila)
chr6_+_115134899 2.479 ENSMUST00000009538.5
ENSMUST00000169345.1
 Syn2

synapsin II

chr10_-_95417099 2.118 ENSMUST00000135822.1
 Socs2
suppressor of cytokine signaling 2
chr12_+_74297474 1.922 ENSMUST00000072100.3
 Dbpht2
DNA binding protein with his-thr domain
chr7_+_107567445 1.812 ENSMUST00000120990.1
 Olfml1
olfactomedin-like 1
chr9_+_107296682 1.710 ENSMUST00000168260.1
 Cish
cytokine inducible SH2-containing protein
chr17_+_26715644 1.701 ENSMUST00000062519.7
ENSMUST00000144221.1
ENSMUST00000142539.1
ENSMUST00000151681.1
 Crebrf



CREB3 regulatory factor



chr3_-_88000350 1.633 ENSMUST00000090971.5
 Bcan
brevican
chr4_+_11704439 1.623 ENSMUST00000108304.2
 Gem
GTP binding protein (gene overexpressed in skeletal muscle)
chr10_+_13966268 1.599 ENSMUST00000015645.4
 Hivep2
human immunodeficiency virus type I enhancer binding protein 2
chr7_-_78577771 1.552 ENSMUST00000039438.7
 Ntrk3
neurotrophic tyrosine kinase, receptor, type 3
chr10_-_95416850 1.540 ENSMUST00000020215.9
 Socs2
suppressor of cytokine signaling 2
chr16_-_67620880 1.417 ENSMUST00000114292.1
ENSMUST00000120898.1
 Cadm2

cell adhesion molecule 2

chr12_+_11265867 1.413 ENSMUST00000020931.5
 Smc6
structural maintenance of chromosomes 6

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 189 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.0 7.9 GO:0014012 peripheral nervous system axon regeneration(GO:0014012)
0.2 6.4 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.2 5.2 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
1.7 5.1 GO:0050925 negative regulation of negative chemotaxis(GO:0050925)
0.2 3.5 GO:0071378 growth hormone receptor signaling pathway(GO:0060396) cellular response to growth hormone stimulus(GO:0071378)
1.1 3.4 GO:0043379 memory T cell differentiation(GO:0043379) negative regulation of isotype switching to IgE isotypes(GO:0048294)
0.5 3.2 GO:1902847 macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518) regulation of neuronal signal transduction(GO:1902847) positive regulation of tau-protein kinase activity(GO:1902949)
0.1 2.9 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.0 2.3 GO:1904893 negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.0 2.2 GO:0043547 positive regulation of GTPase activity(GO:0043547)
0.2 2.0 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.1 1.9 GO:0034340 response to type I interferon(GO:0034340)
0.4 1.8 GO:0071139 resolution of recombination intermediates(GO:0071139)
0.1 1.8 GO:0006491 N-glycan processing(GO:0006491)
0.1 1.8 GO:0095500 acetylcholine receptor signaling pathway(GO:0095500) postsynaptic signal transduction(GO:0098926) signal transduction involved in cellular response to ammonium ion(GO:1903831) response to acetylcholine(GO:1905144) cellular response to acetylcholine(GO:1905145)
0.3 1.7 GO:1900170 negative regulation of glucocorticoid mediated signaling pathway(GO:1900170)
0.0 1.7 GO:0099643 neurotransmitter secretion(GO:0007269) signal release from synapse(GO:0099643)
0.5 1.6 GO:0048686 regulation of sprouting of injured axon(GO:0048686) regulation of axon extension involved in regeneration(GO:0048690)
0.2 1.6 GO:0051409 response to nitrosative stress(GO:0051409)
0.0 1.6 GO:0060612 adipose tissue development(GO:0060612)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 83 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 8.0 GO:0005614 interstitial matrix(GO:0005614)
0.3 5.7 GO:0032279 asymmetric synapse(GO:0032279)
0.2 5.1 GO:0030673 axolemma(GO:0030673)
0.5 3.2 GO:0034366 spherical high-density lipoprotein particle(GO:0034366) neurofibrillary tangle(GO:0097418)
0.1 2.8 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.1 2.7 GO:0032809 neuronal cell body membrane(GO:0032809)
0.0 2.2 GO:0005657 replication fork(GO:0005657)
0.0 1.8 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 1.8 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.1 1.7 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.5 1.6 GO:0017109 glutamate-cysteine ligase complex(GO:0017109)
0.1 1.6 GO:0051233 spindle midzone(GO:0051233)
0.1 1.5 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.5 1.4 GO:0035061 interchromatin granule(GO:0035061)
0.0 1.3 GO:0034451 centriolar satellite(GO:0034451)
0.0 1.3 GO:0030992 intraciliary transport particle B(GO:0030992)
0.0 1.2 GO:0031225 anchored component of membrane(GO:0031225)
0.3 1.0 GO:0031673 H zone(GO:0031673)
0.1 1.0 GO:0042613 MHC class II protein complex(GO:0042613)
0.0 1.0 GO:0001772 immunological synapse(GO:0001772)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 132 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.3 7.9 GO:0045545 syndecan binding(GO:0045545)
0.1 6.4 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.9 5.7 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.6 5.1 GO:0008046 axon guidance receptor activity(GO:0008046)
0.8 3.8 GO:0008269 JAK pathway signal transduction adaptor activity(GO:0008269)
0.1 3.2 GO:0051787 misfolded protein binding(GO:0051787)
0.2 2.9 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161)
0.0 2.4 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.1 2.2 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.2 1.8 GO:0030550 acetylcholine receptor inhibitor activity(GO:0030550)
0.2 1.8 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.5 1.6 GO:0004357 glutamate-cysteine ligase activity(GO:0004357)
0.3 1.6 GO:0005030 neurotrophin receptor activity(GO:0005030)
0.1 1.6 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 1.6 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.0 1.5 GO:0030165 PDZ domain binding(GO:0030165)
0.4 1.3 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.3 1.3 GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.3 1.3 GO:0016972 thiol oxidase activity(GO:0016972)
0.0 1.3 GO:0019003 GDP binding(GO:0019003)