Motif ID: Tcf3

Z-value: 0.653


Transcription factors associated with Tcf3:

Gene SymbolEntrez IDGene Name
Tcf3 ENSMUSG00000020167.8 Tcf3

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tcf3mm10_v2_chr10_-_80433615_804336550.271.8e-01Click!


Activity profile for motif Tcf3.

activity profile for motif Tcf3


Sorted Z-values histogram for motif Tcf3

Sorted Z-values for motif Tcf3



Network of associatons between targets according to the STRING database.



First level regulatory network of Tcf3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr12_+_109459843 2.802 ENSMUST00000173812.1
 Dlk1
delta-like 1 homolog (Drosophila)
chr13_-_116309639 1.723 ENSMUST00000036060.6
 Isl1
ISL1 transcription factor, LIM/homeodomain
chr8_+_105518736 1.658 ENSMUST00000034363.5
 Hsd11b2
hydroxysteroid 11-beta dehydrogenase 2
chr1_+_74791516 1.563 ENSMUST00000006718.8
 Wnt10a
wingless related MMTV integration site 10a
chr5_-_98566762 1.512 ENSMUST00000086912.4
 1700010H22Rik
RIKEN cDNA 1700010H22 gene
chrX_-_106485214 1.470 ENSMUST00000039447.7
 Fndc3c1
fibronectin type III domain containing 3C1
chr5_+_21543525 1.449 ENSMUST00000035651.4
 Lrrc17
leucine rich repeat containing 17
chr6_+_29694204 1.429 ENSMUST00000046750.7
ENSMUST00000115250.3
 Tspan33

tetraspanin 33

chr15_+_34238026 1.428 ENSMUST00000022867.3
 Laptm4b
lysosomal-associated protein transmembrane 4B
chr6_-_72235559 1.395 ENSMUST00000042646.7
 Atoh8
atonal homolog 8 (Drosophila)
chr2_+_103969528 1.235 ENSMUST00000123437.1
ENSMUST00000163256.1
 Lmo2

LIM domain only 2

chr4_-_43523388 1.225 ENSMUST00000107913.3
ENSMUST00000030184.5
 Tpm2

tropomyosin 2, beta

chr14_-_20181773 1.163 ENSMUST00000024011.8
 Kcnk5
potassium channel, subfamily K, member 5
chr7_-_28302238 1.130 ENSMUST00000108315.3
 Dll3
delta-like 3 (Drosophila)
chrX_-_48034842 1.128 ENSMUST00000039026.7
 Apln
apelin
chrX_-_106485367 1.111 ENSMUST00000140707.1
 Fndc3c1
fibronectin type III domain containing 3C1
chr19_-_45560508 1.096 ENSMUST00000026239.6
 Poll
polymerase (DNA directed), lambda
chr19_+_45560569 1.077 ENSMUST00000047057.7
 Dpcd
deleted in primary ciliary dyskinesia
chr2_+_103970221 1.044 ENSMUST00000111140.2
ENSMUST00000111139.2
 Lmo2

LIM domain only 2

chr2_+_131186942 1.043 ENSMUST00000028804.8
ENSMUST00000079857.8
 Cdc25b

cell division cycle 25B


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 177 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 3.2 GO:0097067 negative regulation of erythrocyte differentiation(GO:0045647) cellular response to thyroid hormone stimulus(GO:0097067)
0.1 3.1 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
0.2 2.5 GO:0042487 regulation of odontogenesis of dentin-containing tooth(GO:0042487)
0.2 2.2 GO:0060159 regulation of dopamine receptor signaling pathway(GO:0060159)
0.6 1.9 GO:0003345 proepicardium cell migration involved in pericardium morphogenesis(GO:0003345)
0.2 1.8 GO:0042756 drinking behavior(GO:0042756)
0.6 1.7 GO:0032650 regulation of interleukin-1 alpha production(GO:0032650) positive regulation of interleukin-1 alpha production(GO:0032730) cardiac cell fate determination(GO:0060913)
0.2 1.7 GO:0001977 renal system process involved in regulation of blood volume(GO:0001977)
0.0 1.6 GO:0048384 retinoic acid receptor signaling pathway(GO:0048384)
0.2 1.5 GO:2000491 positive regulation of hepatic stellate cell activation(GO:2000491)
0.2 1.5 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.4 1.4 GO:0048539 bone marrow development(GO:0048539)
0.2 1.4 GO:0045603 positive regulation of endothelial cell differentiation(GO:0045603)
0.3 1.3 GO:0046836 glycolipid transport(GO:0046836)
0.1 1.2 GO:0060272 embryonic skeletal joint morphogenesis(GO:0060272)
0.2 1.1 GO:0007386 compartment pattern specification(GO:0007386)
0.2 1.1 GO:0006287 base-excision repair, gap-filling(GO:0006287)
0.1 1.1 GO:0021678 third ventricle development(GO:0021678)
0.0 1.1 GO:0045747 positive regulation of Notch signaling pathway(GO:0045747)
0.3 1.0 GO:0000087 mitotic M phase(GO:0000087)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 73 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 3.8 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 3.7 GO:0005819 spindle(GO:0005819)
0.3 3.1 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.0 2.0 GO:0044295 axonal growth cone(GO:0044295)
0.2 1.4 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.0 1.3 GO:0031225 anchored component of membrane(GO:0031225)
0.1 1.2 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0 1.2 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.0 1.1 GO:0005689 U12-type spliceosomal complex(GO:0005689)
0.1 1.0 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.1 0.9 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.0 0.9 GO:0032839 dendrite cytoplasm(GO:0032839)
0.0 0.9 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 0.9 GO:0072562 blood microparticle(GO:0072562)
0.0 0.9 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 0.9 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.0 0.8 GO:0031941 filamentous actin(GO:0031941)
0.1 0.7 GO:0033093 Weibel-Palade body(GO:0033093)
0.1 0.7 GO:0097542 ciliary tip(GO:0097542)
0.0 0.7 GO:0005922 connexon complex(GO:0005922)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 107 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 5.0 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.0 2.3 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.1 2.2 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.1 1.9 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.1 1.8 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.1 1.8 GO:0035380 C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity(GO:0000252) mevaldate reductase activity(GO:0004495) gluconate dehydrogenase activity(GO:0008875) epoxide dehydrogenase activity(GO:0018451) 5-exo-hydroxycamphor dehydrogenase activity(GO:0018452) 2-hydroxytetrahydrofuran dehydrogenase activity(GO:0018453) acetoin dehydrogenase activity(GO:0019152) phenylcoumaran benzylic ether reductase activity(GO:0032442) D-xylose:NADP reductase activity(GO:0032866) L-arabinose:NADP reductase activity(GO:0032867) D-arabinitol dehydrogenase, D-ribulose forming (NADP+) activity(GO:0033709) (R)-(-)-1,2,3,4-tetrahydronaphthol dehydrogenase activity(GO:0034831) 3-hydroxymenthone dehydrogenase activity(GO:0034840) very long-chain-3-hydroxyacyl-CoA dehydrogenase activity(GO:0035380) dihydrotestosterone 17-beta-dehydrogenase activity(GO:0035410) (R)-2-hydroxyisocaproate dehydrogenase activity(GO:0043713) L-arabinose 1-dehydrogenase (NADP+) activity(GO:0044103) L-xylulose reductase (NAD+) activity(GO:0044105) 3-ketoglucose-reductase activity(GO:0048258) D-arabinitol dehydrogenase, D-xylulose forming (NADP+) activity(GO:0052677)
0.2 1.7 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.0 1.7 GO:0005109 frizzled binding(GO:0005109)
0.1 1.6 GO:0003708 retinoic acid receptor activity(GO:0003708)
0.0 1.6 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.2 1.5 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.1 1.5 GO:0016769 transferase activity, transferring nitrogenous groups(GO:0016769)
0.0 1.5 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.1 1.4 GO:0070888 E-box binding(GO:0070888)
0.0 1.4 GO:0005112 Notch binding(GO:0005112)
0.4 1.3 GO:0017089 glycolipid transporter activity(GO:0017089)
0.1 1.2 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.2 1.1 GO:0086056 voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056)
0.0 1.1 GO:0004364 glutathione transferase activity(GO:0004364)
0.1 1.0 GO:0022841 potassium ion leak channel activity(GO:0022841)