Motif ID: Tcf4_Mesp1

Z-value: 2.334

Transcription factors associated with Tcf4_Mesp1:

Gene SymbolEntrez IDGene Name
Mesp1 ENSMUSG00000030544.5 Mesp1
Tcf4 ENSMUSG00000053477.9 Tcf4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tcf4mm10_v2_chr18_+_69346143_693462030.291.5e-01Click!


Activity profile for motif Tcf4_Mesp1.

activity profile for motif Tcf4_Mesp1


Sorted Z-values histogram for motif Tcf4_Mesp1

Sorted Z-values for motif Tcf4_Mesp1



Network of associatons between targets according to the STRING database.



First level regulatory network of Tcf4_Mesp1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_-_66831625 24.199 ENSMUST00000164163.1
 Sla
src-like adaptor
chr13_-_57907587 20.931 ENSMUST00000172326.1
 Spock1
sparc/osteonectin, cwcv and kazal-like domains proteoglycan 1
chr11_-_67922136 15.889 ENSMUST00000021288.3
ENSMUST00000108677.1
 Usp43

ubiquitin specific peptidase 43

chr5_+_37028329 14.925 ENSMUST00000173836.1
 Jakmip1
janus kinase and microtubule interacting protein 1
chr13_+_83504032 14.067 ENSMUST00000163888.1
ENSMUST00000005722.7
 Mef2c

myocyte enhancer factor 2C

chr5_-_139130159 11.345 ENSMUST00000129851.1
 Prkar1b
protein kinase, cAMP dependent regulatory, type I beta
chr12_+_82616885 10.281 ENSMUST00000161801.1
 Rgs6
regulator of G-protein signaling 6
chr9_-_29411736 9.382 ENSMUST00000115236.1
 Ntm
neurotrimin
chr10_+_123264076 8.775 ENSMUST00000050756.7
 Fam19a2
family with sequence similarity 19, member A2
chr7_+_16310412 8.705 ENSMUST00000136781.1
 Bbc3
BCL2 binding component 3
chr16_-_97170707 8.446 ENSMUST00000056102.7
 Dscam
Down syndrome cell adhesion molecule
chr17_-_26201328 7.974 ENSMUST00000025019.2
 Arhgdig
Rho GDP dissociation inhibitor (GDI) gamma
chr15_+_98634743 7.676 ENSMUST00000003442.7
 Cacnb3
calcium channel, voltage-dependent, beta 3 subunit
chr19_-_57314896 7.580 ENSMUST00000111524.1
 Ablim1
actin-binding LIM protein 1
chr10_+_89873497 7.511 ENSMUST00000183156.1
ENSMUST00000182936.1
ENSMUST00000099368.4
 Anks1b


ankyrin repeat and sterile alpha motif domain containing 1B


chr16_+_11984581 7.433 ENSMUST00000170672.2
ENSMUST00000023138.7
 Shisa9

shisa homolog 9 (Xenopus laevis)

chr7_-_4546567 7.345 ENSMUST00000065957.5
 Syt5
synaptotagmin V
chr14_+_101729907 7.308 ENSMUST00000100337.3
 Lmo7
LIM domain only 7
chr7_+_123982799 7.199 ENSMUST00000106437.1
 Hs3st4
heparan sulfate (glucosamine) 3-O-sulfotransferase 4
chr11_+_103171081 7.043 ENSMUST00000042286.5
 Fmnl1
formin-like 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 553 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.2 22.0 GO:0031340 positive regulation of vesicle fusion(GO:0031340)
1.3 19.7 GO:0006750 glutathione biosynthetic process(GO:0006750)
0.3 18.9 GO:0010812 negative regulation of cell-substrate adhesion(GO:0010812)
0.1 16.6 GO:0050890 cognition(GO:0050890)
0.4 15.8 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
3.8 15.1 GO:1900740 regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900739) positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900740)
4.9 14.6 GO:0007521 muscle cell fate determination(GO:0007521)
1.3 12.9 GO:0048149 behavioral response to ethanol(GO:0048149)
1.8 12.8 GO:0034047 regulation of protein phosphatase type 2A activity(GO:0034047)
1.0 12.3 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.1 11.4 GO:0016579 protein deubiquitination(GO:0016579)
0.7 11.1 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.5 11.0 GO:0043496 regulation of protein homodimerization activity(GO:0043496)
0.4 10.8 GO:0095500 acetylcholine receptor signaling pathway(GO:0095500) postsynaptic signal transduction(GO:0098926) signal transduction involved in cellular response to ammonium ion(GO:1903831) response to acetylcholine(GO:1905144) cellular response to acetylcholine(GO:1905145)
0.2 10.2 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)
0.1 10.2 GO:0010977 negative regulation of neuron projection development(GO:0010977)
0.3 9.9 GO:0034605 cellular response to heat(GO:0034605)
1.2 9.7 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.2 9.6 GO:0071300 cellular response to retinoic acid(GO:0071300)
0.7 9.4 GO:0060081 membrane hyperpolarization(GO:0060081)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 219 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 31.5 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.1 31.4 GO:0097060 synaptic membrane(GO:0097060)
0.5 26.3 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.1 20.7 GO:0060076 excitatory synapse(GO:0060076)
0.1 20.6 GO:0005769 early endosome(GO:0005769)
0.6 18.2 GO:0033268 node of Ranvier(GO:0033268)
0.0 18.0 GO:0005887 integral component of plasma membrane(GO:0005887)
0.9 17.0 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.4 12.8 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.1 12.6 GO:0070382 exocytic vesicle(GO:0070382)
0.9 12.3 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.1 12.0 GO:0019898 extrinsic component of membrane(GO:0019898)
0.7 11.3 GO:0032279 asymmetric synapse(GO:0032279)
0.2 11.0 GO:0043195 terminal bouton(GO:0043195)
0.2 10.9 GO:0031901 early endosome membrane(GO:0031901)
0.1 10.7 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.3 10.0 GO:0032809 neuronal cell body membrane(GO:0032809)
0.2 9.5 GO:0044295 axonal growth cone(GO:0044295)
0.9 9.3 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.0 9.1 GO:0005768 endosome(GO:0005768)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 348 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.6 26.0 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
1.1 20.7 GO:0050811 GABA receptor binding(GO:0050811)
1.9 17.1 GO:0004416 hydroxyacylglutathione hydrolase activity(GO:0004416)
1.3 17.0 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
1.2 17.0 GO:0008601 protein phosphatase type 2A regulator activity(GO:0008601)
0.3 16.1 GO:0045499 chemorepellent activity(GO:0045499)
0.0 15.5 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
1.4 15.2 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
0.4 15.1 GO:0030552 cAMP binding(GO:0030552)
2.0 14.2 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.7 14.1 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
1.3 13.9 GO:0003680 AT DNA binding(GO:0003680)
0.1 13.1 GO:0101005 thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.4 12.4 GO:0004027 alcohol sulfotransferase activity(GO:0004027)
0.2 12.1 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.7 10.1 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.6 9.8 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.3 9.2 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.4 9.1 GO:0043274 phospholipase binding(GO:0043274)
2.9 8.6 GO:0016167 glial cell-derived neurotrophic factor receptor activity(GO:0016167)