Motif ID: Tbx2

Z-value: 0.641


Transcription factors associated with Tbx2:

Gene SymbolEntrez IDGene Name
Tbx2 ENSMUSG00000000093.6 Tbx2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tbx2mm10_v2_chr11_+_85832551_85832551-0.252.2e-01Click!


Activity profile for motif Tbx2.

activity profile for motif Tbx2


Sorted Z-values histogram for motif Tbx2

Sorted Z-values for motif Tbx2



Network of associatons between targets according to the STRING database.



First level regulatory network of Tbx2

PNG image of the network

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Top targets:


Showing 1 to 20 of 123 entries
PromoterScoreRefseqGene SymbolGene Name
chr1_-_51941261 2.318 ENSMUST00000097103.3
 Gm8420
predicted gene 8420
chr10_-_120899067 1.658 ENSMUST00000092143.5
 Msrb3
methionine sulfoxide reductase B3
chr2_+_124089961 1.483 ENSMUST00000103241.1
 Sema6d
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
chr11_-_84068766 1.466 ENSMUST00000018792.5
 Dusp14
dual specificity phosphatase 14
chr16_+_19028232 1.329 ENSMUST00000074116.4
 Gm10088
predicted gene 10088
chr17_+_3397189 1.258 ENSMUST00000072156.6
 Tiam2
T cell lymphoma invasion and metastasis 2
chr1_+_170214826 1.233 ENSMUST00000159201.1
ENSMUST00000055830.1
 4930500M09Rik

RIKEN cDNA 4930500M09 gene

chr11_-_84068357 1.215 ENSMUST00000100705.4
 Dusp14
dual specificity phosphatase 14
chr1_-_52500679 1.206 ENSMUST00000069792.7
 Nab1
Ngfi-A binding protein 1
chr6_+_115134899 0.929 ENSMUST00000009538.5
ENSMUST00000169345.1
 Syn2

synapsin II

chr2_+_52857844 0.809 ENSMUST00000090952.4
ENSMUST00000049483.6
ENSMUST00000050719.6
 Fmnl2


formin-like 2


chr9_+_53850243 0.790 ENSMUST00000048485.5
 Sln
sarcolipin
chr4_-_58499398 0.704 ENSMUST00000107570.1
 Lpar1
lysophosphatidic acid receptor 1
chr15_+_61987034 0.703 ENSMUST00000159338.1
 Myc
myelocytomatosis oncogene
chr18_-_62741387 0.692 ENSMUST00000097557.3
 Spink13
serine peptidase inhibitor, Kazal type 13
chr12_-_31634592 0.679 ENSMUST00000020979.7
ENSMUST00000177962.1
 Bcap29

B cell receptor associated protein 29

chr10_+_96136603 0.641 ENSMUST00000074615.6
 Gm5426
predicted pseudogene 5426
chrX_-_53269020 0.589 ENSMUST00000114838.1
 Fam122b
family with sequence similarity 122, member B
chr5_+_108065696 0.587 ENSMUST00000172045.1
 Mtf2
metal response element binding transcription factor 2
chr1_-_138847579 0.562 ENSMUST00000093486.3
ENSMUST00000046870.6
 Lhx9

LIM homeobox protein 9


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 43 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.7 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.3 1.7 GO:0030091 protein repair(GO:0030091)
0.0 1.5 GO:0014912 negative regulation of smooth muscle cell migration(GO:0014912)
0.1 1.2 GO:0010457 centriole-centriole cohesion(GO:0010457)
0.0 1.2 GO:0036075 endochondral ossification(GO:0001958) replacement ossification(GO:0036075)
0.2 1.0 GO:0061086 negative regulation of histone H3-K27 methylation(GO:0061086)
0.0 0.9 GO:0090161 Golgi ribbon formation(GO:0090161)
0.2 0.8 GO:1901894 regulation of calcium-transporting ATPase activity(GO:1901894)
0.0 0.8 GO:0030866 cortical actin cytoskeleton organization(GO:0030866)
0.0 0.8 GO:0046513 ceramide biosynthetic process(GO:0046513)
0.2 0.7 GO:0070973 protein localization to endoplasmic reticulum exit site(GO:0070973)
0.2 0.7 GO:1904565 response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904565) cellular response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904566)
0.2 0.7 GO:0044330 canonical Wnt signaling pathway involved in positive regulation of wound healing(GO:0044330) lactic acid secretion(GO:0046722) regulation of metanephric cap mesenchymal cell proliferation(GO:0090095) positive regulation of metanephric cap mesenchymal cell proliferation(GO:0090096)
0.1 0.7 GO:0060467 negative regulation of fertilization(GO:0060467)
0.1 0.7 GO:0015871 choline transport(GO:0015871)
0.1 0.6 GO:0035262 gonad morphogenesis(GO:0035262)
0.0 0.6 GO:0043551 regulation of phosphatidylinositol 3-kinase activity(GO:0043551)
0.2 0.5 GO:0001951 intestinal D-glucose absorption(GO:0001951) terminal web assembly(GO:1902896)
0.2 0.5 GO:0090327 negative regulation of locomotion involved in locomotory behavior(GO:0090327)
0.1 0.5 GO:0007386 compartment pattern specification(GO:0007386)

Gene overrepresentation in cellular_component category:

Showing 1 to 14 of 14 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 1.5 GO:0005814 centriole(GO:0005814)
0.0 1.0 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.1 0.9 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.0 0.9 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.0 0.8 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.0 0.7 GO:0005719 nuclear euchromatin(GO:0005719)
0.0 0.6 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 0.6 GO:0016328 lateral plasma membrane(GO:0016328)
0.1 0.5 GO:1990357 terminal web(GO:1990357)
0.0 0.5 GO:0030992 intraciliary transport particle B(GO:0030992)
0.0 0.4 GO:0070531 BRCA1-A complex(GO:0070531)
0.1 0.3 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.1 0.3 GO:0033093 multivesicular body membrane(GO:0032585) Weibel-Palade body(GO:0033093)
0.0 0.1 GO:0002141 stereocilia ankle link(GO:0002141)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 29 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 2.7 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.2 1.7 GO:0070191 methionine-R-sulfoxide reductase activity(GO:0070191)
0.0 1.5 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 1.3 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 1.0 GO:0035064 methylated histone binding(GO:0035064)
0.0 1.0 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.1 0.8 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.2 0.7 GO:0015220 choline transmembrane transporter activity(GO:0015220)
0.1 0.7 GO:0035727 lysophosphatidic acid binding(GO:0035727) lysophosphatidic acid receptor activity(GO:0070915)
0.0 0.7 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.1 0.6 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0 0.5 GO:0031690 adrenergic receptor binding(GO:0031690)
0.0 0.5 GO:0005112 Notch binding(GO:0005112)
0.0 0.5 GO:0017022 myosin binding(GO:0017022)
0.1 0.3 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.0 0.3 GO:0004652 polynucleotide adenylyltransferase activity(GO:0004652)
0.0 0.3 GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934)
0.0 0.3 GO:0004385 guanylate kinase activity(GO:0004385)
0.0 0.3 GO:0031489 myosin V binding(GO:0031489)
0.1 0.2 GO:0036313 phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313)