Motif ID: Tfap4

Z-value: 1.232


Transcription factors associated with Tfap4:

Gene SymbolEntrez IDGene Name
Tfap4 ENSMUSG00000005718.7 Tfap4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tfap4mm10_v2_chr16_-_4559720_4559747-0.903.4e-10Click!


Activity profile for motif Tfap4.

activity profile for motif Tfap4


Sorted Z-values histogram for motif Tfap4

Sorted Z-values for motif Tfap4



Network of associatons between targets according to the STRING database.



First level regulatory network of Tfap4

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_-_120202104 9.252 ENSMUST00000033198.5
 Crym
crystallin, mu
chr15_-_66812593 7.695 ENSMUST00000100572.3
 Sla
src-like adaptor
chr16_+_91269759 7.347 ENSMUST00000056882.5
 Olig1
oligodendrocyte transcription factor 1
chr6_-_136171722 6.073 ENSMUST00000053880.6
 Grin2b
glutamate receptor, ionotropic, NMDA2B (epsilon 2)
chr9_-_40346290 5.838 ENSMUST00000121357.1
 Gramd1b
GRAM domain containing 1B
chr2_+_170731807 5.720 ENSMUST00000029075.4
 Dok5
docking protein 5
chr4_+_119814495 5.527 ENSMUST00000106307.2
 Hivep3
human immunodeficiency virus type I enhancer binding protein 3
chr2_+_37516618 4.843 ENSMUST00000065441.6
 Gpr21
G protein-coupled receptor 21
chr13_+_54949388 4.791 ENSMUST00000026994.7
ENSMUST00000109994.2
 Unc5a

unc-5 homolog A (C. elegans)

chr4_+_48045144 4.481 ENSMUST00000030025.3
 Nr4a3
nuclear receptor subfamily 4, group A, member 3
chr8_-_115707778 4.432 ENSMUST00000109104.1
 Maf
avian musculoaponeurotic fibrosarcoma (v-maf) AS42 oncogene homolog
chr6_-_58907120 4.363 ENSMUST00000059539.3
 Nap1l5
nucleosome assembly protein 1-like 5
chr7_-_97417730 4.257 ENSMUST00000043077.7
 Thrsp
thyroid hormone responsive
chr3_+_90537242 4.013 ENSMUST00000098911.3
 S100a16
S100 calcium binding protein A16
chr8_+_66386292 3.988 ENSMUST00000039540.5
ENSMUST00000110253.2
 March1

membrane-associated ring finger (C3HC4) 1

chr13_+_29014399 3.436 ENSMUST00000146336.1
ENSMUST00000130109.1
 A330102I10Rik

RIKEN cDNA A330102I10 gene

chr15_-_102722150 3.212 ENSMUST00000023818.3
 Calcoco1
calcium binding and coiled coil domain 1
chr5_+_90772435 3.076 ENSMUST00000031320.6
 Pf4
platelet factor 4
chr10_-_102490418 3.035 ENSMUST00000020040.3
 Nts
neurotensin
chr15_-_71727815 3.035 ENSMUST00000022953.8
 Fam135b
family with sequence similarity 135, member B

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 119 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.9 9.3 GO:0070327 thyroid hormone transport(GO:0070327)
0.5 7.3 GO:0050966 detection of mechanical stimulus involved in sensory perception of pain(GO:0050966)
0.1 6.8 GO:0051592 response to calcium ion(GO:0051592)
0.5 5.7 GO:0051386 regulation of neurotrophin TRK receptor signaling pathway(GO:0051386)
0.1 5.5 GO:0035914 skeletal muscle cell differentiation(GO:0035914)
1.2 4.8 GO:0001920 negative regulation of receptor recycling(GO:0001920)
0.8 4.8 GO:0060158 phospholipase C-activating dopamine receptor signaling pathway(GO:0060158)
0.6 4.8 GO:0033564 anterior/posterior axon guidance(GO:0033564)
1.5 4.5 GO:0038095 positive regulation of mast cell cytokine production(GO:0032765) Fc-epsilon receptor signaling pathway(GO:0038095)
0.0 4.5 GO:0048709 oligodendrocyte differentiation(GO:0048709)
0.2 4.4 GO:0070306 lens fiber cell differentiation(GO:0070306)
0.0 4.4 GO:0030518 intracellular steroid hormone receptor signaling pathway(GO:0030518)
0.0 4.4 GO:0006334 nucleosome assembly(GO:0006334)
0.1 4.3 GO:0010866 regulation of triglyceride biosynthetic process(GO:0010866)
0.2 4.0 GO:0002495 antigen processing and presentation of peptide antigen via MHC class II(GO:0002495)
0.1 3.8 GO:0071625 vocalization behavior(GO:0071625)
0.1 3.3 GO:0060765 regulation of androgen receptor signaling pathway(GO:0060765)
0.6 3.1 GO:0045347 negative regulation of MHC class II biosynthetic process(GO:0045347) negative regulation of cytolysis(GO:0045918)
0.5 3.0 GO:0007021 tubulin complex assembly(GO:0007021)
0.7 2.9 GO:0034145 positive regulation of toll-like receptor 4 signaling pathway(GO:0034145)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 62 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.0 13.1 GO:0005768 endosome(GO:0005768)
0.0 6.8 GO:0005802 trans-Golgi network(GO:0005802)
0.6 6.1 GO:0043083 synaptic cleft(GO:0043083)
0.1 4.8 GO:0032809 neuronal cell body membrane(GO:0032809)
0.0 4.7 GO:0005667 transcription factor complex(GO:0005667)
0.0 4.3 GO:0000790 nuclear chromatin(GO:0000790)
0.1 4.0 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.0 3.8 GO:0043679 axon terminus(GO:0043679)
0.0 3.3 GO:0045211 postsynaptic membrane(GO:0045211)
0.3 3.1 GO:0031091 platelet alpha granule(GO:0031091)
1.0 3.0 GO:0097512 cardiac myofibril(GO:0097512)
0.1 2.9 GO:0005865 striated muscle thin filament(GO:0005865)
0.0 2.7 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.1 2.6 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.1 2.6 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.5 2.5 GO:0070820 tertiary granule(GO:0070820)
0.3 2.4 GO:0005883 neurofilament(GO:0005883)
0.1 2.4 GO:0005637 nuclear inner membrane(GO:0005637)
0.3 2.1 GO:0031315 extrinsic component of mitochondrial outer membrane(GO:0031315)
0.1 2.1 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 80 entries
Log-likelihood per target Total log-likelihoodTermDescription
1.2 9.3 GO:0070324 thyroid hormone binding(GO:0070324)
0.0 7.4 GO:0042803 protein homodimerization activity(GO:0042803)
0.1 7.0 GO:0005158 insulin receptor binding(GO:0005158)
0.6 6.1 GO:0031749 D2 dopamine receptor binding(GO:0031749)
0.2 6.1 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.3 5.2 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
1.6 4.8 GO:0001588 dopamine neurotransmitter receptor activity, coupled via Gs(GO:0001588)
0.8 4.8 GO:0005042 netrin receptor activity(GO:0005042)
0.6 4.8 GO:0001025 RNA polymerase III transcription factor binding(GO:0001025)
0.3 4.5 GO:0001223 transcription coactivator binding(GO:0001223)
0.1 4.1 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.2 4.0 GO:0042287 MHC protein binding(GO:0042287)
0.2 3.7 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 3.3 GO:0052689 carboxylic ester hydrolase activity(GO:0052689)
1.0 3.1 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
0.3 3.0 GO:0005212 structural constituent of eye lens(GO:0005212)
0.7 2.8 GO:0008332 low voltage-gated calcium channel activity(GO:0008332)
0.9 2.6 GO:0010698 acetyltransferase activator activity(GO:0010698)
0.0 2.6 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.3 2.5 GO:0019869 chloride channel inhibitor activity(GO:0019869)