Motif ID: Tfap2a

Z-value: 1.447


Transcription factors associated with Tfap2a:

Gene SymbolEntrez IDGene Name
Tfap2a ENSMUSG00000021359.9 Tfap2a

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tfap2amm10_v2_chr13_-_40733768_40733836-0.262.0e-01Click!


Activity profile for motif Tfap2a.

activity profile for motif Tfap2a


Sorted Z-values histogram for motif Tfap2a

Sorted Z-values for motif Tfap2a



Network of associatons between targets according to the STRING database.



First level regulatory network of Tfap2a

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_-_64046925 6.867 ENSMUST00000107377.3
 Tnc
tenascin C
chr11_+_32296489 6.573 ENSMUST00000093207.3
 Hba-a2
hemoglobin alpha, adult chain 2
chr17_+_69969073 5.641 ENSMUST00000133983.1
 Dlgap1
discs, large (Drosophila) homolog-associated protein 1
chr1_+_159737510 4.987 ENSMUST00000111669.3
 Tnr
tenascin R
chr17_+_69969217 4.979 ENSMUST00000060072.5
 Dlgap1
discs, large (Drosophila) homolog-associated protein 1
chr17_+_69969387 4.937 ENSMUST00000146730.1
 Dlgap1
discs, large (Drosophila) homolog-associated protein 1
chr5_-_146585239 4.436 ENSMUST00000036211.6
 Gpr12
G-protein coupled receptor 12
chr11_-_102897123 4.226 ENSMUST00000067444.3
 Gfap
glial fibrillary acidic protein
chr8_+_70493156 4.151 ENSMUST00000008032.7
 Crlf1
cytokine receptor-like factor 1
chr13_+_54949388 3.789 ENSMUST00000026994.7
ENSMUST00000109994.2
 Unc5a

unc-5 homolog A (C. elegans)

chr5_+_117841839 3.731 ENSMUST00000142742.2
 Nos1
nitric oxide synthase 1, neuronal
chr11_-_116110211 3.286 ENSMUST00000106441.1
ENSMUST00000021120.5
 Trim47

tripartite motif-containing 47

chr10_+_81575306 2.969 ENSMUST00000146916.1
 Tle2
transducin-like enhancer of split 2, homolog of Drosophila E(spl)
chr9_+_26733728 2.759 ENSMUST00000160899.1
ENSMUST00000161431.1
ENSMUST00000159799.1
 B3gat1


beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P)


chr10_-_86498836 2.752 ENSMUST00000120638.1
 Syn3
synapsin III
chr13_-_110280103 2.749 ENSMUST00000167824.1
 Rab3c
RAB3C, member RAS oncogene family
chr10_+_79716588 2.724 ENSMUST00000099513.1
ENSMUST00000020581.2
 Hcn2

hyperpolarization-activated, cyclic nucleotide-gated K+ 2

chr11_-_102897146 2.681 ENSMUST00000077902.4
 Gfap
glial fibrillary acidic protein
chr10_+_100015817 2.535 ENSMUST00000130190.1
ENSMUST00000020129.7
 Kitl

kit ligand

chr4_-_148287927 2.485 ENSMUST00000047720.8
 Ptchd2
patched domain containing 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 219 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.2 15.6 GO:0070842 aggresome assembly(GO:0070842)
0.2 8.4 GO:0048821 erythrocyte development(GO:0048821)
1.9 7.6 GO:0014012 peripheral nervous system axon regeneration(GO:0014012)
1.4 6.9 GO:0010624 regulation of Schwann cell proliferation(GO:0010624)
0.3 6.8 GO:0050650 chondroitin sulfate proteoglycan biosynthetic process(GO:0050650)
1.7 5.0 GO:0048686 regulation of sprouting of injured axon(GO:0048686) regulation of axon extension involved in regeneration(GO:0048690)
0.9 4.4 GO:0070305 response to cGMP(GO:0070305) cellular response to cGMP(GO:0071321)
0.7 4.2 GO:2000672 negative regulation of motor neuron apoptotic process(GO:2000672)
0.5 3.8 GO:0033564 anterior/posterior axon guidance(GO:0033564)
0.9 3.7 GO:1901204 positive regulation of guanylate cyclase activity(GO:0031284) regulation of adrenergic receptor signaling pathway involved in heart process(GO:1901204)
0.6 3.2 GO:0034441 plasma lipoprotein particle oxidation(GO:0034441)
0.1 3.2 GO:0095500 acetylcholine receptor signaling pathway(GO:0095500) postsynaptic signal transduction(GO:0098926) signal transduction involved in cellular response to ammonium ion(GO:1903831) response to acetylcholine(GO:1905144) cellular response to acetylcholine(GO:1905145)
0.0 3.2 GO:0006874 cellular calcium ion homeostasis(GO:0006874)
0.1 2.9 GO:2000310 regulation of N-methyl-D-aspartate selective glutamate receptor activity(GO:2000310)
0.2 2.8 GO:0050832 defense response to fungus(GO:0050832)
0.2 2.7 GO:0090084 negative regulation of inclusion body assembly(GO:0090084)
0.0 2.7 GO:0017157 regulation of exocytosis(GO:0017157)
0.0 2.6 GO:0099643 neurotransmitter secretion(GO:0007269) signal release from synapse(GO:0099643)
0.6 2.5 GO:0033024 mast cell homeostasis(GO:0033023) mast cell apoptotic process(GO:0033024) regulation of mast cell apoptotic process(GO:0033025)
0.0 2.5 GO:0008203 cholesterol metabolic process(GO:0008203)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 105 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 15.9 GO:0045211 postsynaptic membrane(GO:0045211)
2.2 8.8 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.1 8.1 GO:0032589 neuron projection membrane(GO:0032589)
1.7 6.9 GO:0097450 astrocyte end-foot(GO:0097450)
0.4 6.9 GO:0005614 interstitial matrix(GO:0005614)
1.7 5.0 GO:0072534 perineuronal net(GO:0072534)
0.1 4.9 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
1.4 4.2 GO:0097058 CRLF-CLCF1 complex(GO:0097058)
0.3 3.6 GO:0042582 primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.2 3.6 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.1 3.6 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.0 3.3 GO:0030426 growth cone(GO:0030426)
0.2 3.2 GO:0034362 low-density lipoprotein particle(GO:0034362)
0.1 2.9 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.1 2.4 GO:0045334 clathrin-coated endocytic vesicle(GO:0045334)
0.1 2.4 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 2.4 GO:0008021 synaptic vesicle(GO:0008021)
0.3 2.3 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.1 2.3 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.1 2.3 GO:0043218 compact myelin(GO:0043218)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 157 entries
Log-likelihood per target Total log-likelihoodTermDescription
2.2 8.8 GO:0031720 haptoglobin binding(GO:0031720)
0.1 8.0 GO:0017137 Rab GTPase binding(GO:0017137)
0.1 7.5 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
1.2 7.2 GO:0045545 syndecan binding(GO:0045545)
1.1 6.8 GO:0015018 galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity(GO:0015018)
0.4 6.1 GO:0046625 sphingolipid binding(GO:0046625)
0.4 4.4 GO:0031210 phosphatidylcholine binding(GO:0031210)
0.6 4.2 GO:0005127 ciliary neurotrophic factor receptor binding(GO:0005127)
0.0 4.0 GO:0030695 GTPase regulator activity(GO:0030695)
0.6 3.8 GO:0005042 netrin receptor activity(GO:0005042)
1.2 3.7 GO:0004517 nitric-oxide synthase activity(GO:0004517)
0.0 3.6 GO:0003714 transcription corepressor activity(GO:0003714)
0.1 3.4 GO:0030971 receptor tyrosine kinase binding(GO:0030971)
0.3 3.3 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.4 3.2 GO:0003847 1-alkyl-2-acetylglycerophosphocholine esterase activity(GO:0003847) calcium-independent phospholipase A2 activity(GO:0047499)
0.4 2.8 GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934)
0.5 2.7 GO:0005222 intracellular cAMP activated cation channel activity(GO:0005222)
0.1 2.7 GO:0031489 myosin V binding(GO:0031489)
0.1 2.7 GO:0030552 cAMP binding(GO:0030552)
0.9 2.6 GO:0030549 acetylcholine receptor activator activity(GO:0030549)