Motif ID: Tcf7_Tcf7l2

Z-value: 1.078

Transcription factors associated with Tcf7_Tcf7l2:

Gene SymbolEntrez IDGene Name
Tcf7 ENSMUSG00000000782.9 Tcf7
Tcf7l2 ENSMUSG00000024985.12 Tcf7l2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tcf7mm10_v2_chr11_-_52282564_522825790.481.3e-02Click!
Tcf7l2mm10_v2_chr19_+_55742242_557424680.144.9e-01Click!


Activity profile for motif Tcf7_Tcf7l2.

activity profile for motif Tcf7_Tcf7l2


Sorted Z-values histogram for motif Tcf7_Tcf7l2

Sorted Z-values for motif Tcf7_Tcf7l2



Network of associatons between targets according to the STRING database.



First level regulatory network of Tcf7_Tcf7l2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_+_20737306 4.187 ENSMUST00000114606.1
ENSMUST00000114608.1
 Etl4

enhancer trap locus 4

chr13_+_24327415 4.155 ENSMUST00000167746.1
 Cmah
cytidine monophospho-N-acetylneuraminic acid hydroxylase
chr7_-_144939823 2.934 ENSMUST00000093962.4
 Ccnd1
cyclin D1
chr15_+_102296256 2.835 ENSMUST00000064924.4
 Espl1
extra spindle poles-like 1 (S. cerevisiae)
chr3_+_54481429 2.498 ENSMUST00000091130.3
 Gm5641
predicted gene 5641
chr12_-_91384403 2.463 ENSMUST00000141429.1
 Cep128
centrosomal protein 128
chr7_+_67655414 2.463 ENSMUST00000107470.1
 Ttc23
tetratricopeptide repeat domain 23
chr15_+_85859689 2.454 ENSMUST00000170629.1
 Gtse1
G two S phase expressed protein 1
chr10_-_13388753 2.205 ENSMUST00000105546.1
 Phactr2
phosphatase and actin regulator 2
chr1_-_181842334 2.098 ENSMUST00000005003.6
 Lbr
lamin B receptor
chr7_+_45216671 2.035 ENSMUST00000134420.1
 Tead2
TEA domain family member 2
chr11_+_108921648 1.972 ENSMUST00000144511.1
 Axin2
axin2
chr1_-_183147461 1.965 ENSMUST00000171366.1
 Disp1
dispatched homolog 1 (Drosophila)
chr18_+_10725651 1.896 ENSMUST00000165555.1
 Mib1
mindbomb homolog 1 (Drosophila)
chr10_-_13388830 1.885 ENSMUST00000079698.5
 Phactr2
phosphatase and actin regulator 2
chr18_+_10725530 1.871 ENSMUST00000052838.4
 Mib1
mindbomb homolog 1 (Drosophila)
chr5_-_44102032 1.845 ENSMUST00000171543.1
 Prom1
prominin 1
chr4_-_43499608 1.833 ENSMUST00000136005.1
ENSMUST00000054538.6
 Arhgef39

Rho guanine nucleotide exchange factor (GEF) 39

chr10_-_92165159 1.805 ENSMUST00000182567.1
ENSMUST00000181604.2
ENSMUST00000181213.1
 Rmst


rhabdomyosarcoma 2 associated transcript (non-coding RNA)


chr11_-_87108656 1.777 ENSMUST00000051395.8
 Prr11
proline rich 11

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 142 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 4.3 GO:0048706 embryonic skeletal system development(GO:0048706)
1.4 4.2 GO:0046381 CMP-N-acetylneuraminate metabolic process(GO:0046381)
1.0 4.2 GO:2000054 negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification(GO:2000054)
0.3 4.1 GO:0000212 meiotic spindle organization(GO:0000212)
0.1 3.5 GO:0001947 heart looping(GO:0001947)
0.2 3.3 GO:0031987 locomotion involved in locomotory behavior(GO:0031987)
0.4 2.9 GO:0000320 re-entry into mitotic cell cycle(GO:0000320)
0.1 2.3 GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902043)
0.0 2.1 GO:0016126 sterol biosynthetic process(GO:0016126)
0.3 2.0 GO:0072257 metanephric nephron tubule epithelial cell differentiation(GO:0072257) regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072307)
0.2 2.0 GO:0060539 diaphragm development(GO:0060539)
0.1 2.0 GO:0030903 notochord development(GO:0030903)
0.6 1.8 GO:0072139 glomerular parietal epithelial cell differentiation(GO:0072139)
0.1 1.8 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.1 1.8 GO:0007638 mechanosensory behavior(GO:0007638)
0.3 1.6 GO:0015671 oxygen transport(GO:0015671)
0.5 1.5 GO:0014005 microglia differentiation(GO:0014004) microglia development(GO:0014005)
0.1 1.5 GO:0042711 maternal behavior(GO:0042711)
0.0 1.5 GO:1902017 regulation of cilium assembly(GO:1902017)
0.0 1.4 GO:0000245 spliceosomal complex assembly(GO:0000245)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 68 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 9.1 GO:0005667 transcription factor complex(GO:0005667)
0.1 3.4 GO:0030877 beta-catenin destruction complex(GO:0030877)
0.1 2.9 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 2.9 GO:0000922 spindle pole(GO:0000922)
0.1 2.7 GO:0008305 integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636)
0.0 2.7 GO:0072686 mitotic spindle(GO:0072686)
0.0 2.5 GO:0005813 centrosome(GO:0005813)
0.1 2.1 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.0 1.9 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
0.6 1.8 GO:0071914 prominosome(GO:0071914)
0.3 1.7 GO:0036449 microtubule minus-end(GO:0036449)
0.2 1.6 GO:0005833 hemoglobin complex(GO:0005833)
0.1 1.5 GO:0097539 ciliary transition fiber(GO:0097539)
0.1 1.5 GO:0016460 myosin II complex(GO:0016460)
0.1 1.5 GO:0010369 chromocenter(GO:0010369)
0.0 1.5 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.0 1.4 GO:0016605 PML body(GO:0016605)
0.3 1.2 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.2 1.2 GO:0070695 FHF complex(GO:0070695)
0.1 1.2 GO:0030056 hemidesmosome(GO:0030056)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 96 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 5.2 GO:0043774 UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity(GO:0008766) ribosomal S6-glutamic acid ligase activity(GO:0018169) coenzyme F420-0 gamma-glutamyl ligase activity(GO:0043773) coenzyme F420-2 alpha-glutamyl ligase activity(GO:0043774) protein-glycine ligase activity(GO:0070735) protein-glycine ligase activity, initiating(GO:0070736) protein-glycine ligase activity, elongating(GO:0070737) tubulin-glycine ligase activity(GO:0070738)
1.4 4.2 GO:0016716 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen(GO:0016716)
0.2 4.2 GO:0070411 I-SMAD binding(GO:0070411)
0.0 3.4 GO:0008017 microtubule binding(GO:0008017)
0.0 3.0 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.1 2.7 GO:0070064 proline-rich region binding(GO:0070064)
0.0 2.7 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.4 2.4 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.0 2.4 GO:0070491 repressing transcription factor binding(GO:0070491)
0.2 2.3 GO:0001846 opsonin binding(GO:0001846)
0.3 2.1 GO:0070087 chromo shadow domain binding(GO:0070087)
0.2 2.0 GO:0015197 peptide transporter activity(GO:0015197)
0.0 2.0 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.0 2.0 GO:0003714 transcription corepressor activity(GO:0003714)
0.2 1.9 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.0 1.8 GO:0008748 N-ethylmaleimide reductase activity(GO:0008748) reduced coenzyme F420 dehydrogenase activity(GO:0043738) sulfur oxygenase reductase activity(GO:0043826) malolactic enzyme activity(GO:0043883) epoxyqueuosine reductase activity(GO:0052693)
0.1 1.7 GO:0070410 co-SMAD binding(GO:0070410)
0.3 1.6 GO:0005344 oxygen transporter activity(GO:0005344)
0.1 1.6 GO:0017025 TBP-class protein binding(GO:0017025)
0.0 1.6 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)