Motif ID: Tead3_Tead4

Z-value: 2.243

Transcription factors associated with Tead3_Tead4:

Gene SymbolEntrez IDGene Name
Tead3 ENSMUSG00000002249.11 Tead3
Tead4 ENSMUSG00000030353.9 Tead4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tead3mm10_v2_chr17_-_28350600_283506810.671.6e-04Click!


Activity profile for motif Tead3_Tead4.

activity profile for motif Tead3_Tead4


Sorted Z-values histogram for motif Tead3_Tead4

Sorted Z-values for motif Tead3_Tead4



Network of associatons between targets according to the STRING database.



First level regulatory network of Tead3_Tead4

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_+_24595434 13.841 ENSMUST00000020171.5
 Ctgf
connective tissue growth factor
chr10_+_24595623 13.145 ENSMUST00000176228.1
ENSMUST00000129142.1
 Ctgf

connective tissue growth factor

chr4_-_43558386 9.369 ENSMUST00000130353.1
 Tln1
talin 1
chr15_+_6386598 7.508 ENSMUST00000080880.5
ENSMUST00000110664.2
ENSMUST00000110663.2
ENSMUST00000161812.1
ENSMUST00000160134.1
 Dab2




disabled 2, mitogen-responsive phosphoprotein




chr18_+_23415400 7.402 ENSMUST00000115832.2
ENSMUST00000047954.7
 Dtna

dystrobrevin alpha

chr1_+_189728264 7.213 ENSMUST00000097442.2
 Ptpn14
protein tyrosine phosphatase, non-receptor type 14
chr18_+_50030977 6.737 ENSMUST00000145726.1
ENSMUST00000128377.1
 Tnfaip8

tumor necrosis factor, alpha-induced protein 8

chr14_-_54577578 6.616 ENSMUST00000054487.8
 Ajuba
ajuba LIM protein
chr5_-_137314175 6.190 ENSMUST00000024119.9
 Trip6
thyroid hormone receptor interactor 6
chr12_-_80112998 6.093 ENSMUST00000165114.1
ENSMUST00000021552.1
 Zfp36l1

zinc finger protein 36, C3H type-like 1

chr11_-_5381734 5.709 ENSMUST00000172492.1
 Znrf3
zinc and ring finger 3
chr18_+_50053282 5.515 ENSMUST00000148159.2
 Tnfaip8
tumor necrosis factor, alpha-induced protein 8
chr18_-_78206408 5.395 ENSMUST00000163367.1
 Slc14a2
solute carrier family 14 (urea transporter), member 2
chr11_+_112782182 5.183 ENSMUST00000000579.2
 Sox9
SRY-box containing gene 9
chr6_+_146888481 5.161 ENSMUST00000016631.7
ENSMUST00000111623.2
 Ppfibp1

PTPRF interacting protein, binding protein 1 (liprin beta 1)

chr7_-_109616548 5.083 ENSMUST00000077909.1
ENSMUST00000084738.3
 St5

suppression of tumorigenicity 5

chr10_+_93641041 4.984 ENSMUST00000020204.4
 Ntn4
netrin 4
chr11_+_98412461 4.797 ENSMUST00000058295.5
 Erbb2
v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
chr10_-_78591945 4.735 ENSMUST00000040580.6
 Syde1
synapse defective 1, Rho GTPase, homolog 1 (C. elegans)
chr8_-_61760067 4.689 ENSMUST00000121493.1
 Palld
palladin, cytoskeletal associated protein

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 181 entries
Log-likelihood per target Total log-likelihoodTermDescription
6.7 27.0 GO:0070318 positive regulation of G0 to G1 transition(GO:0070318)
0.2 11.9 GO:0032611 interleukin-1 beta production(GO:0032611)
1.4 11.4 GO:0007016 cytoskeletal anchoring at plasma membrane(GO:0007016)
1.5 7.5 GO:0032346 positive regulation of aldosterone metabolic process(GO:0032346) positive regulation of aldosterone biosynthetic process(GO:0032349) regulation of Rho-dependent protein serine/threonine kinase activity(GO:2000298)
0.5 7.4 GO:0035269 protein O-linked mannosylation(GO:0035269)
1.5 7.3 GO:0035331 negative regulation of hippo signaling(GO:0035331)
1.0 7.3 GO:0072257 metanephric nephron tubule epithelial cell differentiation(GO:0072257) regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072307)
1.6 6.6 GO:1903251 multi-ciliated epithelial cell differentiation(GO:1903251)
1.3 6.3 GO:2000065 negative regulation of aldosterone metabolic process(GO:0032345) negative regulation of aldosterone biosynthetic process(GO:0032348) regulation of cortisol biosynthetic process(GO:2000064) negative regulation of cortisol biosynthetic process(GO:2000065)
1.0 6.2 GO:0007253 cytoplasmic sequestering of NF-kappaB(GO:0007253)
0.6 6.1 GO:0060710 chorio-allantoic fusion(GO:0060710)
0.3 6.1 GO:0001946 lymphangiogenesis(GO:0001946) lymph vessel morphogenesis(GO:0036303)
1.2 6.0 GO:0038018 Wnt receptor catabolic process(GO:0038018)
0.0 5.5 GO:0008360 regulation of cell shape(GO:0008360)
1.8 5.4 GO:2001139 negative regulation of postsynaptic membrane organization(GO:1901627) negative regulation of dendritic spine maintenance(GO:1902951) negative regulation of phospholipid efflux(GO:1902999) regulation of lipid transport across blood brain barrier(GO:1903000) negative regulation of lipid transport across blood brain barrier(GO:1903001) positive regulation of lipid transport across blood brain barrier(GO:1903002) negative regulation of phospholipid transport(GO:2001139)
0.8 5.4 GO:0015840 urea transport(GO:0015840) urea transmembrane transport(GO:0071918)
1.7 5.2 GO:0035622 intrahepatic bile duct development(GO:0035622) renal vesicle induction(GO:0072034)
0.1 5.1 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
1.0 5.0 GO:0035426 extracellular matrix-cell signaling(GO:0035426)
1.6 4.8 GO:0044849 estrous cycle(GO:0044849)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 90 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 40.8 GO:0005925 focal adhesion(GO:0005925)
0.5 24.9 GO:0005801 cis-Golgi network(GO:0005801)
0.0 16.3 GO:0005667 transcription factor complex(GO:0005667)
0.5 8.9 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
2.6 7.9 GO:0005595 collagen type XII trimer(GO:0005595) anchoring collagen complex(GO:0030934)
1.9 7.5 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.0 7.1 GO:0005789 endoplasmic reticulum membrane(GO:0005789)
0.1 6.7 GO:0017053 transcriptional repressor complex(GO:0017053)
0.8 6.6 GO:0098536 deuterosome(GO:0098536)
0.5 6.4 GO:0005614 interstitial matrix(GO:0005614)
0.1 5.7 GO:0005871 kinesin complex(GO:0005871)
1.8 5.4 GO:0034363 intermediate-density lipoprotein particle(GO:0034363)
0.1 5.0 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.1 5.0 GO:0005604 basement membrane(GO:0005604)
0.4 4.8 GO:0043219 lateral loop(GO:0043219)
0.2 4.7 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.2 4.7 GO:0002102 podosome(GO:0002102)
0.0 4.5 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
1.5 4.4 GO:0097058 CRLF-CLCF1 complex(GO:0097058)
0.9 3.7 GO:0036454 insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454) insulin-like growth factor ternary complex(GO:0042567)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 123 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.5 34.0 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.1 13.9 GO:0051015 actin filament binding(GO:0051015)
0.2 12.9 GO:0030971 receptor tyrosine kinase binding(GO:0030971)
0.3 11.7 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.9 9.4 GO:0030274 LIM domain binding(GO:0030274)
1.5 7.7 GO:0018121 imidazoleglycerol-phosphate synthase activity(GO:0000107) NAD(P)-cysteine ADP-ribosyltransferase activity(GO:0018071) NAD(P)-asparagine ADP-ribosyltransferase activity(GO:0018121) NAD(P)-serine ADP-ribosyltransferase activity(GO:0018127) 7-cyano-7-deazaguanine tRNA-ribosyltransferase activity(GO:0043867) purine deoxyribosyltransferase activity(GO:0044102)
0.0 7.7 GO:0008022 protein C-terminus binding(GO:0008022)
0.8 7.5 GO:0035615 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.2 7.5 GO:0017091 AU-rich element binding(GO:0017091)
0.3 6.8 GO:0017049 GTP-Rho binding(GO:0017049)
0.6 6.6 GO:0045294 alpha-catenin binding(GO:0045294)
0.9 6.4 GO:0005127 ciliary neurotrophic factor receptor binding(GO:0005127)
0.5 6.2 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.9 6.1 GO:0004716 receptor signaling protein tyrosine kinase activity(GO:0004716)
0.2 5.9 GO:0005109 frizzled binding(GO:0005109)
0.1 5.7 GO:0003777 microtubule motor activity(GO:0003777)
0.0 5.6 GO:0005539 glycosaminoglycan binding(GO:0005539)
1.8 5.4 GO:0046911 hydroxyapatite binding(GO:0046848) metal chelating activity(GO:0046911) phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228)
0.9 5.4 GO:0015265 urea channel activity(GO:0015265)
0.0 5.3 GO:0030165 PDZ domain binding(GO:0030165)