Motif ID: Tfeb_Usf1_Srebf1_Usf2_Bhlhe41_Srebf2

Z-value: 1.124

Transcription factors associated with Tfeb_Usf1_Srebf1_Usf2_Bhlhe41_Srebf2:

Gene SymbolEntrez IDGene Name
Bhlhe41 ENSMUSG00000030256.5 Bhlhe41
Srebf1 ENSMUSG00000020538.9 Srebf1
Srebf2 ENSMUSG00000022463.7 Srebf2
Tfeb ENSMUSG00000023990.12 Tfeb
Usf1 ENSMUSG00000026641.7 Usf1
Usf2 ENSMUSG00000058239.7 Usf2

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
Tfebmm10_v2_chr17_+_47785720_477857390.508.6e-03Click!
Usf1mm10_v2_chr1_+_171411305_171411337-0.291.5e-01Click!
Srebf1mm10_v2_chr11_-_60210410_602104650.262.0e-01Click!
Srebf2mm10_v2_chr15_+_82147238_821472750.154.7e-01Click!
Usf2mm10_v2_chr7_-_30956742_30956803-0.048.4e-01Click!


Activity profile for motif Tfeb_Usf1_Srebf1_Usf2_Bhlhe41_Srebf2.

activity profile for motif Tfeb_Usf1_Srebf1_Usf2_Bhlhe41_Srebf2


Sorted Z-values histogram for motif Tfeb_Usf1_Srebf1_Usf2_Bhlhe41_Srebf2

Sorted Z-values for motif Tfeb_Usf1_Srebf1_Usf2_Bhlhe41_Srebf2



Network of associatons between targets according to the STRING database.



First level regulatory network of Tfeb_Usf1_Srebf1_Usf2_Bhlhe41_Srebf2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr3_-_89773221 5.448 ENSMUST00000038450.1
 4632404H12Rik
RIKEN cDNA 4632404H12 gene
chr17_-_66077022 4.671 ENSMUST00000150766.1
ENSMUST00000038116.5
 Ankrd12

ankyrin repeat domain 12

chr8_-_46294592 4.142 ENSMUST00000058636.7
 Helt
helt bHLH transcription factor
chr2_-_71546745 3.722 ENSMUST00000024159.6
 Dlx2
distal-less homeobox 2
chr16_-_45158566 3.530 ENSMUST00000181177.1
 Slc35a5
solute carrier family 35, member A5
chr16_-_45158650 3.512 ENSMUST00000023344.3
 Slc35a5
solute carrier family 35, member A5
chr16_-_45158624 3.145 ENSMUST00000180636.1
 Slc35a5
solute carrier family 35, member A5
chr16_-_45158183 3.093 ENSMUST00000114600.1
 Slc35a5
solute carrier family 35, member A5
chr6_+_90462562 3.073 ENSMUST00000032174.5
 Klf15
Kruppel-like factor 15
chr4_-_148038769 3.000 ENSMUST00000030879.5
ENSMUST00000137724.1
 Clcn6

chloride channel 6

chr4_-_34882919 2.951 ENSMUST00000098163.2
ENSMUST00000047950.5
 Zfp292

zinc finger protein 292

chr16_-_45158453 2.729 ENSMUST00000181750.1
 Slc35a5
solute carrier family 35, member A5
chr15_+_66577536 2.625 ENSMUST00000048188.8
 Phf20l1
PHD finger protein 20-like 1
chr8_+_13159135 2.600 ENSMUST00000033824.6
 Lamp1
lysosomal-associated membrane protein 1
chr12_-_84450944 2.453 ENSMUST00000085192.5
 Aldh6a1
aldehyde dehydrogenase family 6, subfamily A1
chr13_-_92131494 2.422 ENSMUST00000099326.3
ENSMUST00000146492.1
 Rasgrf2

RAS protein-specific guanine nucleotide-releasing factor 2

chrX_-_85776606 2.421 ENSMUST00000142152.1
ENSMUST00000156390.1
ENSMUST00000113978.2
 Gyk


glycerol kinase


chr4_+_127077374 2.407 ENSMUST00000046751.6
ENSMUST00000094713.3
 Zmym6

zinc finger, MYM-type 6

chr5_-_124425907 2.382 ENSMUST00000065263.5
 Sbno1
sno, strawberry notch homolog 1 (Drosophila)
chr15_-_3995708 2.284 ENSMUST00000046633.8
 AW549877
expressed sequence AW549877

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Showing 1 to 20 of 316 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 17.0 GO:0008643 carbohydrate transport(GO:0008643)
0.1 4.9 GO:0036465 synaptic vesicle recycling(GO:0036465)
1.6 4.7 GO:1901254 positive regulation of intracellular transport of viral material(GO:1901254)
0.3 4.2 GO:0097154 GABAergic neuron differentiation(GO:0097154)
1.0 4.0 GO:0035434 copper ion transmembrane transport(GO:0035434)
1.2 3.7 GO:0021893 cerebral cortex GABAergic interneuron fate commitment(GO:0021893)
0.1 3.7 GO:0015991 energy coupled proton transmembrane transport, against electrochemical gradient(GO:0015988) ATP hydrolysis coupled proton transport(GO:0015991) ATP hydrolysis coupled transmembrane transport(GO:0090662)
0.1 3.6 GO:0010738 regulation of protein kinase A signaling(GO:0010738)
0.9 3.5 GO:0016340 calcium-dependent cell-matrix adhesion(GO:0016340)
0.9 3.4 GO:0033540 fatty acid beta-oxidation using acyl-CoA oxidase(GO:0033540)
0.2 3.2 GO:0072010 renal filtration cell differentiation(GO:0061318) glomerular epithelium development(GO:0072010) glomerular visceral epithelial cell differentiation(GO:0072112) glomerular epithelial cell differentiation(GO:0072311)
0.0 3.1 GO:0070936 protein K48-linked ubiquitination(GO:0070936)
0.2 2.9 GO:0042759 long-chain fatty acid biosynthetic process(GO:0042759)
0.0 2.8 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.1 2.7 GO:0071786 endoplasmic reticulum tubular network organization(GO:0071786)
0.9 2.6 GO:0043323 positive regulation of natural killer cell degranulation(GO:0043323)
0.4 2.6 GO:0045346 regulation of MHC class II biosynthetic process(GO:0045346)
0.8 2.5 GO:0019482 beta-alanine metabolic process(GO:0019482)
0.0 2.5 GO:0043473 pigmentation(GO:0043473)
0.1 2.4 GO:2000310 regulation of N-methyl-D-aspartate selective glutamate receptor activity(GO:2000310)

Gene overrepresentation in cellular_component category:

Showing 1 to 20 of 144 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.1 15.5 GO:0000139 Golgi membrane(GO:0000139)
0.0 5.0 GO:0005777 peroxisome(GO:0005777) microbody(GO:0042579)
1.6 4.7 GO:0042025 viral replication complex(GO:0019034) host cell nucleus(GO:0042025) host cell nuclear part(GO:0044094)
1.0 4.0 GO:0031084 BLOC-2 complex(GO:0031084)
0.4 3.6 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.2 3.5 GO:0043196 varicosity(GO:0043196)
0.1 3.5 GO:0005905 clathrin-coated pit(GO:0005905)
0.0 3.3 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.4 2.9 GO:0071782 endoplasmic reticulum tubular network(GO:0071782)
0.4 2.8 GO:0033263 CORVET complex(GO:0033263)
0.9 2.6 GO:0044194 cytolytic granule(GO:0044194)
0.0 2.6 GO:0055037 recycling endosome(GO:0055037)
0.1 2.4 GO:0035861 site of double-strand break(GO:0035861)
0.0 2.4 GO:0031526 brush border membrane(GO:0031526)
0.4 2.2 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.2 2.2 GO:0071203 WASH complex(GO:0071203)
0.0 2.2 GO:0031225 anchored component of membrane(GO:0031225)
0.2 2.1 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.3 1.8 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.6 1.7 GO:0005927 muscle tendon junction(GO:0005927)

Gene overrepresentation in molecular_function category:

Showing 1 to 20 of 221 entries
Log-likelihood per target Total log-likelihoodTermDescription
0.7 15.9 GO:0005351 sugar:proton symporter activity(GO:0005351)
0.0 6.2 GO:0005096 GTPase activator activity(GO:0005096)
0.0 5.7 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.0 5.2 GO:0035091 phosphatidylinositol binding(GO:0035091)
0.0 5.1 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.2 4.7 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.9 4.6 GO:1990825 sequence-specific mRNA binding(GO:1990825)
0.0 4.4 GO:0008565 protein transporter activity(GO:0008565)
0.1 4.3 GO:0003727 single-stranded RNA binding(GO:0003727)
0.2 4.1 GO:0034236 protein kinase A catalytic subunit binding(GO:0034236)
0.1 4.1 GO:0017022 myosin binding(GO:0017022)
0.1 3.8 GO:0070273 phosphatidylinositol-4-phosphate binding(GO:0070273)
0.6 3.4 GO:0016401 palmitoyl-CoA oxidase activity(GO:0016401)
0.2 3.1 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.1 2.7 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.1 2.5 GO:0004029 aldehyde dehydrogenase (NAD) activity(GO:0004029)
0.8 2.4 GO:0004008 copper-exporting ATPase activity(GO:0004008) copper-transporting ATPase activity(GO:0043682)
0.0 2.3 GO:0005249 voltage-gated potassium channel activity(GO:0005249)
0.0 2.3 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.3 2.2 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)