Motif ID: Tbx4

Z-value: 1.515


Transcription factors associated with Tbx4:

Gene SymbolEntrez IDGene Name
Tbx4 ENSMUSG00000000094.6 Tbx4



Activity profile for motif Tbx4.

activity profile for motif Tbx4


Sorted Z-values histogram for motif Tbx4

Sorted Z-values for motif Tbx4



Network of associatons between targets according to the STRING database.



First level regulatory network of Tbx4

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 127 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_+_26229707 14.046 ENSMUST00000060716.5
ENSMUST00000164660.1
 Samd3

sterile alpha motif domain containing 3

chr2_+_164562579 14.018 ENSMUST00000017867.3
ENSMUST00000109344.2
ENSMUST00000109345.2
 Wfdc2


WAP four-disulfide core domain 2


chr4_-_134018829 11.987 ENSMUST00000051674.2
 Lin28a
lin-28 homolog A (C. elegans)
chr1_+_6730051 11.815 ENSMUST00000043578.6
ENSMUST00000131467.1
ENSMUST00000150761.1
ENSMUST00000151281.1
 St18



suppression of tumorigenicity 18



chr10_-_120899067 9.055 ENSMUST00000092143.5
 Msrb3
methionine sulfoxide reductase B3
chr14_-_70642268 8.330 ENSMUST00000022697.5
 Fgf17
fibroblast growth factor 17
chr6_+_15196949 8.324 ENSMUST00000151301.1
ENSMUST00000131414.1
ENSMUST00000140557.1
ENSMUST00000115469.1
 Foxp2



forkhead box P2



chr1_-_138847579 7.954 ENSMUST00000093486.3
ENSMUST00000046870.6
 Lhx9

LIM homeobox protein 9

chr9_-_43239816 7.731 ENSMUST00000034512.5
 Oaf
OAF homolog (Drosophila)
chr1_+_6730135 7.157 ENSMUST00000155921.1
 St18
suppression of tumorigenicity 18
chr12_+_3891728 6.383 ENSMUST00000172689.1
ENSMUST00000111186.1
 Dnmt3a

DNA methyltransferase 3A

chr17_+_29093763 5.972 ENSMUST00000023829.6
 Cdkn1a
cyclin-dependent kinase inhibitor 1A (P21)
chr4_+_11191726 5.492 ENSMUST00000029866.9
ENSMUST00000108324.3
 Ccne2

cyclin E2

chr5_+_115908644 5.429 ENSMUST00000141101.1
 Cit
citron
chr6_-_94700137 5.375 ENSMUST00000101126.2
ENSMUST00000032105.4
 Lrig1

leucine-rich repeats and immunoglobulin-like domains 1

chr1_+_132316112 4.991 ENSMUST00000082125.5
ENSMUST00000072177.7
 Nuak2

NUAK family, SNF1-like kinase, 2

chr19_+_55894508 4.989 ENSMUST00000142291.1
 Tcf7l2
transcription factor 7 like 2, T cell specific, HMG box
chrX_-_53269020 4.913 ENSMUST00000114838.1
 Fam122b
family with sequence similarity 122, member B
chr2_-_148046896 4.477 ENSMUST00000172928.1
ENSMUST00000047315.3
 Foxa2

forkhead box A2

chr7_-_28302238 4.345 ENSMUST00000108315.3
 Dll3
delta-like 3 (Drosophila)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 65 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.9 12.1 GO:0060159 regulation of dopamine receptor signaling pathway(GO:0060159)
1.3 12.0 GO:0010587 miRNA catabolic process(GO:0010587)
1.8 9.1 GO:0030091 protein repair(GO:0030091)
0.7 8.3 GO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501)
0.3 8.3 GO:0006270 DNA replication initiation(GO:0006270)
0.1 8.3 GO:0008543 fibroblast growth factor receptor signaling pathway(GO:0008543)
2.7 8.2 GO:0045014 detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) carbon catabolite repression of transcription(GO:0045013) negative regulation of transcription by glucose(GO:0045014) detection of glucose(GO:0051594)
1.6 8.0 GO:0035262 gonad morphogenesis(GO:0035262)
0.0 7.8 GO:0010466 negative regulation of peptidase activity(GO:0010466)
0.5 7.0 GO:0097067 negative regulation of erythrocyte differentiation(GO:0045647) cellular response to thyroid hormone stimulus(GO:0097067)
0.8 6.4 GO:0044027 hypermethylation of CpG island(GO:0044027)
0.7 6.0 GO:0071493 cellular response to UV-B(GO:0071493) replicative senescence(GO:0090399)
1.8 5.4 GO:0032474 otolith morphogenesis(GO:0032474)
0.3 5.4 GO:0050774 negative regulation of dendrite morphogenesis(GO:0050774)
0.5 5.1 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.6 5.0 GO:0048625 myoblast fate commitment(GO:0048625)
0.2 5.0 GO:0042149 cellular response to glucose starvation(GO:0042149)
1.5 4.5 GO:0061537 glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537)
0.9 4.3 GO:0007386 compartment pattern specification(GO:0007386)
1.4 4.2 GO:2000852 regulation of corticosterone secretion(GO:2000852)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 31 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.3 12.1 GO:0032809 neuronal cell body membrane(GO:0032809)
0.2 12.0 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 8.9 GO:0005667 transcription factor complex(GO:0005667)
0.3 6.4 GO:0001741 XY body(GO:0001741)
2.0 6.0 GO:0070557 PCNA-p21 complex(GO:0070557)
0.1 5.4 GO:0031985 Golgi cisterna(GO:0031985)
0.1 5.1 GO:0034707 chloride channel complex(GO:0034707)
0.6 5.0 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.3 3.9 GO:0000124 SAGA complex(GO:0000124)
0.0 3.9 GO:0005884 actin filament(GO:0005884)
0.3 3.7 GO:0097542 ciliary tip(GO:0097542)
0.1 3.4 GO:0001750 photoreceptor outer segment(GO:0001750)
0.4 2.9 GO:0031415 NatA complex(GO:0031415)
0.0 2.9 GO:0001669 acrosomal vesicle(GO:0001669)
0.6 2.8 GO:1990357 terminal web(GO:1990357)
0.5 2.8 GO:0032299 ribonuclease H2 complex(GO:0032299)
0.2 2.6 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.1 2.5 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.0 2.4 GO:0000775 chromosome, centromeric region(GO:0000775)
0.0 1.6 GO:0035097 histone methyltransferase complex(GO:0035097)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 46 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 26.2 GO:0008270 zinc ion binding(GO:0008270)
0.3 14.0 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.3 12.1 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.6 12.0 GO:0035198 miRNA binding(GO:0035198)
0.2 10.6 GO:0070888 E-box binding(GO:0070888)
1.3 9.1 GO:0070191 methionine-R-sulfoxide reductase activity(GO:0070191)
0.3 9.0 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.1 8.4 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
2.8 8.3 GO:0005105 type 1 fibroblast growth factor receptor binding(GO:0005105)
0.2 8.2 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.8 6.4 GO:0051718 DNA (cytosine-5-)-methyltransferase activity(GO:0003886) DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates(GO:0051718)
0.4 6.0 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.1 6.0 GO:0097110 scaffold protein binding(GO:0097110)
0.3 5.1 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.2 5.0 GO:0045295 gamma-catenin binding(GO:0045295)
0.0 5.0 GO:0000287 magnesium ion binding(GO:0000287)
0.7 4.5 GO:0015375 glycine:sodium symporter activity(GO:0015375)
0.1 4.3 GO:0005112 Notch binding(GO:0005112)
0.4 3.9 GO:0008889 glycerophosphodiester phosphodiesterase activity(GO:0008889)
0.1 3.9 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)