Motif ID: Tbx5

Z-value: 0.654


Transcription factors associated with Tbx5:

Gene SymbolEntrez IDGene Name
Tbx5 ENSMUSG00000018263.8 Tbx5

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tbx5mm10_v2_chr5_+_119834663_119834663-0.115.9e-01Click!


Activity profile for motif Tbx5.

activity profile for motif Tbx5


Sorted Z-values histogram for motif Tbx5

Sorted Z-values for motif Tbx5



Network of associatons between targets according to the STRING database.



First level regulatory network of Tbx5

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr17_-_8566869 1.991 ENSMUST00000184183.1
 Gm17087
predicted gene 17087
chr10_+_96136603 1.720 ENSMUST00000074615.6
 Gm5426
predicted pseudogene 5426
chr17_-_46440099 1.647 ENSMUST00000166852.1
 Gm5093
predicted gene 5093
chr1_-_16770138 1.513 ENSMUST00000071842.8
 Gm5828
predicted gene 5828
chr11_+_94741782 1.418 ENSMUST00000021240.6
 Cdc34-ps
cell division cycle 34 homolog, pseudogene (S. cerevisiae)
chr9_-_59146210 1.234 ENSMUST00000085631.2
 Gm7589
predicted gene 7589
chr8_+_5639514 1.228 ENSMUST00000051687.3
 Gm1840
predicted gene 1840
chr2_-_54085542 1.177 ENSMUST00000100089.2
 Rprm
reprimo, TP53 dependent G2 arrest mediator candidate
chr1_-_75219245 1.118 ENSMUST00000079464.6
 Tuba4a
tubulin, alpha 4A
chr18_+_58836721 1.004 ENSMUST00000052907.5
 Adamts19
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 19
chr6_+_17307632 0.940 ENSMUST00000115453.1
 Cav1
caveolin 1, caveolae protein
chr5_+_98180866 0.845 ENSMUST00000112959.1
 Prdm8
PR domain containing 8
chr6_+_115134899 0.842 ENSMUST00000009538.5
ENSMUST00000169345.1
 Syn2

synapsin II

chr5_-_22344690 0.817 ENSMUST00000062372.7
ENSMUST00000161356.1
 Reln

reelin

chr6_+_17307272 0.782 ENSMUST00000115454.1
 Cav1
caveolin 1, caveolae protein
chr7_-_104950441 0.724 ENSMUST00000179862.1
 Gm5900
predicted pseudogene 5900
chr11_+_98348404 0.708 ENSMUST00000078694.6
 Ppp1r1b
protein phosphatase 1, regulatory (inhibitor) subunit 1B
chr3_+_75557530 0.665 ENSMUST00000161776.1
ENSMUST00000029423.8
 Serpini1

serine (or cysteine) peptidase inhibitor, clade I, member 1

chr6_+_17307040 0.653 ENSMUST00000123439.1
 Cav1
caveolin 1, caveolae protein
chr1_-_138848576 0.632 ENSMUST00000112030.2
 Lhx9
LIM homeobox protein 9

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 75 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 2.4 GO:1900085 negative regulation of peptidyl-tyrosine autophosphorylation(GO:1900085)
0.1 1.4 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.2 0.8 GO:0097477 lateral motor column neuron migration(GO:0097477)
0.1 0.8 GO:0021540 corpus callosum morphogenesis(GO:0021540)
0.2 0.7 GO:0007621 negative regulation of female receptivity(GO:0007621)
0.1 0.6 GO:0035262 gonad morphogenesis(GO:0035262)
0.1 0.6 GO:0030091 protein repair(GO:0030091)
0.1 0.6 GO:0060022 hard palate development(GO:0060022)
0.0 0.6 GO:0043666 regulation of phosphoprotein phosphatase activity(GO:0043666)
0.2 0.5 GO:0070634 transepithelial ammonium transport(GO:0070634)
0.0 0.5 GO:1904262 negative regulation of TORC1 signaling(GO:1904262)
0.0 0.5 GO:0010457 centriole-centriole cohesion(GO:0010457)
0.1 0.4 GO:0003104 positive regulation of glomerular filtration(GO:0003104) cell communication by chemical coupling(GO:0010643)
0.1 0.4 GO:0003349 epicardium-derived cardiac endothelial cell differentiation(GO:0003349)
0.1 0.4 GO:0007181 transforming growth factor beta receptor complex assembly(GO:0007181)
0.1 0.4 GO:0007386 compartment pattern specification(GO:0007386)
0.1 0.4 GO:0031508 pericentric heterochromatin assembly(GO:0031508)
0.0 0.4 GO:0060272 embryonic skeletal joint morphogenesis(GO:0060272)
0.0 0.4 GO:0031116 positive regulation of microtubule polymerization(GO:0031116)
0.0 0.4 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 28 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 2.4 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.0 1.6 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 0.8 GO:0031201 SNARE complex(GO:0031201)
0.0 0.8 GO:0009925 basal plasma membrane(GO:0009925)
0.0 0.5 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.1 0.4 GO:0048179 activin receptor complex(GO:0048179)
0.0 0.4 GO:0005916 fascia adherens(GO:0005916)
0.0 0.4 GO:0000124 SAGA complex(GO:0000124)
0.0 0.4 GO:0090544 BAF-type complex(GO:0090544)
0.1 0.3 GO:0035061 interchromatin granule(GO:0035061)
0.1 0.3 GO:0032127 dense core granule membrane(GO:0032127)
0.1 0.3 GO:0097025 MPP7-DLG1-LIN7 complex(GO:0097025)
0.0 0.3 GO:0005677 chromatin silencing complex(GO:0005677)
0.0 0.3 GO:0071004 U2-type prespliceosome(GO:0071004)
0.0 0.3 GO:0005721 pericentric heterochromatin(GO:0005721)
0.0 0.2 GO:0033093 multivesicular body membrane(GO:0032585) Weibel-Palade body(GO:0033093)
0.0 0.2 GO:0030915 Smc5-Smc6 complex(GO:0030915)
0.0 0.1 GO:0019815 B cell receptor complex(GO:0019815)
0.0 0.1 GO:0016035 zeta DNA polymerase complex(GO:0016035)
0.0 0.1 GO:0070937 CRD-mediated mRNA stability complex(GO:0070937)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 49 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.5 2.4 GO:0070320 inward rectifier potassium channel inhibitor activity(GO:0070320)
0.0 1.3 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 1.1 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.1 0.8 GO:0070326 very-low-density lipoprotein particle receptor binding(GO:0070326)
0.1 0.8 GO:0046974 histone methyltransferase activity (H3-K9 specific)(GO:0046974)
0.0 0.8 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.2 0.7 GO:0031752 D3 dopamine receptor binding(GO:0031750) D5 dopamine receptor binding(GO:0031752)
0.1 0.6 GO:0070191 methionine-R-sulfoxide reductase activity(GO:0070191)
0.0 0.6 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.1 0.5 GO:0015168 glycerol transmembrane transporter activity(GO:0015168) glycerol channel activity(GO:0015254)
0.1 0.5 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 0.5 GO:0008519 ammonium transmembrane transporter activity(GO:0008519)
0.0 0.5 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.1 0.4 GO:0016361 activin receptor activity, type I(GO:0016361)
0.1 0.4 GO:0071253 connexin binding(GO:0071253)
0.0 0.4 GO:0005112 Notch binding(GO:0005112)
0.0 0.4 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.1 0.3 GO:0004096 catalase activity(GO:0004096)
0.1 0.3 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.1 0.3 GO:0097016 L27 domain binding(GO:0097016)