Motif ID: Tbx19

Z-value: 0.540


Transcription factors associated with Tbx19:

Gene SymbolEntrez IDGene Name
Tbx19 ENSMUSG00000026572.5 Tbx19



Activity profile for motif Tbx19.

activity profile for motif Tbx19


Sorted Z-values histogram for motif Tbx19

Sorted Z-values for motif Tbx19



Network of associatons between targets according to the STRING database.



First level regulatory network of Tbx19

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chrY_+_897782 1.948 ENSMUST00000055032.7
 Kdm5d
lysine (K)-specific demethylase 5D
chr9_-_21760275 0.990 ENSMUST00000098942.4
 Spc24
SPC24, NDC80 kinetochore complex component, homolog (S. cerevisiae)
chr10_+_20347788 0.839 ENSMUST00000169712.1
 Mtfr2
mitochondrial fission regulator 2
chr14_+_115042752 0.786 ENSMUST00000134140.2
 Mir17hg
Mir17 host gene 1 (non-protein coding)
chr11_+_80089385 0.777 ENSMUST00000108239.1
ENSMUST00000017694.5
 Atad5

ATPase family, AAA domain containing 5

chr3_-_97610156 0.732 ENSMUST00000029730.4
 Chd1l
chromodomain helicase DNA binding protein 1-like
chr1_-_93342734 0.682 ENSMUST00000027493.3
 Pask
PAS domain containing serine/threonine kinase
chr3_+_94693556 0.677 ENSMUST00000090848.3
ENSMUST00000173981.1
ENSMUST00000173849.1
ENSMUST00000174223.1
 Selenbp2



selenium binding protein 2



chr2_+_175010241 0.676 ENSMUST00000109069.1
ENSMUST00000109070.2
 Gm14444

predicted gene 14444

chr9_+_15520830 0.639 ENSMUST00000178999.1
 Smco4
single-pass membrane protein with coiled-coil domains 4
chr13_+_58806564 0.619 ENSMUST00000109838.2
 Ntrk2
neurotrophic tyrosine kinase, receptor, type 2
chr16_-_45844303 0.584 ENSMUST00000036355.6
 Phldb2
pleckstrin homology-like domain, family B, member 2
chr7_+_130936172 0.576 ENSMUST00000006367.7
 Htra1
HtrA serine peptidase 1
chr5_-_92278155 0.576 ENSMUST00000159345.1
ENSMUST00000113102.3
 Naaa

N-acylethanolamine acid amidase

chr2_-_177578199 0.572 ENSMUST00000108945.1
ENSMUST00000108943.1
 Gm14406

predicted gene 14406

chr15_+_31276491 0.560 ENSMUST00000068987.5
 Fam136b-ps
family with sequence similarity 136, member B, pseudogene
chr17_-_35027909 0.521 ENSMUST00000040151.2
 Sapcd1
suppressor APC domain containing 1
chr1_+_58646608 0.507 ENSMUST00000081455.4
 Gm10068
predicted gene 10068
chr2_-_175067763 0.498 ENSMUST00000072895.3
ENSMUST00000109066.1
 Gm14393

predicted gene 14393

chr2_-_132253227 0.487 ENSMUST00000028817.6
 Pcna
proliferating cell nuclear antigen
chr7_-_3720382 0.480 ENSMUST00000078451.6
 Pirb
paired Ig-like receptor B
chr6_+_90465287 0.461 ENSMUST00000113530.1
 Klf15
Kruppel-like factor 15
chr7_+_44818437 0.444 ENSMUST00000136861.1
 Nup62
nucleoporin 62
chr4_+_136347286 0.435 ENSMUST00000140052.2
 9130020K20Rik
RIKEN cDNA 9130020K20 gene
chr15_-_98728120 0.425 ENSMUST00000003445.6
 Fkbp11
FK506 binding protein 11
chr6_-_119467210 0.418 ENSMUST00000118120.1
 Wnt5b
wingless-related MMTV integration site 5B
chr17_+_6978860 0.410 ENSMUST00000089119.5
ENSMUST00000179728.1
 Rnaset2b

ribonuclease T2B

chrX_-_56822308 0.392 ENSMUST00000135542.1
ENSMUST00000114766.1
 Mtap7d3

MAP7 domain containing 3

chr5_-_45856496 0.383 ENSMUST00000087164.3
ENSMUST00000121573.1
 Lcorl

ligand dependent nuclear receptor corepressor-like

chr2_+_177080256 0.375 ENSMUST00000134614.1
ENSMUST00000108968.1
 Gm14401

predicted gene 14401

chr11_+_101468164 0.374 ENSMUST00000001347.6
 Rnd2
Rho family GTPase 2
chr6_-_54593139 0.363 ENSMUST00000046520.6
 Fkbp14
FK506 binding protein 14
chr9_+_97179153 0.353 ENSMUST00000177657.1
 Rpl7a-ps10
ribosomal protein L7A, pseudogene 10
chr12_-_98259416 0.349 ENSMUST00000021390.7
 Galc
galactosylceramidase
chr5_+_114707760 0.336 ENSMUST00000094441.4
 Tchp
trichoplein, keratin filament binding
chr11_+_72301613 0.336 ENSMUST00000151440.1
ENSMUST00000146233.1
ENSMUST00000140842.2
 Xaf1


XIAP associated factor 1


chr4_+_122836236 0.332 ENSMUST00000030412.4
ENSMUST00000121870.1
ENSMUST00000097902.4
 Ppt1


palmitoyl-protein thioesterase 1


chr13_-_67332525 0.329 ENSMUST00000168892.1
ENSMUST00000109735.2
 Zfp595

zinc finger protein 595

chr1_-_57406443 0.325 ENSMUST00000160837.1
ENSMUST00000161780.1
 Tyw5

tRNA-yW synthesizing protein 5

chr10_+_88459569 0.314 ENSMUST00000020252.3
ENSMUST00000125612.1
 Sycp3

synaptonemal complex protein 3

chr4_-_45320580 0.306 ENSMUST00000030003.3
 Exosc3
exosome component 3
chr16_+_44347121 0.304 ENSMUST00000050897.6
 Spice1
spindle and centriole associated protein 1
chr19_+_5474681 0.292 ENSMUST00000165485.1
ENSMUST00000166253.1
ENSMUST00000167371.1
ENSMUST00000167855.1
ENSMUST00000070118.7
 Efemp2




epidermal growth factor-containing fibulin-like extracellular matrix protein 2




chr4_+_3940747 0.291 ENSMUST00000119403.1
 Chchd7
coiled-coil-helix-coiled-coil-helix domain containing 7
chr3_-_153944632 0.281 ENSMUST00000072697.6
 Acadm
acyl-Coenzyme A dehydrogenase, medium chain
chr6_+_124808885 0.274 ENSMUST00000143040.1
ENSMUST00000052727.4
ENSMUST00000130160.1
 Spsb2


splA/ryanodine receptor domain and SOCS box containing 2


chr9_+_73044833 0.272 ENSMUST00000184146.1
ENSMUST00000034722.4
 Rab27a

RAB27A, member RAS oncogene family

chr13_-_21453714 0.254 ENSMUST00000032820.7
ENSMUST00000110485.1
 Zscan26

zinc finger and SCAN domain containing 26

chr1_-_72212249 0.251 ENSMUST00000048860.7
 Mreg
melanoregulin
chr1_+_87404916 0.242 ENSMUST00000173152.1
ENSMUST00000173663.1
 Gigyf2

GRB10 interacting GYF protein 2

chr10_-_86011833 0.236 ENSMUST00000105304.1
ENSMUST00000061699.5
 Bpifc

BPI fold containing family C

chr14_-_66124482 0.236 ENSMUST00000070515.1
 Ephx2
epoxide hydrolase 2, cytoplasmic
chr4_+_62525369 0.234 ENSMUST00000062145.1
 4933430I17Rik
RIKEN cDNA 4933430I17 gene
chr8_-_4275886 0.212 ENSMUST00000003029.7
 Timm44
translocase of inner mitochondrial membrane 44
chrX_+_140664908 0.207 ENSMUST00000112990.1
ENSMUST00000112988.1
 Mid2

midline 2

chr9_-_25151772 0.204 ENSMUST00000008573.7
 Herpud2
HERPUD family member 2
chr19_+_34290653 0.200 ENSMUST00000025691.5
ENSMUST00000112472.2
 Fas

Fas (TNF receptor superfamily member 6)

chr9_-_54193442 0.193 ENSMUST00000034811.7
 Cyp19a1
cytochrome P450, family 19, subfamily a, polypeptide 1
chr11_-_35834492 0.191 ENSMUST00000018992.3
 Rars
arginyl-tRNA synthetase
chr2_+_176236860 0.190 ENSMUST00000166464.1
 2210418O10Rik
RIKEN cDNA 2210418O10 gene
chr19_-_41206774 0.183 ENSMUST00000025986.7
ENSMUST00000169941.1
 Tll2

tolloid-like 2

chr2_+_129100995 0.175 ENSMUST00000103205.4
ENSMUST00000028874.7
 Polr1b

polymerase (RNA) I polypeptide B

chr5_-_149051300 0.156 ENSMUST00000110505.1
 Hmgb1
high mobility group box 1
chr14_-_50870557 0.153 ENSMUST00000006444.7
 Tep1
telomerase associated protein 1
chr5_-_143527977 0.150 ENSMUST00000100489.3
ENSMUST00000080537.7
 Rac1

RAS-related C3 botulinum substrate 1

chr2_-_177324307 0.150 ENSMUST00000108959.2
 Gm14412
predicted gene 14412
chr19_+_18713192 0.147 ENSMUST00000062753.2
 D030056L22Rik
RIKEN cDNA D030056L22 gene
chr1_+_183388981 0.143 ENSMUST00000097043.5
 Taf1a
TATA box binding protein (Tbp)-associated factor, RNA polymerase I, A
chr9_-_46319984 0.138 ENSMUST00000159565.1
 4931429L15Rik
RIKEN cDNA 4931429L15 gene
chr7_-_132786914 0.135 ENSMUST00000065371.7
ENSMUST00000106166.1
 Fam53b

family with sequence similarity 53, member B

chr5_+_138187485 0.135 ENSMUST00000110934.2
 Cnpy4
canopy 4 homolog (zebrafish)
chr6_+_42286709 0.132 ENSMUST00000163936.1
 Clcn1
chloride channel 1
chr7_-_132776855 0.131 ENSMUST00000106168.1
 Fam53b
family with sequence similarity 53, member B
chr1_+_156838915 0.126 ENSMUST00000111720.1
 Angptl1
angiopoietin-like 1
chr7_-_116084635 0.117 ENSMUST00000111755.3
 Gm4353
predicted gene 4353
chr6_-_85451248 0.116 ENSMUST00000113770.1
ENSMUST00000032080.2
 Pradc1

protease-associated domain containing 1

chr13_-_23562369 0.116 ENSMUST00000105107.1
 Hist1h3e
histone cluster 1, H3e
chr7_+_39517744 0.109 ENSMUST00000108015.1
 Zfp619
zinc finger protein 619
chr4_-_12087912 0.105 ENSMUST00000050686.3
 Tmem67
transmembrane protein 67
chr6_+_86195214 0.103 ENSMUST00000032066.9
 Tgfa
transforming growth factor alpha
chr5_+_96173940 0.099 ENSMUST00000048361.8
 Gm2840
predicted gene 2840
chr12_-_58269162 0.089 ENSMUST00000062254.2
 Clec14a
C-type lectin domain family 14, member a
chr7_+_12927410 0.080 ENSMUST00000045870.4
 2310014L17Rik
RIKEN cDNA 2310014L17 gene
chr3_-_150073620 0.068 ENSMUST00000057740.5
 Rpsa-ps10
ribosomal protein SA, pseudogene 10
chr7_-_80947765 0.064 ENSMUST00000026818.5
ENSMUST00000117383.1
ENSMUST00000119980.1
 Sec11a


SEC11 homolog A (S. cerevisiae)


chr11_+_74898078 0.062 ENSMUST00000045807.7
 Tsr1
TSR1 20S rRNA accumulation
chr1_+_33719863 0.058 ENSMUST00000088287.3
 Rab23
RAB23, member RAS oncogene family
chrM_+_9870 0.055 ENSMUST00000084013.1
 mt-Nd4l
mitochondrially encoded NADH dehydrogenase 4L
chr1_+_127868773 0.050 ENSMUST00000037649.5
 Rab3gap1
RAB3 GTPase activating protein subunit 1
chr9_-_57606234 0.047 ENSMUST00000045068.8
 Cplx3
complexin 3
chr1_-_24612700 0.044 ENSMUST00000088336.1
 Gm10222
predicted gene 10222
chr2_-_113758638 0.044 ENSMUST00000099575.3
 Grem1
gremlin 1
chr16_-_44746337 0.044 ENSMUST00000023348.4
ENSMUST00000162512.1
 Gtpbp8

GTP-binding protein 8 (putative)

chr17_-_13131791 0.042 ENSMUST00000084966.5
 Unc93a
unc-93 homolog A (C. elegans)
chr1_+_185332143 0.041 ENSMUST00000027916.6
ENSMUST00000151769.1
ENSMUST00000110965.1
 Bpnt1


bisphosphate 3'-nucleotidase 1


chr7_-_110844350 0.040 ENSMUST00000177462.1
ENSMUST00000176746.1
ENSMUST00000177236.1
 Rnf141


ring finger protein 141


chr15_-_78305603 0.033 ENSMUST00000096356.3
 Csf2rb2
colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage)
chr7_+_143830204 0.031 ENSMUST00000144034.1
ENSMUST00000143338.1
 Dhcr7

7-dehydrocholesterol reductase

chr6_-_34177048 0.022 ENSMUST00000019143.8
 Slc35b4
solute carrier family 35, member B4
chr3_-_88372740 0.016 ENSMUST00000107543.1
ENSMUST00000107542.1
 Bglap3

bone gamma-carboxyglutamate protein 3

chr7_-_140955960 0.007 ENSMUST00000081649.8
 Ifitm2
interferon induced transmembrane protein 2
chr1_+_171419027 0.005 ENSMUST00000171362.1
 Tstd1
thiosulfate sulfurtransferase (rhodanese)-like domain containing 1
chr7_-_5014645 0.003 ENSMUST00000165320.1
 Fiz1
Flt3 interacting zinc finger protein 1
chr7_+_143830077 0.001 ENSMUST00000141916.1
 Dhcr7
7-dehydrocholesterol reductase
chrM_+_10167 0.000 ENSMUST00000082414.1
 mt-Nd4
mitochondrially encoded NADH dehydrogenase 4

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.9 GO:0002457 T cell antigen processing and presentation(GO:0002457)
0.2 0.8 GO:0048304 positive regulation of isotype switching to IgG isotypes(GO:0048304)
0.1 0.5 GO:1902990 mitotic telomere maintenance via semi-conservative replication(GO:1902990)
0.1 0.3 GO:0031590 wybutosine metabolic process(GO:0031590) wybutosine biosynthetic process(GO:0031591)
0.1 0.3 GO:0016321 female meiosis chromosome segregation(GO:0016321)
0.1 0.6 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.1 0.6 GO:1903690 negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.1 0.6 GO:0060718 chorionic trophoblast cell differentiation(GO:0060718)
0.1 0.3 GO:0006578 amino-acid betaine biosynthetic process(GO:0006578)
0.1 0.3 GO:0097278 complement-dependent cytotoxicity(GO:0097278)
0.1 0.2 GO:0002538 arachidonic acid metabolite production involved in inflammatory response(GO:0002538) olefin metabolic process(GO:1900673)
0.1 0.3 GO:0071033 nuclear retention of pre-mRNA at the site of transcription(GO:0071033) CUT catabolic process(GO:0071034) CUT metabolic process(GO:0071043) polyadenylation-dependent snoRNA 3'-end processing(GO:0071051)
0.1 0.7 GO:0045719 negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874)
0.1 0.3 GO:0098734 protein depalmitoylation(GO:0002084) positive regulation of pinocytosis(GO:0048549) macromolecule depalmitoylation(GO:0098734)
0.1 0.2 GO:0045819 positive regulation of glycogen catabolic process(GO:0045819)
0.0 0.3 GO:0046477 glycosylceramide catabolic process(GO:0046477)
0.0 0.2 GO:0097527 necroptotic signaling pathway(GO:0097527)
0.0 0.2 GO:0002677 negative regulation of chronic inflammatory response(GO:0002677)
0.0 0.2 GO:0048631 regulation of skeletal muscle tissue growth(GO:0048631)
0.0 0.5 GO:0072010 renal filtration cell differentiation(GO:0061318) glomerular epithelium development(GO:0072010) glomerular visceral epithelial cell differentiation(GO:0072112) glomerular epithelial cell differentiation(GO:0072311)
0.0 0.5 GO:0043011 myeloid dendritic cell differentiation(GO:0043011)
0.0 0.3 GO:1902018 negative regulation of cilium assembly(GO:1902018)
0.0 0.2 GO:0032627 interleukin-23 production(GO:0032627) regulation of interleukin-23 production(GO:0032667)
0.0 0.2 GO:0035372 protein localization to microtubule(GO:0035372)
0.0 0.4 GO:0048672 positive regulation of collateral sprouting(GO:0048672)
0.0 0.0 GO:1901228 positive regulation of transcription from RNA polymerase II promoter involved in heart development(GO:1901228)
0.0 0.8 GO:0000266 mitochondrial fission(GO:0000266)
0.0 0.1 GO:0010826 negative regulation of centrosome duplication(GO:0010826) negative regulation of centrosome cycle(GO:0046606)
0.0 0.2 GO:0007000 nucleolus organization(GO:0007000)
0.0 0.4 GO:0070208 protein heterotrimerization(GO:0070208)
0.0 0.3 GO:0046599 regulation of centriole replication(GO:0046599)
0.0 0.0 GO:1903061 glutamate secretion, neurotransmission(GO:0061535) establishment of protein localization to endoplasmic reticulum membrane(GO:0097051) regulation of protein lipidation(GO:1903059) positive regulation of protein lipidation(GO:1903061)
0.0 0.3 GO:0042640 anagen(GO:0042640)
0.0 0.2 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.0 0.0 GO:0090529 barrier septum assembly(GO:0000917) cell septum assembly(GO:0090529)
0.0 0.1 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.0 0.2 GO:0000722 telomere maintenance via recombination(GO:0000722)
0.0 0.8 GO:0061077 chaperone-mediated protein folding(GO:0061077)
0.0 0.0 GO:0006420 arginyl-tRNA aminoacylation(GO:0006420)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.0 GO:0031262 Ndc80 complex(GO:0031262)
0.2 0.5 GO:0070557 PCNA-p21 complex(GO:0070557)
0.1 0.3 GO:0000802 transverse filament(GO:0000802)
0.1 0.4 GO:0044613 nuclear pore central transport channel(GO:0044613) Flemming body(GO:0090543)
0.1 0.3 GO:0045179 apical cortex(GO:0045179)
0.1 0.3 GO:0033093 multivesicular body membrane(GO:0032585) Weibel-Palade body(GO:0033093)
0.0 0.6 GO:0045180 basal cortex(GO:0045180)
0.0 0.2 GO:0031265 CD95 death-inducing signaling complex(GO:0031265)
0.0 0.1 GO:0000120 RNA polymerase I transcription factor complex(GO:0000120)
0.0 0.3 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.0 0.2 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.0 0.2 GO:0060091 kinocilium(GO:0060091)
0.0 0.6 GO:0048786 presynaptic active zone(GO:0048786)
0.0 0.2 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.0 0.1 GO:0030688 preribosome, small subunit precursor(GO:0030688)
0.0 0.2 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.9 GO:0032453 histone demethylase activity (H3-K4 specific)(GO:0032453)
0.2 0.5 GO:0030337 DNA polymerase processivity factor activity(GO:0030337) dinucleotide insertion or deletion binding(GO:0032139)
0.1 0.6 GO:0005030 neurotrophin receptor activity(GO:0005030)
0.1 0.4 GO:0051425 PTB domain binding(GO:0051425)
0.1 0.2 GO:0034618 arginine binding(GO:0034618)
0.1 0.2 GO:0000402 open form four-way junction DNA binding(GO:0000401) crossed form four-way junction DNA binding(GO:0000402)
0.0 0.7 GO:0008430 selenium binding(GO:0008430)
0.0 0.2 GO:0004301 epoxide hydrolase activity(GO:0004301)
0.0 0.2 GO:0070330 aromatase activity(GO:0070330)
0.0 0.3 GO:0070991 medium-chain-acyl-CoA dehydrogenase activity(GO:0070991)
0.0 0.3 GO:0008474 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.0 0.3 GO:0004534 5'-3' exoribonuclease activity(GO:0004534)
0.0 0.8 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.0 0.6 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.0 0.5 GO:0043747 protein-N-terminal asparagine amidohydrolase activity(GO:0008418) UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity(GO:0008759) iprodione amidohydrolase activity(GO:0018748) (3,5-dichlorophenylurea)acetate amidohydrolase activity(GO:0018749) 4'-(2-hydroxyisopropyl)phenylurea amidohydrolase activity(GO:0034571) didemethylisoproturon amidohydrolase activity(GO:0034573) N-isopropylacetanilide amidohydrolase activity(GO:0034576) N-cyclohexylformamide amidohydrolase activity(GO:0034781) isonicotinic acid hydrazide hydrolase activity(GO:0034876) cis-aconitamide amidase activity(GO:0034882) gamma-N-formylaminovinylacetate hydrolase activity(GO:0034885) N2-acetyl-L-lysine deacetylase activity(GO:0043747) O-succinylbenzoate synthase activity(GO:0043748) indoleacetamide hydrolase activity(GO:0043864) N-acetylcitrulline deacetylase activity(GO:0043909) N-acetylgalactosamine-6-phosphate deacetylase activity(GO:0047419) diacetylchitobiose deacetylase activity(GO:0052773) chitooligosaccharide deacetylase activity(GO:0052790)
0.0 0.2 GO:0051022 Rho GDP-dissociation inhibitor binding(GO:0051022)
0.0 0.3 GO:0031489 myosin V binding(GO:0031489)
0.0 0.2 GO:0001054 RNA polymerase I activity(GO:0001054)
0.0 0.2 GO:0005035 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.0 0.0 GO:0047598 7-dehydrocholesterol reductase activity(GO:0047598)
0.0 0.4 GO:0005109 frizzled binding(GO:0005109)
0.0 0.0 GO:0004441 inositol-1,4-bisphosphate 1-phosphatase activity(GO:0004441)
0.0 0.2 GO:0070034 telomerase RNA binding(GO:0070034)