Motif ID: Stat6

Z-value: 0.860


Transcription factors associated with Stat6:

Gene SymbolEntrez IDGene Name
Stat6 ENSMUSG00000002147.12 Stat6

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Stat6mm10_v2_chr10_+_127642975_1276430340.367.3e-02Click!


Activity profile for motif Stat6.

activity profile for motif Stat6


Sorted Z-values histogram for motif Stat6

Sorted Z-values for motif Stat6



Network of associatons between targets according to the STRING database.



First level regulatory network of Stat6

PNG image of the network

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Top targets:


Showing 1 to 20 of 144 entries
PromoterScoreRefseqGene SymbolGene Name
chr14_-_21989475 4.125 ENSMUST00000043409.7
 Zfp503
zinc finger protein 503
chr3_-_86548268 3.906 ENSMUST00000077524.3
 Mab21l2
mab-21-like 2 (C. elegans)
chr5_+_139543889 3.835 ENSMUST00000174792.1
ENSMUST00000031523.8
 Uncx

UNC homeobox

chr2_-_147186389 3.469 ENSMUST00000109970.3
ENSMUST00000067075.5
 Nkx2-2

NK2 homeobox 2

chr14_-_65425453 2.828 ENSMUST00000059339.5
 Pnoc
prepronociceptin
chr7_-_70366735 2.774 ENSMUST00000089565.5
 Nr2f2
nuclear receptor subfamily 2, group F, member 2
chr11_-_11890394 2.569 ENSMUST00000109659.2
 Ddc
dopa decarboxylase
chr11_-_11890368 2.484 ENSMUST00000155690.1
 Ddc
dopa decarboxylase
chr3_+_102010138 2.261 ENSMUST00000066187.4
 Nhlh2
nescient helix loop helix 2
chr1_+_146497614 2.066 ENSMUST00000132847.1
ENSMUST00000166814.1
 Brinp3

bone morphogenetic protein/retinoic acid inducible neural specific 3

chr4_+_136143497 1.921 ENSMUST00000008016.2
 Id3
inhibitor of DNA binding 3
chr11_-_55419898 1.848 ENSMUST00000108858.1
ENSMUST00000141530.1
 Sparc

secreted acidic cysteine rich glycoprotein

chr18_+_50053282 1.764 ENSMUST00000148159.2
 Tnfaip8
tumor necrosis factor, alpha-induced protein 8
chr5_-_106574706 1.670 ENSMUST00000131029.1
ENSMUST00000124394.2
 RP24-421H18.1

RP24-421H18.1

chr9_-_70421533 1.562 ENSMUST00000034742.6
 Ccnb2
cyclin B2
chr2_+_163225363 1.534 ENSMUST00000099110.3
ENSMUST00000165937.1
 Tox2

TOX high mobility group box family member 2

chr2_-_113848655 1.460 ENSMUST00000102545.1
ENSMUST00000110948.1
 Arhgap11a

Rho GTPase activating protein 11A

chr2_-_113848601 1.416 ENSMUST00000110949.2
 Arhgap11a
Rho GTPase activating protein 11A
chr17_-_89910449 1.404 ENSMUST00000086423.4
 Gm10184
predicted pseudogene 10184
chr13_+_99100698 1.202 ENSMUST00000181742.1
 Gm807
predicted gene 807

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 54 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 5.1 GO:0098700 aminergic neurotransmitter loading into synaptic vesicle(GO:0015842) neurotransmitter loading into synaptic vesicle(GO:0098700)
1.4 4.1 GO:0070315 G1 to G0 transition involved in cell differentiation(GO:0070315)
0.2 3.9 GO:0010172 embryonic body morphogenesis(GO:0010172)
0.5 3.8 GO:0035726 common myeloid progenitor cell proliferation(GO:0035726)
1.2 3.5 GO:0021529 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530)
0.1 3.1 GO:0071300 cellular response to retinoic acid(GO:0071300)
0.6 2.8 GO:0060838 lymphatic endothelial cell fate commitment(GO:0060838) regulation of transcription involved in lymphatic endothelial cell fate commitment(GO:0060849)
0.1 2.8 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.1 2.3 GO:0007617 mating behavior(GO:0007617) multi-organism reproductive behavior(GO:0044705)
0.3 2.0 GO:0009449 gamma-aminobutyric acid biosynthetic process(GO:0009449)
0.1 1.9 GO:0071398 cellular response to fatty acid(GO:0071398)
0.1 1.9 GO:1903077 negative regulation of protein localization to plasma membrane(GO:1903077) negative regulation of protein localization to cell periphery(GO:1904376)
0.0 1.8 GO:0001937 negative regulation of endothelial cell proliferation(GO:0001937)
0.0 1.8 GO:0050830 defense response to Gram-positive bacterium(GO:0050830)
0.0 1.7 GO:0043029 T cell homeostasis(GO:0043029)
0.2 1.6 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.1 1.3 GO:0048642 negative regulation of skeletal muscle tissue development(GO:0048642)
0.1 1.1 GO:0043011 myeloid dendritic cell differentiation(GO:0043011)
0.0 1.1 GO:0097120 receptor localization to synapse(GO:0097120)
0.0 1.1 GO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway(GO:0045744)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 20 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.0 GO:0048786 presynaptic active zone(GO:0048786)
0.5 1.8 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.1 1.6 GO:0035686 sperm fibrous sheath(GO:0035686)
0.0 1.0 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.2 0.9 GO:1990131 EGO complex(GO:0034448) Gtr1-Gtr2 GTPase complex(GO:1990131)
0.1 0.9 GO:0005922 connexon complex(GO:0005922)
0.3 0.8 GO:0070557 PCNA-p21 complex(GO:0070557)
0.0 0.8 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.0 0.7 GO:0016459 myosin complex(GO:0016459)
0.0 0.5 GO:0045239 tricarboxylic acid cycle enzyme complex(GO:0045239)
0.0 0.4 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540)
0.0 0.4 GO:0030992 intraciliary transport particle B(GO:0030992)
0.1 0.2 GO:1990111 spermatoproteasome complex(GO:1990111)
0.0 0.2 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
0.0 0.2 GO:0045298 tubulin complex(GO:0045298)
0.0 0.1 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.0 0.1 GO:0030891 VCB complex(GO:0030891)
0.0 0.1 GO:0034750 Scrib-APC-beta-catenin complex(GO:0034750)
0.0 0.1 GO:0044613 nuclear pore central transport channel(GO:0044613) Flemming body(GO:0090543)
0.0 0.1 GO:0031313 extrinsic component of endosome membrane(GO:0031313)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 42 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.3 5.1 GO:0036468 aromatic-L-amino-acid decarboxylase activity(GO:0004058) L-dopa decarboxylase activity(GO:0036468)
0.0 3.5 GO:0005096 GTPase activator activity(GO:0005096)
0.1 3.4 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.3 2.8 GO:0001972 retinoic acid binding(GO:0001972)
0.0 2.4 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.3 2.0 GO:0004351 glutamate decarboxylase activity(GO:0004351)
0.3 1.8 GO:0001515 opioid peptide activity(GO:0001515)
0.2 1.8 GO:0030550 acetylcholine receptor inhibitor activity(GO:0030550)
0.0 1.8 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.3 1.6 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.0 1.5 GO:0050840 extracellular matrix binding(GO:0050840)
0.0 1.5 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.0 1.3 GO:0030332 cyclin binding(GO:0030332)
0.0 1.2 GO:0005504 fatty acid binding(GO:0005504)
0.1 1.1 GO:0005035 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.1 1.0 GO:0042301 phosphate ion binding(GO:0042301)
0.2 0.9 GO:0071253 connexin binding(GO:0071253)
0.1 0.8 GO:0043426 MRF binding(GO:0043426)
0.1 0.8 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.1 0.8 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)