Motif ID: Tfap2d

Z-value: 0.934


Transcription factors associated with Tfap2d:

Gene SymbolEntrez IDGene Name
Tfap2d ENSMUSG00000042596.7 Tfap2d

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tfap2dmm10_v2_chr1_+_19103022_19103043-0.461.8e-02Click!


Activity profile for motif Tfap2d.

activity profile for motif Tfap2d


Sorted Z-values histogram for motif Tfap2d

Sorted Z-values for motif Tfap2d



Network of associatons between targets according to the STRING database.



First level regulatory network of Tfap2d

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr13_+_72628802 3.440 ENSMUST00000074372.4
 Irx2
Iroquois related homeobox 2 (Drosophila)
chr5_-_24527276 3.275 ENSMUST00000088311.4
 Gbx1
gastrulation brain homeobox 1
chr18_+_82910863 2.934 ENSMUST00000171238.1
 Zfp516
zinc finger protein 516
chr8_+_92357787 2.843 ENSMUST00000034184.10
 Irx5
Iroquois related homeobox 5 (Drosophila)
chr2_-_28916412 2.525 ENSMUST00000050776.2
ENSMUST00000113849.1
 Barhl1

BarH-like 1 (Drosophila)

chr5_+_28165690 2.452 ENSMUST00000036177.7
 En2
engrailed 2
chr4_+_114406717 2.403 ENSMUST00000094894.3
 Trabd2b
TraB domain containing 2B
chr7_-_70360593 2.278 ENSMUST00000032768.7
 Nr2f2
nuclear receptor subfamily 2, group F, member 2
chr4_-_106464167 2.227 ENSMUST00000049507.5
 Pcsk9
proprotein convertase subtilisin/kexin type 9
chr11_+_120949053 2.222 ENSMUST00000154187.1
ENSMUST00000100130.3
ENSMUST00000129473.1
ENSMUST00000168579.1
 Slc16a3



solute carrier family 16 (monocarboxylic acid transporters), member 3



chr2_+_119742306 2.057 ENSMUST00000028758.7
 Itpka
inositol 1,4,5-trisphosphate 3-kinase A
chr4_-_140774196 2.035 ENSMUST00000026381.6
 Padi4
peptidyl arginine deiminase, type IV
chr9_+_107400043 2.034 ENSMUST00000166799.1
ENSMUST00000170737.1
 Cacna2d2

calcium channel, voltage-dependent, alpha 2/delta subunit 2

chr18_+_64340225 1.939 ENSMUST00000175965.2
ENSMUST00000115145.3
 Onecut2

one cut domain, family member 2

chr6_+_107529717 1.869 ENSMUST00000049285.8
 Lrrn1
leucine rich repeat protein 1, neuronal
chr2_-_147085445 1.801 ENSMUST00000067020.2
 Nkx2-4
NK2 homeobox 4
chr7_+_129257027 1.779 ENSMUST00000094018.4
 Ppapdc1a
phosphatidic acid phosphatase type 2 domain containing 1A
chr9_-_119578981 1.745 ENSMUST00000117911.1
ENSMUST00000120420.1
 Scn5a

sodium channel, voltage-gated, type V, alpha

chr11_+_59306920 1.723 ENSMUST00000000128.3
ENSMUST00000108783.3
 Wnt9a

wingless-type MMTV integration site 9A

chr19_+_42147373 1.666 ENSMUST00000061111.9
 Marveld1
MARVEL (membrane-associating) domain containing 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 143 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.8 3.3 GO:0097374 sensory neuron axon guidance(GO:0097374)
0.5 2.8 GO:0060040 retinal bipolar neuron differentiation(GO:0060040)
0.2 2.5 GO:1990403 embryonic brain development(GO:1990403)
0.3 2.4 GO:0018158 protein oxidation(GO:0018158)
0.2 2.4 GO:0006020 inositol metabolic process(GO:0006020)
0.1 2.4 GO:0050873 brown fat cell differentiation(GO:0050873)
0.5 2.3 GO:0006447 regulation of translational initiation by iron(GO:0006447) positive regulation of translational initiation by iron(GO:0045994)
0.5 2.3 GO:0060838 lymphatic endothelial cell fate commitment(GO:0060838) regulation of transcription involved in lymphatic endothelial cell fate commitment(GO:0060849)
0.7 2.2 GO:0010989 negative regulation of low-density lipoprotein particle clearance(GO:0010989)
0.1 2.2 GO:0035873 lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873) plasma membrane lactate transport(GO:0035879)
0.0 2.2 GO:0030901 midbrain development(GO:0030901)
0.2 2.1 GO:0044458 motile cilium assembly(GO:0044458)
0.3 2.0 GO:0060024 rhythmic synaptic transmission(GO:0060024)
0.2 2.0 GO:0019240 citrulline biosynthetic process(GO:0019240)
0.3 1.9 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.6 1.7 GO:0086017 response to inactivity(GO:0014854) response to muscle inactivity(GO:0014870) response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894) Purkinje myocyte action potential(GO:0086017) membrane depolarization during SA node cell action potential(GO:0086046)
0.1 1.7 GO:0032331 negative regulation of chondrocyte differentiation(GO:0032331)
0.4 1.6 GO:0035795 negative regulation of mitochondrial membrane permeability(GO:0035795)
0.4 1.6 GO:1900145 regulation of nodal signaling pathway involved in determination of left/right asymmetry(GO:1900145) regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry(GO:1900175) positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry(GO:1900224)
0.1 1.6 GO:0001973 adenosine receptor signaling pathway(GO:0001973)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 54 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 2.7 GO:0005844 polysome(GO:0005844)
0.7 2.2 GO:1990667 PCSK9-AnxA2 complex(GO:1990667)
0.0 2.1 GO:0043197 dendritic spine(GO:0043197)
0.0 2.1 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.0 2.0 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 2.0 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.0 1.9 GO:0005681 spliceosomal complex(GO:0005681)
0.3 1.8 GO:0005827 polar microtubule(GO:0005827)
0.1 1.7 GO:0034706 voltage-gated sodium channel complex(GO:0001518) sodium channel complex(GO:0034706)
0.0 1.5 GO:0036126 sperm flagellum(GO:0036126)
0.1 1.4 GO:0042612 MHC class I protein complex(GO:0042612)
0.1 1.4 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 1.4 GO:0016459 myosin complex(GO:0016459)
0.0 1.3 GO:0005923 bicellular tight junction(GO:0005923)
0.2 1.2 GO:0001940 male pronucleus(GO:0001940)
0.1 1.2 GO:0042555 MCM complex(GO:0042555)
0.1 1.2 GO:0001741 XY body(GO:0001741)
0.0 1.2 GO:0016591 DNA-directed RNA polymerase II, holoenzyme(GO:0016591)
0.0 1.2 GO:0016605 PML body(GO:0016605)
0.0 1.2 GO:0005925 focal adhesion(GO:0005925)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 104 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 10.7 GO:0043565 sequence-specific DNA binding(GO:0043565)
0.0 9.2 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.2 3.8 GO:0008266 poly(U) RNA binding(GO:0008266)
0.1 3.3 GO:0017147 Wnt-protein binding(GO:0017147)
0.0 3.0 GO:0033613 activating transcription factor binding(GO:0033613)
0.1 2.5 GO:0005109 frizzled binding(GO:0005109)
0.5 2.3 GO:0032027 myosin light chain binding(GO:0032027)
0.4 2.3 GO:0070644 vitamin D response element binding(GO:0070644)
0.3 2.3 GO:0001972 retinoic acid binding(GO:0001972)
0.7 2.2 GO:0034190 very-low-density lipoprotein particle binding(GO:0034189) apolipoprotein receptor binding(GO:0034190)
0.1 2.2 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.3 2.1 GO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440)
0.3 2.0 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.0 2.0 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.2 1.7 GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential(GO:0086006)
0.3 1.6 GO:0008865 fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.1 1.6 GO:0005112 Notch binding(GO:0005112)
0.1 1.5 GO:0001047 core promoter binding(GO:0001047)
0.1 1.5 GO:0048018 receptor agonist activity(GO:0048018)
0.0 1.5 GO:0005179 hormone activity(GO:0005179)