Motif ID: Tcf7l1

Z-value: 0.893


Transcription factors associated with Tcf7l1:

Gene SymbolEntrez IDGene Name
Tcf7l1 ENSMUSG00000055799.7 Tcf7l1

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tcf7l1mm10_v2_chr6_-_72788952_727890610.562.9e-03Click!


Activity profile for motif Tcf7l1.

activity profile for motif Tcf7l1


Sorted Z-values histogram for motif Tcf7l1

Sorted Z-values for motif Tcf7l1



Network of associatons between targets according to the STRING database.



First level regulatory network of Tcf7l1

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr17_-_70851189 2.793 ENSMUST00000059775.8
 Tgif1
TGFB-induced factor homeobox 1
chr14_-_98169542 2.688 ENSMUST00000069334.7
ENSMUST00000071533.6
 Dach1

dachshund 1 (Drosophila)

chr11_+_108920800 2.674 ENSMUST00000140821.1
 Axin2
axin2
chr3_+_131110350 2.641 ENSMUST00000066849.6
ENSMUST00000106341.2
ENSMUST00000029611.7
 Lef1


lymphoid enhancer binding factor 1


chr7_-_49636847 2.045 ENSMUST00000032717.6
 Dbx1
developing brain homeobox 1
chr2_+_70474923 1.789 ENSMUST00000100043.2
 Sp5
trans-acting transcription factor 5
chr7_+_45216671 1.782 ENSMUST00000134420.1
 Tead2
TEA domain family member 2
chr1_-_183147461 1.760 ENSMUST00000171366.1
 Disp1
dispatched homolog 1 (Drosophila)
chr15_+_34238026 1.728 ENSMUST00000022867.3
 Laptm4b
lysosomal-associated protein transmembrane 4B
chrX_-_48034842 1.718 ENSMUST00000039026.7
 Apln
apelin
chr2_-_180889660 1.635 ENSMUST00000137629.1
 Gm14342
predicted gene 14342
chr2_+_173021902 1.399 ENSMUST00000029014.9
 Rbm38
RNA binding motif protein 38
chr2_+_173022360 1.355 ENSMUST00000173997.1
 Rbm38
RNA binding motif protein 38
chr7_+_100493795 1.323 ENSMUST00000129324.1
 Ucp2
uncoupling protein 2 (mitochondrial, proton carrier)
chr18_-_62756275 1.319 ENSMUST00000067450.1
ENSMUST00000048109.5
 2700046A07Rik

RIKEN cDNA 2700046A07 gene

chr11_+_108921648 1.230 ENSMUST00000144511.1
 Axin2
axin2
chr9_+_85842852 1.201 ENSMUST00000098500.3
 Tpbg
trophoblast glycoprotein
chrX_-_134161928 1.194 ENSMUST00000033611.4
 Xkrx
X Kell blood group precursor related X linked
chr7_-_144939823 1.187 ENSMUST00000093962.4
 Ccnd1
cyclin D1
chr17_-_89910449 1.164 ENSMUST00000086423.4
 Gm10184
predicted pseudogene 10184

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 107 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.2 4.7 GO:2000054 negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification(GO:2000054)
0.2 2.9 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.2 2.8 GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest(GO:0006977)
0.9 2.7 GO:0060244 negative regulation of cell proliferation involved in contact inhibition(GO:0060244)
0.9 2.6 GO:0032696 negative regulation of interleukin-13 production(GO:0032696) odontoblast differentiation(GO:0071895) regulation of estrogen receptor binding(GO:0071898) negative regulation of estrogen receptor binding(GO:0071899)
0.1 2.0 GO:0021521 ventral spinal cord interneuron specification(GO:0021521) cell fate specification involved in pattern specification(GO:0060573)
0.2 1.8 GO:0060539 diaphragm development(GO:0060539)
0.1 1.8 GO:0048368 lateral mesoderm development(GO:0048368)
0.1 1.8 GO:0036342 post-anal tail morphogenesis(GO:0036342)
0.2 1.7 GO:0051461 positive regulation of heat generation(GO:0031652) regulation of corticotropin secretion(GO:0051459) positive regulation of corticotropin secretion(GO:0051461)
0.1 1.7 GO:0048617 embryonic foregut morphogenesis(GO:0048617)
0.0 1.5 GO:2001222 regulation of neuron migration(GO:2001222)
0.1 1.3 GO:0061179 negative regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061179)
0.2 1.2 GO:0000320 re-entry into mitotic cell cycle(GO:0000320)
0.2 1.2 GO:1903300 negative regulation of glucokinase activity(GO:0033132) negative regulation of hexokinase activity(GO:1903300)
0.0 1.1 GO:0009409 response to cold(GO:0009409)
0.3 1.0 GO:1904059 regulation of locomotor rhythm(GO:1904059)
0.2 1.0 GO:0072257 metanephric nephron tubule epithelial cell differentiation(GO:0072257) regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072307)
0.2 1.0 GO:0060040 retinal bipolar neuron differentiation(GO:0060040)
0.0 1.0 GO:0071300 cellular response to retinoic acid(GO:0071300)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 38 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 10.9 GO:0005667 transcription factor complex(GO:0005667)
0.2 3.9 GO:0030877 beta-catenin destruction complex(GO:0030877)
0.3 3.4 GO:1990907 beta-catenin-TCF complex(GO:1990907)
0.1 1.5 GO:0071564 npBAF complex(GO:0071564)
0.0 1.5 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.2 1.1 GO:0008623 CHRAC(GO:0008623)
0.1 1.1 GO:0016580 Sin3 complex(GO:0016580)
0.1 1.0 GO:0001739 sex chromatin(GO:0001739)
0.0 1.0 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 1.0 GO:0001772 immunological synapse(GO:0001772)
0.2 0.9 GO:0044294 dendritic growth cone(GO:0044294)
0.1 0.9 GO:0044530 supraspliceosomal complex(GO:0044530)
0.3 0.8 GO:0033193 Lsd1/2 complex(GO:0033193)
0.2 0.7 GO:0031502 dolichyl-phosphate-mannose-protein mannosyltransferase complex(GO:0031502)
0.1 0.6 GO:0070578 RISC-loading complex(GO:0070578)
0.1 0.6 GO:0005851 eukaryotic translation initiation factor 2B complex(GO:0005851)
0.1 0.6 GO:0031105 septin complex(GO:0031105)
0.0 0.6 GO:0036038 MKS complex(GO:0036038)
0.0 0.6 GO:0016460 myosin II complex(GO:0016460)
0.1 0.4 GO:0001533 cornified envelope(GO:0001533)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 64 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.2 4.7 GO:0070411 I-SMAD binding(GO:0070411)
0.2 2.8 GO:0070410 co-SMAD binding(GO:0070410)
0.0 2.8 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.9 2.7 GO:0001075 transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075)
0.4 2.6 GO:0030284 estrogen receptor activity(GO:0030284)
0.1 2.5 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.0 1.7 GO:0071889 14-3-3 protein binding(GO:0071889)
0.0 1.7 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.0 1.7 GO:0001047 core promoter binding(GO:0001047)
0.1 1.6 GO:0015197 peptide transporter activity(GO:0015197)
0.0 1.5 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.1 1.3 GO:0070064 proline-rich region binding(GO:0070064)
0.0 1.1 GO:0033613 activating transcription factor binding(GO:0033613)
0.3 0.9 GO:0008311 double-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008311)
0.3 0.9 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.3 0.9 GO:0005118 sevenless binding(GO:0005118)
0.2 0.9 GO:0005113 patched binding(GO:0005113)
0.1 0.9 GO:0034711 inhibin binding(GO:0034711)
0.0 0.9 GO:0045295 gamma-catenin binding(GO:0045295)
0.0 0.9 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)