Motif ID: Tbr1

Z-value: 1.212


Transcription factors associated with Tbr1:

Gene SymbolEntrez IDGene Name
Tbr1 ENSMUSG00000035033.9 Tbr1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tbr1mm10_v2_chr2_+_61804453_61804538-0.553.4e-03Click!


Activity profile for motif Tbr1.

activity profile for motif Tbr1


Sorted Z-values histogram for motif Tbr1

Sorted Z-values for motif Tbr1



Network of associatons between targets according to the STRING database.



First level regulatory network of Tbr1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_-_120899067 6.199 ENSMUST00000092143.5
 Msrb3
methionine sulfoxide reductase B3
chr10_+_26229707 5.654 ENSMUST00000060716.5
ENSMUST00000164660.1
 Samd3

sterile alpha motif domain containing 3

chr12_+_109459843 3.789 ENSMUST00000173812.1
 Dlk1
delta-like 1 homolog (Drosophila)
chr7_-_144939823 3.770 ENSMUST00000093962.4
 Ccnd1
cyclin D1
chr17_+_87635974 3.525 ENSMUST00000053577.8
 Epcam
epithelial cell adhesion molecule
chr17_+_34263209 3.304 ENSMUST00000040828.5
 H2-Ab1
histocompatibility 2, class II antigen A, beta 1
chr9_-_43239816 3.042 ENSMUST00000034512.5
 Oaf
OAF homolog (Drosophila)
chrX_+_96455359 3.004 ENSMUST00000033553.7
 Heph
hephaestin
chr2_+_164562579 2.968 ENSMUST00000017867.3
ENSMUST00000109344.2
ENSMUST00000109345.2
 Wfdc2


WAP four-disulfide core domain 2


chr1_+_12692430 2.757 ENSMUST00000180062.1
ENSMUST00000177608.1
 Sulf1

sulfatase 1

chr7_-_141443314 2.617 ENSMUST00000106005.2
 Lrdd
leucine-rich and death domain containing
chr13_-_116309639 2.552 ENSMUST00000036060.6
 Isl1
ISL1 transcription factor, LIM/homeodomain
chr17_+_84511832 2.358 ENSMUST00000047206.5
 Plekhh2
pleckstrin homology domain containing, family H (with MyTH4 domain) member 2
chr7_-_116237767 2.287 ENSMUST00000182834.1
 Plekha7
pleckstrin homology domain containing, family A member 7
chr2_+_103970115 2.270 ENSMUST00000111143.1
ENSMUST00000138815.1
 Lmo2

LIM domain only 2

chr19_+_55894508 2.239 ENSMUST00000142291.1
 Tcf7l2
transcription factor 7 like 2, T cell specific, HMG box
chr10_+_62947011 2.217 ENSMUST00000131422.1
 Dna2
DNA replication helicase 2 homolog (yeast)
chr14_+_53324632 2.213 ENSMUST00000178100.1
 Trav7n-6
T cell receptor alpha variable 7N-6
chr1_-_138847579 2.161 ENSMUST00000093486.3
ENSMUST00000046870.6
 Lhx9

LIM homeobox protein 9

chr6_-_94700137 2.119 ENSMUST00000101126.2
ENSMUST00000032105.4
 Lrig1

leucine-rich repeats and immunoglobulin-like domains 1


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 327 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.0 5.0 GO:0030091 protein repair(GO:0030091)
0.8 4.1 GO:0035262 gonad morphogenesis(GO:0035262)
0.3 3.9 GO:0045647 negative regulation of erythrocyte differentiation(GO:0045647)
0.5 3.8 GO:0000320 re-entry into mitotic cell cycle(GO:0000320)
0.6 3.6 GO:0045218 zonula adherens maintenance(GO:0045218)
0.2 3.6 GO:0001913 T cell mediated cytotoxicity(GO:0001913)
0.9 3.4 GO:2000048 negative regulation of cell-cell adhesion mediated by cadherin(GO:2000048)
0.6 3.4 GO:0043137 DNA replication, removal of RNA primer(GO:0043137)
0.8 3.3 GO:0002339 B cell selection(GO:0002339)
0.1 3.1 GO:0016578 histone deubiquitination(GO:0016578)
0.1 3.0 GO:0006825 copper ion transport(GO:0006825)
0.7 2.8 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
0.9 2.6 GO:0032650 regulation of interleukin-1 alpha production(GO:0032650) positive regulation of interleukin-1 alpha production(GO:0032730) cardiac cell fate determination(GO:0060913)
0.3 2.6 GO:0051255 spindle midzone assembly(GO:0051255)
0.0 2.6 GO:0051225 spindle assembly(GO:0051225)
0.1 2.5 GO:0045599 negative regulation of fat cell differentiation(GO:0045599)
0.0 2.3 GO:0007019 microtubule depolymerization(GO:0007019)
0.0 2.3 GO:0030835 negative regulation of actin filament depolymerization(GO:0030835)
0.7 2.2 GO:0061537 glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537)
0.7 2.2 GO:0045014 detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) carbon catabolite repression of transcription(GO:0045013) negative regulation of transcription by glucose(GO:0045014) detection of glucose(GO:0051594)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 137 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.5 GO:0005667 transcription factor complex(GO:0005667)
0.0 5.3 GO:0005925 focal adhesion(GO:0005925)
0.1 4.9 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.1 4.1 GO:0005871 kinesin complex(GO:0005871)
0.3 3.6 GO:0005915 zonula adherens(GO:0005915)
1.1 3.3 GO:0089717 spanning component of plasma membrane(GO:0044214) spanning component of membrane(GO:0089717)
0.5 3.3 GO:0042613 MHC class II protein complex(GO:0042613)
0.2 3.2 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.3 3.1 GO:0000124 SAGA complex(GO:0000124)
0.2 3.0 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.2 3.0 GO:0035686 sperm fibrous sheath(GO:0035686)
0.0 3.0 GO:0016328 lateral plasma membrane(GO:0016328)
0.1 2.8 GO:0034707 chloride channel complex(GO:0034707)
0.0 2.8 GO:0000790 nuclear chromatin(GO:0000790)
0.1 2.7 GO:0001750 photoreceptor outer segment(GO:0001750)
0.0 2.7 GO:0015934 large ribosomal subunit(GO:0015934)
0.3 2.6 GO:0070652 HAUS complex(GO:0070652)
0.0 2.5 GO:0009897 external side of plasma membrane(GO:0009897)
0.1 2.4 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.0 2.3 GO:0030864 cortical actin cytoskeleton(GO:0030864)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 205 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 7.2 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.9 6.2 GO:0070191 methionine-R-sulfoxide reductase activity(GO:0070191)
0.4 4.6 GO:1990405 protein antigen binding(GO:1990405)
0.2 4.5 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.2 3.8 GO:0070064 proline-rich region binding(GO:0070064)
0.5 3.7 GO:0046703 natural killer cell lectin-like receptor binding(GO:0046703)
0.3 3.6 GO:0070097 delta-catenin binding(GO:0070097)
0.0 3.6 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.4 3.5 GO:0098632 protein binding involved in cell-cell adhesion(GO:0098632)
0.7 3.4 GO:0017108 5'-flap endonuclease activity(GO:0017108)
0.1 3.3 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.1 3.3 GO:0048487 beta-tubulin binding(GO:0048487)
0.0 3.3 GO:0008172 S-methyltransferase activity(GO:0008172)
0.6 3.0 GO:0016724 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.2 2.8 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.4 2.6 GO:0015375 glycine:sodium symporter activity(GO:0015375)
0.3 2.6 GO:0038036 sphingosine-1-phosphate receptor activity(GO:0038036)
0.5 2.5 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.3 2.3 GO:0070290 N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.1 2.3 GO:0071855 neuropeptide receptor binding(GO:0071855)